ライフサイエンスコーパス: amidate

1 umans, norUDCA is glucuronidated rather than amidated.

2 cases even aryl chlorides can be efficiently amidated.

3 s CTL epitopes when the carboxyl terminus is amidated.

4 90% of known or predicted neuropeptides are amidated.

5 erminal d-alpha-aminopimelyl carboxylic acid amidated.

6 lly and thermodynamically with electron-rich amidates.

7 e endogenous presence of a highly conserved, amidated, 14-aa neuropeptide called either spexin or NPQ

8 kappa2-amidate ligand to yield an Al(kappa2-amidate)2(kappa1-carboxamide)(NHR) complex, followed by

9 erms of initial hydrolysis of phosphodiester amidates 2a, 2b, 4a, 4b, and 6 catalyzed by intracellula

10 Lipophilic phosphodiester amidates 2a, 2b, 4a, 4b, and 6 derived from anti-HIV age

11 BMCs incubated with the AZT phosphomonoester amidates 3 and 4 was 2- and 3-fold less than that observ

12 In particular, the AZT phosphomonoester amidate 4 displayed comparable antiviral activity to the

13 t TFOs containing N3'-->P5' phosphoramidate (amidate), 5-(1-propynyl)-2'-deoxyuridine (pdU), 2'-O-met

14 acial partitioning of a family of 17-residue amidated-acetylated peptides into both neutral and anion

15 e human KiSS1 gene encodes a COOH-terminally amidated active peptide, and this peptide is the ligand

16 due that provides a substrate for endogenous amidating activity in the mammary gland.

17 show that PHM is required for peptide alpha-amidating activity throughout the life of Drosophila.

18 for maintaining appropriate levels of alpha-amidating activity under changing conditions in vivo.

19 chanism where the M(III) complex engages the amidating agent via oxidative coupling to form a M(V)-im

20 Novel amidating agents containing a 1,4,2-dioxazole moiety all

21 dation of thioamides with robust dioxazolone amidating agents via C(sp(3) )-H bond activation to gene

22 (-) units provides this; a C-terminal Glu to amidated Ala mutation results in a 5-fold retardation of

23 ts of (1) steady-state formation of a Pd(II)-amidate-alkene chelate with release of 1 equiv of pyridi

24 Chiral dimeric tridentate NHC-amidate-alkoxide palladium(II) complexes, 3a and 3b, eff

25 Clavanins are histidine-rich, amidated alpha-helical antimicrobial peptides that were

26 aryl iodides using 1,2-diamine ligated Cu(I) amidates also provide insights into the mechanism of ary

27 e that consists of a mixture of tris-(kappa2-amidate)aluminum(III) complexes.

28 For this purpose, low esterified amidated (AM), low (LM) and high (HM) methoxylated citru

29 esis of Glu-666 revealed that only acidic or amidated amino acids at this position preserved PilQ fun

30 Phosphodiester amidate analogue 6 also exhibited anti-HIV activity in t

31 ications, we show that the single-stranded 3'amidate and 5'amidate backbones are equally well solvate

32 iometric reactions implied that the isolated amidate and imidate complexes are intermediates in the r

33 These results show that amidate and pdU-modified TFOs can be used as reagents to

34 However, of these modified TFOs, only the amidate and pdU-modified TFOs mediate induced recombinat

35 The Pd-amidate and resulting Pd-alkyl species have been crystal

36 Consequently, a series of non-amidated and acetylated polyarginines was synthesized.

37 of such inhibitors using positional scanning amidated and acetylated synthetic l- and d-hexapeptide c

38 erminally acetylated and carboxyl-terminally amidated and consists entirely of D-amino acids.

39 y resolution of tryptic fragments containing amidated and deamidated forms using high pressure liquid

40 The tp10 variants examined include amidated and free peptides, and replacements of tyrosine

41 Approximately 20% of newly synthesized amidated and Gly-extended gastrins were secreted within

42 Our results show that both the amidated and non-amidated peptides had a disordered stru

43 Consistent with this trend, Cu(II)-amidates and Cu(II)-benzoates containing more electron-r

44 These amidates and imidates reacted much more slowly with chlo

45 3'-NHP(O)(O-)O-5'internucleoside linkages (3'amidate) and alternatively modified oligonucleotides con

46 with a series of copper-carboxylate, copper-amidate, and copper-imidate complexes were performed.

47 For comparison, the amidate anion 2, vinylamine 3, and a simulated dimer 4 w

48 olated styelin D, a 32-residue, C-terminally amidated antimicrobial peptide, from the blood cells (he

49 We isolated a novel 22-residue, C-terminally amidated antimicrobial peptide, moronecidin, from the sk

50 AZT phosphomonoester amidates are internalized by lymphocytes to the same ext

51 In contrast, FLT phosphomonoester amidates are rapidly converted to FLT-5'-monophosphate b

52 neuropeptides including those containing an amidated arginine(R)-phenylalanine(F) motif at their C-t

53 ses FLP-13 neuropeptides characterized by an amidated arginine-phenylalanine (RFamide) C-terminus mot

54 s best explained by reduced flux through the amidated arm of the NAD+ salvage pathway due to reduced

55 The inability of peptides amidated at their C termini to effect restoration of act

56 solvation calculations which show that the 3'amidate backbone is favored relative to the 5'amidate ba

57 ckbones are equally well solvated, but the 5'amidate backbone is not adequately solvated in an A-form

58 midate backbone is favored relative to the 5'amidate backbone.

59 how that the single-stranded 3'amidate and 5'amidate backbones are equally well solvated, but the 5'a

60 eaction of aryl- and benzylsulfanopyridinium amidates bearing a methyl group in position 6 with 2 equ

61 ase (PAM), an enzyme required for generating amidated bioactive signaling peptides, in Chlamydomonas

62 An efficient and selective bis(amidate)bis(amido) titanium precatalyst for the anti-Mar

63 yne substrates, a commercially available bis(amidate)bis(amido)Ti catalyst is utilized to yield a cyc

64 ontributes significantly in the cases of the amidate bridges and that this is more important for M =

65 arboxyl group of N-acetylneuraminic acid was amidated by taurine.

66 to Leu substitution, a free N terminus, and amidated C terminus readily forms amyloid.

67 an N-terminal stearic acid attachment and an amidated C terminus were designed, synthesized, and test

68 bridge between residues two and seven and an amidated C terminus.

69 a-carboxyglutamic acid (Gla) residues and an amidated C-terminal asparagine amide, was synthesized ch

70 peptide consisting of 37 amino acids with an amidated C-terminal residue.

71 The role of the amidated C-terminus in amyloid formation by IAPP and in

72 of a set of variants with a free and with an amidated C-terminus shows that disrupting the putative H

73 (O = 4-trans hydroxyproline; * indicates an amidated C-terminus).

74 l14a contains 25 amino acid residues with an amidated C-terminus, an elongated N-terminal tail (six r

75 CP2 is a 41 amino acid peptide with an amidated carboxyl terminal.

76 ination product and regenerate the active Pt-amidate catalyst.

77 Both also make significant quantities of amidated CCK 22, a slightly larger form found in the gut

78 intestinal tumor, process pro-CCK mainly to amidated CCK 8.

79 C-terminus of CCK 8 were mutated to GAA, no amidated CCK was produced.

80 expression or the production of some form of amidated CCK.

81 The model invokes internal amidate chelation to control ester enolate geometry and

82 power ((m2 - m1)/ml) of 118,000 (C terminal amidated cholecystekinin fragment 26-33 (CCK-8), DY(PO3H

83 The resting states were found to be a 2:1 Pt-amidate complex (25, for N-acetamido) of the deprotonate

84 ay that includes photoexcitation of a copper-amidate complex, followed by electron transfer to form a

85 curs through a 1,2-diamine-ligated copper(I) amidate complex.

86 n also prevent the formation of the kappa(2)-amidate complexes and thereby generate more stable catal

87 that suggests that the formation of kappa(2)-amidate complexes is deleterious to the effectiveness of

88 Copper(I) imidate and amidate complexes of chelating N,N-donor ligands, which

89 evealed that the incorporation of C-terminus amidated D-amino acids onto bacterial surfaces substanti

90 yielded a massive and toxic incorporation of amidated DAP into the peptidoglycan that ultimately led

91 with the amidotransferase SsfD produced the amidated decaketide backbone that is required for the fo

92 bacco hornworm, Manduca sexta, including the amidated decapeptide F10.

93 In contrast, 5'amidates do not form duplexes at all.

94 There is no steric reason that the 5'amidate duplex should not form.

95 oside linkages (5'amidate) have shown that 3'amidate duplexes, formed with DNA or RNA complementary s

96 eakdown of the alkoxide to form aldehyde and amidate (E1cB-like).

97 Bifunctional peptidylglycine alpha-amidating enzyme (alpha-AE) catalyzes the O2-dependent c

98 Bifunctional peptidylglycine alpha-amidating enzyme (alpha-AE) catalyzes the two-step conve

99 rs in the bifunctional peptidylglycine alpha-amidating enzyme (alpha-AE) have been investigated by EP

100 beta-hydroxylase and peptidyl glycine alpha-amidating enzyme also co-aggregated with granule content

101 The bifunctional peptidylglycine alpha-amidating enzyme catalyzes the C-terminal amidation of g

102 ses and other modifying enzymes, such as the amidating enzyme complex (PAM), in converting inactive o

103 omain was demonstrated with the bifunctional amidating enzyme of Xenopus laevis.

104 diverse amidated neuropeptides and with the amidating enzyme peptidylglycine alpha-hydroxylating mon

105 ystem to create mosaics for the neuropeptide amidating enzyme PHM; amidation is a highly specific and

106 bstrate specificity of peptidylglycine alpha-amidating enzyme was determined and compared against a c

107 The amidating enzyme, peptidyglycine alpha-amidating mono-ox

108 embrane domain and cytoplasmic domain of the amidating enzyme, peptidylglycine alpha-amidating monoox

109 PCs), carboxypeptidase E, and peptidyl alpha-amidating enzyme, to transform recombinant precursors in

110 ns, Dph1 to Dph5, and an as-yet-unidentified amidating enzyme.

111 oteins, Dph1 to -5, and a still unidentified amidating enzyme.

112 The peptidyl amidating enzymes have previously been identified in cel

113 The intense expression of peptidyl amidating enzymes in type II cell hyperplasia and atypic

114 of cells strongly positive for the peptidyl amidating enzymes.

115 l acid form of Tp1a compared with the native amidated form (IC50 2.1 nM), suggesting that the peptide

116 unable to process this peptide to the mature amidated form, resulting in markedly elevated serum prog

117 lso caused a 2-fold increase in the ratio of amidated forms of GLP-1 immunoreactivity to total glucag

118 zebrafish galanin gene encoded for a single amidated galanin peptide and a galanin message-associate

119 Amidated gastrin (G-17) attenuated the growth suppressin

120 Since mature, amidated gastrin (G-17) can induce cyclin D1, we determi

121 s assessed in transgenic mice overexpressing amidated gastrin (INS-GAS) and mice in which hypergastri

122 e overexpressing either progastrin (hGAS) or amidated gastrin (INS-GAS), compared with that in wild-t

123 labelling experiments, the conversion of the amidated gastrin G34 to G17 was inhibited by biogenic am

124 ithelia following injury, but the effects of amidated gastrin have not previously been assessed.

125 elevated serum progastrin levels and normal amidated gastrin levels.

126 cleavage of G34 (the thirty-four amino acid amidated gastrin) at Lys-74-75 to give G17 (the seventee

127 -74-75 to give G17 (the seventeen amino acid amidated gastrin), and of G34-Gly to G17-Gly (G34 and G1

128 In colorectal cancer, FAK is activated by amidated gastrin, a protumorigenic hormone.

129 avage of 35S-labelled thirty-four amino acid amidated gastrin, i.e. [35S]G34, and of [35S]G34 with CO

130 7, resulting in a twofold elevation of serum amidated gastrin, marked thickening of the oxyntic mucos

131 cholecystokinin-2 receptor was treated with amidated gastrin-17.

132 strin (INS-GAS) transgene that overexpresses amidated gastrin.

133 imary receptor for cholecystokinin (CCK) and amidated gastrin.

134 ice similarly suggested a protective role of amidated gastrins against colon carcinogenesis, which su

135 epithelial differentiation; and C-terminally amidated gastrins stimulate colonic proliferation, gastr

136 y that loss of gastrin expression (and hence amidated gastrins) significantly increases susceptibilit

137 putative growth factors; their products, the amidated gastrins, regulate epithelial cell proliferatio

138 mice lacking normal physiological levels of amidated gastrins.

139 ng pathways initiated by biologically active amidated gastrins.

140 s and if the effects are similar to those of amidated gastrins.

141 xpressing high levels of progastrin, but not amidated gastrins.

142 islet alpha cells, leading to an increase in amidated GLP-1, which can then exert an insulinotropic e

143 ttributed to the meta disposition of the two amidate groups in 4,6-dioxypyrimidinate as compared to t

144 he copper complexes follows the trend Cu(II)-amidate > Cu(II)-imidate > Cu(II)-benzoate.

145 n organism in which the peptidoglycan is not amidated, has a strong preference for a terminal carboxy

146 3'-O(O-)(O)PNH-5'internucleoside linkages (5'amidate) have shown that 3'amidate duplexes, formed with

147 The 37-residue, C-terminally amidated human amylin peptide derives from a proprotein

148 rted expression system for the production of amidated IAPP.

149 This intermediate was esterified or amidated in solution phase.

150 into solution and the four carboxylates are amidated in the sequential order of e, d, b, and g for t

151 de acyl oxygen to form a high-energy O-alkyl amidate intermediate, (2) attack of the 2'-OH group on t

152 esterase(s) to give stable phosphomonoester amidate intermediates with a free carboxyl group.

153 After each round of catalysis the partially amidated intermediates are released into solution and th

154 that dinorCDCA, as norCDCA, is inefficiently amidated, is metabolized as a xenobiotic, and induces hy

155 mbyx mori, and Aedes aegypti: A C-terminally amidated ITP and a C-terminally unblocked ITP-like pepti

156 artially randomized with carboxylate b being amidated last.

157 utational investigations have implicated the amidate ligand in nickel superoxide dismutase (NiSOD) in

158 an intramolecular nucleophilic attack of the amidate ligand on the coordinated alkene.

159 to aluminum and proton transfer to a kappa2-amidate ligand to yield an Al(kappa2-amidate)2(kappa1-ca

160 so employed to construct a variant where the amidate ligand was converted to a secondary amine, H1*-N

161 A new family of tetra-anionic tetradentate amidate ligands, N1,N1'-(1,2-phenylene)bis(N2-methyloxal

162 The effects of oleamide, an amidated lipid isolated from the cerebrospinal fluid of

163 For this purpose, low esterified amidated, low and high methyl esterified citrus and appl

164 e of the peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) domain of peptidylglycine alpha-am

165 d lyase (peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL)) domains.

166 enzyme, peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5), has no known homologu

167 PHM, and peptidyl-alpha-hydroxyglycine alpha-amidating lyase or PAL) that in most eukaryotes are expr

168 introduction of a lipophilic phosphodiester amidate moiety on the HIV activity of inactive unsaturat

169 The amidating enzyme, peptidyglycine alpha-amidating mono-oxygenase (PAM), the prohormone convertas

170 nal enzyme called PAM (peptidylglycine alpha-amidating mono-oxygenase).

171 arboxypeptidase H, and peptidylglycine alpha-amidating mono-oxygenase.

172 Peptidylglycine alpha-amidating monooxygenase (PAM) (EC 1.14.17.3) catalyzes p

173 al domains of membrane peptidylglycine alpha-amidating monooxygenase (PAM) are essential for peptide

174 Peptidylglycine alpha-amidating monooxygenase (PAM) catalyzes a two-step react

175 Peptidylglycine alpha-amidating monooxygenase (PAM) catalyzes the amidation of

176 Peptidylglycine alpha-amidating monooxygenase (PAM) catalyzes the carboxyl-ter

177 Peptidylglycine alpha-amidating monooxygenase (PAM) catalyzes the COOH-termina

178 tide processing enzyme peptidylglycine alpha-amidating monooxygenase (PAM) contains signals that dire

179 g of integral membrane peptidylglycine alpha-amidating monooxygenase (PAM) in the neuroendocrine AtT-

180 n of membrane forms of peptidylglycine alpha-amidating monooxygenase (PAM) in the secretory pathway o

181 Peptidylglycine alpha-amidating monooxygenase (PAM) is an essential enzyme tha

182 Because peptidylglycine alpha-amidating monooxygenase (PAM) is one of the few membrane

183 Peptidylglycine alpha-amidating monooxygenase (PAM), a bifunctional enzyme, ca

184 ing P-type ATPase, and peptidylglycine alpha-amidating monooxygenase (PAM), a copper-dependent membra

185 amined the turnover of peptidylglycine alpha-amidating monooxygenase (PAM), a membrane enzyme involve

186 for full activation by peptidylglycine alpha-amidating monooxygenase (PAM), a transmembrane vesicular

187 o catalytic domains of peptidylglycine alpha-amidating monooxygenase (PAM), a type I integral membran

188 ical tools to identify peptidylglycine alpha-amidating monooxygenase (PAM), a type I secretory granul

189 Peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme essential for b

190 Peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme essential for n

191 We recently identified peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme required for ge

192 sis and trafficking of peptidylglycine alpha-amidating monooxygenase (PAM), an essential cuproenzyme

193 Peptidylglycine alpha-amidating monooxygenase (PAM), an integral membrane prot

194 Peptidylglycine alpha-amidating monooxygenase (PAM), an integral membrane prot

195 zing esterase/lipase, peptidyl glycine alpha-amidating monooxygenase (PAM), peptidase cleavage, and g

196 ion, we find that both peptidylglycine alpha-amidating monooxygenase (PAM), the enzyme responsible fo

197 cyl-CoA synthetase and peptidylglycine alpha-amidating monooxygenase (PAM).

198 the amidating enzyme, peptidylglycine alpha-amidating monooxygenase (PAM).

199 es by the bifunctional enzyme peptidyl-alpha-amidating monooxygenase (PAM).

200 e bifunctional enzyme, peptidylglycine alpha-amidating monooxygenase (PAM).

201 he bifunctional enzyme peptidylglycine alpha-amidating monooxygenase (PAM).

202 outing determinants of peptidylglycine alpha-amidating monooxygenase (PAM).

203 essing is catalyzed by peptidylglycine alpha-amidating monooxygenase (PAM).

204 egral membrane protein peptidylglycine alpha-amidating monooxygenase (PAM; EC 1.14.17.3) contains mul

205 he bifunctional enzyme peptidylglycine-alpha-amidating monooxygenase mediates the conversion of C-ter

206 s of a single protein (peptidylglycine alpha-amidating monooxygenase or PAM).

207 glycine (hippurate) by peptidylglycine alpha-amidating monooxygenase to again yield benzamide and gly

208 lyase (PAL) domain of peptidylglycine alpha-amidating monooxygenase was investigated with respect to

209 processing enzyme PAM (peptidylglycine alpha-amidating monooxygenase) as tools to study the peptiderg

210 y its interaction with peptidylglycine alpha-amidating monooxygenase, an enzyme essential for neurope

211 or to the mature form, peptidylglycine alpha-amidating monooxygenase, were upregulated by inositol de

212 h its interaction with peptidylglycine-alpha-amidating monooxygenase.

213 89SP by treatment with peptidylglycine-alpha-amidating monooxygenase.

214 sed on PS-SCL screening results identified 3 amidated monosubstituted and disubstituted peptides that

215 The resulting amidated N-glycans can then be released from the protein

216 ty purification allowed the sequencing of an amidated neuronostatin peptide of 13 residues from porci

217 In Drosophila, the amidated neuropeptide pigment dispersing factor (PDF) is

218 DIMM is coexpressed with diverse amidated neuropeptides and with the amidating enzyme pep

219 levels and reproducibly altered patterns of amidated neuropeptides in the CNS.

220 ervous system confirms the important role of amidated neuropeptides in these parasitic flatworms.

221 Amidated neuropeptides of the FMRFamide class regulate n

222 ey also support the hypothesis that multiple amidated neuropeptides, acting upstream, downstream, or

223 or amidation and therefore activation of all amidated neuropeptides, and amidated PACAP are expressed

224 We investigated the role of amidated neuropeptides, and specifically pituitary adeny

225 eriments were conducted to determine whether amidated neuropeptides, such as PACAP38, might function

226 reening and characterization of C-terminally amidated neuropeptides.

227 eukaryotic NAD+ synthetases use glutamine to amidate nicotinic acid adenine dinucleotide while many p

228 Moreover, the amidated NPY CTFs protected human neuronal cultures from

229 ino acid carbomethoxy ester phosphomonoester amidate nucleotide prodrugs by PBMCs does not require pr

230 ino acid carbomethoxy ester phosphomonoester amidates of AZT are not significantly metabolized to eit

231 acid carbomethoxy ester aryl phosphodiester amidates of nucleotide prodrugs.

232 t zero binding density) for the +8-charged C-amidated oligopeptide KWK6 and short single-stranded DNA

233 erivatives (acetylated on the N-terminal and amidated on the C-terminal end) of [Ala2,D-Leu5]-Enk, [D

234 es is reflected in the nucleofugality of the amidate once the alkoxide is formed and not in the pKa o

235 ctivation of all amidated neuropeptides, and amidated PACAP are expressed in developing and adult olf

236 Amidated PACAP is highly expressed in proliferative basa

237 These mice had decreased amidated PACAP production and concomitant decreased numb

238 APP or Amylin) is a 37-residue, C-terminally amidated pancreatic hormone, cosecreted with insulin tha

239 del systems containing high methoxylated and amidated pectins, respectively.

240 6-8 PEG chains attached to the non-carboxyl-amidated PEG-rMETase.

241 The carboxyl-amidated PEGylated rMETase was hyper-PEGylated at a mola

242 ir breakdown to the corresponding C-terminal amidated peptide and glyoxylate as final products.

243 prohormones to the active, C-terminal alpha-amidated peptide and glyoxylate.

244 PAM catalyzes the final step in alpha-amidated peptide biosynthesis, and its proposed role in

245 The N-acetylated, C-amidated peptide corresponds to the sequence comprising

246 rus spinnifer, is a 34-residue, C-terminally amidated peptide cross-linked by four disulfide bridges.

247 Pancreastatin, a carboxyl-terminal amidated peptide derived from chromogranin (Cg)A, inhibi

248 Kisspeptin is a C-terminally amidated peptide encoded by the KiSS1 gene.

249 ics of binding and insertion of the free and amidated peptide groups.

250 Carboxyl-terminal amidated peptide hormones are known to be autocrine grow

251 mes necessary for the biosynthesis of active amidated peptide hormones is therefore necessary for aut

252 rmations in catecholamine neurotransmitters, amidated peptide hormones, and collagen biosynthetic pat

253 Dissociation constants (Kd's) of the amidated peptide HPVHHYQ-NH2 to various A-site RNA const

254 ears, and the physiological function of this amidated peptide in regulating gastric acid secretion vi

255 this alpha-hydroxyglycine derivative to the amidated peptide plus glyoxylate.

256 sis behavior by secretion of an unidentified amidated peptide(s).

257 lycine-extended peptides to C-terminal alpha-amidated peptides and glyoxylate.

258 These data establish amidated peptides and specifically PACAP as having impor

259 sodium channels in insects, are C-terminally amidated peptides composed to 36 amino acids, including

260 Recently, a new class of small C-terminally amidated peptides comprising four to seven amino acid re

261 mally and express wildtype levels of several amidated peptides despite having one half the wildtype l

262 However, the non-amidated peptides FKRF, FLRF and nLRF and also WMDFamide

263 results show that both the amidated and non-amidated peptides had a disordered structure in aqueous

264 FF), AF (NPAF), and SF (NPSF) are homologous amidated peptides that were originally identified on the

265 Despite the proposed contribution of amidated peptides to neuronal cell proliferation, no alt

266 n PHM mutants revealed specific disruptions: Amidated peptides were largely absent in strong hypomorp

267 am treatment, which depletes stores of alpha-amidated peptides, increased the specific activity of PH

268 l for the biosynthesis of catecholamines and amidated peptides, respectively.

269 ne protein essential for the biosynthesis of amidated peptides, was used to assess the role of cytoso

270 on may also prove useful in decreasing other amidated peptides.

271 ch toward the synthesis of an array of ortho-amidated phenylimidazo heterocycles without prior activa

272 Acetylated, amidated PHSCN (Ac-PHSCN-NH2) was 30-fold more potent; h

273 The potency of acetylated, amidated PHSRN (Ac-PHSRN-NH(2)) is significantly increas

274 The best compound, the (S)-FPMPA amidate prodrug, exerts anti-HIV-1 activity in TZM-bl an

275 rences displayed by these enzymes toward TFV amidate prodrugs are nearly identical to their preferenc

276 ded peptide intermediate into a C-terminally amidated product.

277 )-H bond activation to generate the desired amidated products is reported.

278 ation of peptidylglycine substrates yielding amidated products stored in secretory granules.

279 e same site completely blocked production of amidated products, whereas serine substitution did not.

280 cine-extended peptides to their active alpha-amidated products.

281 ns that convert peptidyl-Gly substrates into amidated products.

282 rminated in lysine for one isoform and alpha-amidated proline for another isoform.

283 peptides ending in glycine, lysine, or alpha-amidated proline.

284 xazolone, which is an environmentally benign amidating reagent.

285 ino acid carbomethoxy ester phosphomonoester amidates revealed that their decomposition pathway diffe

286 (NMN) and nicotinamide riboside (NR) in the amidated salvage pathway despite no increase in nicotina

287 We describe a method for the production of amidated sCT in the mammary gland of transgenic rabbits.

288 s the endocannabinoid anandamide and related amidated signaling lipids.

289 sary to completely cyclize and aromatize the amidated tetracyclic aglycon.

290 The amidated tetracycline backbone is biosynthesized by the

291 late the misacylated tRNA substrate and then amidate the activated intermediate to form the cognate p

292 Removing the C-terminal alanine alone, or amidating the C terminus carboxyl group, also eliminated

293 ediate, (2) attack of the 2'-OH group on the amidate to form a 1',2'-acyloxonium species, (3) hydroly

294 The enzyme did not amidate tripeptide- and tetrapeptide-truncated versions

295 Protein acids are subsequently amidated under buffered conditions in DMSO using the cou

296 des were used to identify and quantitate the amidated versus deamidated forms of each tryptic fragmen

297 All phosphodiester amidates were more biologically active than their parent

298 The synthetic, amidated white bass moronecidin exhibited broad spectrum

299 CDCA, in contrast, was efficiently amidated with taurine or glycine.

300 roups of polyamide nylon 6/6 to give (eta(2)-amidate)zirconium complexes in high yield.