ライフサイエンスコーパス: amide group

1 everal common donors (Arg, Lys, and backbone amide groups).

2 iride containing a dodecyl (12 carbon units) amide group.

3 icity linked to the aromatic ring through an amide group.

4 pyrazole NH, as well as the free amino or N-amide group.

5 ssociated with introducing the P2'-P3' retro amide group.

6 nding capability associated with the P1'-P2' amide group.

7 f the amino group, and installation of the N-amide group.

8 r molecule in a hydrogen bond with the sugar amide group.

9 posttranslationally converted to a terminal amide group.

10 l changes in this general orientation of the amide group.

11 as achieved by N-methylation of the C2-ethyl amide group.

12 wherein the alkyne bond was replaced with an amide group.

13 the CRF C terminus, including the C-terminal amide group.

14 hs (14.4 and 18.8 T) for 135 of 162 backbone amide groups.

15 the gel matrix by interaction with the amino/amide groups.

16 couplings between (15)N and (1)H in backbone amide groups.

17 interactions with several adjacent backbone amide groups.

18 er rim of the cavity, hydrogen-bonded to the amide groups.

19 by two intramolecular hydrogen bonds between amide groups.

20 are weakened and lead to the rehydration of amide groups.

21 ring C=O-H-N hydrogen bond between backbone amide groups.

22 1)H] NOE were measured for 80 of 91 backbone amide groups.

23 nd (1)H-(15)N NOE) measured for 153 backbone amide groups.

24 of the carboxylate and N-propyl-substituted amide groups.

25 e difference in hydration of carboxylate and amide groups.

26 ium exchange rates of nearly all the peptide amide groups.

27 m channels that are decorated with cyano and amide groups.

28 rboxylate of 4-ACPCA (2) with hydroxamate or amide groups.

29 ar pi-pi stacking and hydrogen bonding among amide groups.

30 less than one per year are observed for some amide groups.

31 cepting and donating a H-bond to neighboring amide groups.

32 ment are much broader than those of backbone amide groups.

33 es in peak intensity for individual backbone amide groups.

34 helical elements and the pattern of backbone amide group 15N nuclear relaxation rates within the cont

35 e its carboxyl group interacts with backbone amide groups 299 to 303 and the side-chain of Arg303.

36 Catalysts bearing tertiary benzylic amide groups afforded highest enantioselectivities, with

37 Analogues containing a diethanolamine amide group and an aryl di(methylphosphonate) were both

38 gen-bonding interactions with both the Asn68 amide group and the imidazole side chain of His64.

39 olumns of four to six ceramides H-bonded via amide groups and arranged as staves in either a parallel

40 entary structural information to that of the amide groups and hence promises to provide a greatly enh

41 centres and responds to that of neighbouring amide groups and in turn influences stereoselective reac

42 ions: one from pi-polarization of beta-sheet amide groups and the other from rotation of an isoleucin

43 , bearing a terminal rotationally restricted amide group, and 30 bearing a terminal achiral bromophen

44 pH jump leads to deprotonation of the Ser-20 amide group, and a subsequent rapid O to N acyl shift re

45 tion bands for the sugar moiety, the protein amide group, and water.

46 nar imidazole rings, an anti relationship of amide groups, and intramolecular (NH(amide).N(imid)) and

47 raction followed by hydrogen-bonding between amide groups, and then van der Waals interactions-paves

48 uring two positive charges, four nonpeptidic amide groups, and variable hydrophobic/hydrophilic (amph

49 ng interactions are induced as the substrate amide group approaches the nucleophile, moving more than

50 tions and solvent exposure of the beta-sheet amide groups are also characterized by increases in homo

51 Furthermore, because these amide groups are important in the assembly process for t

52 nates along the backbone because neighboring amide groups are oriented in opposite directions.

53 tes that a number of side chain and backbone amide groups are perturbed upon Ala substitution at cons

54 When all four beta-sheet amide groups are polarized, the ab initio calculations i

55 persion, and a large portion of the backbone amide groups are solvent-exposed leading to fast hydroge

56 he enthalpy of interaction with water of the amide group as approximately -11.5 kcal/mol.

57 ring, a short ethylene oxide segment, and an amide group as well as a short alkyl chain (propyl or is

58 the selenium atom may serve as acceptor and amide groups as donors.

59 esidues (Met(38) and Ile(41)) as well as two amide groups (Asn(34) and the C-terminal amide) on one f

60 with participation of the oxygen of ester or amide group at C(1) of corresponding 2-azabuta-1,3-diene

61 In this design, an amide group at the 3'-position of the ligand framework d

62 adical stabilizing group such as an alkyl or amide group at the C3-position of indole furnishes the 3

63 teady-state {(1)H}-(15)N NOE of the backbone amide group at three different magnetic field strengths

64 es were determined for 52 of the 65 backbone amide groups at 10 degrees C and ph 6.5 at 11.74 T.

65 nding interactions with neighboring backbone amide groups at positions i + 2/3/4 from Cys-384 and wit

66 R1 but has a clear preference for bulky aryl amide groups at R2, while methylation at R3 increased in

67 Six 2,2'-biimidazoles with various amide groups at the 4- and 4'-positions were prepared fr

68 py has higher sensitivity than does backbone amide group-based NMR spectroscopy.

69 strates where the aromatic ring trans to the amide group bears o-methyl, -chloro, or -bromo substitue

70 spatiotemporal concepts where embedding the amide group between two carboxylic moieties in proper ge

71 ted by a reciprocal exchange of aromatic and amide groups between positions 4 and 111 of Ang II and t

72 minal heterocycles of the dimer stack on the amide groups between the two heterocycles at the C-termi

73 e-reduced arginine onto sterically proximate amide group blocks one of the current mechanisms for ele

74 l histidine 95 and the adjacent glutamine 91 amide group but is not coordinated to the heme iron.

75 rates of more than one third of all backbone amide groups, but had little effect on the longitudinal

76 ently, a one pot reduction of both nitro and amide groups by BH(3)-tetrahydrofuran yielded the nonrad

77 te with H-bonding in circumstances where the amide groups can be brought into a stacking configuratio

78 The motion of water molecules close to amide groups causes their vibrational frequencies to var

79 used three complementary NMR methods, namely amide group chemical shift titrations, NOE and cross-sat

80 e of hydrogen/deuterium exchange of backbone amide groups combined with NMR.

81 Thus, the burial of an amide group contributes more to protein stability than t

82 is extra information, 86 % of all side-chain amide groups could be oriented quite unambiguously.

83 Remarkably, amide groups derived from protein compounds can still be

84 With isolated protein, tertiary amide groups dictate high affinity and high stimulation

85 is stabilized by interaction with a backbone amide group dictates the R stereochemistry of the tetrah

86 The amide group directed ortho-metalation in the julolidine

87 t parallel to the plane of the heme with its amide group directed toward the back of the distal heme

88 Ka of the hydroxyl group indicating that the amide group does not strongly transmit the electronic in

89 Incorporation of the amide group does, however, increase the yields of workin

90 Removing the ligands' derivatized amide group eliminated the effect of the mutations.

91 with three carbons in the side chain and one amide group exhibited a selectivity index of 35 (Ki/IC50

92 H instability, rather it is a consequence of amide groups experiencing two processes; rapid fluctuati

93 tions: (1) identification of the pyrrolidine amide group for a significant LipE improvement, and (2)

94 ire the presence of a carboxy-terminal alpha-amide group for biological activity.

95 e incorporated into the products by means of amide-group formation.

96 ond network that connects, via the inhibitor amide group fragment, two remote functionally essential

97 ding to the selective formation of a primary amide group from a chemically inert alkyl group.

98 In addition, the faster exchange of amide groups from residues at the subunit interfaces sug

99 is coordinated by three Cys residues, two N-amide groups from the protein backbone, and one OH(-).

100 tial imidization between carboxylic acid and amide groups, gave the multilayer good stability at high

101 acement of the carboxyl group of Glu46 by an amide group (Glu46Gln) has shown that changing the natur

102 en-bonding interactions between two backbone amide groups (Gly 721 and Gly 722) and the beta- and gam

103 The readily cleavable amide group has been utilized as a directing group for t

104 ergies of unfolding of some highly protected amide groups have been determined.

105 ontaining residues (N/Q), and the C-terminal amide group in a peptide.

106 one with respect to hydration changes in the amide group in combination with cooperative interactions

107 rder to study base pairing properties of the amide group in DNA duplexes, a nucleoside analog, 1-(2'-

108 The stabilization of the amide group in its high energy, perpendicular conformati

109 C[bond]N vibrational stretching modes of the amide group in the alpha-helix and the parallel and anti

110 hape in the 13-membered chelate in which one amide group in the chiral scaffold projects its NH unit

111 An asymmetrically positioned remote amide group in the designed chiral binaphthyl-based liga

112 electron transfer (ET) quenching by a nearby amide group in the peptide bond.

113 e adsorbed CO2/CH4 molecules and the pendant amide group in the pore.

114 Undesired solvolysis of the amide group in the side chain of Asn or Gln leads to une

115 Replacement of an amide group in this class of compounds with an acetyl gr

116 aragine (Asn) and glutamine (Gln) side-chain amide groups in a dataset of 100 unrelated, high-quality

117 The N-OTases catalyze the glycan transfer to amide groups in asparagines in a reaction named N-linked

118 The amide groups in both the minimized antitau and syntau co

119 ation of the ways side-chain carboxylate and amide groups in high-resolution protein crystal structur

120 n exposure to 2H2O (D2O), 30% of the peptide amide groups in hPLB undergo a slow deuterium/hydrogen e

121 ement of the peptide backbone's carbonyl and amide groups in hydrogen-bond stabilization of helical s

122 ctural and functional importance of backbone amide groups in ion channels for subunit folding, hydrog

123 enable the direct observation of the role of amide groups in substrate binding, representing an examp

124 The protection factors for many of backbone amide groups in the beta-domain of the T70N variant are

125 endence of the number and position of chiral amide groups in the formation of a fibrillar nanomateria

126 Conversion of the carboxylate anions into amide groups in the lower acidic cluster (residues 42 an

127 on at the phenyl, oxime, and right-hand side amide groups in the oximino-piperidino-piperidine series

128 w that two hydrogen bonds formed between the amide groups in the peptide backbone are important in ma

129 urea preferentially interacts with not only amide groups in the peptide backbone but also aliphatic

130 oward CO2 due to higher density of selective amide groups in the polymer network.

131 The hydrogen bonding with the amide groups in the side chains has to be contrasted wit

132 s measure the coupling between the different amide groups in the structure.

133 Ndelta1 atom of the His and the peptide Gln amide group indicates the His of the bound peptide in th

134 avourable conformational switch of the trans-amide group into the cis-form required for protein bindi

135 Once an ester or amide group is introduced into the system (derivatives o

136 These values indicate that the carbon of the amide group is more stiffly bonded in DHO while the slig

137 transfer from the guanidinium group onto the amide group is not observed.

138 ay be one source of destabilization when the amide group is placed in the helix.

139 es have shown that the N-formylamino-salicyl-amide group is responsible for most of the binding speci

140 orter was the 15N-H 2D spectrum of aspartate amide groups labeled with 15N.

141 ation reaction directed by a pyrazole and an amide group leads to the well-controlled construction of

142 The incorporation of the amide group led to an unexpected reversal in selectivity

143 d with N-alkyl substituents or replaced with amide groups led to a significant loss of activity.

144 lytic activity have shown that the glutamine amide group makes only ambiguous hydrogen-bonding intera

145 an N-heterocyclic carbene that features two amide groups N-bound to the carbene nucleus with various

146 acement of the metabolically labile N-methyl amide group of a series of benzoxazinones with small het

147 no group and the second between the backbone amide group of Arg 94 and the sugar C-5' carboxylate.

148 ctrostatically with Arg 242 and the backbone amide group of Asn 245, components of the J loop of the

149 The amide group of Asn(95), the first Asn of the NXN motif,

150 , this residue makes hydrogen bonds with the amide group of Asn-160, and thus, the usual metal-bindin

151 The hydrogen bond between the amide group of Asn-204 and O(4) of uracil is disrupted b

152 te was unoccupied, apparently blocked by the amide group of Asn51.

153 We postulate that the dipole formed by the amide group of asparagine 614 of the epsilon 1 subunit c

154 In the wild-type protein, the side-chain amide group of Gln 143 is about 5 A from the metal and i

155 Unexpectedly, the main-chain amide group of Gln 230 in the universally conserved GGQ

156 [5-(15)N]-glutamine and use the (15)N of the amide group of glutamine to produce labeled uric acid.

157 In addition, the backbone amide group of Gly 159 provides an oxyanion hole for sta

158 the iridal forming a hydrogen bond with the amide group of Gly23.

159 catalysed by a hydrogen bond to the backbone amide group of leucine 126 and the side-chain carboxyl g

160 group of the pT residue with the side-chain amide group of N86 and the guanidino group of R70, and t

161 rk between Asp338, the 2'-OH of IMP, and the amide group of NAD(+).

162 change in the protein structure, moving the amide group of residue 114 out of H-bonding distance, al

163 ol, formed a hydrogen bond with the backbone amide group of Ser(212), which is the key interaction fo

164 for specific H-bonding between Chol and the amide group of SM.

165 The formation of several acyl groups and an amide group of Taxol is catalyzed by regioselective CoA

166 vate beta-lactams by rapidly hydrolyzing the amide group of the beta-lactam ring.

167 We found that the amide group of the glutamine side chain could provide tw

168 toms of Thr-80 and Phe-79 and the side chain amide group of the invariant Gln-78.

169 H ... O==C interchain hydrogen bonds for the amide group of the residue following Gly.

170 The amide group of this asparagine is buried and forms two s

171 position forming two hydrogen bonds with the amide group of Thr12 and with the carbonyl group of Leu

172 But the amide groups of bicyclic bridgehead lactams are highly t

173 uces relatively minor dehydration around the amide groups of dihydrosphingomyelin and a slight enhanc

174 the oxyanion hole, provided by the backbone amide groups of G141 and A98, are important for the form

175 stent with hydrogen bonds between side chain amide groups of Gln18 residues.

176 The backbone amide groups of Gly-165 and Gly-166 participate in hydro

177 Both the backbone amide groups of Gly241 and Leu270, and O(gamma) of Ser47

178 ate group of GAA interacts with the backbone amide groups of L170 and T171.

179 re prepared by deprotection of the ester and amide groups of ortho-benzoxylated cyclic benzamides.

180 urface area of the Phe side chain and of the amide groups of Phe1, Gly2, and Gly3 involved in Ar-HN i

181 ium tetra(tert-butoxide) reacts with surface amide groups of polyamide nylon 6/6 to give (eta(2)-amid

182 The amide groups of residues in helices and sheets are those

183 The results indicate motion in the backbone amide groups of rhodopsin at time scales depending on th

184 The amide groups of the compound likely adsorb onto the pola

185 ricyclic structure of the parent ligand; the amide groups of the methyl-protected cage compound gener

186 cated hydrogen-bonding interactions from the amide groups of the netropsin to the A x T base pairs of

187 GGGL(172)) and forms hydrogen bonds with the amide groups of those amino acid residues, suggesting th

188 ma) of Ser 346 and the backbone carbonyl and amide groups of Val 272, Leu 232, and Gly 347.

189 237 and also hydrogen bonded to the backbone amide groups of Val-201 and Leu-202.

190 3-(2,4-dinitrophenyl)-L-2,3-diaminopropionic amide group on the C-terminal end.

191 Phenol solvates the amide groups on the ligands strongly, increasing the ste

192 oluril dimers (1-8) bearing hydrogen-bonding amide groups on their aromatic rings.

193 ss formation temperature for surface Trp and amide groups over a wide temperature excursion.

194 ridinyl group pointing toward Tyr155 and the amide group placed near a hydrophobic pocket next to Tyr

195 an amine group (K side chain) with a primary amide group (Q side chain) weakens the hydrophobic inter

196 O of the amide linkage, with rotation of the amide group relative to the aromatic ring.

197 he similarity between the orientation of the amide group relative to the bilayer interface in melted

198 to yield a new Blatter-type radical with an amide group replacing a phenyl at the C(3)-position.

199 s and the nitrogens of deprotonated backbone amide groups, resulting in either distorted T-shaped or

200 One family, Series-A, is nonionic and has amide groups separating the long chains from the trehalo

201 Changes in generalized-order parameters of amide groups show a distinct trend towards increased str

202 xation to determine the dynamics of backbone amide groups, side chain methyl groups, and tryptophan s

203 This network formed by amide groups significantly contributes to constructing t

204 broadly similar fashion, but with the larger amide group substituent able to reach and contact the si

205 The dramatic effect of the amide group substitution pattern on the binding affinity

206 mutants, the gain in stability from burying amide groups that are hydrogen bonded to peptide groups

207 e concerted exchange behaviour of subsets of amide groups that become accessible at a given free ener

208 forced by the intermolecular H bonding among amide groups that is evidenced by IR spectroscopy.

209 as a consequence of the additional covalent amide groups that provide a new hydrogen bonding molecul

210 be achieved with rigid compounds containing amide groups: the conformation of the amides can be cont

211 i+3 CO...H-N hydrogen bonds between backbone amide groups; these hydrogen bonds occur in 11-atom ring

212 -energy fluctuation that does not expose its amide group to exchange.

213 Its catalytic site does not utilize backbone amide groups to bind phosphate, as in the common P-loop,

214 obal transition that exposes these protected amide groups to solvent.

215 h contains a benzoxazole ring instead of the amide group was found to be a good alternative, with goo

216 The nicotinamide amide group was found to be in a cis conformation.

217 between the solvent and Phe1, Gly2, and Gly3 amide groups was also lower in conformations with Ar-HN

218 Using this technique, several ester and amide groups were efficiently introduced on the dyes.

219 ene carbon present between the adamantyl and amide groups were essential to produce potent inhibition

220 erent polarization states for the beta-sheet amide groups were identified and linked to the overall c

221 Protection factors for 58 amide groups were measured across the pH range and the h

222 pendent changes in the chemical shifts of 22 amide groups were observed in (1)H-(15)N HSQC NMR spectr

223 Macrocycles containing amide groups were self-assembled in a columnar fashion t

224 nds 10 and 11, which contain a P2'-P3' retro amide group, were modest competitive inhibitors of a ser

225 A significant part (23%) of the amide groups which are buried in pG become exposed to th

226 portant catalytic role for a P-loop backbone amide group, which is eliminated in the A30P mutant, and

227 ned to explore the importance of the P1'-P2' amide group, which is known to form highly conserved hyd

228 Our approach employs a simple N-methoxy amide group, which serves as both a directing group and

229 Replacement of the amide group with a carbamate one led to different stereo

230 ation is the irreversible substitution of an amide group with a carboxylate group.

231 Replacement of the amide group with a methylene-oxime moiety produced compo

232 Previous studies have shown that backbone amide groups within the trypsin-binding region of the wi