ライフサイエンスコーパス: amidation

1 lycosylated threonine, and * = COOH-terminal amidation).

2 file was consistent with defective bile acid amidation.

3 ding blocks were assembled by thioacid amine amidation.

4 efficiently coupled using Grignard-mediated amidation.

5 orms Asn and Asn-tRNA(Asn) by tRNA-dependent amidation.

6 h beta-cyclodextrins (host moieties) through amidation.

7 was found to be uniquely effective for this amidation.

8 e II with increasing receptor methylation or amidation.

9 g macrocyclic ynamides via an intramolecular amidation.

10 with both ends protected by acetylation and amidation.

11 of modification, with the dominant one being amidation.

12 ed with diaminobutane, resulting in carboxyl amidation.

13 cation, and alpha2,3-linked sialic acids via amidation.

14 a decrease was observed following C-terminal amidation.

15 evoid of a tryptophan residue and C-terminal amidation.

16 y the acetyltransferase HolE to catalyze the amidation.

17 s been utilized as a directing group for the amidation.

18 sequence, C-terminal lysine, and C-terminal amidation.

19 vestigated to elucidate the mechanism of the amidation.

20 inal glycine of small peptides for its later amidation.

21 as an essential coupling partner for the C-H amidation.

22 thetic version only in missing of N-terminal amidation.

23 in was synthesized by eight such reiterative amidations.

24 re higher in energy than the thiocarboxylate amidations.

25 a mechanism by which FXR regulates bile acid amidation, a critical component of the enterohepatic cir

26 enase (PAM) (EC 1.14.17.3) catalyzes peptide amidation, a crucial post-translational modification, th

27 lycan structure revealed a total loss of DAP amidation, a modification that was found in 80% of DAP r

28 Carboxyl-terminal amidation, a required post-translational modification fo

29 he rate-limiting enzyme for C-terminal alpha-amidation, a specific and necessary modification of secr

30 CARs demonstrated amidation activity for various acids and amines.

31 No peptide amidation activity was detected in PAM mutant embryos, a

32 The key steps of amidation, alcohol activation, and cyclization are all m

33 same diacyl derivatives of amide (i.e., both amidation and acylation) in high yield was also demonstr

34 directly inhibits Src kinase by simultaneous amidation and ADP ribosylation of the conserved kinase-d

35 oquinone fragments proved unsuccessful, both amidation and C-N bond formation tactics with the more e

36 icipated, highly conserved link between PAM, amidation and ciliary assembly.

37 nce in products formed from copper-catalyzed amidation and copper-catalyzed ODC, reactions of an alky

38 ere coupled together at a late stage through amidation and cross-metathesis in a convergent manner.

39 This allows the sequential amidation and generation of asymmetric squaramides with

40 istinct multistep continuous-flow processes (amidation and Mg-I exchange/nucleophilic addition) to de

41 r used as an electrophile enabled sequential amidation and provided asymmetric squaramides with high

42 ve gamma-C(sp(3))-H arylation/intramolecular amidation and the construction of both C-C and C-N bonds

43 ooxygenase (PAM), the enzyme responsible for amidation and therefore activation of all amidated neuro

44 tization by dimethylamidation and subsequent amidation and transferred this onto formalin-fixed paraf

45 en used for further transformations, such as amidations and Fukuyama coupling reactions.

46 minal residues after proteolysis, C-terminal amidation, and a unique post-translational modification,

47 ed as a coupling reagent for esterification, amidation, and dehydration of carboxylic acids (aliphati

48 conjugation techniques, reductive amination, amidation, and Huisgen cycloaddition, were employed for

49 genase (PAM) are essential for peptide alpha-amidation, and the cytosolic domain (CD) is essential fo

50 mide starting compounds are detailed, as are amidation approaches installing the alpha-ketoamide resi

51 Both type I and type II amidations are utilized in this effort, allowing access

52 d progastrins at Arg-94-95 or Arg-57-58, and amidation at Phe-92 were not influenced by pretreatment

53 lycan structures conserved in Acetobacteria: amidation at the alpha-(l)-carboxyl of meso-diaminopimel

54 y neuropeptides and peptide hormones require amidation at the carboxyl terminus for activity.

55 Direct ortho amidation at the phenyl ring of 2-phenylimidazo heterocy

56 culate forms and demonstrated that even with amidation-based shell cross-linking the core domain rema

57 bon nanotubes (MWCNTs) via diimide-activated amidation between the carboxyl groups on the CNT surface

58 precursors frequently includes COOH-terminal amidation by the bifunctional enzyme peptidylglycine alp

59 equence (azide-alkyne cycloaddition/Goldberg amidation/Camps cyclization/(CH arylation)) for the rapi

60 ents, genetic defects that disrupt bile acid amidation cause fat-soluble vitamin deficiency and growt

61 ia coli type 1 pilus adhesin FimH(A) through amidation chemistry to enable bladder epithelial cell bi

62 The fifth ring was completed by a "one-pot" amidation-cyclization process promoted by palladium acet

63 three steps utilizing a palladium-catalyzed amidation/cyclization strategy.

64 Bile acid amidation defects were predicted to present with fat/fat

65 inborn errors of bile acid metabolism due to amidation defects.

66 trahydoisoquinoline ring, which upon further amidation, deprotection, and sulfation gave the targeted

67 Amidation derivatizes all sialic acids regardless of lin

68 from four families with defective bile acid amidation due to a genetically confirmed deficiency in b

69 e carboxyl group of this arginine residue by amidation, eliminated the binding and internalizing acti

70 Elaboration of the lactam cores via amidation enabled synthesis of novel ACC inhibitors and

71 zyme pair and highlights the first oxidation-amidation enzymatic cascade reaction leading to the sele

72 lude two well-established LDCV proteins, the amidation enzyme PHM and the ascorbate-regenerating elec

73 red via 1,3-dipolar cycloaddition (CuAAC) or amidation/esteryfication reactions.

74 etic transformations such as esterification, amidation, etc., highly efficient and modular simultaneo

75 Different amidation events on chromogranin A, and on peptides proc

76 nitial N-heterocyclic carbene mediated redox amidation exploying these two types of building blocks r

77 Many neuropeptides require amidation for full activation by peptidylglycine alpha-a

78 Palladium-catalyzed oxidative amidation has been used to synthesize hydroxamic acid-co

79 he stabilization of the helical structure by amidation has previously been shown to play a key role i

80 tion, Kornblum oxidation, and intramolecular amidation in a single reactor.

81 nowledge, the occurrence of C-terminal alpha-amidation in mAbs has not been reported previously.

82 We report here that amidation in mild acidic conditions can be used to neutr

83 quential iodination, Kornblum oxidation, and amidation in one pot.

84 Esterification or amidation in solution effectively protects sialic acids,

85 netic and biochemical basis for the terminal amidation in thiotetroamide C biosynthesis, which involv

86 eloping Drosophila melanogaster larvae, FMRF amidation in thoracic ventral (Tv) neurons is strikingly

87 C-terminal amidation in vivo was achieved by extending the sCT by a

88 es catalyzed transesterifications as well as amidations in a manner similar to those of previously re

89 When tested against Escherichia coli, amidation increased toxicity 10-fold (MIC = 31.25 muM) w

90 s for the neuropeptide amidating enzyme PHM; amidation is a highly specific and widespread modificati

91 alpha-Amidation is essential for the function of many peptides

92 t in human, mouse, and insect cells, peptide amidation is exquisitely sensitive to hypoxia.

93 esults indicate that, in Drosophila, peptide amidation is required for neuropeptide regulation of beh

94 Whether the most important effect of peptide amidation is the change in charge or an enhancement of h

95 The preferred site for amidation is the free carboxyl group of the meso-diamino

96 hage-display platform to select for specific amidation, leading to an order of magnitude acceleration

97 although the pathway must involve chelation, amidation, macrocyclic ring reduction, lactamization and

98 could be expected if any alternative peptide amidation mechanism exists in the mouse.

99 An efficient amidation method between readily available 1,1-dicyanoal

100 tivates the development of catalytic, direct amidation methods employing free carboxylic acids and am

101 compared, the latter undergoing Rh-catalyzed amidation more rapidly.

102 Reduced AP-1 function made 18-kDa fragment amidation more sensitive to inhibition by bathocuproine

103 to build the dapdiamide antibiotic scaffold, amidation must occur on the fumaroyl-DAP scaffold, after

104 s required for cellular respiration, peptide amidation, neurotransmitter biosynthesis, pigment format

105 A Rh-catalyzed ortho-amidation of 2-aryloxazolines offers an efficient and di

106 could be applied toward the selective ortho amidation of 2-heteroarylimidazo[1,2-a]pyridine framewor

107 ates were synthesized using copper-catalyzed amidation of 3-amino-N-Boc-4-chloropyridine.

108 e the Cu(II)-catalyzed C-H methoxylation and amidation of a macrocylic arene substrate with O(2) as t

109 curred in OSN, is attributable to C-terminal amidation of a natural peptide derived from osteocalcin.

110 ing to such a compound include the oxidative amidation of a phenol, a Cu(II)-catalyzed cyclocondensat

111 l, is as an effective reagent for the direct amidation of a variety of carboxylic acids with a broad

112 e method is efficient and allows for the C-H amidation of a wide range of functionalized thioamides w

113 Amidation of a wide variety of carboxylate salts with ei

114 ent-free cross-coupling method for oxidative amidation of aldehydes and alcohols via a metal-free rad

115 A practical method for the amidation of aldehydes with economic ammonium chloride o

116 The intramolecular dehydrogenative amidation of aliphatic amides, directed by a bidentate l

117 Notably, chemoselective amidation of aliphatic amines takes place in the presenc

118 es)Pd(TFA)2(H2O)-catalyzed aerobic oxidative amidation of alkene.

119 lective Pd-catalyzed "Wacker-type" oxidative amidation of alkenes.

120 onds is a key step in Pd-catalyzed oxidative amidation of alkenes.

121 cation of the phytosphingosine side chain by amidation of an advanced methyl ester precursor.

122 ther demonstrates a challenging Cu-catalyzed amidation of an ortho-substituted aryl chloride.

123 roamide C involving the tandem oxidation and amidation of an unreactive ethyl group.

124 A Rh(III)-catalyzed protocol for the amidation of anilide and enamide C-H bonds with isocyana

125 We present results on the amidation of aryl halides and sulfonates utilizing a mon

126 ensive catalyst system was developed for the amidation of aryl halides by using 0.2-10 mol % of CuI,

127 d minimal impact on DNA polymerase function, amidation of Asp-358, Glu-401, and Asp-426 eliminated Mg

128 -tRNA formation in most prokaryotes requires amidation of Asp-tRNA or Glu-tRNA by amidotransferases t

129 The amidation of Asp69 and Glu119 caused a 7.6- and 88-fold

130 , this is the first report for the oxidative amidation of benzylamines and decyanation of benzyl cyan

131 genase (PAM) catalyzes the carboxyl-terminal amidation of bioactive peptides through a two-step react

132 nctional enzyme, catalyzes the COOH-terminal amidation of bioactive peptides.

133 A novel Ni-catalyzed reductive amidation of C(sp(2))-O and C(sp(3))-O electrophiles wit

134 um catalyzes the glutamine and ATP-dependent amidation of carboxylates b, d, e, and g within adenosyl

135 Direct amidation of carboxylic acids by reaction with amines in

136 m glutamicum (LtsACg) in the modification by amidation of cell wall peptidoglycan diaminopimelic acid

137 Kinetic and computational studies on the amidation of esters with mixtures of formamide and sodiu

138 min(-1)); and (iii) FdmV also catalyzes the amidation of FDM M-3, a structural analog of FDM C, to a

139 tion and successive arylation/intramolecular amidation of gamma-C(sp(3))-H bonds.

140 that most Bacteria form Gln-tRNA(GLN) by the amidation of Glu-tRNA(GLN), only a few members of the ga

141 glucosamine is produced enzymatically by the amidation of glucose 6-phosphate and can then be further

142 ha-amidating enzyme catalyzes the C-terminal amidation of glycine-extended peptides.

143 zes the first step leading to the C-terminal amidation of glycine-extended peptides.

144 The Ru(II)-catalyzed C-H amidation of indoline at the C7-position en route for sy

145 ed into known biosynthetic pathways, for the amidation of known acceptor molecules (e.g. CTP synthesi

146 tial enzyme that catalyzes the COOH-terminal amidation of many neuroendocrine peptides.

147 For the amidation of N-acetylglycine, N-(tert-butoxycarbonyl)gly

148 The amidation of N-protected amino acids with both primary a

149 In this route, the amidation of NaMN to nicotinamide mononucleotide (NMN) o

150 copper-containing enzyme that catalyzes the amidation of neuropeptides hormones, the first step of w

151 minotransferase domain to supply ammonia for amidation of nicotinic acid adenine dinucleotide (NaAD(+

152 -quinolones that utilizes a copper-catalyzed amidation of o-halophenones followed by a base-promoted

153 d raise the possibility that region-specific amidation of PAM substrates contributes significantly to

154 -extended propeptides, the first step in the amidation of peptide hormones by the bifunctional enzyme

155 ooxygenase (PAM) catalyzes the COOH-terminal amidation of peptide hormones.

156 wo-step reaction resulting in the C-terminal amidation of peptides, a process important for their sta

157 ch together catalyze the COOH-terminal alpha-amidation of peptidylglycine substrates yielding amidate

158 Amidation of Phe-Met-Arg-Phe-amides, a group of cardiomo

159 s been developed based on chelation-assisted amidation of readily available aryl boronic acids at roo

160 Novozym 435 mediated amidation of sophorolipid ethyl ester in dry THF with ph

161 o-beta-ketoesters is developed via oxidative amidation of sp, sp(2), and sp(3) C-H bonds.

162 and binds to the same catalytic site for the amidation of the a-carboxylate.

163 ng muramyl tripeptides, were not affected by amidation of the alpha-carboxylic acid of iso-glutamic a

164 modification at W61, cyanylation at C56, and amidation of the C terminus at G63.

165 terminus and protonation, deprotonation, or amidation of the C terminus.

166 monstrate that CbiA catalyzes the sequential amidation of the c- and a-carboxylate groups of cobyrini

167 alytic mechanism in which CbiA catalyzes the amidation of the c-carboxylate, and then the intermediat

168 of the many bioactive peptides that require amidation of the carboxy terminus for full potency.

169 initial enzymatic adenylation of substrates, amidation of the carboxylic acid proceeds by direct reac

170 Furthermore, amidation of the d-Glu residue did not alter NOD2 activa

171 tion and successive arylation/intramolecular amidation of the gamma-C(sp(3))-H bonds.

172 inyl-tRNA(Asn) were likely formed in LUCA by amidation of the mischarged species, glutamyl-tRNA(Gln)

173 acteria by a pretranslational tRNA-dependent amidation of the mischarged tRNA species, Glu-tRNA(Gln)

174 -tRNA and asparaginyl-tRNA by tRNA-dependent amidation of the mischarged tRNA species, glutamyl-tRNA(

175 Amidation of the oxime ester (23b) with histamine, follo

176 iverdin reductases are less accommodating to amidation of the propionic acid side chains of biliverdi

177 n of O-methyl bromotyrosine methyl ester and amidation of the resulting oxime ester (14) with histami

178 gainst PC2 nearly 3-fold, whereas C-terminal amidation of the same peptide increased the potency by a

179 Many bioactive peptides require amidation of their carboxy terminus to exhibit full biol

180 NA(Asn) or Glu-tRNA(Gln), and the subsequent amidation of these amino acids while they are bound to t

181 -amidating monooxygenase (PAM) catalyzes the amidation of these diverse physiological regulators.

182 nt-free, and selective Cp*Co(III) -catalyzed amidation of thioamides with robust dioxazolone amidatin

183 A catalytic protocol for the base-mediated amidation of unactivated esters with amino alcohol deriv

184 are of unknown function, likely involved in amidation of unknown acceptors.

185 e proposed intermediates in copper-catalyzed amidations of aryl halides, have been synthesized and ch

186 used to gain an insight into the effects of amidation on antimicrobial selectivity.

187 acteria such as Escherichia coli by a single amidation on the peptide side chain.

188 ny that are not compatible with Pd-catalyzed amidation or amination methodology.

189 eutralization of inhibitor charged groups by amidation or esterification.

190 Carboxy-terminal amidation or substitution of tryptophan for tyrosine enh

191 immobilizing short recognition sequences by amidation or thiol-maleimide reactions.

192 1_2.1 enzyme may activate SLs (e.g. GR24) by amidation, or more likely could embody a new pathway for

193 r functionalization via reductive amination, amidation, or other chemistry.

194 the anionic charge by ethyl esterification, amidation, or reduction also abolished MAG-mediated cell

195 t is proposed that this residue enforces the amidation order in the wild type enzyme via charge-charg

196 However, the strict amidation order observed with the wild type CbiP is part

197 utated to address the molecular basis of the amidation order; however, no changes in the order of ami

198 that the advantages conferred by C-terminal amidation outweigh increased amyloidogenicity.

199 post-translationally modified peptides (e.g. amidation, oxidation, lipidation, glycosylation or d-ami

200 arbon position through the diamide and alpha-amidation pathways.

201 dal anti-inflammatory drug, indomethacin, by amidation presents a promising strategy for designing no

202 A useful modification of the Weinreb amidation procedure was applied to the opening of the in

203 ocatalyst in a Cp*Rh(III)-catalyzed C-H bond amidation proceeding by an intramolecular amide transfer

204 The stereoselective amidation proceeds without additional acyl transfer agen

205 nd the target amide using an isodesmic trans-amidation process and is calibrated relative to 1-aza-2-

206 ial role of molecular sieves in this complex amidation process.

207 ogrammed cell death, we demonstrated that an amidation reaction between thio acids and sulfonyl azide

208 This novel amidation reaction involves a catalytic protocol using c

209 In vertebrates, the two-step peptide alpha-amidation reaction is catalyzed sequentially by two enzy

210 The selenocarboxylate/azide amidation reaction is clean and chemoselective.

211 This amidation reaction is operationally straightforward and

212 A simple, one-step amidation reaction is used to produce a range of 12-arm

213 ey step involves a novel palladium-catalyzed amidation reaction of 4-chloro-1-methylindazole 8 with t

214 d in good to very good isolated yields by an amidation reaction of different 2-haloanilines with 2-ca

215 umented is an intramolecular copper-mediated amidation reaction to close the 19-membered macrolactams

216 documented; however, it is very rare for an amidation reaction to occur without activation.

217 duce diphthine and allows the Dph6-catalyzed amidation reaction to occur.

218 The amidation reaction was also employed for the generation

219 hiometric versions of the Ir and Rh-mediated amidation reaction were compared systematically to each

220 gating a subsequent lanthanum(III)-catalyzed amidation reaction, a new multicomponent reaction was de

221 ation of a charge-carried reagent through an amidation reaction.

222 etween rMETase molecules during the carboxyl amidation reaction.

223 mide synthetase catalyzing the ATP-dependent amidation reaction.

224 a has recently been shown to catalyze direct amidation reactions at room temperature in the presence

225 ligand, and base as the catalyst system, the amidation reactions proceed in good yields for a range o

226 rming reaction differs from that of standard amidation reactions, highlighting the ability to control

227 ontaining dyes via zero-length cross-linking amidation reactions.

228 tion of both intra- and intermolecular vinyl amidation reactions.

229 s has been carried out by esterification and amidation reactions.

230 The method is also useful for direct amidation reactions.

231 tide LLRVKR against furin 8-fold, C-terminal amidation reduced the potency < 2-fold.

232 Amidation requires conversion of a glycine-extended pept

233 ariation in the degree of esterification and amidation, respectively, had negligible effects.

234 having similar degrees of esterification and amidation, respectively.

235 A condensation/amidation sequence converts alpha-boryl aldehydes into s

236 t desilylation/dihydropyranone fragmentation/amidation sequence.

237 acid N-terminal propeptide, and a C-terminal amidation signal.

238 of the resulting ester-amide after the first amidation step of the diester.

239 ctive peptides ends with an obligatory alpha-amidation step that is catalyzed only by peptidylglycine

240 e diphthamide synthetase catalyzing the last amidation step using ammonium and ATP.

241 46W or human WDR85) are involved in the last amidation step, with Dph6 being the actual diphthamide s

242 glycan using the solid-phase esterification/amidation strategy.

243 orophenylselenide ring opening, and finally, amidation to afford the ring-D synthon 45 having the pro

244 late-stage intramolecular copper(I)-mediated amidation to complete the assembly of the tetracyclic fr

245 by a nickel-specific chelatase, followed by amidation to form Ni-sirohydrochlorin a,c-diamide.

246 Amidation to generate the physiologically relevant form

247 -alkylation and arylation, deprotection, and amidation to install broad molecular diversity in short

248 properties of proteins, as demonstrated with amidation to modify protein isoelectric point and throug

249 nic acid dinucleotide (NaAD) followed by its amidation to NAD, constitute promising drug targets for

250 tionally simple method for effecting allylic amidation using an environmentally benign oxidant and a

251 The (V/K)app for N-acylglycine amidation varies approximately 1000-fold, with the (V/K)

252 tion, which is the key step of catalytic C-H amidation, was investigated in an integrated experimenta

253 Specifically, by polymer-analogous amidation we conjugated imidazole groups to the epsilon-

254 e enamide side chain and tandem deallylation/amidation were employed in synthetic routes to these der

255 n order; however, no changes in the order of amidation were obtained.

256 HATU-mediated amidation with glycine-OMe resulted in dipeptide (6).

257 Little N-acyl amidation (with glycine or taurine) occurred.