ライフサイエンスコーパス: amino acid

1 ntain local structures not accessible with l-amino acids.

2 g site, supporting a hierarchy of vulnerable amino acids.

3 des containing post-translationally modified amino acids.

4 additional compounds that were unrelated to amino acids.

5 of arginines adjacent to M6CK-phosphorylated amino acids.

6 e change in telomere length, and circulating amino acids.

7 orphisms, as well as imputed HLA alleles and amino acids.

8 s of total cellular protein and several free amino acids.

9 hydantoins and unsaturated alpha-quaternary amino acids.

10 using UPLC-MS/MS identified sixteen peptides/amino acids.

11 ce as human A3C S188I, but through different amino acids.

12 mbered and densely functionalized quaternary amino acids.

13 action, as well as the ability of nucleobase amino acid 1 to stabilize RRM1-DNA interaction.

14 Quantitative proteomic analysis of Cav1-GST (amino acids 1-101) pull downs showed sixfold-increased b

15 esidue Y745 and, essentially, the N-terminal amino acids 1-800.

16 d phosphinothricin over the 20 proteinogenic amino acids (1) , indirect effects of BAR-containing tra

17 bind to the same three A3G tryptic peptides (amino acids 181-194, 314-320, and 345-374) that form par

18 Moreover, the observed polymorphism on amino acid 186 between H3N8 and H3N2 CIVs might be the r

19 h a short "linker" region narrowed to within amino acids 324-348, between its first two coiled coils,

20 tricted CD4 T cell epitope, corresponding to amino acids 37-47 in the PVM matrix protein (M37-47).

21 These studies showed that SOD2 binds in the amino acid 393-537 region of the chaperone.

22 nd requires the replacement of the canonical amino acids (4R)-hydroxyproline and proline by cysteine

23 wnstream of the S2' cleavage site is the FP (amino acids 798-818 SFIEDLLFNKVTLADAGFMKQY for SARS-CoV,

24 ted a recombinant virus (DeltaXX) that lacks amino acids 87 to 106, a portion of the previously descr

25 installed in a range of molecules, including amino acids, a monosaccharide, a fluorophore, and an ana

26 nched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) have been shown to be associated with

27 Plasma concentrations of amino acids (AAs), in particular, branched chain AAs (BC

28 13)C] isotopologs of 43 compounds, including amino acids, amino acid derivatives, and organic acids,

29 The synthesis of a third class of unnatural amino acids, amino tetrazolyl alanines ((ATz)Ala = Ata),

30 nic BAR indeed converts two plant endogenous amino acids, aminoadipate and tryptophan, to their respe

31 mentarity-determining region 3 (CDRH3) of 25 amino acids, among the shortest known for this class of

32 peptides composed of natural and non-natural amino acid analogs, thereby enabling screens in a much d

33 y coupled plasma mass spectrometry (ICP-MS), amino acid analysis, and spectroscopy (ATR-IR, Raman).

34 A novel amino acid and metabolomics signature in mice overexpres

35 starting from diamines derived from natural amino acids and commercially available aminoalkyl polyst

36 hat enables the synthesis of nucleotides and amino acids and epigenetic modifications.

37 isotopes, compound specific analyses (e.g., amino acids and fatty acids), and both biodiversity and

38 ing substrate depletion from a mixture of 19 amino acids and glucose by two Pseudomonas and one Bacil

39 actions with HIV-1 protease (PR) active-site amino acids and is bulkier with a larger contact surface

40 orms of a protein with specific sequences of amino acids and localized post-translational modificatio

41 These findings suggest that amino acids and organic cations may interact with the tr

42 Herein, we use two unnatural aromatic amino acids and several spectroscopic techniques to exam

43 response from molecular structures using the amino acids and their derivatives as a reference set.

44 hydrolyse incorrectly activated non-cognate amino acids and/or misaminoacylated tRNAs.

45 ing of nascent proteins with a non-canonical amino-acid and click chemistry.

46 drates, amino acids, bacterial biomarkers (D-amino acids), and plant protein biomarkers (hydroxyproli

47 ous metabolic pathways, particularly lipids, amino acids, and cofactors/vitamins.

48 The macaque A2*05 allotype prefers the basic amino acid arginine at the second position of the peptid

49 gh consumption of lipids, carbohydrates, and amino acids, as well as governing systemic signaling net

50 adsorbed on the graphene as well as charged amino acids associated with the immobilized protein.

51 codons when aminoacylated (charged) with an amino acid at its 3' end.

52 ds not more than 3 residues after the anchor amino acid at POmega, which enabled them to open the F p

53 ing reverse genetics, we found that a single amino acid at position 158 of the hemagglutinin (HA) pro

54 LDAH alternative-splicing variant missing 90 amino acids at C-terminus does not promote LD fusion or

55 iption factor hnRNP LL containing nucleobase amino acids at specific positions have been prepared and

56 on of the peptide, and hydrophobic and polar amino acids at the C-terminal end.

57 These findings thus demonstrate that amino acid availability controls lysosome positioning th

58 periods using measurements of carbohydrates, amino acids, bacterial biomarkers (D-amino acids), and p

59 Circulating branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) have

60 noacyl-tRNA with a PTC and subsequently, the amino acid becomes incorporated into the nascent polypep

61 Enzymes of amino acid biosynthesis were higher in coculture than in

62 regulation of translation, fermentation, and amino acid biosynthesis.

63 f N,N'-disubstituted hydantoin bearing alpha-amino acids by improving yields, reducing the time and n

64 en proposed to specifically recognize a four-amino acid CAAX C-terminal sequence within their substra

65 to the degeneracy of the genetic code, most amino acids can be encoded by multiple synonymous codons

66 ate that IQF substrates containing unnatural amino acids can be used to investigate protease activiti

67 Chlorination of amino acids can result in the formation of organic monoc

68 lian target of rapamycin, suggesting reduced amino acid catabolism in MS patients.

69 ses our knowledge of the role branched-chain amino acid catabolism plays in seed development and amin

70 in response to different stimuli modulating amino acid catabolism, as were cytokine secretion levels

71 to overcome this obstacle by utilizing the 6-amino-acid (CCPGCC) tetracysteine (TC) tag and FlAsH-EDT

72 y altered mice showed that the corresponding amino acid change (LAMB2-S83R) alone is not pathogenic.

73 An editing defect, leading to an amino acid change, in the mitochondrial nad4 transcript,

74 h a recombinant pH1N1 virus encoding these 6 amino acid changes (pH1N1/NSs-6mut) induced lower levels

75 Several amino acid changes in the Fc region have been reported t

76 ome sequence signature analysis identified 3 amino acid changes, 16 synonymous nucleotide changes, an

77 HPV16 in the controls had significantly more amino acid changing variants throughout the genome.

78 ined by intrinsic local interactions between amino acids close to each other in the protein sequence.

79 icile spores can respond to a diverse set of amino acid co-germinants and reveal that Alr2 can accomm

80 essed VH and VL genes and by influencing the amino acid composition of the Ag binding site.

81 n vitro could be predicted entirely based on amino acid composition.

82 Fractions showed different amino acid compositions and angiotensin I-converting enz

83 iations of physical activity and circulating amino acids concentration in peripubertal girls.

84 mbody a "cholesterol recognition/interaction amino acid consensus" motif.

85 spite often minute concentrations in vivo, d-amino acid containing peptides (DAACPs) are crucial to m

86 duced the lysosomal efflux of most essential amino acids, converting the lysosome into a cellular dep

87 t K464 by interacting with its C-terminal 51 amino acids (CT51), which is required for PTS protein im

88 be recovered only by covalent attachment of amino acid deactivation agents to residual activated car

89 at ectopically express the enzyme aromatic L-amino acid decarboxylase (AADC), which synthesizes trace

90 ied new potential bacterial taxa involved in amino acid degradation.

91 logs of 43 compounds, including amino acids, amino acid derivatives, and organic acids, was performed

92 iety of types of natural and unnatural alpha-amino acid derivatives, with a wide range of biological

93 rasubstituted olefins at the alpha-carbon of amino acid derivatives.

94 ructose transport after introduction of four amino acids derived from GLUT5.

95 Hence, the puzzle remains: how a single-amino-acid difference between the ApoE3 and ApoE4 sequen

96 nce, specifically C(x)3X sequences with four amino acids downstream of the cysteine.

97 s time, however, the assays utilize only one amino acid each.

98 addition has been achieved with a variety of amino acid esters and 2- or 4-vinylpyridine.

99 was identical with the first, except for an amino acid exchange in the stalk region abolishing the N

100 tes-many separated by as few as two or three amino acids-exhibited complex dynamics, including freque

101 tracers has permitted exquisite insight into amino acid, fatty-acid and carbohydrate metabolic regula

102 P-9 was redesigned to incorporate non-native amino acids (Flp and mep), resulting in an increase of 1

103 rs the chemical synthesis of the fluorogenic amino acid Fmoc-Trp(C2-BODIPY)-OH (3-4 d), the preparati

104 range of unique proteins), the processing of amino acids for energy, and disposal of nitrogenous wast

105 at spans the initiating AUG and by codon and amino acid frequency.

106 identified a small conopeptide of only four amino acids from the venom of Conus textile that strongl

107 peptides containing only one or two types of amino acids, here we used modern mass spectrometry (MS)-

108 cid catabolism plays in seed development and amino acid homeostasis.

109 fficacy of a fixed combination of pepsin and amino acid hydrochloride for the treatment of patients w

110 Average nucleotide and amino acid identities revealed that the four Ca.

111 encodes a predicted protease with 54 to 68% amino acid identity to torovirus (ToV) papain-like prote

112 human L-asparaginase 1 (hASNase1) share 70% amino-acid identity, we decided to humanize gpASNase1 by

113 tified a missense mutation, which encodes an amino acid in the tetratricopeptide repeat, in OGT (759G

114 HCF222 encodes a protein of 99 amino acids in Arabidopsis (Arabidopsis thaliana) that h

115 ncy of a small number of linear motifs three amino acids in length can accurately identify a CD4 T ce

116 C I molecules typically bind peptides with 9 amino acids in length with both ends tucked inside the m

117 previously, using stable isotope of labeled amino acids in mammals (SILAM).

118 ecular mechanisms and contribution of single amino acids in OST interaction with its substrates.

119 rocesses through its attachment to different amino acids in proteins.

120 ed, site-specific incorporation of unnatural amino acids in regions essential for activation, followe

121 Molecular modeling suggested a number of amino acids in RRM1 likely to be involved in interaction

122 ion likely results in a further breakdown of amino acids in the liver, mediated by increased glucagon

123 t pTRS1 inhibits PKR by binding to conserved amino acids in the PKR eIF2alpha binding site and blocki

124 , we have explored the use of phosphorylated amino acids in which the phosphate moiety bears a chemic

125 exes regulate the Rag GTPases in response to amino acids, including GATOR1, a GTPase activating prote

126 (.) CF3 reacts with 18 of the 20 common amino acids, including Gly, Ala, Ser, Thr, Asp, and Glu,

127 ance of the volatile compounds produced from amino acids, including the sulfur-containing compounds a

128 ood agreement with established radiolabelled amino acid incorporation assays: TGFbeta1 delivered a po

129 disease, respectively, using the small nine amino acid influenza hemagglutinin tag.

130 Furthermore, amino acid infusion likely results in a further breakdow

131 resolution for each pairwise combination of amino acid ions.

132 ophilic (Ser-109) or a hydrophobic (Ile-305) amino acid is mutated instead.

133 oth the concentration and d/l composition of amino acids is very promising for the study of biologica

134 is a chiral ligand derived from the natural amino acid l-histidine, are replaced by CH3NH3(+).

135 hrough many heterogeneous pathways by way of amino acid-level dynamics biased toward selecting native

136 nvestigated transcriptomes using RNA-seq and amino acid levels with N treatment in tea (Camellia sine

137 macropinocytosis supports the maintenance of amino acid levels within pancreatic tumors.

138 apamycin (both molecules involved in sensing amino acid levels) was assessed in response to different

139 ing transgenes in planta, including modified amino acid levels, have been seen but without the identi

140 Specific loss of the 9000 amino acid long isoform results in vesicle clustering de

141 ulating biochemical pathways associated with amino acid metabolism and redox status.

142 the liver is a major handler of protein and amino acid metabolism as it is responsible for the major

143 metabolism, the citric acid (TCA) cycle, and amino acid metabolism.

144 ons of major pathways for central carbon and amino acid metabolisms to biofilm pH homeostasis.

145 The amino acid metabolite homocysteine activates mTORC1 to i

146 component or plant, benzoate, gamma-glutamyl amino acid, methionine, and tryptophan).

147 reconstitution test, proximate composition, amino acids, minerals and electrophoresis] were determin

148 d/l-Amino acid mixtures play a key role in human physiology

149 Single amino acid modifications identified a novel peptide, DII

150 Mutational analysis of a cyclin F-specific amino acid motif in the C-terminal region of Vif indicat

151 This virus has an amino acid mutation in VP1, which is the enzyme responsi

152 nt antigenic clusters, we inferred a few key amino acids mutation driving the 11 historical antigenic

153 ty is dependent on both the presence of a 22-amino-acid N-terminal 'loop' region and its catalytic ac

154 anding protein chemistries with noncanonical amino acids (ncAAs) and genetically isolating synthetic

155 The use of genetically encoded noncanonical amino acids (ncAAs) to construct crosslinks within or be

156 The extracellular, active 180 amino acid Nogo-A region, named Nogo-A-Delta20, binds to

157 he C terminus (POmega) and contained charged amino acids not more than 3 residues after the anchor am

158 er viruses lacking NSs (expressing just a 12-amino-acid NSs peptide or encoding enhanced green fluore

159 here that a region as small as the first 32 amino acids of Swi1 (Swi11-32) can decorate [SWI(+)] agg

160 mouse strain in which the substitution of 2 amino acids of the endogenous TTP protein renders it con

161 gen peroxide and nutrient stresses caused by amino acid or glucose withdrawal.

162 trategy for the reversible immobilization of amino acid or peptide derivatives on carbon nanomaterial

163 MoFe protein, either by substituting nearby amino acids or transferring the isolated FeMo-cofactor i

164 the evolutionary selection of the current 20 amino acids out of a much larger available pool have rem

165 ion of biosensor which is based on fructosyl amino-acid oxidase (FAO) immobilized nitrogen-doped grap

166 The unnatural amino acid p-Benzoylphenylalanine was successfully incor

167 at incorporates a photoreactive, non-natural amino acid, p-benzoyl-l-phenylalanine, into various posi

168 It is a 35-amino acid peptide cross-linked by two disulfide bridges

169 We combine a 97-amino-acid peptide of human origin that binds hyaluronan

170 rate-transport elicited endocytosis of other amino acid permeases similarly involves unmasking of a c

171 effects of hyperaccumulation of the aromatic amino acid phenylalanine (Phe) in animals, known as phen

172 lar, we show that peptides incorporating the amino acid phenylalanine, a functional group that is con

173 Here, we have used unnatural amino acid photo-cross-linking to investigate the dynami

174 The nonprotein amino acid pipecolic acid (Pip) regulates plant systemic

175 show that the largest effect is caused by an amino acid polymorphism that arose when an ancestral thr

176 , which suggests important roles of specific amino acid polymorphisms in the antigen-binding clefts.

177 tuted glutamic acid (E) for glutamine (Q) at amino acid position 623 (E623Q) displayed a titration cu

178 post-translational labeling at the specific amino acid positions.

179 y imputing classical alleles and polymorphic amino acid positions.

180 Most of the amino acids presented the highest concentrations when th

181 VEGFxxxa isoforms (VEGF165a, 165 for the 165 amino acid product) and antiangiogenic VEGFxxxb (VEGF165

182 th the estimated surface areas, we derive an amino-acid propensity scale that enables prediction of a

183 s of selection and assessments of changes in amino acid properties provide evidence of positive selec

184 Thus, functional rather than structural amino acid properties were decisive during the finalizat

185 95 substitution matrices reflecting various amino acids properties in predicting the antigenicity of

186 TaADF4 encodes a 139-amino-acid protein containing five F-actin-binding sites

187 , and the release of soluble molecules (free amino acids, proteins and glucidic colloids), but the ef

188 cently developed silk dating technique using amino acid racemization (AAR) in conjunction with capill

189 dichloramines, depending on the chlorine to amino acid ratio (Cl:AA).

190 hough pharmacologic modulation of excitatory amino acid receptors is well studied, minimal considerat

191 Removal of the 1291-1302-amino acid region of the C-terminal extension is critica

192 ptophan, plant component, and gamma-glutamyl amino acid-related metabolites.

193 rity of wheat grain nitrogen is derived from amino acids remobilized from vegetative organs.

194 The effects of amino acid replacements on lipid association of the C-te

195 allele knock-in of the most commonly mutated amino acid residue, tyrosine 537, in the estrogen-respon

196 or to peptides containing a cyclobutane beta-amino acid residue.

197 Five highly represented signature amino acid residues (37A, 95K, 224N, and 242N in the M1

198 at the interaction region in BB0323 requires amino acid residues 22-200, suggesting that the binding

199 sults show that interactions between charged amino acid residues are important both to directly stabi

200 These results delineate the role of amino acid residues contributing to the alpha4:alpha4 su

201 t Glu(446) and Arg(447) cooperate with other amino acid residues in the GERAMT-binding site for prope

202 ge equilibria to measure the propensities of amino acid residues to participate in helical secondary

203 that involves just 7-8 out of a total of 148 amino acid residues was clearly detected.

204 egatively charged DNA and positively charged amino acid residues, the translocation speed of DNA can

205 hemical property and occurrence frequency of amino acid residues.

206 l and yet accounts for 90 of the toxin's 387 amino acid residues.

207 y limited to a peptide resolution of 5 to 20 amino acid residues.

208 ences of the two isozymes only differ at six amino acid residues.

209 (+/-) mice displayed an amplification of the amino acid response and ER stress response transcription

210 Although positively charged amino acids result in the Tyr-84 swing, amino acids that

211 cular disease risk (including branched-chain amino acids, select unsaturated lipid species, and trime

212 Selenoproteins contain the amino acid selenocysteine (Sec), co-translationally inse

213 ic code allows for UGA codons to specify the amino acid selenocysteine (Sec).

214 links messenger RNA nucleotide sequence with amino acid sequence during protein synthesis.

215 proteins also display extreme divergence in amino acid sequence identity between STs (i.e., 59%-61%

216 in domain organization they display just 31% amino acid sequence identity.

217 n at multiple sites along the spectrin-betaV amino acid sequence in the lineage leading to mammals, t

218 s of decoy peptides derived from the primary amino acid sequence in the SOD2-binding site in hsp70.

219 The amino acid sequence of the RBS naturally varies across a

220 Substance P (SP) [SP + 3H](3+) ion (SP(3+); amino acid sequence RPKPQQFFGLM-NH2).

221 f dimers are generated by threading a target amino acid sequence through several structural templates

222 actin are nearly indistinguishable in their amino acid sequence, but are encoded by different genes

223 ied eukaryotes possess a tandemly repeated 7-amino-acid sequence, called the canonical CTD, which orc

224 At the level of entry, differences in the amino acid sequences between the human and mouse ortholo

225 Analysis of amino acid sequences of three bZIPs does not identify in

226 ifferent enzyme kinetic profiles and primary amino acid sequences.

227 ely, which differ solely in their N-terminal amino acid sequences.

228 A protocol for mapping amino-acid sequences to coarse-grained beads enables the

229 Amino acids serve as building blocks for proteins but al

230 ed benzene rings (a simple model of aromatic amino acid side chains) can switch inherent dynamical te

231 Principal component analysis showed a serum amino acid signature composed of arginine, leucine/isole

232 ntains an amphipathic helix and exhibits 42% amino acid similarity with SM N100.

233 ication of a single H7 epitope by changing 3 amino acids so that it is homologous with a known H3 imm

234 tions or PTEN deletion to grow using diverse amino acid sources.

235 de synthase, encoded by mps1, contains three amino acid specifying modules in ovine strains, compared

236 APhe (5%), but not deacylated tRNAPhe during amino acid starvation, limiting Gcn2p kinase activity an

237 titutively active and resistant to serum and amino acid starvation.

238 nge, among all the other naturally occurring amino acids studied.

239 ns carried hly mutations leading to a single amino acid substitution (G299V) or a premature stop codo

240 f the missense polymorphism resulting in the amino acid substitution Glu326Lys.

241 Amino acid substitution mutations within a PMS2 C-termin

242 ealed that some escape mutants possessing an amino acid substitution other than K166Q showed superior

243 lysis of the two iNK TCR types with a single amino acid substitution revealed that the staining inten

244 We used an unbiased D-amino acid substitution strategy to determine structure-

245 the effect of the shaker-1 mutation, a R502P amino acid substitution, on the motor function is unclea

246 A single amino acid substitution-based adaptive coevolution of th

247 ic prediction method relies on the choice of amino acids substitution matrices.

248 Here we identified a two-amino-acid substitution in RORgammat (RORgammat(M)) that

249 activation because trimming the Phe by small amino acid substitutions abolished alphaLbeta2 binding w

250 head subdomain, which is highly tolerant of amino acid substitutions and continual addition of glyco

251 follows: experimentally evaluated effects of amino acid substitutions at toggle positions are binary,

252 populations possessed mutations that caused amino acid substitutions from ClO2-labile to ClO2-stable

253 tructural assessment predicted that the five amino acid substitutions have damaging effects on DNA bi

254 Together, these findings demonstrate that amino acid substitutions in Fn-binding repeat-9 can sign

255 and growth selection approach, we identified amino acid substitutions in human and mouse Ctr2 protein

256 The amino acid substitutions lie in two highly conserved loo

257 the Galpha:RGS protein pair based on single amino acid substitutions.

258 Consumption of amino acids such as arginine and tryptophan by immunoreg

259 nthesizes trace amines directly from dietary amino acids (such as tryptophan).

260 elements, such as K, Ca and P, and essential amino acids, such as tryptophan, valine, and threonine,

261 ermined that the charge type and identity of amino acids surrounding FG sequences impact the structur

262 ate binding pocket and the plasticity of the amino acids surrounding the allyl group of the prenyl do

263 nction; 13 pathways including branched chain amino acid synthesis were significantly enriched in base

264 o were the most abundant and rapidly labeled amino acids synthesized.

265 luorescence-based biorthogonal non-canonical amino acid tagging (BONCAT) - for studying the activity

266 Here, we adapt bioorthogonal noncanonical amino acid tagging (BONCAT) to interrogate protein synth

267 For M. smegmatis TopoI-CTD, a 27-amino-acid tail that is rich in basic residues at the C-

268 alized form of autophagy, providing critical amino acids that activate mTOR and enable the metabolic

269 rged amino acids result in the Tyr-84 swing, amino acids that are negatively charged induce a not pre

270 that it is controlled by a set of conserved amino acids that couple RNA and ATP binding to the prote

271 major cause of resistance is changes in the amino acids that form the drug-target binding site.

272 f a flexible loop region containing aromatic amino acids, the caveolin-binding motif.

273 ntly catalyze peptide bond synthesis by most amino acids, the imino acid proline is a poor substrate

274 1) is a central growth regulator that senses amino acids through a pathway that converges on the Rag

275 nvironment and was used directly to generate amino acids through GDH activity.

276 -leucine, diaminopimelate, and several other amino acids to generate oxoacids or derived products in

277 not only catalyse the attachment of cognate amino acids to their respective tRNAs, but also selectiv

278 These neurons also release the amino acid transmitter GABA, which can inhibit downstrea

279 epithelia, where it has an important role in amino acid transport.

280 ndent trafficking of the neuronal excitatory amino acid transporter 3 (EAAT3) blocks potentiation, su

281 aracter is dependent on vesicular inhibitory amino acid transporter-mediated signaling.

282 Amino acid transporters have roles in amino acid uptake

283 such as induction of potassium channels and amino acid transporters, derepression of genes marked wi

284 ound derived from the decarboxylation of the amino acid tyrosine, and is therefore present at importa

285 n flux toward the shikimate-derived aromatic amino acids tyrosine and tryptophan.

286 radiation of a photo-crosslinkable unnatural amino acid (UAA) cotranslationally incorporated into the

287 inking growth factor receptor signaling with amino acid uptake and utilization.

288 Amino acid transporters have roles in amino acid uptake from soil, long-distance transport, re

289 confirmed the functional relevance of these amino acids using a targeted mutagenesis strategy.

290 CO2, and N2O were measured for the 20 common amino acids using low-pressure, ambient-temperature ion

291 ies, we measured DeltaDeltaGsc(o) for all 20 amino acids using the transmembrane beta-barrel E. coli

292 HLA association was the previously reported amino acid variant located at position 71, within the pe

293 incorporation of a fluorescent noncanonical amino acid, we show that there is a rearrangement in the

294 Four nucleobase amino acids were introduced into RRM1 at one or both of

295 Only natural amino acids were used as probes, and thus possible struc

296 proteins containing unmodified proteinogenic amino acids, which can be altered readily by site-direct

297 the STING protein define a novel cluster of amino acids with functional importance in the regulation

298 esent, especially for individual derivatized amino acids with increasing acyl chain lengths.

299 Mutagenesis of the critical Y amino acids within the CRAC and CARC sequences blocked T

300 (PCET) steps along a pathway of redox active amino acids (Y122beta <--> [W48beta?] <--> Y356beta <-->