ライフサイエンスコーパス: amine oxidase

1 ess it is oxidized to spermidine by the Fms1 amine oxidase.

2 ytochrome oxidase, superoxide dismutase, and amine oxidase.

3 equine plasma amine oxidase and human kidney amine oxidase.

4 nesis has been carried out on a yeast copper amine oxidase.

5 al peptide was identified for human placenta amine oxidase.

6 cquisition of Cu(I) by nascent H. polymorpha amine oxidase.

7 lective mechanism-based inhibitors of copper amine oxidases.

8 nhibitors of the mammalian copper-containing amine oxidases.

9 nucleus found in the plasma and other copper amine oxidases.

10 quinone (TPQ) cofactor in copper-containing amine oxidases.

11 that is highly selective over LOX and other amine oxidases.

12 gn: (a) PTS selectivity and (b) stability to amine oxidases.

13 ies: monomeric globins and copper-containing amine oxidases.

14 hich occurs in cofactor biogenesis in copper amine oxidases.

15 turally similar to aromatic hydroxylases and amine oxidases.

16 The X-ray crystal structures of copper amine oxidase-1 from the yeast Hansenula polymorpha (HPA

17 Together, these results link the amine oxidase activity of VAP-1 with hepatic inflammatio

18 antibody only blocking the adhesion, not the amine oxidase activity of VAP-1.

19 Amine oxidase activity regulates the development of pulm

20 that circulating renalase lacks significant amine oxidase activity under basal conditions (prorenala

21 5C behave similarly with regard to aliphatic amine oxidase activity, showing 3-7-fold decreases in ki

22 nia despite the fact that this mutant has no amine oxidase activity.

23 ced Smad3 phosphorylation likely through its amine oxidase activity.

24 oxidase (KDAO), and Arthrobacter globiformis amine oxidase (AGAO) to examine the effect of different

25 f substrate-reduced Arthrobacter globiformis amine oxidase (AGAO) under a wide range of conditions.

26 ne oxidase (rhDAO), Arthrobacter globiformis amine oxidase (AGAO), and Pichia pastoris amine oxidase

27 ine oxidase (PSAO), Arthrobacter globiformis amine oxidase (AGAO), Escherichia coli amine oxidase (EC

28 corresponding sections of other flavoprotein amine oxidases, although the overall identity of aligned

29 dopa decarboxylase and a membrane-associated amine oxidase, amiloride-binding protein 1.

30 ular adhesion protein-1 (VAP-1) is a primary amine oxidase and a drug target for inflammatory and vas

31 d tissue-specific expression of LOXL2, a new amine oxidase and a member of an emerging family of huma

32 The activities of plasma amine oxidase and diamine oxidase were only minimally re

33 Here, we demonstrate that Hp has both amine oxidase and ferroxidase activity in cultured cells

34 wo mammalian enzymes examined, equine plasma amine oxidase and human kidney amine oxidase.

35 in confirms that zinc binds to H. polymorpha amine oxidase and prevents reconstitution with copper.

36 lism of a branched primary amine by a copper amine oxidase and suggests a novel type of reversible me

37 onstituents, are the semicarbazide-sensitive amine oxidase and the scavenger lipoprotein receptor CD3

38 and may have influenced the distribution of amine oxidases and catalase in cells.

39 The homology of FMS1 to FAD-containing amine oxidases and its role in beta-alanine biosynthesis

40 This PTI exhibited decreased sensitivity to amine oxidases and low toxicity as well as high potency

41 semble the ortho-quinone cofactors in copper amine oxidases and mediate the efficient and selective a

42 actor in several wild-type copper-containing amine oxidases and mutants of the amine oxidase from Han

43 riplasmic topaquinone- and copper-containing amine oxidase, and FeaB is a cytosolic NAD-linked aldehy

44 is an acute-phase protein with ferroxidase, amine oxidase, and pro- and antioxidant activities.

45 ongly influenced PTI potency, sensitivity to amine oxidases, and cytotoxicity.

46 such as topaquinone in the copper-containing amine oxidases, and lysine tyrosylquinone in lysyl oxida

47 us to conclude that the cofactor in A. niger amine oxidase AO-I has been misidentified.

48 en reported to exist in an Aspergillus niger amine oxidase AO-I.

49 esis of the covalently bound topa quinone in amine oxidase are discussed.

50 Copper amine oxidases are a family of enzymes with quinone cofa

51 e been identified as Cu(II) ligands in other amine oxidases are conserved in the human placenta amine

52 this study establishes the 97-kDa rat/human amine oxidase as the first integral membrane amine oxida

53 n-gel and spectrophotometric ferroxidase and amine oxidase assays demonstrated that Cp activity was e

54 tutes for tyrosine and the substrate used in amine oxidase assays.

55 from Arthrobacter globiformis, pea seedling amine oxidase at pH 7.1, and the E406Q mutant of HPAO.

56 ant, bacterial, and fungal copper-containing amine oxidases: bovine plasma amine oxidase (BPAO), equi

57 enantioselectively (S >> R) by bovine plasma amine oxidase (BPAO) both as a temporary inactivator and

58 Incubation of bovine plasma amine oxidase (BPAO) with benzylamine and various p-subs

59 per-containing amine oxidases: bovine plasma amine oxidase (BPAO), equine plasma amine oxidase (EPAO)

60 nt irreversible inactivator of bovine plasma amine oxidase (BPAO), exhibiting a 30 min IC(50) of 2.9

61 pastoris lysyl oxidase (PPLO), bovine plasma amine oxidase (BPAO), human kidney diamine oxidase (KDAO

62 novel fluorogenic substrate of bovine plasma amine oxidase (BPAO), namely, (2-(6-(aminomethyl)naphtha

63 the copper-containing proteins, bovine serum amine oxidase (BSAO) and human kidney diamine oxidase (D

64 Bovine serum amine oxidase (BSAO) catalyzes the oxidative deamination

65 Bovine serum amine oxidase (BSAO) exhibits a similar nu(C=O) mode at

66 e copper-containing quinone-dependent plasma amine oxidase but that the activity recovers over time,

67 imilation pathway: the replacement of copper amine oxidase by a flavin-dependent backup enzyme.

68 chanism of inactivation of quinone-dependent amine oxidases by normal substrates in vitro if the prod

69 during the reoxidation of substrate-reduced amine oxidases by O(2) has not yet been definitively est

70 The expression of a copper amine oxidase (CAO) from Hansenula polymorpha in Sacchar

71 Copper amine oxidase (CAO) is a dual-functioning enzyme that ca

72 of the topaquinone (TPQ) cofactor of copper amine oxidase (CAO) is self-catalyzed and requires coppe

73 Copper amine oxidases (CAOs) are responsible for the oxidative

74 The copper amine oxidases (CAOs) catalyze both the single-turnover

75 The copper amine oxidases (CAOs) catalyze the O(2)-dependent, two-e

76 Copper amine oxidases (CAOs) catalyze the two-electron oxidatio

77 Copper amine oxidases (CAOs) contain 2,4,5-trihydroxyphenylalan

78 All known copper amine oxidases (CAOs) contain 2,4,5-trihydroxyphenylalan

79 ificity are investigated in a pair of copper amine oxidases (CAOs) from Hansenula polymorpha (HPAO-1

80 The copper amine oxidases (CAOs) have evolved to catalyze oxidative

81 actor to O2 in the catalytic cycle of copper amine oxidases (CAOs) remains controversial.

82 ite sequences of all known copper-containing amine oxidases (CAOs).

83 (2HP) is an irreversible inhibitor of copper amine oxidases (CAOs).

84 The copper amine oxidases carry out two copper-dependent processes:

85 The copper amine oxidases catalyze the O(2)-dependent, two-electron

86 Among these, the copper amine oxidases catalyze the oxidative deamination of pri

87 Lysyl oxidase (LOX), an extracellular amine oxidase, catalyzes the cross-linking of collagen a

88 flavin adenine dinucleotide (FAD)-dependent amine oxidases, certain inhibitors of monoamine oxidases

89 Copper amine oxidases contain a buried protein-derived quinone

90 At their active sites, copper amine oxidases contain both a mononuclear copper ion and

91 Amine oxidase copper containing-3 (AOC3) is a cell-surfa

92 Amine oxidase copper-containing 1 (AOC1; formerly known

93 We now have identified AOC3 (amine oxidase, copper containing 3), a surface monoamine

94 Lysyl oxidase (LOX), an amine oxidase critical for the initiation of collagen an

95 alculated O(2) free energy maps using copper amine oxidase crystal structures in the absence of xenon

96 Copper amine oxidases (CuAOs) catalyze the oxidative deaminatio

97 usly identified substrate analogue of copper amine oxidases (CuAOs) has been screened against six dif

98 Based on luciferase assays, the amine oxidase domain of LSD1 is important in suppressing

99 rated that the SNAG domain of Snail1 and the amine oxidase domain of LSD1 were required for their mut

100 The second enzyme, DMSP-amine oxidase (DOX), requires O(2) for activity, shows a

101 ormis amine oxidase (AGAO), Escherichia coli amine oxidase (ECAO), and Pichia pastoris lysyl oxidase

102 ctive site copper in Escherichia coli copper amine oxidase (ECAO), we initiated a metal-substitution

103 mately 430 nm (adduct I) in Escherichia coli amine oxidase (ECAO).

104 the four SPE genes and by the FAD-dependent amine oxidase encoded by FMS1.

105 e yeast Saccharomyces cerevisiae, a putative amine oxidase, encoded by FMS1, was found to be rate-lim

106 A copper amine oxidase encoding gene, atao1, has been isolated an

107 LSD1 belongs to the amine oxidase enzyme superfamily which utilize molecular

108 rs are (a) topa quinone in copper-containing amine oxidases, enzymes found in nearly all forms of lif

109 e plasma amine oxidase (BPAO), equine plasma amine oxidase (EPAO), pea seedling amine oxidase (PSAO),

110 ompounds were screened against equine plasma amine oxidase (EPAO), Pisum sativum amine oxidase (PSAO)

111 4g14940 (AtAO1) encodes an apoplastic copper amine oxidase expressed at the early stages of vascular

112 of compounds acting as an inactivator of one amine oxidase family and a pure substrate of another ami

113 s co-expressed with other members of the LOX amine oxidase family in most mammalian cells.

114 idase family and a pure substrate of another amine oxidase family represents a unique lead to the dev

115 is the subject of controversy in the copper amine oxidase family.

116 Here we show that amine oxidase (flavin-containing) domain 1 (AOF1), a pro

117 eversibly inhibit the activity of the copper amine oxidase from Arthrobacter globiformis (AGAO), with

118 xchange was observed for wild-type HPAO, the amine oxidase from Arthrobacter globiformis, pea seedlin

119 n of the copper-containing quinone-dependent amine oxidase from bovine plasma (BPAO).

120 ange (t(1/2) < 30 min) were observed for the amine oxidase from Escherichia coli and the N404A mutant

121 action of the copper-containing quinoprotein amine oxidase from Escherichia coli have been determined

122 methyltryptophan oxidase, a flavin-dependent amine oxidase from Escherichia coli, was studied using a

123 n of a cobalt-substituted form of the copper amine oxidase from Hansenula polymorpha (HPAO).

124 containing amine oxidases and mutants of the amine oxidase from Hansenula polymorpha (HPAO).

125 In this study, the structure of an amine oxidase from Hansenula polymorpha has been solved

126 rved active site tyrosine Y305 in the copper amine oxidase from Hansenula polymorpha kinetically, spe

127 ray structure for the active form of a yeast amine oxidase from Hansenula polymorpha, a hydrophobic s

128 ype and mutant forms of a recombinant copper amine oxidase from Hansenula polymorpha, expressed in Sa

129 Previously, using the amine oxidase from the yeast Hansenula polymorpha (HPAO)

130 the aminotransferase mechanism of the copper amine oxidase from the yeast Hansenula polymorpha has be

131 n in enzymatic studies by using the purified amine oxidase from yeast.

132 The similar (18)O KIEs reported for copper amine oxidases from other sources raise the possibility

133 ypeptide (ATAO1) with 48% identity to copper amine oxidases from pea and lentil.

134 riable experimental observations with copper amine oxidases from plant versus other eukaryotic source

135 e that LSD1 (KIAA0601), a nuclear homolog of amine oxidases, functions as a histone demethylase and t

136 The Arabidopsis (Arabidopsis thaliana) amine oxidase gene At4g14940 (AtAO1) encodes an apoplast

137 The H. polymorpha amine oxidase gene was subsequently expressed in Escheri

138 Because amine oxidases generally produce aldehyde derivatives of

139 Copper-containing amine oxidases have peptidyl 2,4,5 tri(oxo)phenylalanine

140 They showed that LSD 1, a nuclear amine oxidase homolog, is a bona fide histone H3 lysine

141 In contrast to prokaryotic copper amine oxidases, however, it has not been possible to ini

142 factor formation in the Hansenula polymorpha amine oxidase (HPAO) provided evidence for the coordinat

143 eady state kinetic data of the second copper amine oxidase (HPAO-2) are presented for comparison to t

144 The related copper-containing amine oxidase human vascular adhesion protein-1 also exc

145 tosidase and subsequently observed in copper amine oxidase, hyaluronate lyase, chondroitinase, and ma

146 A crystal structure of H. polymorpha amine oxidase in complex with xenon gas, which serves as

147 in vivo assembly of heterologously expressed amine oxidases in S. cerevisiae and E. coli.

148 Lysyl oxidase differs from other copper amine oxidases in that its active quinone cofactor refle

149 aldehydes produced by polyamine oxidase and amine oxidases include the 2-alkenal acrolein, the aceto

150 emethylase 1 (LSD1) belongs to the family of amine oxidases including polyamine oxidase and monoamine

151 amino acid sequence of the 97-kDa rat/human amine oxidase indicates that the protein consists of a v

152 est that the development of highly selective amine oxidase inhibitors is feasible.

153 enylalanine quinone (TPQ) cofactor in copper amine oxidases involves a key water addition to the dopa

154 sses of enzymes, including the FAD-dependent amine oxidases KDM1A/B.

155 Lysyl oxidase (LOX) is a copper-containing amine oxidase known to catalyze the covalent cross-linki

156 exogenous copper to precursor H. polymorpha amine oxidase lacking copper.

157 iscovery of lysyl demethylases using flavin (amine oxidases) or Fe(II) and 2-oxoglutarate as cofactor

158 Copper amine oxidases oxidize the polyamine putrescine (Put), p

159 polyamines spermine and spermidine by plasma amine oxidase (PAO) was specified many years ago to occu

160 n to inactivate the quinone-dependent plasma amine oxidases, possibly through active-site modificatio

161 is amine oxidase (AGAO), and Pichia pastoris amine oxidase (PPLO) have been examined.

162 reactions that are catalyzed by bovine serum amine oxidase proceed through tunneling.

163 oxyacid dehydrogenase, and copper-containing amine oxidase protein families.

164 oxidases are conserved in the human placenta amine oxidase protein sequence.

165 we show that substrate-reduced pea seedling amine oxidase (PSAO) exists predominantly in the Cu(I),

166 ne plasma amine oxidase (EPAO), pea seedling amine oxidase (PSAO), Arthrobacter globiformis amine oxi

167 e plasma amine oxidase (EPAO), Pisum sativum amine oxidase (PSAO), Pichia pastoris lysyl oxidase (PPL

168 and oxidative half-reactions of pea seedling amine oxidase (PSAO), the recombinant human kidney diami

169 that the apoform of the Hansenula polymorpha amine oxidase readily binds Cu(I) under anaerobic condit

170 novel flavin adenine dinucleotide-dependent amine oxidase (renalase) that is secreted into the blood

171 4q27 (rs2069763) and renalase, FAD-dependent amine oxidase (RNLS)/10q23.31 (rs10509540), were associa

172 Renalase, an amine oxidase secreted by the proximal tubule, degrades

173 al finding that the quinone-dependent copper amine oxidases specifically metabolize primary amines.

174 ecule that possesses semicarbazide-sensitive amine oxidase (SSAO) activity, is involved in leukocyte

175 Semicarbazide-sensitive amine oxidase (SSAO) catalyses oxidative deamination of

176 ect of inhibition of semicarbazide-sensitive amine oxidase (SSAO; EC 1.4.3.6, also known as VAP-1) as

177 essential for organic cofactor formation in amine oxidases such as lysyl oxidase.

178 copper- and lysine tyrosylquinone-dependent amine oxidase that has been proposed to function both ex

179 ht binding fluorogenic substrate of a copper amine oxidase that is able to respond directly to the en

180 rotein-1 (VAP-1) is an adhesion molecule and amine oxidase that is expressed at high levels in the hu

181 (LOXL) protein is a novel copper-containing amine oxidase that is required for the cross-linking of

182 scriptional repressor and a flavin-dependent amine oxidase that is responsible for the removal of met

183 fy renalase as what we believe to be a novel amine oxidase that is secreted by the kidney, circulates

184 oth spermidine synthase and the FMS1-encoded amine oxidase that oxidizes spermine to spermidine.

185 hesion protein-1 (VAP-1) is a membrane-bound amine oxidase that promotes leukocyte recruitment to the

186 iously identified renalase, a secreted novel amine oxidase that specifically degrades circulating cat

187 LOX is a hypoxia-inducible amine oxidase, the activity of which enhances breast can

188 Unrelated to other amine oxidases, this enzyme contains haem, flavin mononu

189 amine oxidase as the first integral membrane amine oxidase to be cloned.

190 onversion of prorenalase, an inactive plasma amine oxidase, to renalase, which can degrade catecholam

191 from those of other topa quinone-containing amine oxidases under similar conditions.

192 Copper and topaquinone (TPQ) containing amine oxidases utilize O2 for the metabolism of biogenic

193 The membrane amine oxidase was more abundant in the plasma membranes

194 f the available crystal structures of copper amine oxidases, we propose that a histidine residue in t

195 ctions of 1,4-diamino-2-butyne with selected amine oxidases were also examined.

196 to the copper, D630N in Hansenula polymorpha amine oxidase, which greatly increases the concentration

197 he corresponding region of a human placental amine oxidase, which was cloned simultaneously and propo

198 oxidase (LOX) is a secreted copper-dependent amine oxidase whose primary function is to drive collage

199 MTOX is one of several flavin-dependent amine oxidases whose chemical mechanism is still debated

200 Comparison of the human placenta amine oxidase with DNA sequences found in GenBank sugges

201 ofactor of wild-type Escherichia coli copper amine oxidase (WT-ECAO) is stable at neutral pH, 25 degr