ライフサイエンスコーパス: amenable

1 at C-C, C-N and C-S bond formations are also amenable.

2 amenable to exon skipping than in those not amenable.

3 ented a platform-independent high-throughput-amenable analysis pipeline for the high-confidence annot

4 from this study mark the establishment of an amenable drug delivery vehicle and highlight the advanta

5 ing therapeutic targets of interest in these amenable experimental platforms.

6 This amenable experimental system should facilitate the trans

7 edded, fully exposed structures particularly amenable for a multidisciplinary study of this problem,

8 These new thaumatin variants are amenable for bioconjugation, providing chemical biology

9 PLC-derived organoids are amenable for biomarker identification and drug-screening

10 ll molecules targeting this protein that are amenable for clinical testing has been challenging.

11 Although members of MCs are often not amenable for cultivation in pure culture, it is possible

12 The methods reported herein are highly amenable for fast and efficient heterocycle synthesis as

13 e four C-H bonds of methane and thus make it amenable for further chemical conversion into valuable c

14 tudied in a luciferase assay, which could be amenable for future identification of small molecule inh

15 concentrations of coupling partners, make it amenable for in vivo radiolabelling using pretargeting m

16 ergy compared to that of the complex, may be amenable for inhibition and the peptide sequence and str

17 cessary to document a large-vessel occlusion amenable for intervention.

18 was developed to makeS. mediterraneatissues amenable for MSI.

19 e via miniaturization for microplate format, amenable for screening of compounds or interventions tha

20 he Arabidopsis thaliana plant model uniquely amenable for small RNA regulatory circuit studies in a m

21 ly associate with human U1 snRNP and are not amenable for structural studies, while their Saccharomyc

22 e of tumor-associated self-antigens that are amenable for T-cell therapy, but also allows TCR targeti

23 lly discrete and potentially therapeutically amenable functional role for Treg cells and CTLA-4 in li

24 n transfers upon photoexcitation, proving an amenable model system to study PCET.

25 in viral vectors or as synthetic, clinically amenable, molecules.

26 responses in other complex pharmacologically amenable pathways.

27 f the method was enlarged to 35 GC and 63 LC amenable pesticides, its overall performance was evaluat

28 y-tandem mass spectrometry (GC-MS/MS) for GC-amenable pesticides; (ii) hydrophilic interaction liquid

29 These are all amenable risk factors.

30 r that regulates lipoapoptosis and may be an amenable target for the prevention of CKD progression.

31 ealed that certain endogenous genes are more amenable than others to transcriptional activation, and

32 NSCs are 'hard-to-transfect' but amenable to 'magnetofection'.

33 For many years, the range of (hetero)arenes amenable to (18)F-fluorination was limited by the lack o

34 The reaction was amenable to a broad range of alkyl, aryl, alkenyl, and a

35 ectrostatic repulsion but, at the same time, amenable to a closer approach if D21 is mutated into the

36 Thus, visual learning is amenable to a controlled environment in which tethered b

37 Although she was not amenable to a full neurologic examination, she reported

38 ve primary and quaternary structures made it amenable to a genetic analysis using in-frame insertions

39 ficity for an individual promoter structure, amenable to a large array of promoters.

40 cause their development is likely to be more amenable to a pharmaceutical than a food delivery route,

41 issingness or uncertainty, and are thus more amenable to a probabilistic representation.

42 , simplifies mechanical requirements, and is amenable to a range of analytes.

43 he tunability of their properties, make them amenable to a range of industrial applications.

44 factors across all countries, which might be amenable to a standardised approach for early recognitio

45 ydrolysis reaction, a simpler system that is amenable to a thorough mechanistic treatment.

46 The reaction was amenable to a variety of aryl boronic acids and disubsti

47 ly be adapted to any cell type and is highly amenable to a wide range of complex biomolecules.

48 om temperature reaction is high yielding and amenable to a wide range of glycal donors and OH nucleop

49 opia and associated refractive errors may be amenable to AAV gene therapy.

50 Hepatic metastases are amenable to ablation; however, many patients are not sui

51 robust in vitro cell culture system that is amenable to addressing mechanisms underlying Vpr-mediate

52 r organic compounds that are relatively more amenable to aerobic biodegradation.

53 e pairs of the recognition sequence are more amenable to alterations than others.

54 nd concentrate the NAs into a volume that is amenable to amplification processes, such as PCR or LAMP

55 nical noise and make GC/MS metabolomics data amenable to analyses describing biologically relevant va

56 which displays complex kinetic behavior not amenable to analysis by more traditional methods.

57 n D, and {Te8W116}, unknown E, which are not amenable to analysis by other means with the approximate

58 The medium throughput approach is amenable to analysis of biological replicates, offering

59 f the GABAA beta3 homopentamer that might be amenable to analysis using the substituted Cys accessibi

60 Two very simple models amenable to analytical treatment are developed to examin

61 ted in VS pathogenesis represent targets not amenable to antibody-based or small molecule therapeutic

62 owed a more severe disease course than those amenable to any exon skipping.

63 intermediate electron-richness, they are not amenable to any of the previously developed N-protection

64 The assay is readily amenable to application in 96- and 384-well microtiter p

65 tes has illuminated behaviours that are also amenable to archaeological examination, permitting direc

66 by a stereoconvergent mechanism and is thus amenable to asymmetric catalysis using a chiral bioxazol

67 that of a standard 96-well plate, thus being amenable to automated sample handlers and multichannel p

68 shift reproducibility, making the procedure amenable to automation and suitable to routine analysis.

69 rsatility and tunability thus making it more amenable to be employed in practical application which m

70 tter-defined neural circuit that may be more amenable to behavioral or pharmacological manipulation.

71 s in the pipeline, alignment is particularly amenable to benchmarking with simulated data.

72 lants could produce a phenotype that is more amenable to biomass processing.

73 This method is amenable to both conventional solvothermal conditions an

74 jection fraction </=35% and coronary disease amenable to CABG were randomized to CABG or MED in the S

75 n of 35% or less and coronary artery disease amenable to CABG were randomly assigned to undergo CABG

76 e colon, which may foster a microenvironment amenable to cancer development.

77 ol of CAF activation with epigenetic changes amenable to cancer- and stroma-focused intervention.

78 alth outcomes over time that are potentially amenable to change include illness perception, self-effi

79 sociated with long-term recovery that may be amenable to change through intervention.

80 ing a variety of ionic soft matters that are amenable to chemical reactions in situ.

81 te functionally conserved compounds that are amenable to click chemistry and can be used as molecular

82 n be extended to other disease models and is amenable to clinical translation for assessing and monit

83 ntiated epithelial cells renders these cells amenable to clonogenic outgrowth.

84 nodes of the PTEN/PI3K pathway that would be amenable to combined therapy with MAPK pathway inhibitor

85 sive oxidants or reaction media that are not amenable to commercialization.

86 dly applicable to diverse microorganisms and amenable to comparative analysis.

87 l junctures at which perturbations initially amenable to compensatory feedback transform into irrever

88 eases are well understood and they should be amenable to control with use of established and effectiv

89 veral previously "uncultivated" bacteria are amenable to conventional cultivation.

90 These compact conformations are amenable to cooperative, high-affinity histone binding.

91 oof-of-principle that the folding deficit is amenable to correction in vivo by two means, the cognate

92 A chimeric GT-1a3a NS3/4A protease amenable to crystallization was engineered to recapitula

93 hilic organisms known so far that are poorly amenable to cultivation.

94 genomic regions and structural variants not amenable to current labeling methods that rely on uneven

95 ntification for cells that are otherwise not amenable to current single-cell platforms.

96 lytes, surfaces, and experimental conditions amenable to DESI-MSI, especially for analytes that are w

97 rd while remaining physically consistent and amenable to detailed analysis.

98 ron microscopy suggests that the samples are amenable to detailed structural analyses of spherules en

99 The recovered agents were shown to be amenable to detection by a downstream tandem MS analysis

100 que architecture of laminin is not currently amenable to determination at high resolution, as its fle

101 esponse factors within the MDP family may be amenable to development into therapeutics for protein-mi

102 e and reduced cefixime susceptibility appear amenable to development of sequence-based diagnostic tes

103 lter the delivery of DHA to the brain may be amenable to DHA supplementation in predementia stages of

104 interactions in real materials but are also amenable to direct characterization.

105 ecause central retinal anatomy is not easily amenable to direct physiological assessment.

106 emical reactions in liquid solutions are now amenable to direct study using ultrafast laser spectrosc

107 abnormalities in cellular signaling pathways amenable to directed therapies.

108 e approach has excellent substrate scope, is amenable to diverse guanidine-containing substrates, and

109 ADPL should be amenable to diverse probe and protein families to detect

110 e unpredictable in frequency and timing, but amenable to effective contemporary treatments, and infre

111 elop tractable count-based models, which are amenable to efficient estimation through the introductio

112 lt to generate and localize in a way that is amenable to efficient generation of streaming.

113 he proportion with somatic mutation profiles amenable to either immunotherapy or targeted therapy.

114 aintained in culture for >10 d, and they are amenable to electrophysiological recording, calcium imag

115 ry glands, which lack clock function but are amenable to electrophysiological recording, CRY prevents

116 This oxidation potential-gated technology is amenable to endogenous peptides and has been successfull

117 rated LUVs provide a purified defined system amenable to EPR, optical and vibrational spectroscopy, a

118 vivo targets of an RBP are imperfect and not amenable to examining small numbers of cells.

119 The subset of patients amenable to exon 51 skipping showed a more severe diseas

120 ory DMD patients who were >/=7 years old and amenable to exon 51 skipping were randomized to eteplirs

121 sion was observed in patients with mutations amenable to exon skipping than in those not amenable.

122 mulative cohorts, individuals with deletions amenable to exons 44 and 46 skipping declined at a slowe

123 f memory and naive T cell traits, is broadly amenable to experimental acceleration or retardation, an

124 nformation between organisms has also become amenable to experimental investigation.

125 al studies, we demonstrate that D. pachys is amenable to experimental manipulation by RNA interferenc

126 nd show that they predict essential features amenable to experimental validation, including pore dist

127 ximately 70% of primary NSCLC specimens were amenable to explant culture with tissue integrity intact

128 These species are amenable to facile modification with a variety of thiol-

129 This low-cost wearable device is amenable to facilitating healthcare in low-resource sett

130 r volumetric sample collection method may be amenable to field-use followed by fully automated, HCT-i

131 sting; that is, the DART hair scan method is amenable to forensic cases.

132 low to high microgram sample quantity and is amenable to full automation.

133 ic compounds into functional small molecules amenable to further diversification.

134 l viability assay, suggesting that it may be amenable to further structure-activity relationship (SAR

135 This platform will be amenable to future studies of the effects of mutations a

136 Cultured NPCs are amenable to gene targeting and can form nephron organoid

137 ve response to bacterial inoculation and was amenable to genetic and molecular research methods.

138 abeling and broader application to all cells amenable to genetic engineering.

139 e, and reveals that Salmonella is remarkably amenable to genome-scale modification.

140 cient genetic perturbation in organisms less amenable to germ line transmission based approaches.

141 dexed multiplexed biomimetic membrane assays amenable to high-throughput flow cytometric detection.

142 mic the natural membrane environment, (2) be amenable to high-throughput implementation, and (3) be e

143 integrate molecular and functional endpoints amenable to high-throughput screening.

144 Young women were very amenable to home screening for BV, gonorrhea, and chlamy

145 t are soluble in liquid phases and therefore amenable to homogeneous catalytic transformations.

146 hydride (PTCDA), an organic solid, is highly amenable to host divalent metal ions, i.e., Mg(2+) and C

147 the range of molecular structures and sites amenable to hyperpolarization via low-cost parahydrogen-

148 To expand the behavioral repertoire amenable to imaging, we have developed a tracking micros

149 populations may identify breast cancers more amenable to immunomodulation and indicate additional str

150 cancer may aid in identifying subtypes more amenable to immunomodulation.

151 s of the transformation, and the reaction is amenable to in situ carboxylic acid activation.

152 f the infectious cycle of CHIKV in vivo, and amenable to in vitro applications such as transfection,

153 ransmembrane segments, thus rendering HiGlpG amenable to in vitro studies of membrane-protein folding

154 , this enzyme-free, isothermal blood test is amenable to incorporation into low-cost portable devices

155 ure of heart muscle and might, therefore, be amenable to industrial (eg, drug screening) and clinical

156 r, ultrasensitive biosensors that are highly amenable to integration.

157 e heme biosynthesis pathway was particularly amenable to inter-kingdom exchange, with each yeast enzy

158 They are hence amenable to interacting strongly with various other exci

159 This strategy is further amenable to intermolecular coupling between cinnamyl bro

160 ted by the structural model, which is highly amenable to intervention and explains why combining econ

161 Early childhood represents a pivotal period amenable to intervention strategies that could delay or

162 upted by inflammatory signaling and could be amenable to interventions that restore elastic fiber ass

163 ified potential causes of labour dysfunction amenable to investigation in older primigravid women.

164 aptic and behavioral phenotypes, making them amenable to investigation of early pathophysiological, a

165 e related organism S. mansoni, which is more amenable to laboratory studies.

166 aphosphole (BOP) core 1 is developed that is amenable to large scale preparation of the related ligan

167 screening platform for metabolomics that is amenable to large-scale clinical and epidemiological stu

168 GS-5734 is amenable to large-scale manufacturing, and clinical stud

169 pha-amino ketones at room temperature and is amenable to late-stage coupling of complex and biologica

170 Amenable to late-stage preparation of analogues, a flexi

171 Although these analytes are amenable to LC and LC-MS detection an additional major b

172 ith TV leaflet mobility or coaptation and is amenable to lead extraction or valve repair or replaceme

173 f tyrosine and tryptophan generates peptides amenable to liquid chromatography-tandem mass spectromet

174 and acid content matrices for 175 pesticides amenable to liquid- and gas chromatography-mass spectrom

175 ort a method for creating honeycomb surfaces amenable to liquid-impregnation.

176 This zebrafish larval model is highly amenable to live imaging of leukocyte behavior, and we r

177 he magnetic field homogeneity making it more amenable to low-power portable applications.

178 at Pluronic (Poloxamer) block copolymers are amenable to low-temperature processing to strip away all

179 rstanding of developmental pathways that are amenable to manipulation by directed differentiation.

180 on strategies involve complex approaches not amenable to mass production, limiting the ability to use

181 wn as well-documented examples are often not amenable to mechanistic analysis or rely on artificial r

182 These devices require materials that are amenable to micro- and nano-fabrication, but also preser

183 tionally, electrochemical methods are highly amenable to miniaturization and possess the potential to

184 t under oxidizing conditions they are highly amenable to modification.

185 -dependent window during which that trace is amenable to modification.

186 Because urinary Cu levels are amenable to modulation, augmentation of the Cu-based hos

187 We demonstrate that EsxA variants are amenable to MS analysis and remain functional in establi

188 This strain was found amenable to multiplex SILAC by case study of responses t

189 This sensor technology is versatile, amenable to multiplexing, easily integrated to POC devic

190 to a robust inclusion criterion for patients amenable to nanotherapy.

191 s virtually any peptide or expressed protein amenable to NCL.

192 of alpha/beta-substituted enals hitherto not amenable to NHC-catalyzed transformations.

193 This approach may be amenable to numerous enzymes and to engineering and scre

194 strategy shows broad substrate scope and is amenable to o-bromobenzyl tertiary/secondary/primary alc

195 es (GUIs), which, however intuitive, are not amenable to operate within console terminals and therefo

196 ng, the system we report here is also highly amenable to optimization, as each of its components can

197 lack of close living relatives may still be amenable to palaeogenomic analysis through iterative map

198 This study demonstrates that PSC-CMs are amenable to partial neuronal conversion, yielding a popu

199 be cumbersome if data is not given in a form amenable to particular analyses.

200 al stimulation, and electric pacing, and are amenable to patch clamp and adenoviral gene transfer tec

201 e iCVD topcoat can be as thin as 7 nm, it is amenable to pattern transfer without removal.

202 oteins, and show that the gene fragments are amenable to PCR-based gene assembly and recombinant expr

203 onary artery bypass grafting in patients not amenable to percutaneous coronary intervention.

204 vity in the setting of hypercholesterolemia, amenable to pharmaceutical intervention.

205 on, suggesting a potential treatment pathway amenable to pharmacologic modulation.

206 by inducing an Ih channelopathy that may be amenable to pharmacological intervention.

207 afficking defects, the majority of which are amenable to pharmacological rescue by glibenclamide and

208 tions identified those mutations most likely amenable to pharmacological rescue in the affected child

209 ed with differential reductions in mortality amenable to PHC between racial groups.

210 tumor of significant complexity that is not amenable to PN or for whom PN may result in unacceptable

211 ures, allowing the assay platform to be more amenable to point-of-care applications.

212 of other enzyme classes, and was found to be amenable to predictable structural modifications that mo

213 easily identifiable by maternal serology and amenable to prevention messages.

214 ES has a low computational complexity and is amenable to problems of extremely large dimensionality.

215 nclusion bodies, which would not normally be amenable to production in bacteria.

216 investigators in choosing which subtypes are amenable to properly designed, large-scale, clinical tri

217 The crevice is amenable to protein engineering to further enhance both

218 been viewed as difficult to treat but may be amenable to psychological approaches such as cognitive-b

219 mers that contain carbon-carbon double bonds amenable to radical polymerization.

220 at for patients with 1 to 3 brain metastases amenable to radiosurgery, SRS alone may be a preferred s

221 s complex, functionalized aromatic scaffolds amenable to rapid diversification and more broadly demon

222 R95 and rTR18 with rK39 in serological tests amenable to rapid or high-throughput screening may enabl

223 vides a simple and robust variant of CP-MIMS amenable to rapid screening of analytes in complex sampl

224 A laboratory practice pattern that was amenable to reform was identified, and a multistep modif

225 AGI, with a particular emphasis on diseases amenable to regenerative medicine and strategies to deal

226 n has targeted these features to favor uORFs amenable to regulation over constitutively repressive uO

227 n transport robust yet rapidly adaptable and amenable to regulation.

228 The concept also renders itself amenable to remote delivery and to the miniaturization o

229 s, which, given their chirality, may even be amenable to resolution into optically pure enantiomers.

230 hidden biological risk, and a phenotype less amenable to revascularization.

231 he most widely used optical detection format amenable to screens of unprecedented size, paving the wa

232 estion is then if/how this protein search is amenable to selection and biological control.

233 , obesity and diabetes in db/db mice are not amenable to selective ERRgamma-directed programming of c

234 However, this model is not readily amenable to semi-high throughput screening of candidate

235 dioresistant breast cancer xenografts highly amenable to sensitization by cotreatment with a miR-139-

236 subclass of metal-organic frameworks (MOFs) amenable to significant property tuning by altering the

237 hic bacteria; however, these enzymes are not amenable to standard enzyme immobilization approaches.

238 e fungi, being dikaryotic, are not generally amenable to strain improvement.

239 consistent with SZ being a circuit disorder amenable to striatal modulation with DBS.

240 of the adult mouse retina, a part of the CNS amenable to structural and functional analysis, to inves

241 n primary and quaternary structure, they are amenable to structure-function analyses using in-frame i

242 The results demonstrate that the method is amenable to structures with symmetry, of very large size

243 patible and tunable, rendering this platform amenable to studies of dynamic mechanics on cell behavio

244 te a "visual" kinetic profile that should be amenable to studying many other protein-protein interact

245 ammability of this platform makes it readily amenable to studying more complicated systems where auxi

246 yl platforms have proven quite versatile and amenable to studying various parameters that govern prod

247 or undemineralized thin sectioning, which is amenable to subsequent dynamic bone formation measuremen

248 nd which of these stages of neurogenesis are amenable to such extrinsic influences.

249 potent source of acute kidney injury and is amenable to sugar-specific blockade.

250 ely due to increased inflammation and may be amenable to suppressive therapeutics.

251 dvanced medullary thyroid cancer that is not amenable to surgery or of distant metastases needs caref

252 Lynch syndrome-associated cancers are amenable to surveillance strategies that may improve sur

253 andom process, with certain genes being more amenable to survive duplication events than others.

254 e concentration, as type II neurons are more amenable to synchronization by mutual excitation.

255 predictive of functional regulation and less amenable to systematic elucidation of complete networks

256 nd common type of stroke and show that it is amenable to systemic intervention to promote recovery.

257 upstream of PLCgamma2 and renders leukemias amenable to targeted therapeutic inhibition.

258 ich have been recently characterized and are amenable to targeted therapy, as a reflection of the pow

259 revealing potential BTIC cancer dependencies amenable to targeted therapy.

260 set of patients with KRAS mutant tumors most amenable to targeting of the K-Ras pathway, and identify

261 superposition of Gaussian components, easily amenable to the analysis of variable flows.

262 we demonstrate that this strategy is further amenable to the construction of quadrigemine H-type alka

263 it exhibits a catalytic tautomerase activity amenable to the design of high affinity small molecule i

264 chloro, bromo, hydroxy, and cyano were also amenable to the developed reaction.

265 al products, these methods are generally not amenable to the direct construction of carbon-carbon (C-

266 to models that are hard to interpret and not amenable to the generation of hypotheses that can be exp

267 tive total synthesis of uncialamycin that is amenable to the synthesis of novel analogues and renders

268 d derivatives and dialkylmalononitriles were amenable to the transnitrilation.

269 The protocol is scalable and is amenable to the use of peptide retention prediction in a

270 yn conformers in a reversible manner that is amenable to therapeutic intervention by GSL reducing age

271 This mouse model of sporadic GIST model was amenable to therapeutic intervention, and it recapitulat

272 lack of high-frequency "driver" alterations amenable to therapeutic intervention.

273 These phenotypes may identify patients amenable to therapeutic intervention.

274 These processes may be amenable to therapeutic interventions to limit the exten

275 pathways at the molecular level that may be amenable to therapeutic interventions.

276 and disease, defining an axis that might be amenable to therapeutic targeting.

277 th a focus on cells and pathways that may be amenable to therapeutic targeting.

278 Whether Cpc-PH is amenable to therapies targeting the pulmonary circulatio

279 al cross talk in COPD pathogenesis, which is amenable to therapy.

280 kilotherms that live in water, zebrafish are amenable to thermal and pharmacological perturbations.

281 rter (AADS) that extends the range of assays amenable to this approach.

282 is indicated and who possess a tumor that is amenable to this approach.

283 , 8.5% of infants randomized to egg were not amenable to this primary prevention.

284 iverse amide and olefin coupling partners is amenable to this transformation.

285 r-superconductor system demonstrated here is amenable to top-down processing and provides a new avenu

286 cts of the cyclopropenone ligation were also amenable to traceless Staudinger ligations, setting the

287 y facilitated maize research, but may not be amenable to traditional analysis techniques that were op

288 of new networking architectures that are not amenable to traditional methods of secure communication

289 ery specific research questions that are not amenable to traditional mouse models of injury, for exam

290 , and electron-rich alkynylated heterocycles amenable to trans-hydrometalation which are otherwise ca

291 As a flatworm amenable to transgenesis, it complements the historicall

292 states of well-defined molecules, which are amenable to transient absorbance spectroscopy, the study

293 ed by kinase-activating alterations that are amenable to treatment with tyrosine kinase inhibitors.

294 mechanics of myocardial ischemia that may be amenable to treatment.

295 nical and immunological characteristics more amenable to treatment.

296 c LC fragments, whereas other LCs are not as amenable to unfolding and endoproteolysis and are theref

297 antibodies by advanced ligands that are more amenable to use in humans.

298 There were 26 BMs that were amenable to visual assessment of nonuniformity, of which

299 y be of particular utility for compounds not amenable to x-ray crystallography.

300 nd reliable alcohol detections are currently amenable typically through the sophisticated instrument