ライフサイエンスコーパス: amidine

1 ance stabilized iminoquinone (i.e., extended amidine).

2 cyclization to form the corresponding cyclic amidine.

3 f the second generation PAD inhibitor, BB-Cl-amidine.

4 ylamide are good alternatives for the second amidine.

5 sosteres for the parent pan PAD inhibitor Cl-amidine.

6 hesize 1,3,5-trizines from acetophenones and amidines.

7 ore the remarkable behavior of the residue 4 amidines.

8 pre-organized for a fit to the heterocyclic amidines.

9 e reduced binding to DNA relative to similar amidines.

10 ial relationship with the groove relative to amidines.

11 azoles in the preparation of polysubstituted amidines.

12 azole-biphenyl isomers with terminal charged amidines.

13 amidine substituents and DB226 has 3-pentyl amidines.

14 d sulfonamide enables efficient synthesis of amidines.

15 oduce five-, six-, and seven-membered cyclic amidines.

16 robic [3+2]-annulation reaction of N-alkenyl amidines.

17 ute toxicity usually exhibited by the parent amidine 1 at a dosage level of 22 micromol/kg/day on int

18 -carbonate ethoxycarbonyloxy (11) of the bis-amidine 1 have been synthesized and evaluated.

19 For example, proline ester amidine 1 is converted to 2-arylpyrrolidine 3 in the pre

20 Most noteworthy were amidines 1, 10, and 11 with IC50 of 4 nM against T. b. r

21 Planar amidine 2, which was designed to explore the importance

22 % yields in two steps from the corresponding amidines 2.

23 Diamidine 1 and di( N-isopropyl)amidine 45, administered at 4 x 1 mg/kg, exhibited poten

24 Amidine 6 and guanidine 7 were comparably effective agai

25 nzotriazoles 6a-w gave diversely substituted amidines 7a-Aa in 76-94% yields.

26 Amidines (8, 13) had greatest selectivity for the kappa

27 ifluoromethyl-4-iodo-nicotinic acid (2) with amidine 9a catalyzed by Pd(2)(dba)(3) and Xantphos, foll

28 2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine), a PAD4 inactivator with enhanced potency.

29 2-chloro-1-iminoethyl)-L-ornithine amide (Cl-amidine), a recently described pan-PAD inhibitor, could

30 We recently found that Cl-amidine, a peptidylarginine deiminase (PAD) inhibitor, i

31 ted for 11 weeks with daily injections of Cl-amidine, a peptidylarginine deiminase inhibitor.

32 rted the synthesis and characterization of F-amidine, a potent and bioavailable irreversible inactiva

33 In the case of the pyrrolidine-derived amidines, about 25% of the decomposition results in clea

34 transformation of the 5-cyano group into an amidine allows synthesis of 2,5-terpyrimidinylenes with

35 potent PAD4 inhibitors, we show here that Cl-amidine also exhibits a strong inhibitory effect against

36 Tertiary amidines also produce nitrosamines in minor, but signifi

37 ion in group 3 metal (Y and Sc) complexes of amidine-amidopyridinate ligands.

38 NZM mice were treated with Cl-amidine, an inhibitor of peptidylarginine deiminases (PA

39 f mechanistic studies of NOS inactivation by amidine analogues of l-arginine and other previous mecha

40 affinities for related amidine and reversed amidine analogues.

41 nces arise from specific interactions of the amidine and amine groups with the active-site residues o

42 We confirmed survival-improving effect of Cl-amidine and are the first to explore the role of Cl-amid

43 investigation of the activity of a series of amidine and bisamidine compounds against Staphylococcus

44 ir assessment indicates that combined pocket amidine and CBP peripherally modified analogues exhibit

45 novel and diverse compounds based on cyclic amidine and guanidine cores were synthesized with the go

46 In this respect, amidine and guanidine derived catalysts have been shown

47 of the literature on the N-arylation of the amidine and guanidine functionalities.

48 Importantly, PAD4 inhibitor Cl-amidine and HDAC inhibitor suberoylanilide hydroxamic ac

49 zed oxidative cyclization of 2-aminopyridine/amidine and isothiocyanate via N-S bond formation at amb

50 ICs = 0.06-0.005 and 0.5-0.06 mug/mL for the amidine and methylene analogues, respectively) and likel

51 phase behavior and microstructure of diC(14)-amidine and of the lipid/DNA (circular plasmid, 5.4 kb)

52 omplexes or Ti(NMe2)4, promotes formation of amidine and oxotitanium products.

53 cin stems from its unprecedented macrocyclic amidine and rare beta-methylated amino acid residues.

54 ifferences in binding affinities for related amidine and reversed amidine analogues.

55 etic compounds containing the core residue 4 amidine and thioamide modifications are reported.

56 m exchanges in the binding pocket (residue 4 amidine and thioamide) are disclosed as well as their pe

57 , mainly been exploited for the synthesis of amidines and amidine-containing heterocycles.

58 specific review covering the N-arylation of amidines and guanidines appeared.

59 Amidines and guanidines are considered as fundamental en

60 Amidines and guanidines are often only thought of as str

61 An efficient "one-step" synthesis of cyclic amidines and guanidines has been developed.

62 to the formation of the corresponding cyclic amidines and guanidines, typically in good to excellent

63 he first time the development of phosphonate amidines and sulfonate amidines as isosteres of pArg and

64 gnificant difference in the positions of the amidines and their DNA interaction strength.

65 emonstrated by 33 examples with a variety of amidines and three different 4H-pyrido[1,3]oxazin-4-one

66 multicomponent synthesis of pyrimidines from amidines and up to three (different) alcohols.

67 A series of guanylhydrazone, amidine, and hydrazone derivatives of 2-phenylimidazo[1,

68 ion with substituents between the vinylogous amidine, and hydrolytic properties that can be controlle

69 mall molecules and macromolecules containing amidine, and to a lesser extent, guanidine functional gr

70 vided by a benzimidazole (or indole) -NH and amidines, and (iii) appropriate curvature of the dimer c

71 d from reaction of carboxylic acids, primary amidines, and monosubstituted hydrazines.

72 ored with the synthesis of series of amides, amidines, and ureas.

73 r of potency in the series was: guanidines > amidines approximately quaternary ammonium > amines.

74 al proteins observed in mice treated with Cl-amidine are consistent with the notion that Cl-amidine d

75 to an aromatic ring and a sterically compact amidine are key pharmacophores for this class of NOS inh

76 Both amidines are positively charged under experimental condi

77 These diazeniumdiolated amidines are shown to be useful NO donor compounds which

78 These compounds, denoted F4- and Cl4-amidine, are the most potent PAD3 inhibitors ever descri

79 The amidine arylation method was found applicable for the sy

80 The use of 5,6-bicyclic amidines as arginine surrogates in the design of a novel

81 opment of phosphonate amidines and sulfonate amidines as isosteres of pArg and then use these mimics

82 ncy and selectivity for this class of cyclic amidines as NOS inhibitors is described.

83 The manifold uses amidines as the nitrogen source and activated skipped di

84 oxylation step during inactivation of NOS by amidines as well as the HO-catalyzed reaction, the essen

85 interaction of a key compound, which has the amidine at the phenyl shifted from the para position in

86 itively charged group such as an amine or an amidine at this position results in improved affinity fo

87 ensation of 4H-pyrido[1,3]oxazin-4-ones with amidines at room temperature or under microwave irradiat

88 rom PFAA-enamine cycloadditions rearrange to amidines at room temperature, while (3 + 2) cycloadditio

89 In contrast, Cl-amidine attenuated these CLP and lipopolysaccharide-indu

90 col substituted phthalocyanines utilizing an amidine-base-promoted phthalonitrile tetramerization rea

91 Amidine-based catalysts (ABCs), a new class of enantiose

92 Asymmetric N-acylation promoted by amidine-based catalysts, particularly Cl-PIQ 2 and BTM 3

93 r to the previously published structures for amidine-based inhibitors complexed with factor Xa.

94 to the discovery of a novel series of cyclic amidine-based inhibitors of beta-secretase (BACE-1).

95 We report here a new class of amidine-based sphingosine analogues that are competitive

96 ed from (3 to 106) x 10(-5) s(-1), while the amidine basicity ranged over 5 pK(a) units.

97 Rate constants corrected for amidine basicity showed the pyrrolidine derived amidines

98 Compounds with linked, one or two amidine-benzimidazole-phenyl (ABP) motifs were designed,

99 Four crystal structures of diverse amidines binding in the active site are deposited and di

100 oroaryl ring, and a phenyl ring linked by an amidine bond, were efficiently synthesized by a straight

101 conformer relative to rotation about the P-C(amidine)() bond; however, DFT calculations indicate a lo

102 containing natural products are converted to amidines by a C-H amination-oxidation sequence or to hyd

103 constitutes a bioorthogonal approach toward amidines by avoiding the use of amines and transition-me

104 o radius of curvature from amidine carbon to amidine carbon but a significant dihedral twist across t

105 ives for targeting the minor groove have the amidine carbon linked to a central heterocyclic system,

106 mpounds have a zero radius of curvature from amidine carbon to amidine carbon but a significant dihed

107 bstrate by hydrogen atom abstraction from an amidine carbon, the 5'-deoxyadenosyl radical abstracts h

108 en atom that had migrated from the substrate amidine carbon.

109 is their ability to carry out methylation of amidine carbons of the adenosine substrate.

110 An amidine-carboxylic acid interface is observed for electr

111 orin associated to NI are consistent with an amidine-carboxylic acid interface, which is also verifie

112 n transfer (PCET) through well-characterized amidine-carboxylic acid interfaces.

113 oton to the carboxylate to form a nonionized amidine-carboxylic acid two-point hydrogen network, wher

114 e diphenyl ether core that is flanked by the amidine cations.

115 ne) (14), has been reported to give a cyclic amidine complex when treated with 2 equiv of 2,6-dimethy

116 compounds, biphenyl tetrazole tert-butyl Cl-amidine (compound 13), exhibits enhanced cell killing in

117 Many dicationic amidine compounds bind in the DNA minor groove and have

118 , reflecting the extent of vinylogous amide (amidine) conjugation.

119 A number of novel amidine containing heterocycles were designed to reprodu

120 Amidines containing more than one replaceable hydrogen p

121 ly observed for iNOS inactivation by another amidine-containing compound, N5-(1-iminoethyl)-L-ornithi

122 exploited for the synthesis of amidines and amidine-containing heterocycles.

123 These cyclic amidines could be converted into mono-benzyl-protected v

124 d on the basis of the N'-(4-halopyrazol-5-yl)amidine cyclization under the conditions of copper-catal

125 Surprisingly, unlike the amidine derivative, the pyrrole -NH of DB884 formed an H

126 In all cases, six-membered amidine derivatives 1 showed higher barriers than the co

127 or the preparation of alpha,beta-unsaturated amidine derivatives appears to offer high yield, mild co

128 ken together, the data indicate that several amidine derivatives display functional selectivity for m

129 Several amidine derivatives displayed high efficacy at m1 recept

130 Amidine derivatives for targeting the minor groove have

131 mechanisms of decomposition of guanidine and amidine derivatives in aqueous solution and the rate enh

132 ic guanidine, N-alkylguanidine, and reversed amidine derivatives of fused ring systems have been synt

133 d provides authentic residue 4 thioamide and amidine derivatives of the vancomycin aglycon that will

134 ituted cyclohexanone analogues, and modified amidine derivatives.

135 idine are consistent with the notion that Cl-amidine derives its efficacy from its ability to inhibit

136 would be transformed into superelectrophilic amidine dications.

137 Importantly, the amidines display effective dual, balanced binding affini

138 hanced van der Waals interactions in the bis-amidine-DNA complex.

139 ional bonding overlaps in the HOMO, and this amidine effect predicts lower N-inversion barriers in an

140 l-N'-tetradecylamino-propionamidine (diC(14)-amidine), efficiently ports DNA into mammalian cells in

141 Compound 1 was the first non-amidine factor Xa inhibitor from our lab that had measur

142 h possesses the ethylene tether and extended amidine feature found in the pyrroloiminoquinone natural

143 we show the versatility of these vinylogous amidines for organic synthesis, including the following:

144 Competitive amidine formation and transamidation are observed with C

145 yield, presumably via novel Sn (IV)-mediated amidine formation from the initial aniline reduction pro

146 Amidine formation using DMF-acetal followed by cyclizati

147 ary carboxamides exhibit different outcomes, amidine formation versus transamidation, depending on th

148 d with Cp*TiIV complexes, generally favoring amidine formation.

149 cules exist as zwitterions with a protonated amidine fragment of the eight-membered ring neutralizing

150 diamine tautomer of a variety of substituted amidine free bases reacts with nitric oxide (NO) to prod

151 at the active site prevent the inhibitor S1 amidine from forming direct hydrogen bonds with Asp189 b

152 ecarboxylation cascade synthesis of sulfonyl amidines from sulfonyl azides and substituted amides at

153 elationships determined that, apart from the amidine function, an indole or benzimidazole and an orth

154 ystal, a solution of inhibitor containing an amidine functional group on a naphthalene ring was added

155 yclic rings to iminoquinones with vinylogous amidine functionality.

156 Acid-catalyzed loss of an amidine gave the final aromatic product.

157 lation, which liberates the desired sulfonyl amidines, generating N2 and CO2 as the only reaction byp

158 ion of a hydroxyl group para to the proximal amidine group increases the potency vs fXa by 1-2 orders

159 ne nitroxides bearing an N',N'-disubstituted amidine group is reported.

160 te that substitution of the thiourea with an amidine group leads to greatly enhanced cytotoxicity in

161 Certain exogenous nucleobases that share the amidine group of adenine restored activity to abasic rib

162 ural and biochemical evidence implicated the amidine group of an active site adenosine, A38, in a pH-

163 The amidine group of PNAAN can be protonated into a hydrophi

164 f either carboxylic acid ligands through the amidine group or pyridine-type ligands through the Zn(II

165 interaction and a replacement for the distal amidine group that binds in the S3/S4 pocket of fXa.

166 optimizing the angle of presentation of the amidine group to the S1 pocket of FXa.

167 that of inhibitors containing a guanidine or amidine group.

168 terminal phenyl substituent on the reversed amidine groups as critical components in the strong bind

169 he new synthetic compounds have two aromatic-amidine groups for A/T recognition, and these are connec

170 The amidine groups in the dimer are oriented in the 5' direc

171 In the presence of dCO2, the amidine groups in the NAEAA block protonate and convert

172 ements indicate that the position of the two amidine groups on the carbazole ring influences signific

173 Compounds with one or both of the amidine groups substituted with N-alkyl substituents or

174 acrylamide), or P(DMA-co-NAEAA), containing amidine groups was synthesized.

175 have demonstrated the importance of the two amidine groups, the cycloheptanone ring, and the (Z,Z) o

176 as well as the nature of substituents on the amidine groups.

177 This tutorial review highlights the use of amidine, guanidine, and related isothiourea catalysts in

178 wis pair catalysts composed of a Lewis base (amidine, guanidine, or quaternary onium salts) and a Lew

179 l review is largely organized by the type of amidine/guanidine and transition metal used and covers l

180 were employed for this purpose were amines, amidines, guanidines, and quaternary ammonium.

181 ll nitrogen bases: nitriles, azoles, azines, amidines, guanidines, vinamidines, biguanides, and phosp

182 For cyclic amidines/guanidines only systems which possess an exocyc

183 BB-Cl-amidine had a pro-apoptotic effect on all Th subsets in

184 ns, but the linking group for the two phenyl amidines has a pK(a) of 6.3 that is susceptible to a pro

185 ethod for the synthesis of bi- and tricyclic amidines has been developed through copper-catalyzed aer

186 ne-pot domino reaction of 1,2-diketones with amidines has been identified that enables their transfor

187 ies of benzimidazole-based derivatives of Cl-amidine, hypothesizing that this scaffold would allow ac

188 the enzyme-bound structure of ZK-816042, an amidine-imidazoline inhibitor of human factor Xa (FXa).

189 and are the first to explore the role of Cl-amidine in immune response.

190 ile MeCN was used in the formation of N-aryl amidines in moderate to high yield.

191 lts were utilized to synthesize monoarylated amidines in moderate to high yields with ligand-free con

192 The amidines in this series show high levels of selectivity

193 , a third mechanism is proposed in which the amidine inactivators of iNOS bind as does substrate L-ar

194 Moreover, Cl-amidine increased circulating monocytes.

195 Further, Cl-amidine increased the differentiation capacity of bone m

196 steric and leaving group requirements for F-amidine-induced PAD4 inactivation, the structure of the

197 boratory has developed a series of novel non-amidine inhibitors of factor Xa.

198 alogue 2 can be used when the product cyclic amidine is organic-soluble, thus producing water-soluble

199 bonds of N-alkylamidines and N-(2-alkylaryl)amidines is described that utilizes the CuBr.SMe(2)/2,2'

200 reaction for the conversion of thioamides to amidines is disclosed.

201 most potent PAD4 inhibitors (i.e., F- and Cl-amidine) known to date.

202 The amidine labels also promote specific fragmentation pathw

203 echanisms of hydrogen exchange in amides and amidines led to the influence of hydrogen bonding and to

204 y a direct reaction between Ca metal and the amidine ligands in the presence of ammonia.

205 Proteolysis is the action of an amidine lyase (EC 4.3.2).

206 Cl-amidine may represent a novel class of disease-modifying

207 (2) abstraction of a hydrogen atom from the amidine methyl group followed by attachment to the heme

208 oes substrate L-arginine, but because of the amidine methyl group, the heme peroxy intermediate canno

209 etween the electronegative tip and guanidine-amidine moiety extends the conjugation and facilitates n

210 mical and structural analyses pinpointed the amidine moiety of base Ade38 as a key functional group i

211 the introduction of fluorine adjacent to the amidine moiety, resulting in in vivo brain reduction of

212 uent with the formally sp(2) nitrogen in the amidine moiety.

213 g at different sites of a (Zn)phthalocyanine-amidine molecule (Pc1), enables the dissociation of the

214 rd the Ala190 enzymes is observed due to the amidine N1 nitrogen of the bound inhibitor being deprive

215 0 or Ala190 enzymes, hydrogen bonds with the amidine N1 nitrogen of the inhibitor.

216 The conjugate containing an amidine-NH donor group cis to the chloride leaving group

217 val of a single methylene bridge between the amidine nitrogen and phenyl ring to give N-(3-(aminometh

218 stem, whereas in the reverse orientation, an amidine nitrogen provides the link.

219 Pseudo-first-order rate constants for amidine nitrosation in aqueous acetic acid with excess n

220 involved water-mediated H-bonds between one amidine of the compound and DNA bases at the floor of th

221 stal structure of the complex shows that the amidine of ZK-807834 forms a salt bridge with Asp189 in

222 ran that, when amplified out to the terminal amidines of the benzimidazole compounds, yields a very s

223 ty by treating mice in the CIA model with Cl-amidine on days 0-35.

224 rvival, focusing on protective effects of Cl-amidine on immune response.

225 cooperative dimer to form but removal of one amidine or addition of an alkyl group to the amidine str

226 It was also demonstrated that the required amidine or iminocarbamate directing group fulfills two m

227 cribed here was the discovery of a novel bis(amidine) organocatalyst that provides high enantioselect

228 Two novel mono(amidine) organocatalysts (MAM) were discovered to provid

229 mpared with 2-PAM, the most promising cyclic amidine-oxime (i.e., 12e) showed comparable or greater r

230 Even at 25% of the initial dose of amidine-oxime (i.e., a dose of 36 mumol/kg, i.p.), 7b an

231 Amidine-oxime reactivation rates for OP-inactivated acet

232 A new class of amidine-oxime reactivators of organophosphate (OP)-inhib

233 hat caused lethality in 6/11 animals without amidine-oxime.

234 t (i.e., 5 min after OP exposure, i.p,) with amidine oximes 7a-c and 12a, 12c, 12e, 12f, and 15b (145

235 Amidine-oximes were tested in vitro, and reactivation ra

236 Amidine-oximes were tested in vivo for protection agains

237 istry of nine acyclic secondary and tertiary amidines (Ph-N=C(R(1))NR(2)R(3); R(1) = H, CH(3), Ph; R(

238 nd that an aromatic dication, DB293, with an amidine-phenyl-furan-benzimidazole-amidine structure can

239 be lead optimization focused on reducing the amidine pKa while optimizing interactions in the BACE1 a

240 The nitro- or cyano-substituted guanidine/amidine planes of the neonicotinoids provide a unique el

241 Collectively, our results demonstrate Cl-amidine plays protective roles by significantly decreasi

242 iminium ion generated from alpha-(phenylthio)amidine precursor 16 by reaction with Cu(OTf)(2) undergo

243 conjugation of novel alpha,beta-unsaturated amidine precursors with proteins, methylarginine mimics

244 In the present study we investigated how Cl-amidine promotes survival, focusing on protective effect

245 g addition and intramolecular cyclization of amidine pronucleophiles on arylpropiolates.

246 ible region upon alteration of the amidinium/amidine protonation state; no such change is observed fo

247 yano group and replacement of guanidine with amidine, pyrimidine, pyridine, or the imidazole moieties

248 PAD4 inhibition by Cl-amidine reduced NETting neutrophils and rescued wound he

249 Treatment with the PAD inhibitor, Cl-amidine, reduced the abundance of deiminated-histone 3,

250 ycloaddition (C4/N1 vs C5/N2) as well as the amidine regioselectivity were unaffected by introduction

251 The acyl amidine represented by the 4,5-dihydro-2(3H)-pyrazinone

252 at both the N-terminus and C-terminus of Cl-amidine result in >100-fold increases in PAD2 potency an

253 HCl to alkenylaldimines, -formamidines, and -amidines results in the protonation of the sp2-nitrogen

254 cant dihedral twist across the tricyclic and amidine-ring junctions.

255 Copper-catalyzed cross-coupling reactions of amidine salts were utilized to synthesize monoarylated a

256 The use of Cu(OTf)2 (5 mol %) produces amidines selectively without Glaser-Hay alkyne homocoupl

257 Diverse heterocyclic amidines, several of which are known to be poorly reacti

258 Because of the large dihedral, the reversed amidines should have reduced binding to DNA relative to

259 4',6-Bis-amidines show some activity but are more toxic; 4'- or 6

260 ded water network in the minor groove at one amidine site, which alters the orientation of the isopro

261 ion revealed a novel rearrangement affording amidines, specifically compound 45, which was found to p

262 amidine or addition of an alkyl group to the amidine strongly inhibited dimer formation.

263 The amidine structural motif within each core forms a bident

264 , with an amidine-phenyl-furan-benzimidazole-amidine structure can recognize specific sequences of DN

265 ne-derived inhibitors of factor Xa (fXa), an amidine substituent was incorporated on one of the benzo

266 ine substituents while DB244 has cyclopentyl amidine substituents and DB226 has 3-pentyl amidines.

267 was found to be modulated by the location of amidine substituents on the core phenyl-furan-phenyl rin

268 iplets, along with proper positioning of its amidine substituents to occupy the minor and the major-m

269 parent compound, furamidine (DB75), has two amidine substituents while DB244 has cyclopentyl amidine

270 heterocyclic cations, a series of "reversed amidine" substituted heterocycles has been prepared.

271 A detailed study of amidine synthesis from N-allyl-N-sulfonyl ynamides is de

272 ly one amino-pyrrole-carboxamide unit and an amidine tail is connected to either side of a central di

273 Cyclization of the amidine-tethered anthranilate then affords 2,3-disubstit

274 benzimidazole-biphenyl system with terminal amidines that gives the compound a linear conformation w

275 benzimidazole-biphenyl system with terminal amidines that results in a linear conformation that does

276 of vancomycin aglycon residue 4 substituted amidines that were used to clarify their interaction wit

277 s from the arthritic mice treated with BB-Cl-amidine, there was a decrease in total cell numbers but

278 dine basicity showed the pyrrolidine derived amidines to be most reactive.

279 Conversion of the amidines to guanidinium groups does permit the cooperati

280 C3 deposition were significantly lower in Cl-amidine-treated mice compared with vehicle controls.

281 Cl-amidine treatment had no ameliorative effect on collagen

282 Cl-amidine treatment inhibited NZM NET formation in vivo an

283 Cl-amidine treatment reduced total synovial and serum citru

284 The two most potent fragments exhibiting an amidine-type scaffold are not the most enthalpic binders

285 be excellent reagents for the preparation of amidines under mild reaction conditions.

286 roach involves Ph3P-I2-mediated formation of amidine upon condensation of an amide or the intermediat

287 e been introduced at the 5 position: amides, amidines, ureas, guanidines, amines, heterocycles, heter

288 -haloenones with 1,3-dicarbonyl compounds or amidines utilizing K2CO3/DMSO at ambient temperature tha

289 The reaction proceeds by dual acylation of amidines via oxidative C(CO)-C(CO) bond cleavage of 1,2-

290 simple protocol, a diverse range of sulfonyl amidines was obtained in moderate to excellent yields.

291 d a highly functionalized and chiral primary amidine, which forms the pyrimidine cores and introduces

292 tion of the mechanism of NOS inactivation by amidines, which leads to heme degradation, also provides

293 de reaction of A(3)-coupling of heterocyclic amidine with aldehyde and alkyne, 5-exo-dig cycloisomeri

294 finity of compounds containing the residue 4 amidine with the model D-Ala-D-Ala ligand 2 was found to

295 -3-ones, available from cyclocondensation of amidines with dimethyl acetylenedicarboxylate (DMAD), un

296 Condensation of amidines with readily prepared alpha,beta-unsaturated al

297 D4 inactivation, the structure of the PAD4-F-amidine x calcium complex, and in vivo studies with N-al

298 he aforementioned dimer is assembled by dual amidine-Zn(II) coordination between neighboring Pc1 mole

299 and idazoxan produced monodiazeniumdiolated amidine zwitterions from which NO release was observed f

300 the preparation of the monodiazeniumdiolated amidine zwitterions.