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1 disclose an efficacious hybrid molecule 4-(5-Amino-1,2,3-oxadiazol-3-yl)-2,2,6,6-tetramethyl-1-piperi
2 lators of the ligand-binding domain of (S)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propanoic acid
3 statement: dendritic spine morphology, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMP
4 ld-type mice, these compounds blocking alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA
5 receptors and decreased expression of alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid (AMP
6 incorporates three key features: (a) a bis(4-amino-3-hydroxyphenyl)squaraine core with bright deep-re
7 ent compound of the present series, sodium 1-amino-4-[4-(2,4-dimethylphenylthio)phenylamino]-9,10-dio
8 gned and developed a one-step synthesis of 5-amino-4-carboxamidothiazoles 1 by an yttrium-triflate-ca
9 radiation of a photo-crosslinkable unnatural amino acid (UAA) cotranslationally incorporated into the
11 peptides composed of natural and non-natural amino acid analogs, thereby enabling screens in a much d
12 y coupled plasma mass spectrometry (ICP-MS), amino acid analysis, and spectroscopy (ATR-IR, Raman).
14 The macaque A2*05 allotype prefers the basic amino acid arginine at the second position of the peptid
16 ds not more than 3 residues after the anchor amino acid at POmega, which enabled them to open the F p
17 ing reverse genetics, we found that a single amino acid at position 158 of the hemagglutinin (HA) pro
19 noacyl-tRNA with a PTC and subsequently, the amino acid becomes incorporated into the nascent polypep
22 en proposed to specifically recognize a four-amino acid CAAX C-terminal sequence within their substra
24 ses our knowledge of the role branched-chain amino acid catabolism plays in seed development and amin
25 in response to different stimuli modulating amino acid catabolism, as were cytokine secretion levels
26 h a recombinant pH1N1 virus encoding these 6 amino acid changes (pH1N1/NSs-6mut) induced lower levels
27 ome sequence signature analysis identified 3 amino acid changes, 16 synonymous nucleotide changes, an
32 spite often minute concentrations in vivo, d-amino acid containing peptides (DAACPs) are crucial to m
33 be recovered only by covalent attachment of amino acid deactivation agents to residual activated car
35 logs of 43 compounds, including amino acids, amino acid derivatives, and organic acids, was performed
37 was identical with the first, except for an amino acid exchange in the stalk region abolishing the N
38 rs the chemical synthesis of the fluorogenic amino acid Fmoc-Trp(C2-BODIPY)-OH (3-4 d), the preparati
40 fficacy of a fixed combination of pepsin and amino acid hydrochloride for the treatment of patients w
42 encodes a predicted protease with 54 to 68% amino acid identity to torovirus (ToV) papain-like prote
43 tified a missense mutation, which encodes an amino acid in the tetratricopeptide repeat, in OGT (759G
49 nvestigated transcriptomes using RNA-seq and amino acid levels with N treatment in tea (Camellia sine
51 apamycin (both molecules involved in sensing amino acid levels) was assessed in response to different
52 ing transgenes in planta, including modified amino acid levels, have been seen but without the identi
55 the liver is a major handler of protein and amino acid metabolism as it is responsible for the major
60 Mutational analysis of a cyclin F-specific amino acid motif in the C-terminal region of Vif indicat
64 trategy for the reversible immobilization of amino acid or peptide derivatives on carbon nanomaterial
67 rate-transport elicited endocytosis of other amino acid permeases similarly involves unmasking of a c
68 effects of hyperaccumulation of the aromatic amino acid phenylalanine (Phe) in animals, known as phen
69 lar, we show that peptides incorporating the amino acid phenylalanine, a functional group that is con
71 show that the largest effect is caused by an amino acid polymorphism that arose when an ancestral thr
72 , which suggests important roles of specific amino acid polymorphisms in the antigen-binding clefts.
73 tuted glutamic acid (E) for glutamine (Q) at amino acid position 623 (E623Q) displayed a titration cu
76 VEGFxxxa isoforms (VEGF165a, 165 for the 165 amino acid product) and antiangiogenic VEGFxxxb (VEGF165
77 s of selection and assessments of changes in amino acid properties provide evidence of positive selec
78 cently developed silk dating technique using amino acid racemization (AAR) in conjunction with capill
80 hough pharmacologic modulation of excitatory amino acid receptors is well studied, minimal considerat
82 allele knock-in of the most commonly mutated amino acid residue, tyrosine 537, in the estrogen-respon
84 sults show that interactions between charged amino acid residues are important both to directly stabi
85 t Glu(446) and Arg(447) cooperate with other amino acid residues in the GERAMT-binding site for prope
86 ge equilibria to measure the propensities of amino acid residues to participate in helical secondary
88 egatively charged DNA and positively charged amino acid residues, the translocation speed of DNA can
93 (+/-) mice displayed an amplification of the amino acid response and ER stress response transcription
97 proteins also display extreme divergence in amino acid sequence identity between STs (i.e., 59%-61%
99 n at multiple sites along the spectrin-betaV amino acid sequence in the lineage leading to mammals, t
100 s of decoy peptides derived from the primary amino acid sequence in the SOD2-binding site in hsp70.
102 actin are nearly indistinguishable in their amino acid sequence, but are encoded by different genes
103 At the level of entry, differences in the amino acid sequences between the human and mouse ortholo
107 Principal component analysis showed a serum amino acid signature composed of arginine, leucine/isole
113 ealed that some escape mutants possessing an amino acid substitution other than K166Q showed superior
114 lysis of the two iNK TCR types with a single amino acid substitution revealed that the staining inten
116 the effect of the shaker-1 mutation, a R502P amino acid substitution, on the motor function is unclea
118 activation because trimming the Phe by small amino acid substitutions abolished alphaLbeta2 binding w
119 head subdomain, which is highly tolerant of amino acid substitutions and continual addition of glyco
120 follows: experimentally evaluated effects of amino acid substitutions at toggle positions are binary,
121 populations possessed mutations that caused amino acid substitutions from ClO2-labile to ClO2-stable
122 tructural assessment predicted that the five amino acid substitutions have damaging effects on DNA bi
123 Together, these findings demonstrate that amino acid substitutions in Fn-binding repeat-9 can sign
124 and growth selection approach, we identified amino acid substitutions in human and mouse Ctr2 protein
127 nction; 13 pathways including branched chain amino acid synthesis were significantly enriched in base
128 luorescence-based biorthogonal non-canonical amino acid tagging (BONCAT) - for studying the activity
129 Here, we adapt bioorthogonal noncanonical amino acid tagging (BONCAT) to interrogate protein synth
132 ndent trafficking of the neuronal excitatory amino acid transporter 3 (EAAT3) blocks potentiation, su
134 such as induction of potassium channels and amino acid transporters, derepression of genes marked wi
135 HLA association was the previously reported amino acid variant located at position 71, within the pe
136 at incorporates a photoreactive, non-natural amino acid, p-benzoyl-l-phenylalanine, into various posi
137 incorporation of a fluorescent noncanonical amino acid, we show that there is a rearrangement in the
138 hrough many heterogeneous pathways by way of amino acid-level dynamics biased toward selecting native
139 to overcome this obstacle by utilizing the 6-amino-acid (CCPGCC) tetracysteine (TC) tag and FlAsH-EDT
141 Hence, the puzzle remains: how a single-amino-acid difference between the ApoE3 and ApoE4 sequen
142 human L-asparaginase 1 (hASNase1) share 70% amino-acid identity, we decided to humanize gpASNase1 by
143 ty is dependent on both the presence of a 22-amino-acid N-terminal 'loop' region and its catalytic ac
144 ion of biosensor which is based on fructosyl amino-acid oxidase (FAO) immobilized nitrogen-doped grap
146 th the estimated surface areas, we derive an amino-acid propensity scale that enables prediction of a
148 ied eukaryotes possess a tandemly repeated 7-amino-acid sequence, called the canonical CTD, which orc
152 d phosphinothricin over the 20 proteinogenic amino acids (1) , indirect effects of BAR-containing tra
153 nd requires the replacement of the canonical amino acids (4R)-hydroxyproline and proline by cysteine
154 nched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) have been shown to be associated with
157 anding protein chemistries with noncanonical amino acids (ncAAs) and genetically isolating synthetic
158 The use of genetically encoded noncanonical amino acids (ncAAs) to construct crosslinks within or be
159 (PCET) steps along a pathway of redox active amino acids (Y122beta <--> [W48beta?] <--> Y356beta <-->
161 bind to the same three A3G tryptic peptides (amino acids 181-194, 314-320, and 345-374) that form par
162 tricted CD4 T cell epitope, corresponding to amino acids 37-47 in the PVM matrix protein (M37-47).
163 wnstream of the S2' cleavage site is the FP (amino acids 798-818 SFIEDLLFNKVTLADAGFMKQY for SARS-CoV,
164 ted a recombinant virus (DeltaXX) that lacks amino acids 87 to 106, a portion of the previously descr
165 starting from diamines derived from natural amino acids and commercially available aminoalkyl polyst
166 isotopes, compound specific analyses (e.g., amino acids and fatty acids), and both biodiversity and
167 ing substrate depletion from a mixture of 19 amino acids and glucose by two Pseudomonas and one Bacil
168 actions with HIV-1 protease (PR) active-site amino acids and is bulkier with a larger contact surface
169 orms of a protein with specific sequences of amino acids and localized post-translational modificatio
172 adsorbed on the graphene as well as charged amino acids associated with the immobilized protein.
173 LDAH alternative-splicing variant missing 90 amino acids at C-terminus does not promote LD fusion or
175 f N,N'-disubstituted hydantoin bearing alpha-amino acids by improving yields, reducing the time and n
176 to the degeneracy of the genetic code, most amino acids can be encoded by multiple synonymous codons
177 ate that IQF substrates containing unnatural amino acids can be used to investigate protease activiti
179 ined by intrinsic local interactions between amino acids close to each other in the protein sequence.
183 range of unique proteins), the processing of amino acids for energy, and disposal of nitrogenous wast
184 identified a small conopeptide of only four amino acids from the venom of Conus textile that strongl
186 ncy of a small number of linear motifs three amino acids in length can accurately identify a CD4 T ce
187 C I molecules typically bind peptides with 9 amino acids in length with both ends tucked inside the m
188 ed, site-specific incorporation of unnatural amino acids in regions essential for activation, followe
189 Molecular modeling suggested a number of amino acids in RRM1 likely to be involved in interaction
190 ion likely results in a further breakdown of amino acids in the liver, mediated by increased glucagon
191 t pTRS1 inhibits PKR by binding to conserved amino acids in the PKR eIF2alpha binding site and blocki
192 , we have explored the use of phosphorylated amino acids in which the phosphate moiety bears a chemic
193 oth the concentration and d/l composition of amino acids is very promising for the study of biologica
194 nt antigenic clusters, we inferred a few key amino acids mutation driving the 11 historical antigenic
195 he C terminus (POmega) and contained charged amino acids not more than 3 residues after the anchor am
196 here that a region as small as the first 32 amino acids of Swi1 (Swi11-32) can decorate [SWI(+)] agg
197 mouse strain in which the substitution of 2 amino acids of the endogenous TTP protein renders it con
199 95 substitution matrices reflecting various amino acids properties in predicting the antigenicity of
201 ication of a single H7 epitope by changing 3 amino acids so that it is homologous with a known H3 imm
204 ermined that the charge type and identity of amino acids surrounding FG sequences impact the structur
206 alized form of autophagy, providing critical amino acids that activate mTOR and enable the metabolic
207 rged amino acids result in the Tyr-84 swing, amino acids that are negatively charged induce a not pre
208 that it is controlled by a set of conserved amino acids that couple RNA and ATP binding to the prote
209 1) is a central growth regulator that senses amino acids through a pathway that converges on the Rag
212 CO2, and N2O were measured for the 20 common amino acids using low-pressure, ambient-temperature ion
213 ies, we measured DeltaDeltaGsc(o) for all 20 amino acids using the transmembrane beta-barrel E. coli
215 the STING protein define a novel cluster of amino acids with functional importance in the regulation
217 drates, amino acids, bacterial biomarkers (D-amino acids), and plant protein biomarkers (hydroxyproli
218 installed in a range of molecules, including amino acids, a monosaccharide, a fluorophore, and an ana
219 13)C] isotopologs of 43 compounds, including amino acids, amino acid derivatives, and organic acids,
220 nic BAR indeed converts two plant endogenous amino acids, aminoadipate and tryptophan, to their respe
221 mentarity-determining region 3 (CDRH3) of 25 amino acids, among the shortest known for this class of
222 gh consumption of lipids, carbohydrates, and amino acids, as well as governing systemic signaling net
223 periods using measurements of carbohydrates, amino acids, bacterial biomarkers (D-amino acids), and p
224 duced the lysosomal efflux of most essential amino acids, converting the lysosome into a cellular dep
225 peptides containing only one or two types of amino acids, here we used modern mass spectrometry (MS)-
226 exes regulate the Rag GTPases in response to amino acids, including GATOR1, a GTPase activating prote
227 (.) CF3 reacts with 18 of the 20 common amino acids, including Gly, Ala, Ser, Thr, Asp, and Glu,
228 ance of the volatile compounds produced from amino acids, including the sulfur-containing compounds a
229 reconstitution test, proximate composition, amino acids, minerals and electrophoresis] were determin
230 , and the release of soluble molecules (free amino acids, proteins and glucidic colloids), but the ef
231 cular disease risk (including branched-chain amino acids, select unsaturated lipid species, and trime
232 elements, such as K, Ca and P, and essential amino acids, such as tryptophan, valine, and threonine,
234 ntly catalyze peptide bond synthesis by most amino acids, the imino acid proline is a poor substrate
235 proteins containing unmodified proteinogenic amino acids, which can be altered readily by site-direct
247 enamides toward the synthesis of cis vicinal amino alcohols and tetrasubstituted alpha-borylamido com
249 in transfected cells, we determined that the amino and carboxyl termini reside in the extracellular s
252 ides allowed expedient preparations of alpha-amino boronic acids, often with high stereoselectivity,
254 s characterized in vitro by delivering gamma-amino butyric acid to a target solution, and demonstrate
255 ivative 2 was converted to a cyclic (alkyl) (amino)carbene (cAAC) via 1,2-hydrogen migration triggere
256 r the synthesis of storable bicyclic (alkyl)(amino)carbenes (BICAACs), which feature enhanced sigma-d
260 ination reaction proceeds via a nucleophilic amino cyclization followed by an intermolecular C-N bond
261 a blend of biodegradable polymer, poly(beta-amino ester) (PBAE), with PBAE conjugated with 5kDa poly
264 s substituted with an equatorial hydroxyl or amino group in the newly formed ring are considerably mo
265 d that the PRNTase domain recognizes the C-2-amino group, but not the C-6-oxo group, N-1-hydrogen, or
266 he highest pKa values ever reported for this amino group, providing a rational for the observed need
267 ile transfer of primary (-NH2) and secondary amino groups (-NHR) to heteroaryl- as well as arylcuprat
268 aphene oxide (GO) and GO functionalized with amino groups (GONH2) on 15 immune cell populations, inte
269 asurement of the rotation rate of individual amino groups could give insight into the dynamic process
271 eals a distinct approach to install aromatic amino groups in metabolites and raises questions about t
272 ium(II)-aryl complex and a weak base, lysine amino groups underwent C-N bond formation at room temper
274 4-chloro-3-(trifluoromethyl)phenyl]carbamoyl}amino)hexadecanoic acid (13b) decreased proliferation an
276 ive binding of both an acetato ligand and an amino ligand to zinc occurs in distinct confined environ
277 ic synthesis, the direct transfer of primary amino (-NH2) and hydroxyl (-OH) groups to arylmetals in
278 f reducing sugars, ethanol, acetic acid, and amino nitrogen did not differ significantly (p<0.05) bet
281 boxy-5-[(6-(18)F-fluoro-pyridine-3-carbonyl)-amino]-pentyl}-ureido)-p entanedioic acid) and more rece
283 ortholog responsible for the transfer of the amino-residue phosphoethanolamine (pEtN) to the lipid A
284 llowed incorporation of functionalized alpha-amino substituents appropriate for enhancement of antibi
285 assumptions that the tau torsion of the meta-amino-substituted BDI systems leads to a zwitterionic tw
286 based and high-throughput screens against an amino-sugar acetyltransferase enzyme, PglD, involved in
287 ncorporation of extraneous nitrogen (N) into amino sugars (AS) could reflect the contribution of micr
288 of FGF2, whereas IGF1 displayed homogeneous amino-terminal cleavage with complete removal of the bom
292 previously characterized viruses expressing amino-terminal fusions, this virus expresses more VP26 f
293 lue of serial measurement of soluble ST2 and amino-terminal pro-B-type natriuretic peptide to clinica
294 hat MLO homooligomerization, mediated by the amino-terminal region of the protein, and carboxyl-termi
295 findings demonstrate that the occurrence of amino-terminal structural homogeneity may be associated
296 erogeneity of signal peptide cleavage at the amino terminus of FGF2, whereas IGF1 displayed homogeneo
297 CD11(+) DCs, the mutant virus that lacks the amino terminus of gamma134.5 undergoes temporal replicat
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