ライフサイエンスコーパス: amide nitrogen

1 hilic attack by the only weakly nucleophilic amide nitrogen.

2 nd the (15)N chemical shift from the labeled amide nitrogen.

3 P-cluster along with ligation by a backbone amide nitrogen.

4 d by the number of alkyl substituents on the amide nitrogen.

5 hinge helices creates TS, burying sidechain amide nitrogens.

6 (4) Signals from amide nitrogens affected by the paramagnetic center are

7 Cl(-) binds far more weakly to the amide nitrogen/alpha-carbon binding site, while SO(4)(2-

8 In particular, the amide nitrogen, amide proton, and carbonyl carbon chemic

9 ng coordination sites occupied by a backbone amide nitrogen and a water molecule.

10 These preliminary results suggest that amide nitrogen and amide proton chemical shifts in a sel

11 e chlorine, suggesting that LiCl shields the amide nitrogen and prevents its direct protonation.

12 utamate with a one-carbon bridge between the amide nitrogen and the 6'-position of the p-aminobenzoyl

13 a a hybrid binding site that consists of the amide nitrogen and the adjacent alpha-carbon.

14 ely correlated with the distance between the amide nitrogen and the metal in the X-ray structure, out

15 ces designed to satisfy the helices unpaired amide nitrogens and carbonyl oxygens, respectively.

16 xation rates for magnetization involving the amide nitrogens and protons have been measured for 15N-l

17 uring the distance between specific backbone amide nitrogens and the first equivalent of metal throug

18 e, while KGlu interactions with cationic and amide nitrogen are favorable.

19 proton-transfer reaction from His162 to the amide nitrogen are highly coupled, whereas a tetrahedral

20 diene fragment (<Zr-C> = 2.43(5) A), and the amide nitrogen atom (Zr-N = 2.0312(5) A) of the second l

21 correlates well with the atomic depth of the amide nitrogen atom and the secondary structure type, bu

22 A large substituent group on the amide nitrogen atom causes the reactive s- trans conform

23 Thanks to the amenability of the amide nitrogen atom to be substituted with bulky groups,

24 lic attack step, and then shuttles it to the amide nitrogen atom to facilitate the cleavage of the am

25 Congeners in which the amide nitrogen atom was attached to the aralkyl moiety o

26 neralised order parameter (S2) values of the amide nitrogen atom, for residues 70-74, shows that the

27 ligand enantiomer and the substituent on the amide nitrogen atom.

28 te includes deprotonated C-terminal backbone amide nitrogen atoms and the N-terminal amino nitrogen a

29 d side chain, and alkylation of the backbone amide nitrogen atoms around the macrocycle.

30 auser effects were measured for the backbone amide nitrogen atoms at 290 K, 300 K, and 310 K.

31 tional correlation times associated with the amide nitrogen atoms of the N-terminal domain are on ave

32 s of the cysteinyl ligands, and the backbone amide nitrogen atoms that results in tightening of the C

33 mical shifts indicate the imidazole ring and amide nitrogen atoms to the N terminus of both His96 and

34 Methylation of the amide nitrogen atoms was found to greatly decrease activ

35 e negative charge developed on the departing amide nitrogen by the second zinc ion.

36 low pH (<6) became negative, consistent with amide-nitrogen chlorination.

37 opy, we have detected significant amounts of amide nitrogen directly bonded to aromatic rings in a hu

38 involving coordination through deprotonated amide nitrogens, exhibits a weaker affinity characterize

39 catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to the C-4 position of UTP

40 rovided evidence for an unusual amide proton-amide nitrogen hydrogen bond within the ethylglutathiony

41 The ligation by four deprotonated amide nitrogens in macrocyclic motifs is the signature o

42 tion of hydrogen bonds with each of the four amide nitrogens in the AIP-4 macrocyclic ring.

43 f N-donor metal ligands and peptide backbone amide nitrogens in these modes as well.

44 the substrate analogue ACOV, which lacks an amide nitrogen, IPNS exhibits oxygenase activity.

45 how that a hydrogen originally located at an amide nitrogen is transferred away in the formation of a

46 f asparagine at pH 8.0, the amide carbon and amide nitrogen isotope effects have values of 1.0231 and

47 f 1.0245 and 1.0095 for the amide carbon and amide nitrogen isotope effects, respectively.

48 r a carbonyl group to the proximal, hindered amide nitrogen, leading to a very facile amide hydrolysi

49 the carbonyl carbon, proton transfer to the amide nitrogen leaving group, and C-N bond cleavage.

50 , in spite of the fact that this involves an amide nitrogen located trans to the H(2), has the H/H bo

51 f a hydrophilic tail, Q-->A substitution, or amide nitrogen methylation.

52 s mode at low copper levels to a single-His, amide nitrogen mode at high levels.

53 sible surface area (ASA) and accumulation at amide nitrogen (N) and oxygen (O) ASA leads to a predict

54 The relaxation rates of the amide nitrogen nuclei were found to be correlated with t

55 attaching a hydrogen bond donor group to the amide nitrogen of 2 or to the secondary amine nitrogen o

56 ecificity provided by the interaction of the amide nitrogen of a conserved asparagine with the oxygen

57 ns with the ammonium moiety of L-Trp and the amide nitrogen of a glycine residue.

58 tonated nitrogen of an imidazole residue and amide nitrogen of a peptide group.

59 The hydrogen bonds from hydroperoxide to the amide nitrogen of ACV polarize the sigma* orbital of the

60 up interacts with Lys161, and the main chain amide nitrogen of Asn167.

61 M is the methyltransferase that modifies the amide nitrogen of Asn71/72 of CpcB, ApcB, and ApcF.

62 hydrogen bonding to the 2'-OH of FAD and the amide nitrogen of Glu370.

63 As seen for the RF1 complex, the main-chain amide nitrogen of glutamine in the GGQ motif is position

64 The isotope effect in the amide nitrogen of glutamine is 1.0217 at 37 degrees C wi

65 roteins interact to catalyze transfer of the amide nitrogen of glutamine to chorismate, forming 4-ami

66 analog, G17 psi, in which the scissile bond amide nitrogen of Gly-17f has been replaced by a methyle

67 S involves the direct phosphorylation of the amide nitrogen of l-glutamine with ATP by the catalytic

68 the cysteine sulfhydryls, and another by the amide nitrogen of Phe (3)/Tyr (3).

69 structure of Q143N shows that the side-chain amide nitrogen of residue 143 is 1.7 A more distant from

70 een the carbonyl carbon of residue i and the amide nitrogen of residue i + 2 and, therefore, preorgan

71 s of the mutant enzyme increased because the amide nitrogen of Ser308 shifts 0.4 A toward the catalyt

72 the pyrimidine and imidazole rings, and the amide nitrogen of the beta-hydroxyhistidine fragment as

73 lographic studies indicate that the backbone amide nitrogen of the catalytic Ser 90 and the hydroxyl

74 icant deactivation of C-H bonds alpha to the amide nitrogen of these substrates.

75 mine coordinated for N-NH 2 peptides and the amide nitrogen of Thr (6) for peptides with acetylated N

76 ESEEM N1 modulation; (ii) one or both of the amide nitrogens of alpha-356-glycine/alpha-357-glycine a

77 systems that have been studied, the backbone amide nitrogens of Asp224 and Thr223 create an oxyanion

78 ur of Cys92 is introduced by movement of the amide nitrogens of Phe94 and Ala94 much closer to the th

79 ched on the pentapeptide, one on each of the amide nitrogens of Y, I, and L.

80 preferentially at the amino- rather than the amide-nitrogen of the benzanilide.

81 mbered lactams by nucleophilic attack of the amide nitrogen onto the triple bond.

82 cilitating proton abstraction from the Gly67 amide nitrogen or the Tyr66 alpha-carbon.

83 tern is consistent with the variation of the amide nitrogen pK values with the metal charge-dependent

84 rostatic potential-dependent shifting of the amide nitrogen pK.

85 rivative containing active hydrogens only at amide nitrogens plus the C-terminus, and its active H/D

86 oduced at selected alpha-carbon (Calpha) and amide nitrogen positions.

87 to be correlated with the angle between the amide nitrogen-proton bond vectors and the long axis of

88 itudinal and transverse relaxation rates and amide nitrogen-proton nuclear Overhauser effects.

89 d 44 distinct substituents on the alpha-keto amide nitrogen (R2).

90 of deamidation as a measure of the amount of amide nitrogen released in ammonia as well as constant r

91 te interestingly, methylation of the central amide nitrogen strongly altered the high affinity for AB

92 turing highly steric demanding groups at the amide nitrogen, suggested that, despite their molecular

93 rent pK(a) of 6.5 in R96M and that the Gly67 amide nitrogen titrates with an apparent pK(a) of 9.2 in

94 various comparisons, the ability of the PNP amide nitrogen to pi-donate to an otherwise unsaturated

95 Nucleophilic addition of the Gly67 amide nitrogen to the Ser65 carbonyl carbon is catalyzed

96 equential functionalization of the amine and amide nitrogens to rapidly produce diverse analogues.

97 roduce a variety of functional groups at the amide nitrogens to tune the properties of the ligand wit

98 ine amidotransferases whose members catalyze amide nitrogen transfer from glutamine to various specif

99 mide of glutamine, nor as a general acid for amide nitrogen transfer.

100 r citrulline flux, with diminished glutamine amide-nitrogen transfer to citrulline.

101 the tryptophan Nepsilon-H resonance and the amide nitrogen transverse relaxation rates (R2s) for var

102 Amide nitrogen transverse relaxation rates for GB1 in th

103 The amide nitrogen, which is notorious for undergoing tandem

104 S preferentially buries aromatic carbons and amide nitrogens while leaving amide oxygens exposed.