ライフサイエンスコーパス: ameliorate disease

1 helper cells should lower AChR Ab levels and ameliorate disease.

2 herefore, immune modulation has potential to ameliorate disease.

3 herefore, altering a person's microbiota may ameliorate disease.

4 iled to restore normal levels of Tregs or to ameliorate disease.

5 The net effect of DC deletion was to ameliorate disease.

6 s may rebalance Treg/T effector activity and ameliorate disease.

7 cal step in which to intervene to prevent or ameliorate disease.

8 ctive CRAC channel inhibitor after EAE onset ameliorated disease.

9 thality, whereas targeted depletion of MDSCs ameliorated disease.

10 ice to neonates before aeroallergen exposure ameliorated disease.

11 d nephritis, whereas ablating IFN-I activity ameliorated disease.

12 s, and IRF5 deficiency in lupus mouse models ameliorates disease.

13 D1 mice restores dysfunctional microglia and ameliorates disease.

14 s restores the cerebral microvasculature and ameliorates disease.

15 ore, administration of exogenous adiponectin ameliorates disease.

16 treatment of SLE mice with BAFF antagonists ameliorates disease.

17 ent of MS, correcting BBB function and hence ameliorating disease.

18 nisms that benefit the host by preventing or ameliorating disease.

19 nding disease pathogenesis and as a means of ameliorating disease?

20 ponsible for such accumulations is likely to ameliorate disease, a therapeutic strategy has been deve

21 prevent and treat nutrient deficiencies and ameliorate disease activity in individuals with inflamma

22 ) T cells beneficially in EAE have failed to ameliorate disease activity in multiple sclerosis, and s

23 own that the pregnancy hormone, estriol, can ameliorate disease and can cause an immune shift.

24 d infection with a high dose (50 mug) of CpG ameliorated disease and lowered parasite burden.

25 cologic activation of PGC1alpha successfully ameliorated disease and restored mitochondrial integrity

26 suppresses each distinct phase of pathology, ameliorate disease, and prevent disease progression.

27 F suppress each distinct phase of pathology, ameliorate disease, and prevent disease progression.

28 ss-switched and hypermutated autoantibodies, ameliorated disease, and extended survival in lupus MRL/

29 ies such as anti-TNF or anti-CD20 antibodies ameliorate disease, but at the cost of some increase in

30 iency, suggesting that therapies designed to ameliorate disease by inhibition of apoptosis are more l

31 y specific for the TNF family member, CD154, ameliorates disease by reducing levels of self-reactive

32 Those patients had an ameliorated disease course with longer survival but stil

33 yelitis, which correlated with substantially ameliorated disease course.

34 In contrast, TLR7-deficient mice had ameliorated disease, decreased lymphocyte activation, an

35 Treatment with RANK-Fc significantly ameliorated disease development and attenuated bone dest

36 ase of EAE in mice resulted in significantly ameliorated disease development and progression.

37 Factors in young blood have the potential to ameliorate disease in a model of AD.

38 in a Th2-dominated susceptible mouse and can ameliorate disease in a Th1-dominated resistant strain,

39 selectively inhibit endosomal TLR signaling, ameliorate disease in CIA, and suppress inflammatory cyt

40 he adhesion molecule VLA-4 has been shown to ameliorate disease in human multiple sclerosis patients

41 tion, we investigated whether CEP-1347 could ameliorate disease in laboratory models of HAND.

42 hat affect DNA methylation can exacerbate or ameliorate disease in this transgenic murine lupus model

43 itro and/or to passively protect against, or ameliorate, disease in vivo.

44 ansion of GM-CSF-producing Th17 cells led to ameliorated disease in mice deficient for IL-1R1 specifi

45 The ameliorated disease in the absence of ADAP was not due t

46 Importantly, the absence of MyD88 in T cells ameliorated disease in the experimental autoimmune encep

47 optosis through TNFalpha or RIPK1 inhibition ameliorated disease in the virally triggered IBD model.

48 by the helminth parasite Fasciola hepatica, ameliorated disease in two different murine models of au

49 asal administration of CD3-specific antibody ameliorates disease in a progressive animal model of mul

50 Treatment with melatonin ameliorates disease in an experimental model of multiple

51 Previous work has shown that Bz-423 ameliorates disease in animal models of systemic lupus e

52 type T cells into RAG-1(-/-) mice results in ameliorated disease levels.

53 7b(-/-) mice with the LXR agonist, T0901317, ameliorated disease manifestations despite significant c

54 Treatment with an anti-B7RP-1 Ab ameliorates disease manifestations and leads to a decrea

55 on and was no more effective than placebo in ameliorating disease manifestations.

56 de of the OX40 (CD134) costimulatory pathway ameliorated disease mediated by both memory and effector

57 y as prophylaxis or treatment to effectively ameliorate disease or reduce disease severity and fatali

58 de of cPLA(2)alpha was highly efficacious in ameliorating disease pathogenesis during the effector ph

59 d forms of agrin (mAgrin) have been shown to ameliorate disease pathology in a laminin-alpha2 knockou

60 l use for the treatment of AD, cytokines can ameliorate disease pathology in certain experimental mod

61 macological strategies with the potential to ameliorate disease pathology to a clinically significant

62 Conversely, normal glia can ameliorate disease phenotype in transgenic HD mice, as s

63 igand (FASL)-dependent FAS pathway and could ameliorate disease phenotypes in fibrillin-1 mutated sys

64 To determine whether an FTI would ameliorate disease phenotypes in vivo, we created gene-t

65 letion of PTEN boosted protein synthesis and ameliorated disease phenotypes in mutant neurons.

66 Farnesyltransferase inhibitors have ameliorated disease phenotypes in preclinical studies.

67 uclear shape abnormalities in HGPS cells and ameliorates disease phenotypes in mice harboring a knock

68 vement of SHED-mediated T-cell apoptosis and ameliorating disease phenotypes in dextran sodium sulfat

69 odifiable environmental risk factor that may ameliorate disease progression in patients with NAFLD.

70 to influence biological processes thought to ameliorate disease progression.

71 treatment of adults was not curative but did ameliorate disease progression.

72 Probiotics and omega-3 fatty acids may ameliorate disease progression.

73 ection and targeted intervention to delay or ameliorate disease progression.

74 matory stimuli, the conjugate may be able to ameliorate disease progression.

75 l autoimmune encephalomyelitis (R-EAE) would ameliorate disease progression.

76 myelitis virus-induced demyelinating disease ameliorated disease progression for 80 days, reduced imm

77 harmacologic targeting of GLS1 in this model ameliorated disease progression.

78 t of SLE mice with a BLyS protein antagonist ameliorates disease progression and enhances survival.

79 murine model, infusion of regulatory T cells ameliorates disease progression.

80 n to develop effective therapeutics that can ameliorate disease-related complications and lead to bet

81 nalysis, we discover that nicotinamide (NAM) ameliorated disease-related phenotypes by inhibiting dru

82 cking antibody to CLEC12A that significantly ameliorated disease scores in MOG35-55-induced progressi

83 ime of uveitogenic immunization reproducibly ameliorated disease scores.

84 eagents that neutralize IL-17A significantly ameliorate disease severity in several mouse models of h

85 host responses to arenavirus infection could ameliorate disease severity.

86 l, Smad2 deficiency in T cells significantly ameliorated disease severity and reduced generation of T

87 ular administration of sCD59-APT542 markedly ameliorated disease severity in CD59a(-/-) mice, knee sw

88 In addition to ameliorated disease severity, MDSC-treated EAMG mice sho

89 ase-coupled fixed spleen cells significantly ameliorated disease severity, suggesting that this prote

90 The 3 highest doses (20, 80, and 320 microg) ameliorated disease severity, whereas the lowest dose (5

91 f TGF-beta2 during the effector phase of EAE ameliorated disease severity.

92 gest the importance of Treg-derived IL-10 in ameliorating disease severity and in modulating both the

93 tion may not be therapeutically effective at ameliorating disease severity.

94 may represent a novel therapeutic concept to ameliorate disease state in PH.

95 nduce antigen-specific immune responses that ameliorate disease states as diverse as malignancy, infe

96 30,000, but considering such treatments only ameliorate disease symptoms they seem relatively expensi

97 they attenuate the inflammatory response and ameliorate disease symptoms.

98 phalomyelitis is sufficient to significantly ameliorate disease symptoms.

99 This treatment can reduce virus load and ameliorate disease symptoms.

100 andemic A/California/04/2009 (CA04) H1N1 IAV ameliorated disease symptoms and resulted in the restora

101 Vaccination also ameliorated disease symptoms when infection was not prev

102 y interallelic trans suppression is known to ameliorate disease, there is reason to be optimistic tha

103 Yet, although Tlr7 deficiency ameliorated disease, Tlr9 deficiency exacerbated it.

104 tion represents a long-held strategy towards ameliorating disease via intestinal microbial community

105 lockade of complement cascade at the C5 step ameliorates disease, we evaluated the effect of administ

106 th rabbit anti-TNF-alpha serum significantly ameliorated disease when given during the afferent stage

107 that, in recombinant form, has been shown to ameliorate disease, whereas laminin alpha1, another dise

108 therapeutic agent to a site of pathology to ameliorate disease while limiting exposure at undesired