ライフサイエンスコーパス: amelioration

1 ifepristone prevented stress-induced disease amelioration.

2 nd suggest non-pharmacological means for its amelioration.

3 se and propose potential solutions for their amelioration.

4 of mitochondria in energy supply and stress amelioration.

5 and, when inhibited, which result in disease amelioration.

6 n impacts both cell types leading to disease amelioration.

7 feron-gamma and TNF, which lagged behind the amelioration.

8 n of either IL-17A or IL-22 leads to disease amelioration.

9 ness of RYGB for weight loss and comorbidity amelioration.

10 r oceanic reorganization with global climate amelioration.

11 before dysfunction occurs and to monitor its amelioration after diagnosis and treatment.

12 B allows to obtain an effective GERD symptom amelioration and a reduction in acid exposure.

13 h precipitation are synonymous with climatic amelioration and cold and wet conditions are combined in

14 gnificant biochemical impact with phenotypic amelioration and extension in lifespan.

15 merges has far-reaching implications for the amelioration and/or prevention of developmental language

16 umatic brain injury (TBI) is the prevention, amelioration, and treatment of secondary neuronal dysfun

17 Multiple transcripts associated with stress amelioration are preferentially translated through uORF-

18 Temporary environmental amelioration arising from such fluctuations could either

19 T cells was necessary for DHEA-mediated EAE amelioration, as well as for direct downregulation of Th

20 The clinical response was correlated with amelioration biologic markers such as cytokine productio

21 emia-reperfusion and the impact of ER stress amelioration by a small molecule chaperon 4-phenylbutyri

22 nduction of depressive-like behavior and its amelioration by environmental enrichment in mice.

23 etabolite transport, reactive oxygen species amelioration, chaperone activity, and ribosome biogenesi

24 The extent of neglect amelioration correlated with activation gain in the righ

25 The paquinimod-induced amelioration correlated with reduced priming of antigen-

26 nities in Antarctica will respond to climate amelioration directly and indirectly through changes in

27 months (P < 0.001); 36 months (P < 0.001)], amelioration for life quality [QoL scores improvement (P

28 m of garden bird food, coupled with climatic amelioration, has enabled a successful new wintering pop

29 sothelial to fibroblastic transition and its amelioration in caspase-1 knockout mice.

30 These changes facilitate amelioration in cognitive function.

31 ore represent a promising avenue for disease amelioration in HD.

32 The polyphenolic reduction and clarity amelioration in mixed juice of berry and pomegranate was

33 This finding helps understand better the amelioration in selectivity that temperature modulation

34 No significant amelioration in symptoms was observed after sham stimula

35 n the upper limbs and trunk with more-modest amelioration in the lower limbs was observed in all pati

36 Dramatic and significant neurological amelioration in the upper limbs and trunk with more-mode

37 er suggest a cell-based strategy for disease amelioration in this disorder.

38 utoimmune regulator, displayed a significant amelioration in thymic epithelial compartment and an imp

39 Climate amelioration is likely to allow a greater influx of non-

40 verse neuronal hypertrophy, resulting in the amelioration of a subset of PTEN-associated abnormal beh

41 CX3CL1 in regulating the microglia-mediated amelioration of Abeta pathology, as well as provide insi

42 This amelioration of Abeta toxicity is associated with a redu

43 d cardiac function and dimensions as well as amelioration of abnormal cardiac beta-adrenergic recepto

44 te the M2 macrophage phenotype, resulting in amelioration of acid-induced lung injury.

45 novel techniques that promote the concurrent amelioration of acidic waste waters and selective recove

46 utively active form of HIF-1alpha results in amelioration of acrylamide-induced axonal degeneration i

47 1 inducer cobalt protoporphyrin demonstrated amelioration of active colitis.

48 ing to cognitive enhancement and possibly to amelioration of AD pathologic findings.

49 Amelioration of Adipo-IR by pioglitazone is closely rela

50 its target gene expression, concurrent with amelioration of age-associated metabolic dysfunction at

51 The amelioration of age-associated phenotypes by epigenetic

52 The longevity phenotype is associated with amelioration of age-related gut pathology and functional

53 prove, new directions for the prevention and amelioration of AKI will emerge.

54 This included significant amelioration of all the ingenuity pathway analysis noted

55 ion by helminth parasites is associated with amelioration of allergic reactivity, but mechanistic ins

56 ies TRPA1 as a bona fide drug target for the amelioration of alpha-DC stress, which represents a viab

57 ted to explore if BPOZ-2 participates in the amelioration of alpha-syn in vivo in basal ganglia.

58 z-2 gene delivery could have prospect in the amelioration of alpha-synucleinopathy in PD and other Le

59 e models via potentiation of BDNF levels and amelioration of alterations in neurotrophin signaling pa

60 sent novel pharmacologic lead agents for the amelioration of Alzheimer disease.

61 of SIRT1 might provide opportunities for the amelioration of Alzheimer's-disease-type neuropathology

62 n hAPP and HMGR protein contents and lead to amelioration of amyloid pathology.

63 se and prevented apoptosis, concomitant with amelioration of Ang-induced cardiac hypertrophy, diastol

64 nophils, normalization of liver enzymes, and amelioration of any clinical symptoms.

65 t ventricular function, vascularization, and amelioration of apoptosis and hypertrophy.

66 l viability, preservation of ATP levels, and amelioration of apoptosis.

67 This amelioration of arthritis involves a reduction in CIA mo

68 e administration of L-kynurenine resulted in amelioration of arthritis.

69 ncluding reduced plasma triglyceride levels, amelioration of atherosclerosis and increased insulin se

70 lood glucose levels that correlated with the amelioration of atherosclerosis.

71 died in the context of induced tolerance and amelioration of atherosclerotic symptoms.

72 gamma and its transactivator Tbx21/Tbet, and amelioration of autoimmune diabetes.

73 These data indicate that HSCT-mediated amelioration of autoimmune disease involves renewal of t

74 fficking poses an attractive opportunity for amelioration of autoimmune diseases such as multiple scl

75 atty acids candidates for the prevention and amelioration of autoimmune diseases.

76 xp3+ Treg-mediated suppression that leads to amelioration of autoimmune responses.

77 in an MCP-1-dependent manner and subsequent amelioration of autoimmunity.

78 orny bamboo is a successful practice for the amelioration of badland soils.

79 ase K-resistant fraction of alpha-synuclein, amelioration of behavioral aberrations and protection fr

80 tantly with a reduction in lesion volume and amelioration of behavioral deficits in aged transgenic m

81 Nevertheless, no amelioration of behavioral deficits was seen.

82 s after a 7-d VLCD, was primarily due to the amelioration of beta cell function, whereas no contribut

83 l of Alzheimer's disease (AD) resulted in an amelioration of beta-amyloid (Abeta)-induced synaptic de

84 ); Cpeb1(-/-) double-knockout mice displayed amelioration of biochemical, morphological, electrophysi

85 sult in the development of approaches to the amelioration of blinding eye diseases associated with vi

86 nhibitor (6-bromoindirubin-3'-oxime BIO) for amelioration of bone destruction in a murine model of MB

87 In conclusion, the amelioration of bradykinesia by dopaminergic medication

88 s a potential new therapy for prevention and amelioration of C. difficile disease.

89 also replenished the mucus layer, leading to amelioration of C. rodentium- and DBZ-induced colitis in

90 levels of NR2A- and NR2B-containing NMDARs, amelioration of Ca(2+) overload required the inhibition

91 The amelioration of carotid artery stiffness by wheel runnin

92 wild-type mice (p < 0.0001), and significant amelioration of cell loss by BDNF (p < 0.001).

93 Amelioration of cerebrovascular reactivity or white matt

94 UDCA modulates ADAM17 activity, resulting in amelioration of cholestasis in a murine model of bile du

95 2 in IL-10(-/-) mice resulted in significant amelioration of chronic colitis, indicating that NOD2 si

96 Sex-specific amelioration of chronic neuroinflammation rescues the br

97 reduction of the insulin pathway also led to amelioration of circadian and memory defects.

98 ng infection with A/Cal, consistent with its amelioration of clinical disease.

99 We show that reduction of FLAP leads to amelioration of cognition and memory along with the resc

100 with significant amyloid pathology, a rapid amelioration of cognitive deficits was observed despite

101 tes reductions in AD pathology and resultant amelioration of cognitive deficits.

102 on of splenic and colonic GMPs, resulting in amelioration of colitis.

103 roach for long-term treatment of obesity and amelioration of comorbidities.

104 mance may lead to earlier identification and amelioration of complications and improve patient outcom

105 pollen SIT does not correlate well with the amelioration of concomitant food allergies.

106 ecific to this site could provide short-term amelioration of corrosive conditions at certain times of

107 Amelioration of CRF with the three rhubarb extracts was

108 Administration of Val might lead to amelioration of CsA nephrotoxicity by probably diminishi

109 ed in CXCL10-deficient mice, resulting in an amelioration of cuprizone toxicity at later time points.

110 bitor, captopril, to evaluate sensitivity to amelioration of DDT-associated hypertension by ACE inhib

111 dence that IL-3 has therapeutic potential in amelioration of degeneration of articular cartilage and

112 himerism, it did not strictly correlate with amelioration of diabetes.

113 utrophin, restoration of laminin binding and amelioration of disease in the mdx mouse model of DMD.

114 as B cell depletion therapy (BCDT) leads to amelioration of disease irrespective of autoantibody abl

115 Moreover, amelioration of disease manifestations was related to an

116 However, amelioration of disease severity has been shown to resul

117 ile current therapies for PAH do provide for amelioration of disease symptoms and acute survival bene

118 n vivo, leading to measurable phenotypes and amelioration of disease symptoms.

119 of ITF2357-treated animals, resulting in the amelioration of disease.

120 edly, the treated animals showed significant amelioration of disease; in addition, both the intensity

121 The striking amelioration of diverse deficits in animal AD models by

122 ate as a potential therapeutic agent for the amelioration of DKD.

123 ther DGKalpha is involved in the VtE-induced amelioration of DN in vivo remains unknown.

124 that DGKalpha is involved in the VtE-induced amelioration of DN in vivo, suggesting that DGKalpha is

125 Therefore, we investigated the VtE-induced amelioration of DN in wild-type (DGKalpha(+/+)) and DGKa

126 e mediated Nlrp3 inflammasome inhibition and amelioration of dNP are abolished in diabetic Nrf2(-/-)

127 with both therapies also yielded impressive amelioration of dystrophic pathology.

128 activity, and in turn, leading to the rapid amelioration of EAE.

129 In support of this view, amelioration of either OBSB or OBSD locks the system in

130 y GSK-3beta as a newly identified target for amelioration of empyema-related pleural fibrosis and pro

131 fects of MAPK inhibitors and agonists in the amelioration of endothelial function.

132 Prednisolone may lead to a prompt amelioration of eosinophilia and associated symptoms.

133 Br2 expression via the ER stress pathway and amelioration of ER stress in mice completely abolishes h

134 chemical chaperone PBA to ob/ob mice led to amelioration of ER stress, increased sortilin-1 expressi

135 paBp65 activation, ultimately culminating in amelioration of excess collagen synthesis in cardiac hyp

136 g normalization of fasting hyperglycemia and amelioration of excessive postprandial glucose excursion

137 blood flow were associated with more robust amelioration of excited factor symptoms during active me

138 n of signaling through MyD88, and subsequent amelioration of experimental autoimmune arthritis was ob

139 yelin-specific Foxp3(+) Tregs in WT mice and amelioration of experimental autoimmune encephalomyeliti

140 uring myelin antigenic challenge resulted in amelioration of experimental autoimmune encephalomyeliti

141 ulted in the generation of Tr1 cells and the amelioration of experimental autoimmune encephalomyeliti

142 Moreover, the amelioration of experimental autoimmune uveitis in Il1r-

143 eight recovery associated with a significant amelioration of ferritin, fibrinogen, and alanine aminot

144 nsion, demonstrated clinical improvement and amelioration of fibrosis in the dy(2J) /dy(2J) mouse mod

145 mpressive improvement in muscle strength and amelioration of fibrosis.

146 wed significant increases in muscle mass and amelioration of fibrotic changes normally seen in 8-mont

147 The observed progressive amelioration of functional deficits, recovery of dopamin

148 Hence, the amelioration of HD and other neurodegenerative diseases

149 ted mitral regurgitation, thereby leading to amelioration of heart failure symptoms.

150 c phenotype of DIO mice, which was linked to amelioration of hepatic steatosis and reduced inflammati

151 and 150 days in KO we observed a significant amelioration of hepatocyte injury.

152 We conclude that tadalafil amelioration of high glucose stimulation of synthesis of

153 K1 as a potential therapeutic target for the amelioration of hippocampal injury and cognitive deficit

154 identify unique therapeutic targets for the amelioration of hippocampal injury and cognitive deficit

155 dentify CTMP as a therapeutic target for the amelioration of hippocampal injury and cognitive deficit

156 timulate neurogenesis, with implications for amelioration of hippocampal-dependent learning impairmen

157 01 prolongs survival after Tx, paralleled by amelioration of histologic signs of acute rejection.

158 pression in limb musculature and significant amelioration of histological and functional parameters.

159 replacement therapy (ERT) provides long-term amelioration of homocystinuria-associated phenotypes in

160 ul deployment of both MSCs and MAPCs for the amelioration of human autoimmunity and allograft rejecti

161 hway (that is, kynurenine pathway), leads to amelioration of Huntington's-disease-relevant phenotypes

162 We found that amelioration of hyperglycemia by different hypoglycemic

163 and 530-543, with the former associated with amelioration of hyperglycemia.

164 osclerotic vascular diseases, presumably via amelioration of hyperlipidemia-induced monocytosis, and

165 ed with restoration of renal vasculature and amelioration of hypoxia through increased renal tubular

166 According to this scenario, amelioration of immune-mediated chronic liver injury may

167 d lower erythropoietin levels, a significant amelioration of ineffective erythropoiesis (IE) and sple

168 icantly increased proliferation coupled with amelioration of infarction injury and increased hemodyna

169 Spontaneous amelioration of inflammation (often accompanied by fibro

170 e deficient for c-Jun in macrophages show an amelioration of inflammation and bone destruction in the

171 a therapeutically viable drug target for the amelioration of inflammatory disease.

172 uggesting SAhRMs may have application in the amelioration of inflammatory disorders.

173 iarrhythmic therapies have limited efficacy, amelioration of inflow cannula contact with the endocard

174 ve stress and related protein modifications, amelioration of insulin resistance, and increased plasma

175 ight the potential role of dietary fibers in amelioration of intestinal inflammation.

176 nodes which was accompanied with a distinct amelioration of intestinal inflammation.

177 a novel potential therapeutic target in the amelioration of intestinal inflammatory diseases like NE

178 mmune-associated effects were accompanied by amelioration of IR and improved insulin signaling in liv

179 This interleukin 6-induced amelioration of ischaemic insults was abolished by trans

180 g 2.5 g/kg IVIG in FcgammaRIIB(-/-) B6 mice, amelioration of ITP was as in wild-type in all animals.

181 less sensitive than BALB/c to IVIG-mediated amelioration of ITP, requiring approximately 2- to 2.5-f

182 ctly restores electric stability through the amelioration of key arrhythmogenic substrate (ie, cardia

183 ted in inhibition of cell-cycle progression, amelioration of kidney injury, and improved overall surv

184 The amelioration of lipid accumulation in TgCRND8 by removin

185 The amelioration of liver damage by systemic application of

186 migration by blocking CD44 or CXCR4 lead to amelioration of lupus in lupus-prone mice.

187 r 12 weeks of treatment, all patients showed amelioration of lymphoproliferation with lymph node size

188 The amelioration of lysosomal function in TgCRND8 markedly d

189 jor actions of CYCLO on autophagy underlying amelioration of lysosomal pathology.

190 o preservation of mitochondrial function and amelioration of mitochondria-driven apoptosis.

191 More importantly, the amelioration of mitochondrial dynamic deficits by mdivi-

192 Significant amelioration of motor and cognitive functions was reveal

193 have reported promising findings in terms of amelioration of motor asymmetry in adult, 6-hydroxydopam

194 The reason for this sudden amelioration of motor control in REM sleep is unknown, h

195 lpha-synuclein, protection of SN neurons and amelioration of motor performance.

196 om wild-type littermates and demonstrated an amelioration of muscle disease as evidenced by an absenc

197 We show that sarcospan-mediated amelioration of muscular dystrophy in DMD mice is depend

198 f duration and severity showed a significant amelioration of myalgia (P = .003), headache (P = .025),

199 highlight a pharmacogenetic approach for the amelioration of narcolepsy.

200 rable side effects, and provide only partial amelioration of negative and cognitive symptoms.

201 Although HSF1 activation has been linked to amelioration of neurodegenerative disease, cancer cells

202 resent a dietary route to the retardation or amelioration of neurodegenerative-related dysfunctions.

203 roved body weight gain and survival with the amelioration of neuronal histopathology in motor units s

204 ral, but not dorsal, hippocampus resulted in amelioration of nicotine withdrawal-induced anxiety-like

205 Amelioration of ophthalmologic education in diabetic pro

206 rated by reduced autoantibody production and amelioration of organ pathologies.

207 Amelioration of outer nuclear layer thinning indicated t

208 proaches for preventing preeclampsia through amelioration of oxidative stress include the use of supp

209 aling pathway plays an important role in the amelioration of oxidative stress.

210 ophil depletion in infected mice resulted in amelioration of pathogenic responses, as evidenced by a

211 cal study demonstrating sildenafil-dependent amelioration of pathological remodeling, the cardioprote

212 Amelioration of pathology coincided with decreased trans

213 No amelioration of pathology was observed in the recombinas

214 ed by deletion of PTP1B, indicating specific amelioration of peripheral insulin resistance.

215 offset costs of phenotypes through ontogeny, amelioration of phenotypic costs across environments, an

216 ct, LM-PLP infection resulted in significant amelioration of PLP178-191-induced EAE.

217 Altogether, our results suggest that amelioration of potassium leaks through potassium homeos

218 Amelioration of pre-rRNA imbalance is achieved through r

219 (NaPi2a(-/-)/klotho(-/-)) strain resulted in amelioration of premature aging-like features.

220 n domain that may serve as a drug target for amelioration of prion neurotoxicity.

221 ry of miR-146a mimics into the skin leads to amelioration of psoriasiform skin inflammation, decrease

222 ified in humans as neurosurgical targets for amelioration of psychiatric disorders.

223 titis and may be useful in the prevention or amelioration of radiation changes in the skin.

224 nd the levels of metabolites associated with amelioration of redox stress in various cellular compart

225 mice with an inhibitor of cathepsin L led to amelioration of reovirus infection.

226 Sustained amelioration of retinal vascular permeability (RVP) was

227 ustained improvement in locomotor skills and amelioration of secondary tissue damage.

228 sequent treatment, notably radiotherapy, for amelioration of side effects.

229 features were independently associated with amelioration of significant MR after CRT by multivariabl

230 biotic intervention resulting in significant amelioration of skin inflammation and reductions in skin

231 pathway in vivo by Jnk3 knockout results in amelioration of SMA phenotype.

232 pression in SMADelta7 mice, correlating with amelioration of SMA-related defects in motor neurons and

233 The amelioration of spatial neglect symptoms in the activiti

234 e insulin sensitivity in adipose tissue, and amelioration of spontaneous atherosclerosis.

235 sed rsFC in these circuits may contribute to amelioration of subjective withdrawal symptoms.

236 As in previous studies an amelioration of symptoms is seen immediately after surge

237 We show that the amelioration of symptoms was proportional to the extent

238 enerative diseases are limited mostly to the amelioration of symptoms, although promising new therape

239 se is limited to a few treatment options for amelioration of symptoms.

240 bitor produces an immediate and long-lasting amelioration of synaptic function, CREB phosphorylation,

241 nt, rescue of their synaptic dysfunction and amelioration of synaptic integrity.

242 cell epitope peptide mixture demonstrated an amelioration of systemic allergic symptoms and a signifi

243 ased therapeutic approaches to prevention or amelioration of T21 effects on brain structure and funct

244 nceptually novel therapeutic targets for the amelioration of the affective, cognitive and systemic ma

245 Il17a lacking mutants exhibited amelioration of the aforementioned fibrosis, whereas Tnf

246 targeting without nucleases and demonstrate amelioration of the bleeding diathesis in haemophilia B

247 of the fear-conditioning performance, and an amelioration of the brain amyloidosis.

248 sruption in intracellular calcium levels, so amelioration of the calcium alteration could serve as an

249 eclampsia as well as therapeutic targets for amelioration of the clinical disease.

250 Fasting is beneficial in the prevention and amelioration of the clinical manifestations of autoimmun

251 hepcidin is the subject of interest for the amelioration of the detrimental effects of either iron d

252 g the survival of the cancer patient through amelioration of the disease burden of gram-positive bact

253 eatment approach can lead to a more profound amelioration of the disease pathology.

254 gical assessment of colon sections confirmed amelioration of the disease phenotype.

255 of alphaLNNd in dy2J mice resulted in strong amelioration of the dystrophic phenotype, manifested by

256 y TrkB.T1 deletion, which was revealed by an amelioration of the enhanced aggression and weight gain

257 tion using 5-iodotubercidin, we demonstrated amelioration of the epigenetic effects of irradiation.

258 over 12 months, consistent with progressive amelioration of the HF syndrome.

259 apeutic approach (1) resulted in substantial amelioration of the low growth factor activity with sign

260 l, sustained Treg cell expansion in vivo and amelioration of the manifestations of chronic GVHD in a

261 he antioxidant, oral N-acetylcysteine led to amelioration of the muscle atrophy and weakness in Gne m

262 and identify a novel therapeutic target for amelioration of the neurodegeneration and cognitive defi

263 tase 2 as a potential therapeutic target for amelioration of the neurologic sequelae caused by HSE.

264 of into the retina can achieve long-lasting amelioration of the pathologic findings of optic pit mac

265 The overall result was the amelioration of the pathological hallmarks and the cogni

266 with 4-phenylbutyrate resulted in remarkable amelioration of the pathological phenotypes in plectin-d

267 Targeting BATF expression resulted in amelioration of the pathophysiologic responses seen in c

268 Amelioration of the phenotype by the alternative transcr

269 reatment of PKD mice with this drug leads to amelioration of the renal cystic disease similar to gene

270 h an ion yield enhancement and a significant amelioration of the salt suppression effects when compar

271 Amelioration of the sensory phenotypes caused by specifi

272 H4R(-/-) mice showed a clear amelioration of the skin lesions, with a diminished infl

273 o and in vitro are consistent with a partial amelioration of the supposed increase in energy demand o

274 E2 secretion by IL-1beta was associated with amelioration of their myofibroblast differentiation in v

275 ng components of these signalling responses, amelioration of their toxic effects and so the treatment

276 c potential of epigenetic treatments for the amelioration of these conditions.

277 This study evaluated the amelioration of these poor soils by thorny bamboo, one o

278 tion of novel therapeutic strategies for the amelioration of these serious human conditions.

279 emand mismatching in OZRs, and suggests that amelioration of this dysfunction must involve a multi-fa

280 e SnRK2.6 overexpressors were accompanied by amelioration of those physiological processes that requi

281 clearance of necrotic tissue interferes with amelioration of tissue injury and induces abnormal tissu

282 should remain a focus in the development or amelioration of vaccines to treat infections in humans.

283 ons for overall health and the prevention or amelioration of various chronic diseases.

284 l health implications in both prevention and amelioration of various diseases involving oxidative str

285 gher plant diversity was associated with the amelioration of warming-induced environmental conditions

286 Significant amelioration of weight reduction was noted in treated mi

287 for, and potential molecular targets for the amelioration of, the hyperprolactinemia and sexual dysfu

288 platelet counts, and their levels indicated amelioration or exacerbation of the disease.

289 ards significant role for MusaSAP1 in stress amelioration pathways of banana.

290 orization, resulting in long-term functional amelioration persisting up to 60 d after ischemia.

291 ds the equatorial edges the magnitude of the amelioration provided by shaded microhabitats is largely

292 Periodic environmental amelioration (short periods of reduced temperature) caus

293 direction of interactions (i.e., from stress amelioration to exacerbation).

294 atorial pharmaceutical approaches to symptom amelioration upon FMRP attenuation.

295 Disease amelioration was associated with reduced IL-17 and IFN-g

296 ed experimental autoimmune encephalomyelitis amelioration was canceled in mice with ERbeta-deficient

297 nduction of ischemia, whereas no significant amelioration was observed when beta2AR knock out (KO) EP

298 nes that mostly associated with the clinical amelioration were Ccr7, its ligand, Ccl19, and dendritic

299 The authors also observed an amelioration with tDCS of other symptoms as measured by

300 tically ill patients, TAVI provides clinical amelioration, with early improvement in LVEF.