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1 how the toll of defense can be generated and ameliorated.
2 rage was reduced, and skeletal phenotype was ameliorated.
5 dation of protein tyrosine phosphatases, and ameliorated activation of peroxisome proliferator-activa
8 ucts with isogeneic cells to be effective in ameliorating adverse effects of hormone deficiency, incl
10 nction can lead to therapeutic advances that ameliorate age-related neurodegenerative pathologies.
12 be tested if increasing CREB expression also ameliorates age-related behavioral and biophysical defic
13 dothelial growth factor receptor 3 (VEGFR-3) ameliorated aGVHD and improved survival in murine models
15 indings demonstrated that Lyn overexpression ameliorated airway mucus hypersecretion by down-regulati
17 hat post-AIT sera with IgE-blocking activity ameliorate allergic airway inflammation in a human/mouse
18 y T cells, decreased lung TH2 responses, and ameliorated allergic airway inflammation and hyperrespon
20 dings by demonstrating that TREM2 deficiency ameliorates amyloid pathology early, but exacerbates it
21 hypoxia provides novel druggable targets to ameliorate and, perhaps, reverse the EC plexiform phenot
23 otinib (MMB) demonstrated that MMB treatment ameliorated anemia, which was unexpected for a JAK1/2 in
27 transfer of WT bone marrow progenitor cells ameliorates asthma pathology in Sema3e(-/-) recipients.
28 utions to global biogeochemical cycling, and ameliorate atmospheric accumulation of carbon dioxide by
30 -expressing and IL-35-expressing B cells and ameliorates autoimmune uveitis in mice by antagonizing p
33 immunizations targeting alpha-syn partially ameliorate behavioral deficits and alpha-syn accumulatio
36 activated Stat3, specifically in beta-cells ameliorated beta-cell EMT and beta-cell loss and prevent
37 by heat shock transcription factor 1 (HSF1) ameliorates biochemical and neurobiological defects caus
40 These results indicate that glycyrrhizin ameliorates bleomycin-induced dermal fibrosis through th
41 tion to suppress excessive immune responses, ameliorated blood-brain barrier damage after cerebral is
42 eliorate the cellular stress and indeed 4PBA ameliorated bone mineralization in larvae and skeletal d
43 icate that specifically targeting pSMAD3 can ameliorate both the direct and indirect fibroproliferati
46 types reminiscent of aspects of human mania, ameliorated by antimania drugs lithium and valproate.
47 CD4(+) T cells, with the induction of cGVHD ameliorated by BCL6 deficiency and completely suppressed
48 els of only the long isoform, which could be ameliorated by emetine, suggesting that the mutation ind
52 OCR) and ATP production by mitochondria were ameliorated by NTZ in real time by virtue of its mild un
53 lop spontaneous pulmonary fibrosis, which is ameliorated by restoration of lung chitinase activity by
54 me, the clinical manifestations of which are ameliorated by strategies that block IL-1beta or its rec
55 ith high morbidity and mortality that can be ameliorated by surgical valve repair or replacement.
56 that results from TGF-beta1 stimulation was ameliorated by the allosteric modifier of Sirt1 deacetyl
57 nsequences of c-Fos expression are partially ameliorated by the anti-inflammatory drug sulindac and l
58 oxicity and localised Nrf2-luc response were ameliorated by the cytochrome P450 inhibitor aminobenzot
60 I imbalance, and histological damage are all ameliorated by treatment with NitroSynapsin, a new dual-
61 r, in some patients, hypothyroidism has been ameliorated by unusually large amounts of dietary I(-).
64 tailed in Ip3r2-deficient mice, resulting in ameliorated calcium overload in neurons and astrocytes.
66 a VDR reporter gene assay, and significantly ameliorated cardiac hypertrophy in cell culture studies
67 inistration of Act-A-iTreg cell-modified DCs ameliorated cardinal asthma manifestations in preventive
70 Thus, targeting inflammasome components may ameliorate chronic inflammation and various other age-as
71 eceptor (S1PR) modulator fingolimod (FTY720) ameliorated chronic progressive experimental autoimmune
80 ctions, and might also bear the potential to ameliorate conditions like depression and aging, where d
81 s have often targeted downstream pathways to ameliorate consequences of protein dysfunction; however,
82 sult in a beneficial therapeutic strategy to ameliorate contractile dysfunction associated with sepsi
84 ht a trophic pathway that can be targeted to ameliorate dendrite loss in pathological conditions.
85 rocesses, with cocaine consumption partially ameliorating dependence-related insensitivity to reinfor
87 genetically inactivating CB1Rs in the RPTCs ameliorated diabetes-induced renal structural and functi
88 hepatic glucose production (HGP) effectively ameliorates diabetes and can be exploited for its treatm
90 nt of F-75 with unfortified rice porridge to ameliorate diarrhea was associated with a higher risk of
91 ctivities represents a promising approach to ameliorate diet-induced obesity and leptin resistance.
92 Overall, targeted activation of Hh signaling ameliorates diet-induced obesity and may be explored for
93 current study suggests that blocking of CB1 ameliorates Diet-Induced Obesity and metabolic disorder
94 d forms of agrin (mAgrin) have been shown to ameliorate disease pathology in a laminin-alpha2 knockou
95 ansion of GM-CSF-producing Th17 cells led to ameliorated disease in mice deficient for IL-1R1 specifi
96 cking antibody to CLEC12A that significantly ameliorated disease scores in MOG35-55-induced progressi
98 nalysis, we discover that nicotinamide (NAM) ameliorated disease-related phenotypes by inhibiting dru
99 nclude optimizing metrics to assess quality, ameliorating disparities, enhancing education and resear
104 d, it has been reported that vitamin E (VtE) ameliorates DN in rat by activating DGK, and we recently
107 dings suggest that ADHD medications may help ameliorate educationally relevant outcomes in individual
108 ding light on the mechanisms involved in the ameliorating effects of AD symptoms observed in AD/TTR(+
110 Finally, we show that ablation of TRIP-Br2 ameliorates ER stress-induced inhibition on lipolysis, f
114 on of the miR291b --> Tollip pathway by HA35 ameliorated ethanol-induced sensitization of TLR4 signal
115 nhibition of GOT1 with (aminooxy)acetic acid ameliorated experimental autoimmune encephalomyelitis in
116 crophage differentiation within the lung may ameliorate fibrosis without the adverse consequences ass
124 ivo delivery of Cas9-guide RNA complexes can ameliorate hearing loss in a mouse model of human geneti
125 T. arjuna compound, arjunolic acid (AA), in ameliorating hemodynamic load-induced cardiac fibrosis a
126 o neutralization of IL-17A in humanized mice ameliorated hepatic and intestinal damage and reduced mo
128 Blockade of CD8 and L-selectin, but not CD4, ameliorated hepatocellular injury, confirming that CD8(+
129 n of Fas improves mitochondrial function and ameliorates high-fat-diet-induced hepatic steatosis, glu
131 Lastly, we observed that S1P administration ameliorated hypotension and microvascular leakage follow
137 ein is effective in reducing viral titre and ameliorating infection in rodents and neonatal lambs.
138 tion of inflammation-associated angiogenesis ameliorates inflammatory diseases by reducing the recrui
140 -3'-oxime improved cardiac contractility and ameliorated intraventricular conduction defects in LmnaH
141 ally observed in IRI, we speculated that aPC ameliorates IRI by inhibiting inflammasome activation.
145 Our data show that anti-VEGFR-3 treatment ameliorates lethal aGVHD and identifies the lymphatic va
147 get; improved fatty acid beta-oxidation; and ameliorated liver steatosis and glucose intolerance.
148 nhibition of NIK activity by chemical probes ameliorates liver inflammation and injury is largely unk
152 rophages after their recruitment to the lung ameliorated lung fibrosis, whereas tissue-resident alveo
154 ly treatment with the hypotonic 2-PMPA enema ameliorated macroscopic and microscopic symptoms of IBD
157 nistration of D-4F or E06 to rats profoundly ameliorated mechanical hyperalgesia and inflammation in
158 eminence (MGE) into adult mouse spinal cord ameliorates mechanical and thermal hypersensitivity in p
159 16 showed memory-enhancing properties and it ameliorated memory deficits induced by scopolamine.
166 Genetic elevation of MeCP2 T158M expression ameliorated multiple RTT-like features, including motor
171 e cerebral Abeta levels, whether it also can ameliorate neural circuit and memory impairments remains
172 ochondrial function as a potential target to ameliorate neurogenesis-defects in the aging hippocampus
173 ify alpha-SYN and DA as potential targets to ameliorate neurogenic defects in the aging and diseased
174 ington's disease, genetic knockdown of PIP4K ameliorated neuronal dysfunction and degeneration as ass
178 kely explain why B cell depletion can either ameliorate or exacerbate inflammatory diseases; however,
179 and testing of therapeutic interventions to ameliorate or potentially reverse prostatic enlargement.
180 e studies should assess whether therapies to ameliorate pain and inflammation in RA restores autonomi
182 underlying the ability of these platforms to ameliorate passive and active porphyrin delivery to tumo
183 derstanding of how DMF may act clinically to ameliorate pathological processes in neurodegenerative d
184 geting the cGAS-STING-LCD-NLRP3 pathway will ameliorate pathology in inflammatory conditions that are
185 lood glucose levels, delayed diabetes onset, ameliorated pathology scores in pancreas, and down-regul
186 t abundant PDH kinase isoforms (e.g., PDK3), ameliorating PDH activity and mitochondrial metabolism a
187 kdown improves endocytosis in SMA models and ameliorates pharmacologically induced endocytosis defect
188 ia and kidney histological changes, but also ameliorated podocyte and glomeruli injury in diabetic mi
190 thelial cells (podocytes) indicated that VtE ameliorates podocyte pathology and prevents podocyte los
191 presence of a novel extendable loop may help ameliorate poor packing geometry of the rigid main parti
192 elevate circulating S1P levels, nor does it ameliorate post-MI dysfunction, as in wild-type mice.
193 asteride (10-100 mg/kg, IP) dose-dependently ameliorated PPI deficits, hyperactivity, and risk-taking
196 ver, the mechanisms by which glucocorticoids ameliorate proteinuria and glomerular disease are not we
198 athway activation as a potential approach to ameliorate regenerative defects in WNT10A patients.
201 ate the inflammatory reflex to significantly ameliorate rheumatoid arthritis and inflammatory bowel d
202 Intravitreal injection of IL-4 and IL-10 ameliorated RPE toxicity that was induced by NaIO3Ex viv
203 mouse model of salivary gland exocrinopathy ameliorated salivary gland inflammation and enhanced car
206 of STAT3, or its pharmacological inhibition, ameliorate skin fibrosis in experimental mouse models.
209 ntibiotics or a single antibiotic vancomycin ameliorate SLE-like disease in MRL/lpr mice by changing
210 combined with SMN2 splicing modification to ameliorate SMA and demonstrates the promise of combinato
211 Importantly, NCALD knockdown effectively ameliorates SMA-associated pathological defects across s
213 ould provide more targeted therapies to help ameliorate social deficits in autism spectrum disorder.
214 either early or advanced stages of diabetes ameliorated STAT activity and resulted in reduced serum
216 ive T cells and helps to understand how MSCs ameliorate symptoms in lupus-prone MRL.Fas(lpr) mice.
218 this inhibitor reduces tau and APP cleavage, ameliorates synapse loss and augments long-term potentia
219 e brains decreases synaptic Abeta levels and ameliorates synapse loss, thus rescuing cognitive impair
220 d that antibiotics given after disease onset ameliorated systemic autoimmunity and kidney histopathol
221 an be envisioned as a therapeutic target for ameliorating Tat-mediated neuroinflammation.SIGNIFICANCE
222 ould simultaneously restore MT stability and ameliorate tau pathology in AD and related tauopathies.
223 how loss of D2-family dopamine receptors can ameliorate tau toxicity, we screened a collection of C.
224 ly that loss of D2-family dopamine receptors ameliorated tauopathy in multiple models including a Cae
225 ivo, as genetic reduction in RanBP9 not only ameliorates tauopathy in Tau-P301S mice but also rescues
226 used on enhancing supportive parenting could ameliorate the association between exposure to poverty a
227 cal chaperones, 4PBA and TUDCA, were used to ameliorate the cellular stress and indeed 4PBA ameliorat
230 ia, population-based solutions are needed to ameliorate the deleterious effects of neighborhood disad
231 7 in Treg-specific Il27ra(-/-) mice fails to ameliorate the disease even in the presence of IL-27-res
233 ha2delta-1 receptor, and thus may reverse or ameliorate the effects of AIE on hippocampal function.
234 Altogether cilostazol showed potential to ameliorate the gliovascular damage and working memory im
237 lipid, sphingosine-1-phosphate (S1P), could ameliorate the microvascular leakage following alcohol i
238 dence that positive maternal parenting might ameliorate the negative effects of socioeconomic disadva
239 ent treatment options have not been shown to ameliorate the neurological pathology observed in the mo
240 BET inhibitors (GSK151 and JQ1) were able to ameliorate the progression of inflammation in EAU and in
242 he early posttransplant period could help to ameliorate the severity of delayed graft function and co
243 l biomarkers or therapeutics that could help ameliorate the toll that infections take during the trea
245 Is into germ-free or antibiotic-treated mice ameliorated the antitumor effects of PD-1 blockade, wher
246 Loss of the C. elegans DDC gene, bas-1, ameliorated the behavioral deficits of tau transgenic wo
251 PEX5 transgene exacerbated pex26 defects and ameliorated the defects of only a subset of pex6 alleles
252 the overexpression of TrkB in the mouse PFC ameliorated the depressive-like phenotype of TG2-overexp
253 ve stress (H2O2 or menadione), significantly ameliorated the H2O2-dependent increase in matrix kerati
254 nt-induced arthritis rat model, CHMFL-BTK-11 ameliorated the inflammatory response through blockage o
256 ivity of PRMT5 with this substrate, but also ameliorated the low activity of PRMT5 at low substrate c
257 ed AKT and ERK activation, respectively, and ameliorated the observed alterations in neuronal differe
259 free fatty acid (FFA) levels (P < 0.001) and ameliorated the oxidative damage by reducing malondialde
260 h the cholesterol-lowering drug atorvastatin ameliorated the pathology, implicating statins as potent
261 Y 3-36 increased 5-HT turnover in the LH and ameliorated the ppDIO-induced sleep disturbances, sugges
265 stration of GDP and ferrous sulphate (FeSO4) ameliorated the turpentine-induced AI in mice (indicated
267 omain TF Ventral veins lacking (Vvl) largely ameliorates the airway morphogenesis defects of grh muta
269 histone deacetylase inhibitor (HDACi) AR-42, ameliorates the deficiency of adult neurogenesis in the
270 , we demonstrated that the knockout strategy ameliorates the dilated cardiomyopathy phenotype in vitr
271 t DNMT1-specific inhibition in arterial wall ameliorates the disturbed flow-induced atherosclerosis t
273 diated GT for patients with OS significantly ameliorates the immunodeficiency, even in an inflammator
275 The lower barrier to access of makerspaces ameliorates the otherwise poor accessibility and scalabi
276 reduces muscle performance at baseline, but ameliorates the progression of dystrophic pathology.
277 ling from endosomes or reducing BMP activity ameliorates the severity of HD pathology and improves vi
278 uppress heme catabolism may be beneficial in ameliorating the anemia and ineffective erythropoiesis i
279 benefits of noise-mediated plasticity while ameliorating the potentially detrimental effects of stoc
281 ulture represents a strategic alternative to ameliorate these drivers of pollinator decline while sup
288 e propose an approach, called XP-BLUP, which ameliorates this ethnic disparity by combining trans-eth
294 an improve microvascular barrier function to ameliorate trauma-induced hypotension, offering a novel
295 sociated maladaptive responses, which can be ameliorated upon receptor antagonism even during injury
296 This reduced tissue colonization, along with ameliorated weight loss and prolonged survival, depends
297 d-type mice undergoing iAKI is significantly ameliorated when exposed to luteolin, a recently discove
299 ly increased rate of apoptosis that could be ameliorated with cysteamine, the human cystine depleting
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