ライフサイエンスコーパス: amidohydrolase

1 ilization protein (acuC) and acetylpolyamine amidohydrolase.

2 udes pyrazinamidase and N-carbamoylsarcosine amidohydrolase.

3 a larger class of prokaryotic and eukaryotic amidohydrolases.

4 N-terminal nucleophile structural family of amidohydrolases.

5 al mechanism of N-terminal nucleophile (Ntn)-amidohydrolases.

6 vate water for hydrolysis in other class III amidohydrolases.

7 /alpha)(8)-barrel fold characteristic of the amidohydrolases.

8 , and (iii) cleavage under the action of the amidohydrolases.

9 ne (ARGAH1 or ARGAH2 encoding arginine [Arg] amidohydrolase-1 and -2, respectively) resulted in incre

10 Anandamide amidohydrolase (AAH) catalyzes the hydrolysis of arachid

11 thaliana), (1) allantoinase, (2) allantoate amidohydrolase (AAH), (3) ureidoglycine aminohydrolase,

12 in extracts of wheat seedlings possess auxin amidohydrolase activity.

13 In its crystalline form, allantoate amidohydrolase adopts a relatively open conformation.

14 Histone deacetylase and acetylpolyamine amidohydrolase also share profound functional similariti

15 ASPS, to the haloacid dehalogenase, enolase, amidohydrolase and crotonase superfamilies and to the se

16 HAEA and 15-HAEA are poor substrates for AEA amidohydrolase and do not bind to the AEA uptake carrier

17 Two acetylpolyamine amidohydrolases, AphA and AphB, were found to be involve

18 essing of other proteins such as inteins and amidohydrolases, but their mechanisms in such proteins a

19 Allantoate amidohydrolase catalyzes the conversion of allantoate to

20 , the activity of the cobyric acid-producing amidohydrolase CbiZ enzyme is essential for the conversi

21 ay, of archaeal origin, depends on an AdoCbi amidohydrolase (CbiZ) enzyme to generate adenosylcobyric

22 These results indicate that amidohydrolases contribute free IAA to the auxin pool du

23 9 is similar to that of N-carbamoylsarcosine amidohydrolase (CSHase) of Arthrobacter sp. and YcaC of

24 The enzyme penicillin acylase (penicillin amidohydrolase EC 3.5.1.11) catalyses the cleavage of th

25 N-acylase IA (or N(alpha)-acyl-l-amino acid amidohydrolase, EC 3.5.1.14).

26 omega-Amidase (omega-amidodicarboxylate amidohydrolase, EC 3.5.1.3) isolated from rat liver cyto

27 rom five functionally diverse superfamilies (amidohydrolase, enolase, glutathione transferase, haloal

28 salvaging pathway for cobinamide in which an amidohydrolase enzyme cleaves off the aminopropanol moie

29 es the function of a previously unidentified amidohydrolase enzyme that converts adenosylcobinamide t

30 The existence of an adenosylcobinamide amidohydrolase enzyme would explain the lack of an adeno

31 induces the AEA-degrading enzyme fatty acid amidohydrolase (FAAH), and inhibition of FAAH activity p

32 a membrane-bound amidohydrolase, fatty acid amidohydrolase (FAAH).

33 An enzyme from the amidohydrolase family from Deinococcus radiodurans (Dr-O

34 Certain members of an Arabidopsis amidohydrolase family hydrolyze these conjugates to free

35 hosphate synthase, another member of the Ntn-amidohydrolase family of enzymes.

36 s how the ILR1-like indole acetic acid (IAA) amidohydrolase family of genes has functionally evolved

37 zA and AtzB proteins also belong to the same amidohydrolase family.

38 sequence signature of the Ser-Ser-Lys triad amidohydrolase family.

39 amidase is a member of the Ser-Ser-Lys triad amidohydrolase family.

40 anandamide is performed by a membrane-bound amidohydrolase, fatty acid amidohydrolase (FAAH).

41 mily; GalB is structurally distinct from the amidohydrolase fold of LigJ.

42 ogy models of a functionally uncharacterized amidohydrolase from Agrobacterium radiobacter K84 (Arad3

43 d sequence identity to TrzD, a cyanuric acid amidohydrolase, from Pseudomonas sp. strain NRRLB-12227.

44 We examined amidohydrolase gene expression using northern and promot

45 An ortholog for the Arabidopsis IAR3 auxin amidohydrolase gene has been isolated from wheat (TaIAR3

46 Cs) and a bacterial histone deacetylase-like amidohydrolase (HDAH) from Bordetella/Alcaligenes.

47 We characterize here two amidohydrolases, IAR3 and ILL6, that define a second pat

48 agmatine deiminase and N-carbamoylputrescine amidohydrolase in archaea, and of S-adenosylmethionine d

49 docked each metabolite into seven different amidohydrolases in both the ground-state and the high-en

50 Acid ceramidase (N-acylsphingosine amidohydrolase) is the lysosomal enzyme required to hydr

51 terminal Gln by Nt(Q)-amidase, an N-terminal amidohydrolase, is a part of the N-end rule pathway of p

52 The enzyme is able to function as an amidohydrolase, liberating hydroxylamine from LGH with h

53 mples of enzyme superfamilies, including the amidohydrolase, metallo-beta-lactamase, and enolase supe

54 the sequence of the NTA1-encoded N-terminal amidohydrolase of the yeast Saccharomyces cerevisiae, wh

55 se (SLT), and cysteine-, histidine-dependent amidohydrolase/peptidase (CHAP) domains.

56 sis revealed a cysteine, histidine-dependent amidohydrolase/peptidase domain within PlyCA.

57 ntains a CHAP (cysteine, histidine-dependent amidohydrolase/peptidase) domain found in bacterial mure

58 d a C-terminal cysteine, histidine-dependent amidohydrolases/peptidases (CHAP) domain in its C-termin

59 sly recognized cysteine, histidine-dependent amidohydrolases/peptidases catalytic domain.

60 AtzC is thus assigned to the amidohydrolase protein family that includes cytosine dea

61 inase and dihydroorotase, both members of an amidohydrolase protein superfamily.

62 o be homologous to metalloenzymes within the amidohydrolase protein superfamily.

63 residue proposed to activate water in other amidohydrolases, reduced the kcat to a much lesser exten

64 oid anandamide by an inhibitor of fatty acid amidohydrolase reduces blood pressure, cardiac contracti

65 ll fractionation studies showed that the NAE amidohydrolase, responsible for FFA production, was asso

66 nomes sequenced to date, indicating that the amidohydrolase route of ureide degradation is universal

67 extent than what has been reported for other amidohydrolases, suggesting that His-223 has a different

68 URI is a member of the amidohydrolase superfamily (AHS), a highly divergent gro

69 e end of beta-strand 8 in all members of the amidohydrolase superfamily abstracts a proton from the m

70 hat AtzB contained the conserved mononuclear amidohydrolase superfamily active-site residues His74, H

71 These proteins are members of the amidohydrolase superfamily and are currently misannotate

72 These enzymes are members of the amidohydrolase superfamily and belong to cog0402 within

73 te hydrolase, EC 3.5.2.7) is a member of the amidohydrolase superfamily and catalyzes the conversion

74 NagA is a member of the amidohydrolase superfamily and catalyzes the deacetylati

75 spartyl dipeptidase (IAD) is a member of the amidohydrolase superfamily and catalyzes the hydrolytic

76 possess the signature sequence motifs of the amidohydrolase superfamily and likely share the same str

77 Two uncharacterized enzymes from the amidohydrolase superfamily belonging to cog1228 were clo

78 inosa has been identified as a member of the amidohydrolase superfamily by a comprehensive amino acid

79 The amidohydrolase superfamily comprises a remarkable set of

80 ce alignment between HutF and members of the amidohydrolase superfamily containing mononuclear metal

81 Dr0930, a member of the amidohydrolase superfamily in Deinococcus radiodurans, w

82 The amidohydrolase superfamily is a functionally diverse set

83 Two proteins from the amidohydrolase superfamily of enzymes were cloned, expre

84 s group of enzymes is closely related to the amidohydrolase superfamily of enzymes.

85 This protein is a member of the amidohydrolase superfamily of enzymes.

86 d-aminoacylase, and dihydroorotase from the amidohydrolase superfamily of enzymes.

87 and Nocardioides spp., is reportedly in the amidohydrolase superfamily of metalloenzymes, but previo

88 is enzyme is a member of the metal-dependent amidohydrolase superfamily of the (beta/alpha)(8) TIM ba

89 ctrum characteristic of other members of the amidohydrolase superfamily replaced with cobalt.

90 etal-ion dependent esterase MGS0169 from the amidohydrolase superfamily revealed a novel active site

91 Other members of the amidohydrolase superfamily that are not guanine deaminas

92 915 is the second enzyme from cog3618 of the amidohydrolase superfamily that does not require a dival

93 This is the first enzyme from the amidohydrolase superfamily that does not require a dival

94 e only documented example of a member in the amidohydrolase superfamily that does not require one or

95 refore the first characterized member in the amidohydrolase superfamily that represents a C-C breakin

96 rogation of uncharacterized enzymes from the amidohydrolase superfamily using a structure-guided appr

97 otated enzymes belonging to cog3964 from the amidohydrolase superfamily were determined.

98 catalytic activities of three members of the amidohydrolase superfamily were discovered using amino a

99 beta/alpha)(8) barrel and is a member of the amidohydrolase superfamily with a single zinc in the act

100 .0 A confirms that Bh0493 is a member of the amidohydrolase superfamily with conserved residues commo

101 nd 6 that places it in a small subset of the amidohydrolase superfamily with imperfect folds.

102 been suggested to consist of members of the amidohydrolase superfamily, a large class of metallohydr

103 A member of the amidohydrolase superfamily, BmulJ_04915 from Burkholderi

104 Uronate isomerase, a member of the amidohydrolase superfamily, catalyzes the isomerization

105 ization displays the landmark feature of the amidohydrolase superfamily, showing a metal ligand (iron

106 ructure established that LigY belongs to the amidohydrolase superfamily, unlike previously characteri

107 y further suggests that ACMSD belongs to the amidohydrolase superfamily, whose structurally character

108 racterized ADDs, yet both are members of the amidohydrolase superfamily.

109 tion by the HPP family of enzymes within the amidohydrolase superfamily.

110 etals both argue against a connection to the amidohydrolase superfamily.

111 (8) barrel, characteristic of members of the amidohydrolase superfamily.

112 tated as nonspecific dipeptidases within the amidohydrolase superfamily.

113 he known range of reactions catalyzed by the amidohydrolase superfamily.

114 r, we restricted ourselves to enzymes of the amidohydrolase superfamily.

115 aspartyl dipeptidase into the urease-related amidohydrolase superfamily.

116 e that ligates the metal in most mononuclear amidohydrolases superfamily members.

117 ene (termed Ntan1) that encode a 310-residue amidohydrolase (termed NtN-amidase) specific for N-termi

118 ryotic enzyme similar to the acetylpolyamine amidohydrolases that relied on reversible acetylation an

119 have been discovered, including the enolase, amidohydrolase, thiyl radical, crotonase, vicinal-oxygen

120 opanol group of AdoCbi using the CbiZ AdoCbi amidohydrolase to generate adenosylcobyric acid, which i

121 cine aminohydrolase, and (4) ureidoglycolate amidohydrolase (UAH), catalyze the complete hydrolysis o

122 The highest activity toward NAE by amidohydrolase was observed 4 to 8 h after imbibition an

123 structure of a ternary complex of allantoate amidohydrolase with its substrate allantoate and an allo

124 nic--semialdehyde decarboxylase, a class III amidohydrolase, with a single zinc ion coordinated by Hi