ライフサイエンスコーパス: amination

1 ion and transition-metal-catalyzed arene C-H amination.

2 l biocatalyst for formal stereoselective C-H amination.

3 cribe the utility of this strategy for arene amination.

4 aromatic substitution occurs instead of C-H amination.

5 h are obtained with a low ee value using PAL amination.

6 beyond classical hydroformylation/reductive amination.

7 aryl halides undergo efficient and selective amination.

8 free energy of benzylic versus tertiary C-H amination.

9 ent one-pot catalytic deprotection-reductive amination.

10 lides [Cl2NN]Cu-NHAr that participate in C-H amination.

11 olled and site-selective silver-promoted C-H amination.

12 of a [Cl2NN]Cu fragment from 3 prior to C-H amination.

13 nalization to olefin isomerization/oxidative amination.

14 es alkylnitrene complexes unsuitable for C-H amination.

15 lineN(t)Bu is the active intermediate in C-H amination.

16 razine sulfamate zwitterions by an unusual N-amination.

17 C-N bond forming dearomatization or aryl C-H amination.

18 d by an intramolecular Pd-catalyzed aromatic amination.

19 es C) and a similar reactor setup as for the amination.

20 nic acids, leading to chemoselective primary amination.

21 ta(3)-methallyl) catalyst 1 used for allylic aminations.

22 er barriers and faster catalysis for allylic aminations.

23 nzimidazole-forming reactions, and reductive aminations.

24 fford diazatetracenes using Buchwald-Hartwig aminations.

25 The scope of the NCS-mediated amination/[2,3]-sigmatropic rearrangement of enantioenri

26 o2 (mu-NH2 )(PMe3 )2 ](3+) (n=2, 3), and C-H amination [((3) PDI2 *-mu-NH)Co2 (PMe3 )2 ](3+) products

27 y acetate ligand-assisted intramolecular C-H amination.a This reaction is high-yielding and straightf

28 nce is applied to the enantioselective alpha-amination, aldol, and alpha-aminoxylation/alpha-hydroxya

29 for further functionalization via reductive amination, amidation, or other chemistry.

30 Amination and alkynylation of heterocyclic substrates in

31 for visible-light-activated asymmetric alpha-amination and alpha-alkylation, respectively, of 2-acyl

32 i(0)/Ni(II) couple for this nickel-catalyzed amination and are inconsistent with a Ni(I) halide inter

33 and antidepressant sertraline by late-stage amination and azidation reactions.

34 ed radical recombination to afford the major amination and aziridination products but also one-electr

35 reactivity was successfully explored by C-H amination and borylation reactions, although C-H fluorin

36 s highlighted through the development of C-H amination and carbonylation processes, leading to the sy

37 lly useful transformations, including olefin amination and directed carbon-hydrogen (C-H) bond functi

38 t application of free radical mediated vinyl amination and Hwu's oxidative allylation in a total synt

39 tifunctional reagents for the direct primary amination and hydroxylation of structurally diverse aryl

40 GSK852A (1) was obtained after reductive amination and mesylation with conditions amenable to the

41 Meta-C-H amination and meta-C-H alkynylation using a modified nor

42 substrates are compatible with both meta-C-H amination and meta-C-H alkynylation.

43 '-tetranitro-2H,2'H-3,3'-bipyrazole (4) by N-amination and N-azo coupling reactions is described.

44 been designed and synthesized using Buchwald amination and oxidative homocoupling as key steps.

45 lopment of formal anti-Markovnikov reductive amination and oxidative hydration reactions to access li

46 rocarbazolone core via a palladium-catalyzed amination and oxidative indole formation.

47 hemo- and regioselective reactions combining amination and palladium-catalyzed cross-coupling reactio

48 file the conditions for the Buchwald-Hartwig amination and rapidly identify bespoke conditions for ch

49 ivatives using copper-catalyzed azidation or amination and reductive alkylation of benzylazide by a h

50 ied conditions lead to an apparent reductive amination and the formation of o-hydroxybenzylamines in

51 ameters of ICL formation by double reductive amination and yield a set of diverse ICLs that will be i

52 onalization, transimination, ortho-selective amination, and a cyclization sequence.

53 onomer impregnation, in situ polymerization, amination, and alkaline ion exchange.

54 l involving a Staudinger reaction, reductive amination, and benzyloxy carbonyl protection yielded an

55 ene (NBE-CO2 Me) as the mediator, arylation, amination, and chlorination of benzylamines are realized

56 ersion of alcohols to imidates, directed C-H amination, and hydrolysis to NH2).

57 f the heterotricyclic core, an electrophilic amination, and the stereoselective hydrogenation of a te

58 functionalizations that lead to oxidations, aminations, and halogenations are also presented.

59 The products from C-H amination are formed in up to 98% yield and approximatel

60 Most currently used catalysts for C-H bond amination are ill suited to the intermolecular functiona

61 arrangement, Michael addition, and reductive amination as key steps.

62 lude a sterically demanding Buchwald-Hartwig amination as well as a unique C(sp(3) )-H amination/indo

63 NNRTI relies on two sequential Pd-catalyzed aminations as the key steps.

64 mann, and classical amine-carbonyl reductive aminations, as it tolerates aryl halides and carbonyl co

65 e and sodium cyanoborohydride, the reductive amination-based method can be utilized to generate novel

66 h yield library of compounds via a reductive amination by flow hydrogenation.

67 actions, various oxidations, rearrangements, aminations, C-C bond-forming reactions, and transition m

68 trate that the pathway of a classic pyridine amination can be adapted for selective fluorination of a

69 Strain-release amination can diversify a range of substrates with a mul

70 marily assimilated ammonia through reductive amination catalyzed by glutamate dehydrogenase (GDH); se

71 Reductive amination chemistry was used to synthesize all possible

72 A short sequence of catalytic C(sp(3))-H amination-cyclization-[3 + 2] cycloaddition has then bee

73 Complementary to known reductive aminations, effective C-N bond construction proceeds und

74 The asymmetric ruthenium-catalyzed reductive amination employing ammonia and hydrogen to primary amin

75 te influence the site-selectivity of the C-H amination event.

76 C-H amination experiments employing 1,4-dimethylcyclohexane

77 rough a cascade process of Rh(III)-catalyzed amination followed by intramolecular electrophilic aroma

78 ouble functionalization via an electrophilic amination followed by nucleophilic trapping.

79 e, we present a mild dirhodium-catalyzed C-H amination for conversion of structurally diverse monocyc

80 benzene (PIDA)-mediated direct oxidative C-H amination for the synthesis of 3-amino substituted imida

81 mines based on a palladium-catalyzed allylic amination has been developed.

82 The Buchwald-Hartwig amination has been investigated theoretically and experi

83 A sequence of oxidative cleavage/reductive amination/hydrogenolysis enables the preparation of N-su

84 sin II receptor) through copper-mediated C-H amination, hydroxylation, thiolation, arylation, and tri

85 n aldehyde-active solid support by reductive amination; (ii) stabilization of fragile sialic acids by

86 nd aliphatic chains to mannose via reductive amination in order to increase both the affinity and sel

87 mplexes are generally poor catalysts for C-H amination: in this catalyst, the enzyme's protein framew

88 ig amination as well as a unique C(sp(3) )-H amination/indole formation.

89 Arene amination is achieved by site-selective C-H zincation fo

90 An outstanding challenge in the field of C-H amination is catalyst-controlled regioselectivity.

91 The chemoselectivity for C-H bond amination is greater than 20:1 in all cases.

92 Dirhodium-catalyzed C-H amination is hypothesized to proceed via Rh2-nitrene int

93 Reductive amination is one of the most important methods for the s

94 HAT is rate-limiting, whereas intramolecular amination is product- and stereo-determining.

95 The metalloradical amination is suitable for both secondary and tertiary pr

96 ediates support a dynamic kinetic asymmetric amination mechanism based on the labilization of the ste

97 This amination method provides an efficient and rapid approac

98 This Synopsis presents recent amination methods using nitrogen-heteroatom bonds as a p

99 uding those previously inaccessible using CH amination methods.

100 bilized glycoproteins on resin via reductive amination, modified alpha2,6-linked sialic acids through

101 '-CAp sequence under conditions of reductive amination (NaCNBH(3), pH 5.2) generated much higher yiel

102 ibly converted under conditions of reductive amination (NaCNBH(3)/pH 5.2) to a stable amine linkage.

103 etrazine-trans-cyclooctene, oxime, reductive amination, native chemical ligation, Suzuki, Sonogashira

104 tions including deoxygenation, C-alkylation, amination, O- and N-methylation, which are characteristi

105 This intramolecular amination occurs readily at both benzylic and tertiary a

106 A detailed kinetic study for C(sp(3))-H amination of 1-azido-4-phenylbutane (S1) revealed zero o

107 loride functionalization in the Pd-catalyzed amination of 3,2- and 5,2- Br/Cl-pyridines is reported.

108 The mechanism of l-proline-catalyzed alpha-amination of 3-phenylpropionaldehyde was studied using a

109 lowed by mixed copper-copper oxide-catalyzed amination of 4-bromophthalazin-1(2H)-ones 4 with primary

110 ronic state (GES), redox potentials, and C-H amination of [Rh2(II,III)(O2CCH3)4(L)n](+) (1_L) (L = no

111 zed the challenging intramolecular sp(3) C-H amination of a series of alkyl azides to afford alpha-su

112 chloride catalyzed chemoselective reductive amination of a variety of carbonyl compounds with aromat

113 a nitroxyl radical, promotes site-selective amination of a variety of simple and complex aromatics w

114 ction conditions for the palladium-catalyzed amination of a wide variety of (hetero)aryl halides usin

115 A radical-mediated strategy for beta C-H amination of alcohols has been developed.

116 The first dynamic kinetic asymmetric amination of alcohols via borrowing hydrogen methodology

117 The mechanistic course of the amination of alcohols with ammonia catalyzed by a struct

118 The direct, asymmetric alpha-amination of aldehydes has been accomplished via a combi

119 ved high activity of 1 in catalyzing the C-H amination of alkanes under mild conditions.

120 -benzoylhydroxylamine-promoted electrophilic amination of alkenes.

121 he wavelength filters used demonstrates that amination of all linkers of the MOF is not required to o

122 sfully demonstrated using the example of the amination of allyl alcohol.

123 Although protocols for direct oxidation and amination of allylic C-H bonds (that is, C-H bonds where

124 oped by using copper-catalyzed electrophilic amination of alpha-phosphonate zincates with O-acyl hydr

125 Here we report the direct asymmetric amination of alpha-substituted cyclic ketones catalyzed

126 Herein, we present a stereoselective alpha-amination of amides employing simple azides that proceed

127 ctet-Spengler reaction and an intramolecular amination of an N-guanidyl pyrrole by a sulfonyl guanidi

128 ible light photocatalyzed method for the C-H amination of arenes and heteroarenes.

129 The direct catalytic C-H amination of arenes is a powerful synthetic strategy wit

130 elevated temperatures that allows the direct amination of arenes to be completed within 3 min at 90 d

131 We report the Pd-catalyzed amination of arenes to form N-aryl phthalimides with reg

132 for the direct stoichiometric electrophilic amination of aromatic hydrocarbons and the Schmidt react

133 e reaction conditions for the Chan-Evans-Lam amination of aryl BPin with alkyl and aryl amines.

134 Kinetic studies showed that the amination of aryl chlorides and bromides is first order

135 We report the amination of aryl chlorides and bromides with primary al

136 The nickel-catalyzed amination of aryl chlorides to form primary arylamines o

137 successfully applied in the Buchwald-Hartwig amination of aryl chlorides, bromides, and iodides.

138 amination, the Buchwald-Hartwig-Ullmann-type amination of aryl halides stands as one of the most empl

139 ly efficient and direct asymmetric reductive amination of arylacetones catalyzed by an iridium comple

140 Substrate-directed ortho C-H amination of azoarenes using TMSN3 as the source of nitr

141 here to be good catalysts for the reductive amination of benzaldehydes using formate salts as hydrog

142 , we report a copper(II)-mediated C(sp(2))-H amination of benzamides with electronically neutral or e

143 ioselectivity for C-H amination-one favoring amination of benzylic C-H bonds and the other favoring h

144 ng chemoselective borylation, silylation and amination of benzylic C-H bonds, as well as hydrogenatio

145 r the highly enantioselective intermolecular amination of benzylic C-H bonds.

146 or copper-catalyzed, aminoquinoline-assisted amination of beta-C(sp(2))-H bonds of benzoic acid deriv

147 Amine meets arene: A method for direct amination of beta-C(sp(2))-H bonds of benzoic acid deriv

148 for the first time, a general, electrophilic amination of boronic acids at ambient temperature.

149 as the resting state of the catalyst in the amination of both aryl chlorides and bromides.

150 igand for promoting a Pd-catalyzed ortho-C-H amination of both benzamides and triflyl-protected benzy

151 Dynamic kinetic asymmetric amination of branched allylic acetimidates has been appl

152 iron catalyst for intra- and intermolecular amination of C(sp(3))-H bonds.

153 ne of several iron complexes observed in the amination of C-H bond substrates or styrene aziridinatio

154 been limited by low chemoselectivity for the amination of C-H bonds over competing reduction of the a

155 The intermolecular amination of C-H bonds represents a particularly desirab

156 CPF-5) is described that promotes the direct amination of C-H bonds with exceptional activity.

157 f copper-catalyzed oxidative dehydrogenative amination of cyclohexane to generate a mixture of N-alky

158 ve in promoting the intermolecular sp(3) C-H amination of cyclohexene using unprotected anilines to p

159 escribes the development of Buchwald-Hartwig amination of different bromoflavones with amino acid and

160 e-pot two-step method for intermolecular C-H amination of electron-rich heteroarenes and arenes has b

161 roup tolerance and it is well-suited for the amination of electron-rich, electron-deficient as well a

162 strategy is based on the diastereoselective amination of enantioenriched trans-gamma,delta-unsaturat

163 asymmetric synthesis of 1,2-diamines through amination of enecarbamates has been proposed as a highly

164 iral phosphoric acid catalyzed electrophilic amination of enecarbamates with dibenzyl azodicarboxylat

165 Kinetic studies involving the stoichiometric amination of ethylbenzene by {[Cl2NN]Cu}2(mu-N(t)Bu) (3)

166 An efficient direct electrophilic amination of fluoroalkyl groups was developed.

167 A general Pd-catalyzed method for the double amination of functionalized pyridinyl-1,2,4-triazines wi

168 ups found to promote the palladium-catalyzed amination of gamma C(sp(3) )H and C(sp(2) )H bonds of se

169 Direct amination of heteroarenes and arenes has been achieved i

170 gy is also applicable for the regioselective amination of indolizines.

171 governing selective Rh2(esp)2-catalyzed C-H amination of isoamylbenzene derivatives are investigated

172 rmations they require either an amine donor (amination of ketones) or an amine acceptor (deamination

173 The direct alpha-amination of ketones, esters, and aldehydes has been acc

174 A novel and efficient copper-catalyzed amination of N-aryl imines is described.

175 two key steps: organocatalyzed electrophilic amination of pent-4-ynal with dialkyl azodicarboxylate p

176 We present a biocatalytic hydrogen-borrowing amination of primary and secondary alcohols that allows

177 Highly chemoselective intramolecular amination of propargylic C(sp(3))-H bonds has been demon

178 e is presented, including the selective meta-amination of pyridine derivatives.

179 ough intramolecular oxidative C-H activation-amination of readily available 2-(het)aryl-3-(het)aryl/a

180 lucidate the mechanism of a metal-free alpha-amination of secondary amines.

181 Our method is also amenable to electrophilic amination of several common boronic acid derivatives (e.

182 In this work, we have demonstrated selective amination of SiNx surface as compared to Si surface.

183 rimental observations validate that the ipso amination of substituted boronic acids involves the form

184 Sequential amination of substrates containing several carbon-carbon

185 C-H insertion: A method for intermolecular amination of tertiary CH bonds is described that uses li

186 The study of the oxidative amination of tetrahydroisoquinolines under chiral-anion

187 n-atom transfer to form N-H bonds, or 3) C-H amination of the alkyl linker of the (n) PDI2 ligand.

188 anocatalytic fluorination, chlorination, and amination of the homo-Roche building blocks was performe

189 R)(SO2R')]2 promote the selective direct C-H-amination of the indole core of various tryptamines.

190 The amination of thioethers with a chiral N-mesyloxycarbamat

191 Fe(NHAd), and can mediate intermolecular C-H amination of toluene [PhCH3/PhCD3 kH/kD: 15.5(3); PhCH2D

192 hod for catalytic intermolecular allylic C-H amination of trans-disubstituted olefins is reported.

193 challenging intramolecular direct C(sp(3))-H amination of unactivated organic azides to generate a ra

194 alt-catalysed intermolecular dehydrogenative amination of unactivated sp(3) carbons is also realized.

195 The Cdelta -H amination of unactivated, secondary C-H bonds to form a

196 r developments in transition metal-catalyzed aminations of aryl halides to form anilines, a common st

197 possess enzymes that catalyse the analogous aminations of C-H bonds.

198 t provide divergent regioselectivity for C-H amination-one favoring amination of benzylic C-H bonds a

199 by either a new silver-promoted nucleophilic amination or a rhodium-catalyzed C-H amination protocol.

200 ted substrates undergo alternative oxidative amination or allylic amination pathways, and these react

201 wide variety of aliphatic hydrocarbons (C-H amination or amidination in the presence of nitriles) an

202 otricycles in one step by intramolecular C-H amination or Pictet-Spengler cyclization.

203 development of a general catalytic Chan-Lam amination, overcoming long-standing and unsolved amine a

204 distinct conditions to give the products of amination, oxidation, and arylation.

205 products are converted to amidines by a C-H amination-oxidation sequence or to hydrazine sulfamate z

206 process, which is proposed to proceed via an amination-oxidation sequence, selectively promotes the t

207 pper-catalyzed radical methylation/sp(3) C-H amination/oxidation reaction for the facile synthesis of

208 o alternative oxidative amination or allylic amination pathways, and these reactions will also be dis

209 e combinations, it was demonstrated that the amination pattern of the reaction could be tuned to achi

210 s, and (2) a regioselective Buchwald-Hartwig amination procedure installs para-amine functionality.

211 CH zincation/copper-catalyzed electrophilic amination procedure.

212 t)Bu-IbuPhyrin, the cobalt(II)-catalyzed C-H amination proceeds effectively under neutral and nonoxid

213 atalytically active species in the thioether amination process.

214 rformed to illustrate one application of the amination product.

215 itive formation of aziridination and allylic amination products.

216 ove the selectivity and scope of this direct amination protocol, aromatic carboxylic acids were addit

217 ophilic amination or a rhodium-catalyzed C-H amination protocol.

218 s approach is limited by a lack of practical amination protocols.

219 amma-CH arylation step, the gamma-C(sp(3) )H amination provided access to complex pyrrolidones from r

220 This amination provides the first example of CN bond formatio

221 ies on a stereoselective Tsuji-Trost allylic amination reaction and a ring-closing metathesis.

222 Extension of the method to the alpha-amination reaction by using azodicarboxylate esters as e

223 A method for enantioselective direct alpha-amination reaction catalyzed by a sterically "frustrated

224 uential one-pot multicomponent carbonylation/amination reaction has been developed.

225 of an enantioselective Pd(II)-catalyzed C-H amination reaction is described.

226 An efficient aerobic linear allylic C-H amination reaction is reported under palladium(II)/bis-s

227 erimental and theoretical studies of the C-H amination reaction mediated by the iron dipyrrinato comp

228 The C-H amination reaction occurs only with certain tethers conn

229 The direct amination reaction of heterocyclic thiols has been devel

230 A rhenium-catalyzed N-selective allylic amination reaction of N-hydroxycarbamates has been devel

231 tuted alkenes were obtained by an unexpected amination reaction promoted by ethyl nosyloxycarbamate o

232 sphine ligand is crucial for this C(sp(3))-H amination reaction to occur.

233 , a ring-closing metathesis reaction, and an amination reaction.

234 g an iterative double ring-closing reductive amination reaction.

235 subsequent Rh(II)2-catalyzed sp(2)-C-H bond amination reaction.

236 efficiently used as an organocatalyst in the amination reaction.

237 We report an investigation of the Chan-Lam amination reaction.

238 -conjugated DPCs were generated by reductive amination reactions between the Lys and Arg side chains

239 escribe the use of rhodium(II)-catalysed C-H amination reactions developed by Du Bois to carry out si

240 The application of Rh- and Ir-catalyzed C-H amination reactions in complex settings were used to gai

241 by palladium-catalyzed double-carbonylative amination reactions is discussed.

242 yze enantioselective intramolecular C-H bond amination reactions of sulfonyl azides.

243 NR, solvent, or anion) are proposed in these amination reactions on the basis of experimental studies

244 ilic Lewis acids, undergo intramolecular C-H amination reactions to form pyrazolines in good to excel

245 e the key intermediates in aziridination and amination reactions using azides as the nitrogen source.

246 cant progress, copper-catalyzed/mediated C-H amination reactions with electron-rich anilines remain a

247 ted arenes lacking a directing group undergo amination reactions with moderate to high yields and hig

248 engineered to catalyze abiological C-H bond amination reactions, but the yields of these reactions h

249 M-N bonds for alkene alkoxylation and alkene amination reactions, respectively.

250 Among C-H bond amination reactions, those forming a C-N bond at a terti

251 e limitations of palladium(II)-catalyzed C-H amination reactions.

252 diates in copper-catalyzed aziridination and amination reactions.

253 dberg" and "Oxidative-Buchwald-Hartwig" type amination reactions.

254 those previously obtained using allylic C-H amination reactions.

255 suitable enzymes to catalyze challenging C-H amination reactions.

256 dical", enabling subsequent radical-type C-H amination reactivity with Pd(II).

257 able hydroxylamine derivative is used as the amination reagent and oxidant.

258 A sequence of oxidative cleavage/reductive amination/reductive cleavage enables the preparation of

259 per describes a Heck reaction/C-H activation/amination sequence for forming indolines using di-tert-b

260 through a deprotection and double-reductive amination sequence to give 4,5,6,7-tetrahydropyrazolo[1,

261 of promoting predictable and chemoselective aminations solely through reagent control.

262 highly enantioselective electrophilic alpha-amination step in the presence of europium triflate and

263 The use of mild, Cu-catalyzed electrophilic amination strategies for the regioselective preparation

264 Starting from a general C2-amination strategy, subsequent transformations enable a

265 More rapid C-H amination takes place, however, when (t)BuOO(t)Bu is use

266 Herein, we report remarkable chemoselective aminations that employ a single metal (Ag) and a single

267 mation, Suzuki cross-coupling, and reductive amination, the Buchwald-Hartwig-Ullmann-type amination o

268 sequent Reissert-Henze chlorination and SNAr amination, the decarboxylative arylation provides an eff

269 he 1-aza-2-azoniaallene cation undergoes C-H amination through a hydride transfer transition state to

270 We also observed reductive amination to form alanine and reduction to form propioni

271 The scope of the propargylic amination to yield optically active triazolyl amines is

272 A reduction and intramolecular reductive amination transformed the intermediate disaccharide 24 t

273 f catalysts capable of fast, robust C-H bond amination under mild conditions is an unrealized goal de

274 work describes the combination of reductive amination using 3-amino-9-ethylcarbazole, with a new LC

275 An intermolecular C(sp(3))-H amination using a Pd(0) /PAr3 catalyst was developed.

276 on by Cu(I)-catalyzed asymmetric propargylic amination using a single chiral complex and a subsequent

277 hesized by periodate oxidation and reductive amination using a variety of R-NH2 substituents.

278 ch as Wittig olefination or Buchwald-Hartwig amination using an expert system.

279 of a distinct mechanistic paradigm for aryl amination using ligand-free nickel(II) salts, in which f

280 A Pd and norbornene-catalyzed ortho-arene amination via Catellani-type C-H functionalization is re

281 relevant to stoichiometric and catalytic C-H amination via isolable beta-diketiminato dicopper alkyln

282 iating challenging C(sp(3))-H oxidations and aminations via high-valent iron oxos and nitrenes, C(sp(

283 rapid mono and diselective Buchwald-Hartwig aminations via microwave irradiation.

284 alytic bond-weakening protocol for conjugate amination wherein the strong N-H bonds in N-aryl amides

285 chemo- and enantioselective silver-catalyzed aminations which transform di- and trisubstituted homoal

286 e installation of a chiral amine through C-H amination, which is a challenging chemical transformatio

287 ic C-H bonds in the natural products undergo amination while olefins undergo aziridination, and terti

288 c organosulfur compounds (OSCs) by reductive amination with (13)C, D2-formaldehyde, and developed an

289 can samples to be compared undergo reductive amination with 2-aminobenzoic acid and 2-(13)[C6]-aminob

290 y coupling phenylalanine ammonia lyase (PAL) amination with a chemoenzymatic deracemization (based on

291 Subsequent amination with a large variety of amines provided the fi

292 s and ICL formation using a double reductive amination with a variety of amines.

293 While olefin amination with aminium radical cations is a classical me

294 t with aldehyde silane followed by reductive amination with heterobifunctional amine-poly(ethylene gl

295 s) for absolute quantification via reductive amination with isotopic formaldehydes.

296 xane) reveals inefficient stoichiometric C-H amination with these copper(II) anilides.

297 dation of the third digitoxose and reductive amination with various R-NH2 substituents and identified

298 talyst 3 performs similarly to 1 for allylic aminations with diethylamine.

299 is able to catalyze stereoselective benzylic aminations with ee values of 97.5%.

300 also demonstrate preparative scale reductive aminations with wild-type and Q240A variant biocatalysts