ライフサイエンスコーパス: amide bond

1 stereocenter promotes a cis-alanine-proline amide bond.

2 FOA after 8 days due to the stability of the amide bond.

3 cyclization of amino alcohol to form the key amide bond.

4 ester carbonyl carbon, which favors a trans amide bond.

5 nal glycine of a protein via formation of an amide bond.

6 rogen atom to facilitate the cleavage of the amide bond.

7 matic increase in nonplanarity about the C-N amide bond.

8 NC overlayer to afford a biologically stable amide bond.

9 of which synthesizes a single intramolecular amide bond.

10 investigate the effect of locking a proline amide bond.

11 l or a carboxyl conjugated to glycine via an amide bond.

12 icantly more compact conformation with a cis amide bond.

13 ive metal insertion into the carbon-nitrogen amide bond.

14 to an aliphatic diamine spacer chain via an amide bond.

15 cyclization reactions led us to alkylate the amide bond.

16 ine dendrimer and silanized glass through an amide bond.

17 attributed to the resonance stability of the amide bond.

18 eloped due to resonance stabilization of the amide bond.

19 ric contacts between the substituents on the amide bond.

20 nic acid analogue and holothin, linked by an amide bond.

21 ng heterocycles via polarity reversal of the amide bond.

22 e N-terminus of the acpcPNA probe through an amide bond.

23 d the interaction of proteases with backbone amide bonds.

24 the formation of peptidyl and glycopeptidyl amide bonds.

25 to Pro-cis-Pro-aromatic and aromatic-cis-Pro amide bonds.

26 onation of nitrogens in the peptide backbone amide bonds.

27 nd thioacids with amines to form challenging amide bonds.

28 atural peptides and proteins are composed of amide bonds.

29 the cis-trans isomerization of pSer/pThr-Pro amide bonds.

30 n adjacent carbonyl groups of the main-chain amide bonds.

31 o acids, which are linked to one another via amide bonds.

32 alysts have been developed that bear Xaa-Pro amide bonds.

33 shes a strong energetic preference for trans-amide bonds.

34 bic environment and a periphery of secondary amide bonds.

35 e helical structures featuring repeating cis-amide bonds.

36 cting covalent crosslinking via formation of amide bonds.

37 a greater understanding of the properties of amide bonds.

38 d, therefore, retain protons at the relevant amide bonds.

39 partner) approaches for the construction of amide bonds.

40 s) residues using succinimidyl chemistry via amide bonds.

41 ble NP isomer residues via reversible ester (amide) bonds.

42 ond rather than at the Th=C(carbene) or Th-N(amide) bonds.

43 to Py/Py-COOH/MNP modified gold WEs through amide bonding.

44 idely occurring biaryl compounds through N-C amide bond activation is reported.

45 ologue, catalyses the formation of the first amide bond, an N-acyl-beta-peptide link, in andrimid bio

46 s proline on the carboxy terminal side of an amide bond and aspartic acid on the amino terminal side

47 tability; this was overcome by reversing the amide bond and changing the heterocycle.

48 e second having glycine connected through an amide bond and displaying a terminal carboxylic acid (DB

49 hesized with a PEG group attached through an amide bond and examined for water solubility, antitumor

50 the azPro derivatives can stabilize the cis-amide bond and mimic a type VI beta-turn without incorpo

51 pon collisional activation, cleavages of the amide bond and of one ether bond were observed to procee

52 cess is a low barrier to rotation around the amide bond and the alpha-substituent Z.

53 sition, the length of the linker between the amide bond and the phenyl ring B, and the amino substitu

54 of the (D)P diastereomer to support a trans-amide bond and the proclivity of (L)P for a cis-amide bo

55 tly bound with succinimidyl group on SAM via amide bond and unreacted active groups of LC-SPDP were b

56 for sequencing of large peptides with labile amide bonds and peptides with C-terminal arginine.

57 is linked with structural changes at nearby amide bonds and that this perturbation is mediated by th

58 The effect of geometry on the reactivity of amide bonds and the amide bond distortion range that mar

59 ion of factors affecting the conformation of amide bonds and their effects on cyclization reactions l

60 ligonucleotide probes to the surface (via an amide bond), and (3) washing of the surface.

61 bone amides, significant nonplanarity of the amide bonds, and a unique "basket" arrangement of (S)-N(

62 h secondary and tertiary aminomethyl groups, amide bonds, and hydroxymethylene groups, respectively.

63 NA B domains of BcpA generate intramolecular amide bonds, and one of these contributes also to pilus

64 ions resulting from cleavage between the HP amide bond are observed.

65 the 19-20 position and surrounding backbone amide bonds are compared to the fibrillization and toxic

66 s of compounds and that the direction of the amide bonds (as in 1) is obligatory.

67 ained many amino acids on either side of the amide bond associated with a strong neutral loss peak.

68 ne-peptide, to yield a product with a native amide bond at the ligation site.

69 avbeta3 integrin, and differs for a modified amide bond at the main protease cleavage site.

70 ptide tags that are able to form spontaneous amide bonds, based on harnessing reactions of adhesion p

71 udinger ligation enables the formation of an amide bond between a phosphinothioester (or phosphinoest

72 udinger ligation provides a means to form an amide bond between a phosphinothioester and azide.

73 rolysis is utilized for the formation of the amide bond between actin subunits.

74 The phosphinate replaced the amide bond between Gly-Val in the P1-P1' subsites of the

75 n O- to N-acyl transfer to form the hindered amide bond between N-methyl tubuvaline and isoleucine.

76 itor for the first time the formation of the amide bond between reactive SAM surfaces and the project

77 ine-containing protein fragments to form the amide bond between respective protein fragments signific

78 N motif as a nucleophile, sortase A forms an amide bond between the BcpA C-terminal carboxyl group of

79 talloporphyrins of magnesium and zinc via an amide bond between the bipyridine and one phenyl substit

80 of the major pilin, BcpA, sortase D forms an amide bond between the C-terminal threonine and the amin

81 RavZ hydrolyzed the amide bond between the carboxyl-terminal glycine residue

82 the synthesis include the installation of an amide bond between the indole-nitrogen of tryptophan and

83 The amidases cleave the amide bond between the lactyl group of muramic acid and

84 otrexate (MTX) in which free rotation of the amide bond between the phenyl ring and amino acid side c

85 y an N-terminal poly-Gly sequence to form an amide bond between the Thr and N-terminal Gly.

86 nta-amino acid motif, LPXTG, and cleaves the amide bond between Thr and Gly to form a thioacyl-linked

87 sorting signal and catalyzes formation of an amide bond between threonine (T) of the sorting signal a

88 PXTG motif and catalyzes the formation of an amide bond between threonine at the C-terminal end of po

89 ation is an effective means to synthesize an amide bond between two groups of otherwise orthogonal re

90 We demonstrate the controlled formation of amide bonds between amino acids or peptides in the gas p

91 action of amide synthetases which construct amide bonds between aminocoumarins and various acyl moie

92 (5) (b(5)) through the formation of specific amide bonds between complementary charged residue pairs.

93 Amide bonds between G1-NH2 and PA free carboxylic groups

94 The scheme to form amide bonds between proteins by using adipic acid dihydr

95 cribe tetrazole analogs as suitable backbone amide bond bioisosteres for the parent pan PAD inhibitor

96 d intensity with ion type, the dependence of amide bond breakage on the residues surrounding the clea

97 the bridgehead nitrogen and twist about the amide bond, but the most puckered penem system still ret

98 nding indicates that the poor mimicry of the amide bond by many peptidomimetics stems from their inab

99 s of an existing "anchor" peptide to form an amide bond by protonating the anchor peptide's basic res

100 leasing and thus more delocalized across the amide bond by resonance.

101 The data suggest that distortion of these amide bonds by approximately 50 degrees is sufficient fo

102 recognition of reverse turns containing cis-amide bonds by the incorporation of type VI beta-turn sc

103 e, which appear to form by hydrolysis of the amide bonds (C(O)-N).

104 on, allowing differentiation of one of seven amide bonds central to the vancomycin core structure, th

105 hosphate acts as the nucleophilic species in amide bond cleavage and implications for Dop function ar

106 ide cross-coupling reactions with the N-C(O) amide bond cleavage as a key step.

107 to only a 2400-fold increase in the rate of amide bond cleavage as compared with the rate of hydroly

108 seudoallylic strain to the enormous rates of amide bond cleavage in tertiary amide derivatives of Kem

109 acids P, W, D, and R had a strong effect on amide bond cleavage when situated next to the breakage s

110 ffect could not compensate for the extensive amide bond cleavage, resulting in declined rejection.

111 s obtained from modified SM lipid anions via amide bond cleavage.

112 c groups, the latter produced as a result of amide bond cleavage.

113 tegy and suggests that cytotoxicity requires amide bond cleavage.

114 similar to that of enzymes catalyzing single-amide-bond cleavage reactions.

115 richer sequence information (77% of backbone amide bond cleavages) than did ion trap CID (52% of back

116 ages) than did ion trap CID (52% of backbone amide bond cleavages).

117 Two vicinal J-couplings sensitive to amide bond conformation (cis and trans amide) were also

118 Here, we investigated the influence of the amide bond conformation on the stereoselectivity of H-Pr

119 The ratio of the cis and trans amide bond conformers was determined by NMR study, highl

120 specialized serine peptidase that cleaves an amide bond connecting the peptidyl or aminoacyl moieties

121 phore synthetase AsbB catalyzes formation of amide bonds crucial for petrobactin assembly through use

122 A fourth amide bond, derived from the Ig fold of CNA(1), is forme

123 lly suited to span the whole spectrum of the amide bond distortion energy surface.

124 try on the reactivity of amide bonds and the amide bond distortion range that marks the boundary of a

125 ning aromatic residues exhibiting 45-60% cis amide bonds, due to Pro-cis-Pro-aromatic and aromatic-ci

126 Through a combination of ester-amide bond exchange and ester bond hydrolysis, depsipept

127 significance of a trans conformation prolyl amide bond for the pi-clamp reactivity.

128 their sequence, as well as the synthesis of amide bonds for other purposes.

129 eactivity of aldehydes and amines to enforce amide bond formation between amino acid residues and pep

130 sing EDC/NHS chemistry, which results in the amide bond formation between amino groups of PANI and CO

131 in cytoskeleton by catalyzing intermolecular amide bond formation between E270 and K50 residues of ac

132 l]carbodiimide hydrochloride (EDC)-catalyzed amide bond formation between the carboxyl group of 5caC

133 s after the conserved threonine, followed by amide bond formation between threonine and the pentaglyc

134 This modality was found to be general in amide bond formation from a number of activated esters i

135 reaction scope, generating biocatalysts for amide bond formation from carboxylic acid and amine.

136 Chemoselective reactions for amide bond formation have transformed the ability to acc

137 The amide bond formation in FDM A biosynthesis is proposed t

138 n, as an amide synthetase that catalyzes the amide bond formation in FDM A biosynthesis.

139 ly from improved E2 recruitment and enhanced amide bond formation in the E2 active site.

140 In these ligations, amide bond formation is accelerated by transient enforce

141 immobilization of enzymes at electrodes via amide bond formation is usually carried out by a two-ste

142 Surprisingly, amide bond formation occurred at a similar rate at 4 and

143 s been prepared involving an anion-templated amide bond formation reaction at the macrocyclization st

144 t of relative reaction rates for competitive amide bond formation reaction with up to five parameters

145 atible with commonly used esterification and amide bond formation techniques, including the Fmoc/tBu

146 In this way we have accessed reversible amide bond formation that allows crystalline order to de

147 enes, which usually undergoes intramolecular amide bond formation to impart mechanical and proteolyti

148 action uses the same activating principle as amide bond formation to replace a carboxylic acid moiety

149 of oxidative activation, thereby undergoing amide bond formation upon reaction with N-terminal pepti

150 Amide bond formation was accomplished via coupling of th

151 The amide bond formation was independent of redox state and

152 fact that minute levels of oxidation actuate amide bond formation with high turnover is offered.

153 lation of unprotected peptides, and on-resin amide bond formation with protected peptides.

154 arkably, SgcC5 is also capable of catalyzing amide bond formation, albeit with significantly reduced

155 It first catalyzes amide bond formation, and then the intramolecular cyclod

156 gcC5 is capable of catalyzing both ester and amide bond formation, providing an evolutionary link bet

157 Along with amide bond formation, Suzuki cross-coupling, and reducti

158 The most frequently used reactions were amide bond formation, Suzuki-Miyaura coupling, and SNAr

159 entral chemical step of peptide synthesis is amide bond formation, which is typically catalyzed by th

160 ttachment of the various side chains through amide bond formation.

161 is enzyme cleaves ATP to ADP and P(i) during amide bond formation.

162 macrocyclization is efficiently achieved by amide bond formation.

163 lic acids and coupling agents widely used in amide bond formation.

164 o generate 1 by a route other than classical amide bond formation.

165 ed to standard direct conjugation methods of amide bond formation.

166 ebiotically plausible mechanism for peptide (amide) bond formation that is enabled by alpha-hydroxy a

167 t to be the sole enzyme responsible for this amide-bond formation.

168 at the biosynthesis involves two conspicuous amide bond formations accomplished by an amidotransferas

169 sonitriles to furnish secondary and tertiary amide bond formations have been applied to a novel total

170 y reported bias toward reaction classes like amide bond formations or Suzuki couplings.

171 o ligases acting sequentially in untemplated amide bond formations using attack of substrate carboxyl

172 sis is highly convergent and consists of two amide bond formations, one etherification, and one ring-

173 chia coli, and established its ATP-dependent amide bond forming activity with a variety of polyenoic

174 nes, which are substrates for chemoselective amide-bond forming reactions with alpha-ketoacids.

175 The scope of isonitrile-mediated amide bond-forming reactions is further explored in this

176 in backbone cleavages mainly occurred at the amide bonds from C-terminal to aspartic acid residues (e

177 ., c(5), ion series of c(29) and c(63)), and amide bonds from C-terminal to glutamic acid residues (e

178 nciples used for decades to make simple C-N (amide) bonds from carboxylic acids with loss of water ca

179 Re(I) complexes have been prepared with the amide bond functionality located on a pendant phosphine

180 s are accessible in peptoids featuring trans amide bond geometries.

181 herein explore the role of stereochemistry, amide bond geometry, transannular hydrogen bonding, and

182 e N-CO cleavage catalyzed by Pd(0) utilizing amide bond ground-state destabilization.

183 sts in an extended conformation with a trans amide bond; however, it binds to Hsp90 in a significantl

184 /20-kDa heterodimer with full gamma-glutamyl amide bond hydrolase activity.

185 A phosphodiester linkages, but DNA-catalyzed amide bond hydrolysis has been elusive.

186 The mechanism of PBP 5 catalysis of amide bond hydrolysis is initial acylation of an active

187 m N40 or N100 random pools initially seeking amide bond hydrolysis, although they both cleave simple

188 effect of structure on the reversibility of amide bond hydrolysis, which we attributed to the transa

189 he mechanistic details of autoprocessing and amide bond hydrolysis.

190 cleaved proenzyme serves as a nucleophile in amide bond hydrolysis.

191 ases that use NAD(+)as a co-substrate during amide bond hydrolysis.

192 The catalytic hydrogenolysis of the titanium-amide bond in (eta(5)-C5Me4SiMe3)2Ti(Cl)NH2 to yield fre

193 to a single CPP were carried out through an amide bond in one case and through a triazole linkage ('

194 r linkage on the bead surface but through an amide bond in the bead interior.

195 tate NMR chemical shifts indicate the prolyl amide bond in the pi-clamp motif adopts a 1:1 ratio of t

196 gues have a cis-configuration at the Val-Dil amide bond in their functionally relevant tubulin bound

197 Remote amide bonds in simple N-acyl amino acid amide or peptide

198 vestigate whether the polypeptide main chain amide bonds in the N-terminus of SDF-1alpha play a role

199 rnalization is dependent upon the main chain amide bonds in the N-terminus of SDF-1alpha.

200 s/trans isomerization by rotation around the amide bonds in the peptoids studied is generally slower

201 ng a cyclic secondary amine to form the C-28 amide bond increased the metabolic stability of the deri

202 ropose that a structural perturbation of the amide bond is driven by redox-linked electrostatic chang

203 As the NHS or sulfo-NHS group leaves, an amide bond is formed between a free, unprotonated, prima

204 e is cleaved following the threonine, and an amide bond is formed between the threonine and the penta

205 e energy barrier for rotation around the C-N amide bond is lowered by up to 3.6 kcal/mol upon encapsu

206 The amide bond is one of nature's most common functional and

207 es, which is unusual because no typical beta-amide bond is present in the Trp-mannosyl moiety.

208 de bond and the proclivity of (L)P for a cis-amide bond is sterically driven and can be reversed by s

209 Cleavage of the amide bond is then accomplished by a nucleophilic attack

210 steric environment surrounding the tertiary amide bonds is the key promoter of conformational prefer

211 Proline amide bond isomerization is the slow step in collagen fo

212 Substantial cis/trans amide bond isomerization, however, gives rise to conform

213 Current methods for constructing amide bonds join amines and carboxylic acids by dehydrat

214 n DNA and RNA templates is shown to catalyze amide bond ligation and controlled bPNA chain extension.

215 hey are the only enzymes known to cleave the amide bond linking the gamma-carboxylate of glutamate to

216 ng curve where on average four alpha-helical amide bonds melt upon a temperature increase from 4 to 7

217 recently enabled the development of elusive amide bond N-C cross-coupling reactions with organometal

218 With the surfactants containing an amide bond near the headgroup, the MINPs had a layer of

219 the conventional acylation of amines when an amide bond needs to be formed without going through an a

220 enging due to the intrinsic stability of the amide bond; nevertheless, the ability to reduce highly s

221 proteolytic) cleavages on both disulfide and amide bond of iRGD peptide.

222 tivated enzyme hydrolyzed the gamma-glutamyl amide bond of several substrates with comparable rates,

223 e enzyme hydrolytically processes the lactyl amide bond of the 1,6-anhydro-N-acetylmuramyl moiety.

224 the cis and trans isomers of the N-terminal amide bond of the amino acid proline.

225 rogen bonds between the hinge region and the amide bond of the core structure and a hydrogen bond bet

226 ase-type mechanism for the hydrolysis of the amide bond of the substrate, N-acetyl- l-aspartate.

227 oton to the amino group upon cleavage of the amide bond of the substrate.

228 e reclamation by cleaving the gamma-glutamyl amide bond of the tripeptide.

229 equilibria of cis/trans isomerization of the amide bonds of N-acetylated peptoid monomers, dipeptoids

230 cis and trans conformations of the backbone amide bonds of peptoids can be significantly populated.

231 addition of trypsin was found to cleave the amide bonds of protein, triggering the dissociation of p

232 pressed in Escherichia coli, form the tandem amide bonds of the dapdiamide scaffold at the expense of

233 ndicate the cis conformation of the backbone amide bonds of the peptoids studied is more populated th

234 y to degrade these compounds by cleaving the amide bond or the lactone ring.

235 )-fluoroproline, which favors the native cis amide bond, or the stereoisomeric (2S,4R)-fluoroproline,

236 ls upon nucleophilic addition to the twisted amide bonds present in the lactam precursors.

237 show that the reduced amidicity of aziridine amide bonds provides an entry point for the site-specifi

238 -catalyzed chemistry, but the substrates are amide bonds rather than thioesters.

239 d a direct correlation between the trans/cis amide bond ratio and the enantio- and diastereoselectivi

240 e envisioned that control over the trans/cis amide bond ratio may provide a tool to optimize the cata

241 tumor uptake in vivo in comparison to a (all amide bond) reference compound.

242 t amyloid polypeptide with the Ser-19 Ser-20 amide bond replaced by an ester circumvents these proble

243 is strongly dependent on the location of the amide bond replaced.

244 nted findings strongly support the classical amide bond resonance model in predicting the properties

245 dyldisulfide groups linked via carbamate and amide bonds, respectively.

246 experimental evidence that N-protonation of amide bonds results in a dramatic increase in nonplanari

247 ct of structural variations on the cis-trans amide bond rotamer equilibria in a selection of monomer

248 1)H NMR spectroscopy was used to monitor the amide bond rotation between the catecholate and salicyla

249 Isosteric replacement of amide bond(s) of peptides with surrogate groups is an im

250 ependent cis/trans isomerization of backbone amide bonds, side chain stereochemistry, and flexibility

251 orbital on a positive site to a disulfide or amide bond site and (ii) intermolecular transfer from an

252 the ability to direct the presence of trans-amide bonds specifically at N-aryl positions.

253 ne bond strength while diminishing the metal-amide bond strength.

254 ,2,3-triazoles as metabolically stable trans-amide bond surrogates in radiolabeled peptides in order

255 ficient method has been developed for direct amide bond synthesis between carboxylic acids and amines

256 The activating principles used in amide-bond synthesis can therefore be used, with nickel-

257 genous and exogenous McC7 by hydrolyzing the amide bond that connects the peptide and nucleotide moie

258 bond more readily than the peptide backbone amide bonds that enabled the identification of disulfide

259 o the formation of intra- and intermolecular amide bonds that stabilize the protein structure and imp

260 hat bacillaene is a linear molecule with two amide bonds: the first links an alpha-hydroxy carboxylic

261 hesize a discrete sequence of intramolecular amide bonds, thereby conferring structural stability and

262 s as a tool to enforce the presence of trans-amide bonds, thereby engendering structural stability.

263 cleavage of albicidin at a peptide backbone amide bond, thus abolishing its antimicrobial activity.

264 gh cleavages of the enol double bond and the amide bond, thus furnishing fully substituted 5-isoxazol

265 ino acid peptide that spontaneously forms an amide bond to a protein partner, via reaction between ly

266 Mutating the Abeta 1-40 Phe19-Phe20 backbone amide bond to an isostructural E-olefin bond enables for

267 th a molecule of aryne by insertion into the amide bond to form a 2,3-dihydroquinolin-4-one, which su

268 dified ITO electrode was accomplished via an amide bond to further enhance red-light-driven, direct e

269 gratory insertion of olefin into the rhodium-amide bond to generate an aminoalkyl intermediate that u

270 obtained a peptide (SpyTag) which formed an amide bond to its protein partner (SpyCatcher) in minute

271 nerally the case for the analogous secondary amide bond to proline residues in acyclic peptides.

272 nsfer time scale only by rotation around the amide bond to the C-terminal peptoid residue.

273 re of peptoids, from the conformation of the amide bond to the formation of protein-like tertiary str

274 a nitrone spin trap, 4, that is tethered via amide bonds to a beta-cyclodextrin (beta-CD) and a dodec

275 studied is generally slower than that around amide bonds to proline residues and takes place on the N

276 (ACP) to covalently link fatty acids, via an amide bond, to specific internal lysine residues of the

277 lkylation activates the otherwise unreactive amide bond towards sigma N-C cleavage by switchable coor

278 C(gamma)-exo pucker typically display a high amide bond trans/cis (K(T/C)) ratio.

279 Novel methodology for the formation of amide bonds under neutral conditions is described.

280 The construction of amide bonds using available methods relies principally o

281 ntational harmonic potential of the backbone amide bond vector orientations and it is applied to the

282 that is initiated by the polarization of the amide bond via complexation to the beta-metal ion of the

283 the Phe(3) side chain flexibility, the final amide bond was N-methylated and Phe(3) was replaced by a

284 Further investigation revealed that the amide bond was the source for the poor blood stability o

285 Chemical bioisosteres of amide bonds were explored to improve cell-based potency.

286 The amide bonds were replaced with triazole rings, and alpha

287 yzes the phosphorylation of peptide backbone amide bonds, which leads to the formation of azolines an

288 y occupied orbitals in multiple, consecutive amide bonds, which may by separated by one to three meth

289 Tag is a peptide that spontaneously forms an amide bond with its protein partner SpyCatcher.

290 SpyTag is a peptide that forms a spontaneous amide bond with its protein partner SpyCatcher.

291 Moreover, one-step construction of imide and amide bonds with a long-chain alkyl group is an attracti

292 and after adjustment for pairings across the amide bonds with particularly labile residues.

293 An amine-containing PS forms amide bonds with peptidic cargo, a thiol derivative is d

294 The enzyme CapD generates amide bonds with peptidoglycan cross-bridges to anchor c

295 poly-gamma-D-glutamate capsule and generates amide bonds with peptidoglycan cross-bridges to deposit

296 minimal neutral loss, with the exception of amide bonds with proline on the carboxy terminal side, w

297 xploited differences in the acid lability of amide bonds within high-molecular-weight (HMW) DON to sh

298 proceeds in aqueous buffer to afford native amide bonds without the use of additives.

299 Insertion of Me-N=CH2 into a Ta-amide bond yields the unusual -N(Me)CH2NMe2 ligands.

300 e meta position of the benzoyl group (via an amide bond) yields the trans isomer with a diastereosele