ライフサイエンスコーパス: amide

1 nd even alternative X-H donors (alcohols and amides).

2 ecyl)phosphonium bis(trifluoromethylsulfonyl)amide.

3 lving an acidic hydrolysis of the methylated amide.

4 eplacing the vinylic carboxylic acid with an amide.

5 s and resulting in the formation of an ortho-amide.

6 tevia for the first time, such as fatty acid amides.

7 enables their transformation into imides and amides.

8 squaramic acids is quite similar to that of amides.

9 atic compounds and functional groups such as amides.

10 (lithium benzhydryl(1-benzylpyrrolidin-3-yl)amide, 1-Li) is protected, up to a certain limit, agains

11 led synthesis of N-nitrosoamide from N-alkyl amides, (2) hydrolysis of N-methoxyamides to carboxylic

12 yclic core was accessed by electrophilic C19-amide activation and transannular spirocyclization.

13 teridine metabolites functionalized with cis-amide acyl-side chains, termed pepteridine A (1) and B (

14 tion with lithium-magnesium and lithium-zinc amides affords C-2 or C-8 functionalized derivatives in

15 , fatty acids, esters, monoglycerides, fatty amides, aldehydes, ketones, alcohols, epoxides, furans,

16 lpha-iodo ketones, esters, nitriles, primary amides, alpha-fluorinated halo-acetates and perfluoroalk

17 In addition, linear amides also prove to be competent substrates, and the ph

18 gen bonding between the guest anions and the amide/ammonium protons of the receptor also contributes

19 pid synthesis of acrylate ketone, ester, and amide analogs.

20 ffers an effective approach to installing an amide and an azide from two diffenent amino precursors o

21 sp(2)O, amide sp(2)N, aliphatic sp(3)C, and amide and aromatic sp(2)C unified atoms in water.

22 pH sensitivity stems from the integration of amide and hydroxyl CEST effects that show base- and acid

23 d and highly chemoselective reduction of the amide and lactam functionalities using IrCl(CO)[P(C6 H5

24 scaffold's core design combines (ortho-tolyl)amide and o,o,o'-trisubstituted biphenyl structural unit

25 ethylimidazolium bis(trifluoromethylsulfonyl)amide and trihexyl(tetradecyl)phosphonium bis(trifluorom

26 metal-free oxidation of amides to alpha-keto amides and alpha-hydroxy amides is presented.

27 Along with benzyl nitriles, aryl Weinreb amides and anilides have been evaluated for the transfor

28 mma-methylene C(sp(3) )-H bonds of aliphatic amides and delta-methylene C(sp(3) )-H bonds of nosyl-pr

29 ctive generation of aminoketyl radicals from amides and derivatives.

30 rpenoids; amino acids and derivatives; fatty amides and derivatives; fatty acids and derivatives; oli

31 In light of the importance of amides and phosphonates as synthetic intermediates, we e

32 esses involving Sm(II)-mediated reduction of amides and reductive umpolung cyclizations via aminokety

33 es, followed by a [2 + 2] cycloaddition with amides and subsequent decarboxylation, which liberates t

34 focal microscopy to map histamine (HA), FMRF-amide, and gamma-aminobutyric acid (GABA) immunoreactivi

35 erved with the non-hydrolyzable PGE2-serinol amide, and were completely prevented by methyl-arachidon

36 hange of aqueous NH4(+), for C-N rotation in amides, and for a hydride transfer.

37 ylene active compounds, formation of amines, amides, and imines, and metal catalyzed reactions.

38 e of (hetero)aromatic and aliphatic tertiary amides, and N-alkyl lactams is reported.

39 methyl-containing amines and amides, primary amides, and novel N-acetylated sugars, which together ac

40 plied to the late-stage functionalization of amide- and lactam-containing drugs, and naturally occurr

41 These results show that amides are practical substrates for alkene carboacylatio

42 The chiral beta-borylated amides are useful synthons for the synthesis of chiral b

43 ted ureas, and other amides by osmometry and amide-aromatic hydrocarbon interactions by solubility.

44 gate of functional groups such as olefin and amide as well.

45 The versatility of beta-carboline amides as directing groups is evidenced by other delta-C

46 We report here beta-carboline amides as intrinsic directing groups for C(sp(2))-H func

47 We recently found that amides as non-ionic replacements for phosphodiesters may

48 n the presence of lithium bis(trimethylsilyl)amide at elevated temperatures.

49 midines from sulfonyl azides and substituted amides at low CO pressure is reported.

50 tes functionalized alpha-phenoxy and related amides at room temperature under 4 atm H2 pressure to gi

51 iation of the longer and shorter chain alkyl amides at the depth of the cultural transition may refle

52 have explored the effect of bending aromatic amide beta-sheets using building blocks that impart curv

53 mobilized onto the CMD chip through covalent amide binding formation.

54 ding, representing an example of probing gas-amide binding interactions by such experiments.

55 tability; this was overcome by reversing the amide bond and changing the heterocycle.

56 ine-containing protein fragments to form the amide bond between respective protein fragments signific

57 s obtained from modified SM lipid anions via amide bond cleavage.

58 Here, we investigated the influence of the amide bond conformation on the stereoselectivity of H-Pr

59 significance of a trans conformation prolyl amide bond for the pi-clamp reactivity.

60 reaction scope, generating biocatalysts for amide bond formation from carboxylic acid and amine.

61 In this way we have accessed reversible amide bond formation that allows crystalline order to de

62 It first catalyzes amide bond formation, and then the intramolecular cyclod

63 Along with amide bond formation, Suzuki cross-coupling, and reducti

64 entral chemical step of peptide synthesis is amide bond formation, which is typically catalyzed by th

65 m N40 or N100 random pools initially seeking amide bond hydrolysis, although they both cleave simple

66 tate NMR chemical shifts indicate the prolyl amide bond in the pi-clamp motif adopts a 1:1 ratio of t

67 d a direct correlation between the trans/cis amide bond ratio and the enantio- and diastereoselectivi

68 e envisioned that control over the trans/cis amide bond ratio may provide a tool to optimize the cata

69 SpyTag is a peptide that forms a spontaneous amide bond with its protein partner SpyCatcher.

70 gh cleavages of the enol double bond and the amide bond, thus furnishing fully substituted 5-isoxazol

71 ng heterocycles via polarity reversal of the amide bond.

72 stereocenter promotes a cis-alanine-proline amide bond.

73 The activating principles used in amide-bond synthesis can therefore be used, with nickel-

74 Moreover, one-step construction of imide and amide bonds with a long-chain alkyl group is an attracti

75 ng direct arylation of an aliphatic tertiary amide by using density functional theory.

76 ractions of urea, alkylated ureas, and other amides by osmometry and amide-aromatic hydrocarbon inter

77 od for (i) direct synthesis of alcohols from amides by the challenging N-C bond scission and (ii) syn

78 trolled degradation of terminal alkynes into amides (by loss of one carbon) or ureas (by loss of two

79 I)-catalyzed beta- and gamma-alkynylation of amide C(sp(3) )-H bonds is enabled by pyridine-based lig

80 cal substrates for alkene carboacylation via amide C-N bond activation, and this approach bypasses ch

81 ggered by oxidative addition of an activated amide C-N bond to a Ni(0) catalyst and proceeds via alke

82 Our results suggest that an amide can mimic important hydrogen bonding interactions

83 Secondary and primary amides can be masked as N-Ns amides to undergo remote ox

84 Chemoselective activation of amide carbonyl functionality and subsequent umpolung via

85 (delta-) charge-dipole attraction compel the amide carbonyl groups to orient antiperiplanar to the C-

86 a zinc-bound hydroxide ion onto the ceramide amide carbonyl.

87 cyclizations involving radicals derived from amide carbonyls by single electron transfer take place u

88 A functional group such as an amide, carboxylic acid, imidazole, or phenol appeared to

89 t were observed, the cis conformation of the amide carrying the triazolium ranging from 83 to 94% in

90 al changes to both CaM lobes as indicated by amide chemical shifts of the amino acids of CaM in (1)H-

91 This reaction is compatible with carbocyclic amides containing alpha-tertiary as well as alpha-quater

92 ed to the synthesis of highly functionalized amide-containing medicinal drugs, such as O-Me-alibendol

93 Amide-containing molecules are ubiquitous in natural pro

94 ary benzamides with aromatic acids by weak O-amide coordination in the presence of [{RuCl2(p-cymene)}

95 thermally hydrosilylated pSi surface though amide coupling, with unreacted surface area rendered sta

96 Herein, we report an efficient on-bead amide-coupling approach to prepare SMDHs with multiple o

97 The N- to C-terminus amide cyclized peptide with one d-amino acid (k) display

98 emoselective process involving Tf2O-mediated amide cyclodehydration, followed by intramolecular C-H a

99 Creation of CO2-philic, amide-decorated cavities in the polymer matrix led to a

100 These results demonstrate that amide derivatives can be used as building blocks for the

101 We have synthesized novel amide derivatives that retain potency and have much impr

102 Libraries of nonpurified resorcinol amide derivatives were screened by surface plasmon reson

103 f functional groups, and a variety of biaryl amide derivatives were successfully prepared in good to

104 cedure for labeling arylcarboxylic acids and amide derivatives with the short-lived positron emitter

105 n-decarbonylative Mizoroki-Heck reactions of amide derivatives.

106 meta-selective borylation is demonstrated on amides derived from benzylamines, phenethylamines and ph

107 The analogous amides did not show a nuN-H red-shifted band, as the ele

108 f LGa (L = Dipp(4-(Dipp-imino)pent-2-en-2-yl)amide; Dipp: 2,6-diisopropylphenyl) and white phosphorus

109 ciclasine is accomplished by the late-stage, amide-directed C-H hydroxylation of a lycoricidine inter

110 The amide directing group plays a dual role as a cleavable c

111 pying process, yet some radical triazole and amide DNA backbones perform surprisingly well, indicatin

112 alization between a lone pair (n) of a (thio)amide donor and the antibonding sigma* orbital of an acc

113 ppaBalpha binds to the dimerization domains, amide exchange throughout the DNA-binding domains is dec

114 N-acetylcysteine amide eye drops were administered beginning on week 3 un

115 of chloro-substituted quinolines with metal amides followed by reaction with different electrophiles

116 " products possessing structurally different amide fragments are detected either by (1)H or (13)C NMR

117 ication to the synthesis of amino esters and amides from dehydroalanine monomers, a process which was

118 horough study of the reactivity of the ortho-amide functionality revealed the second domino reaction

119 s of carbon dioxide and acetylene in a tetra-amide functionalized metal-organic framework, MFM-188, a

120 rthermore, for the first time, certain fatty amides, gamma- and delta-lactones of high molecular weig

121 an amine group (K side chain) with a primary amide group (Q side chain) weakens the hydrophobic inter

122 adical stabilizing group such as an alkyl or amide group at the C3-position of indole furnishes the 3

123 spatiotemporal concepts where embedding the amide group between two carboxylic moieties in proper ge

124 ding to the selective formation of a primary amide group from a chemically inert alkyl group.

125 The readily cleavable amide group has been utilized as a directing group for t

126 one with respect to hydration changes in the amide group in combination with cooperative interactions

127 An asymmetrically positioned remote amide group in the designed chiral binaphthyl-based liga

128 to yield a new Blatter-type radical with an amide group replacing a phenyl at the C(3)-position.

129 e incorporated into the products by means of amide-group formation.

130 ement of the peptide backbone's carbonyl and amide groups in hydrogen-bond stabilization of helical s

131 enable the direct observation of the role of amide groups in substrate binding, representing an examp

132 The hydrogen bonding with the amide groups in the side chains has to be contrasted wit

133 re prepared by deprotection of the ester and amide groups of ortho-benzoxylated cyclic benzamides.

134 ) for the formation of intramolecular phenol-amide H-bonds as a function of solvent composition.

135 ot trifluoromethylative functionalization of amides has been accomplished for the synthesis of variou

136 Enoldiazo esters and amides have proven to be versatile reagents for cycloadd

137 On the basis of a Weinreb amide hit compound, we designed and synthesized a divers

138 e-electron transfer to unactivated aliphatic amides; however, little variation in terms of steric inf

139 Measuring amide hydrogen exchange (HX) of intrinsically disordered

140 ls required for hydrogen bond disruption and amide hydrogen exchange have a higher activation energy

141 displacement of a single coil to facilitate amide hydrogen exchange in either the terminal or penult

142 onal global stability, backbone dynamics, or amide hydrogen exchange rates.

143 NMR and amide hydrogen-deuterium exchange mass spectrometry show

144 ound phosphodiesterase8 (PDE8), monitored by amide hydrogen-deuterium exchange mass spectrometry, we

145 Here, we report amide hydrogen/deuterium exchange data that reveal long-

146 In this study, we used amide hydrogen/deuterium exchange mass spectrometry, a s

147 Dehydrogenative coupling and the subsequent amide hydrogenation proceed with good yields (90% and >9

148 exert combined activity at human fatty acid amide hydrolase (FAAH) and dopamine receptor subtype D3

149 A recent phase 1 trial of the fatty acid amide hydrolase (FAAH) inhibitor BIA 10-2474 led to the

150 We found that both the fatty acid amide hydrolase (FAAH) inhibitor URB597 and the syntheti

151 CB N-arachidonoylethanolamine via fatty acid amide hydrolase (FAAH), although it is unclear whether c

152 eral metabolic enzymes, including fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL),

153 gistic antiallodynic effects with fatty acid amide hydrolase and monoacylglycerol lipase inhibitors i

154 ndocannabinoid-regulating enzymes fatty acid amide hydrolase and monoacylglycerol lipase produce reli

155 ir metabolizing enzymes URB597 (a fatty acid amide hydrolase inhibitor) and JZL184 (a monoacylglycero

156 their degradation (by inhibiting fatty acid amide hydrolase) enhanced the effects of OEA and PEA.

157 an be suggested: 1) inhibition of fatty acid amide hydrolase-induced increases in anandamide or 2-ara

158 a strong sharp peak (1675 cm(-1)) within the amide I' band of the spectral region.

159 ure as determined by the highly reproducible amide-I band widths, linking aggregation propensity and

160 an spectral differences were observed in the amide-I, amide-III, and fingerprint regions, indicating

161 The amide-III band was found to be particularly sensitive, w

162 FTIR where spectra displayed a shift of the amide-III peak.

163 al differences were observed in the amide-I, amide-III, and fingerprint regions, indicating that seco

164 ieved by using the directing group nature of amide in the presence of Cu(OAc)2.H2O as an oxidant and

165 s delivering fully substituted unsymmetrical amides in high yields (up to 96%).

166 ach to access a variety of imides as well as amides in high yields.

167 ain features that makes remote oxidations of amides in peptide settings possible, we developed an imi

168 for a rapid and modular synthesis of various amides, including challenging beta-diaryl and beta-cycli

169 tein Vivid (VVD) demonstrate that the Gln182 amide indeed reorients by approximately 180 degrees in r

170 onic polar groups (primary amine and primary amide) influence hydrophobic interactions of neighboring

171 Sensitive detection of the amide intermediate by UVRR spectroscopy enabled discrimi

172 replaced by another anion, i.e. a halide or amide ion; and metal borohydrides modified with neutral

173 The model amide is cleaved at an enzyme-like rate that renders the

174 The observed prevalence for a trans-amide is extraordinary, and in this regard, 2,4-methanop

175 een aryl halides and alkenes bearing pendant amides is described.

176 mides to alpha-keto amides and alpha-hydroxy amides is presented.

177 e one-step synthesis of chiral beta-branched amides is reported through the highly enantioselective i

178 Co(III)-catalysis, directed by N-tert-butyl amides, is achieved to avail mono- or dihydroarylated am

179 synthesis and evaluation of nonhydrolyzable amide isosteres based on this class, leading to highly p

180 ic replacement of a single phosphate with an amide linkage throughout the guide strand of siRNAs.

181 The design and synthesis of amide-linked saccharide oligomers and polymers, which ar

182 t resulted in the discovery of a macrocyclic amide linker which was found to form a key hydrogen bond

183 ites obtained from two molecular precursors, amides M(N(SiMe3)2)3 vs siloxides (M(OSi(O(t)Bu)3)3.L wi

184 late that directs the assembly of a benzylic amide macrocycle around the axle to form [2]rotaxanes in

185 We suggest that alkyl amides may have potential as new biomarkers in archeolog

186 3b)) undergo migratory insertion to iron(II) amides (Me2IPr)RFe{NR(Ad)} (R = (neo)Pe (4a), 1-nor (4b)

187 rovided by the first crystal structure of an amide-modified RNA-DNA with Bacillus halodurans RNase H1

188 aza-aromatic compounds and the hydrolysis of amides, moieties frequently shared by the majority of dr

189 This was achieved by substituting the amide moiety by five- and six-membered aromatic heterocy

190 d improved brain penetration relative to the amide moiety.

191 Dienes metalate via tetrasolvated sodium amide monomers, whereas 1-pentene is isomerized by triso

192 While introduction of the amide-motif in the phytosphingosine chain is tolerated f

193 to evaluate the efficacy of N-acetylcysteine amide (NACA) eye drops in reversing the cataract formati

194 r rearrangement, the carbene-ligated Al(III) amide, NacNac'Al(NHTol)(SIMe) (6).

195 w naphthalene bis(4,8-diamino-1,5-dicarboxyl)amide (NBA) building block for polymeric semiconductors.

196 ynthesis of practically irreversible ordered amide networks that are stable thermally and under both

197 Thanks to the amenability of the amide nitrogen atom to be substituted with bulky groups,

198 S involves the direct phosphorylation of the amide nitrogen of l-glutamine with ATP by the catalytic

199 turing highly steric demanding groups at the amide nitrogen, suggested that, despite their molecular

200 hilic attack by the only weakly nucleophilic amide nitrogen.

201 The ligation by four deprotonated amide nitrogens in macrocyclic motifs is the signature o

202 equential functionalization of the amine and amide nitrogens to rapidly produce diverse analogues.

203 S preferentially buries aromatic carbons and amide nitrogens while leaving amide oxygens exposed.

204 hinge helices creates TS, burying sidechain amide nitrogens.

205 Most significantly, we demonstrate that amide nN --> pi*C horizontal lineO resonance in simple a

206 aved at an enzyme-like rate that renders the amide nonisolable at 35 degrees C and pH 4 owing to the

207 shown to effectively promote the coupling of amide nucleophiles to a wide variety of oxidative additi

208 ation pathway by employing N-monosubstituted amide nucleophiles to afford acyl sulfonyl ureas in good

209 , DFT computations indicate that the lithium amide of a 3-aminopyrrolidine (lithium benzhydryl(1-benz

210 4)A) investigated, confirm that the backbone amide of at least one Thr (Thr(304)), adjacent to conser

211 tion measurements indicate that the backbone amides of [Formula: see text] have significant mobility,

212 d by an oxyanion hole formed by the backbone amides of Ala102 and Leu186.

213 in two closely related forms, the secondary amides of peptides and of N-acetylated hexose sugars.

214 e hydrogen-exchange rate at the adjacent two amides, often the autocatalytic nucleophiles in deamidat

215 er lithium (R)-N-allyl-N-(alpha-methylbenzyl)amide or lithium (R)-N-(but-3-en-1-yl)-N-(alpha-methylbe

216 formation of amidine upon condensation of an amide or the intermediate amide with methyl anthranilate

217 Readily available N-substituted amides or their requisite carboxylic acids or acid chlor

218 tion of halogenated aminopyrazoles and their amides or ureas with a range of aryl, heteroaryl, and st

219 abilize RO by favoring burial/dehydration of amide oxygens and anionic phosphate oxygens all reduce k

220 ic carbons and amide nitrogens while leaving amide oxygens exposed.

221 The spectral location of the affected amide peaks, partial NMR assignments, and JM mutants (ST

222 talytic oxidation-reduction-condensation for amide/peptide construction.

223 y intercepted by amine reactants to generate amides/peptides and o-mercaptobenzamides.

224 ydrogen-bond-like interactions involving the amide pi network.

225 a system possessing an otherwise unactivated amide positioned between two carboxy groups.

226 acterized derivative, [Fe(III)S2(Me2)N(Me)N2(amide)(Pr,Pr)](-) (8), shows that oxo atom donor reactiv

227 hyperfine coupling to nitrogen only when the amide precursor is used, consistent with the presence of

228 ted efficiently to provide a wide variety of amides (primary, secondary) and lactams under operationa

229 ntified novel N-methyl-containing amines and amides, primary amides, and novel N-acetylated sugars, w

230 trate that inhibition of the catalyst by the amide product can be avoided using a high amine concentr

231 s achieved to avail mono- or dihydroarylated amide products selectively in an atom and step economic

232 formation has been identified between the NH amide proton of the upper side chain (proton donor) and

233 Amide proton transfer (APT) imaging is a noninvasive mol

234 In addition to significant changes in amide proton transfer and semisolid macromolecular magne

235 o phosphate ratio and decreased Phosphate to amide ratio together with disrupted trabeculae, loss of

236 The trans/cis amide ratio was measured in model compounds under low te

237 er the dominant stereocontrol of the lithium amide reagent in both cases, thus augmenting the accessi

238 ereoselective conjugate additions of lithium amide reagents in the key stereodefining steps.

239 secretase modulators obtained via isosteric amide replacement and critical consideration of conforma

240 ded for defining protein stability at single amide resolution.

241 Residues with variable amide shifts are localized mostly to N- and C-terminal r

242 Results for 53 backbone amides show narrow clustering with protection occurring

243 ptide regions on IL-23 with reduced backbone amide solvent accessibility upon antibody binding were i

244 Hence, amide sp(2)O-amide sp(2)N interactions (proposed n-sigma* hydrogen bo

245 aphthalene results show that aromatic sp(2)C-amide sp(2)N interactions in water are unfavorable while

246 of ureas and naphthalene with amide sp(2)O, amide sp(2)N, aliphatic sp(3)C, and amide and aromatic s

247 Interactions of amide sp(2)O with urea and naphthalene are favorable, wh

248 of interaction of ureas and naphthalene with amide sp(2)O, amide sp(2)N, aliphatic sp(3)C, and amide

249 th urea and naphthalene are favorable, while amide sp(2)O-alkylurea interactions are unfavorable, bec

250 Hence, amide sp(2)O-amide sp(2)N interactions (proposed n-sigma

251 ctions (proposed n-sigma* hydrogen bond) and amide sp(2)O-aromatic sp(2)C (proposed n-pi*) interactio

252 ) interactions are favorable in water, while amide sp(2)O-sp(3)C interactions are unfavorable.

253 Heteroatomic peptide amide substituents have received less attention due, in

254 on, the range of alpha-C(sp(3))-H containing amide substrates is virtually unlimited highlighting the

255 zimidazoles, and alpha-C(sp(3))-H containing amides, such as N,N-dimethylacetamide, N,N-dimethylbenza

256 and indicate how amounts of hydrocarbon and amide surfaces buried in protein folding and other biopo

257 We found that N-acyl amide synthase genes are enriched in gastrointestinal ba

258 NMR-derived backbone amide temperature coefficients for many residues show a

259 andidate network-forming chemistries such as amide that are irreversible under conventional low tempe

260 in the studies which provided many such 20' amides that exhibit substantial and some even remarkable

261 logy to mine the human microbiota for N-acyl amides that interact with G-protein-coupled receptors (G

262 An amide-thiourea compound, operating through a novel ion p

263 diates are easily hydrolyzed into imides and amides through vanadium catalysis.

264 quential functional group interconversion of amide to acid has also been examined using IR spectrosco

265 n advanced intermediate alkyne and a Weinreb amide to complete the C1-C13 alkyl scaffold, and a Yamag

266 both RNA and protein conformation allow the amide to establish hydrogen bonding interactions with th

267 (R)-N-(but-3-en-1-yl)-N-(alpha-methylbenzyl)amide to tert-butyl sorbate was followed by ring-closing

268 s for the transition-metal-free oxidation of amides to alpha-keto amides and alpha-hydroxy amides is

269 ples of a catalytic isomerization of N-allyl amides to form nonpropenyl disubstituted, tri- and tetra

270 he isomerization of a broad range of N-allyl amides to form Z-di-, tri-, and tetrasubstituted enamide

271 The Mn-catalyzed reduction of tertiary amides to tertiary amines, with a useful scope, is demon

272 ary and primary amides can be masked as N-Ns amides to undergo remote oxidation.

273 of hexafluoroisopropanol with a mixed Mg/Li amide, to give pentafluoroalcohols.

274 ormation, whereas it is suppressed following amide-to-ester backbone substitutions at Gly77 and Tyr78

275 like nonconductive conformation and that the amide-to-ester backbone substitutions at Gly77 and Tyr78

276 nd amidation proceeding by an intramolecular amide transfer in N-phenoxyacetamide derivatives.

277 es, triggered by single electron transfer to amide-type carbonyls by SmI2-H2O-LiBr, provide efficient

278 clizations triggered by electron transfer to amide-type carbonyls, using SmI2 -H2 O, provide straight

279 can be converted readily to enantioenriched amides, unactivated esters, and carboxylic acids in a on

280 t on the water concentration and the type of amide undergoing the reduction.

281 raditional torsion balance, the (ortho-tolyl)amide unit offers restricted rotation around an N-aryl b

282 synthetically useful secondary and tertiary amide, urea, and pyrazole directing groups.

283 amidative phosphorylation of a wide range of amides using a palladium or nickel catalyst giving aryl

284 ardly cleaved to the corresponding esters or amides using a retro-Friedel-Crafts reaction.

285 udy was performed on eight tertiary biaryl 2-amides using variable-temperature (VT) NMR and exchange

286 clic core is obtained from readily available amides via a chemoselective process involving Tf2O-media

287 es of lithium N-benzyl-N-(alpha-methylbenzyl)amide was found to proceed under the dominant stereocont

288 postpartum day 10, whereas N-acetylcysteine amide was injected intraperitoneally on postpartum days

289 A series of alkyl amides was detected and identified in the sedimentary re

290 ) and side chains bulkiness in promoting cis-amides was essentially investigated with peptoid aromati

291 ylates, acrylamides, vinyl esters, and vinyl amides were polymerized by RAFT/iniferter and ATRP metho

292 A series of 180 vinblastine 20' amides were prepared in three steps from commercially av

293 typical linear cationic peptides: magainin 2 amide (which is selective for bacterial cells) and melit

294 Because of the presence of a carboxylic amide, which has a preference for a trans-conformation,

295 ther optimization through replacement of the amide with a variety of five- and six-membered heterocyc

296 condensation of an amide or the intermediate amide with methyl anthranilate.

297 to 1 include bioisosteric replacement of the amide with oxadiazole and alpha,alpha-dimethylation of t

298 pha-quaternary carboxylic acids, esters, and amides with a high degree of enantioselectivity.

299 The reduction of U(VI) uranyl halides or amides with simple Ln(II) or U(III) salts forms highly s

300 d from the trifluoromethylated hemiaminal of amide, with various substituted indoles.