ライフサイエンスコーパス: amino acid residue

1 or to peptides containing a cyclobutane beta-amino acid residue.

2 ered from the wild-type receptor in only one amino acid residue.

3 in which one Ala has been replaced by a beta-amino acid residue.

4 y limited to a peptide resolution of 5 to 20 amino acid residues.

5 twork of water molecules, chloride ions, and amino acid residues.

6 slational modifications (PTM) of Trp and Arg amino acid residues.

7 and visualization of pairwise coevolution of amino acid residues.

8 invoked non-canonical N-terminal or internal amino acid residues.

9 e of the inhibitor and important interacting amino acid residues.

10 hether this modulation depends on particular amino acid residues.

11 m the global pattern of interactions between amino acid residues.

12 parin, binding proteins with clustered basic amino acid residues.

13 macrocyclic amidine and rare beta-methylated amino acid residues.

14 CHFV NSs protein was determined to be 93-140 amino acid residues.

15 /SET domain, where they differ by only three amino acid residues.

16 with convergence centers comprised of polar amino acid residues.

17 ions were 800-2100 Da. and consisted of 6-21 amino acid residues.

18 brane voltage and pH and involving different amino acid residues.

19 ave been identified, all consisting of 11-12 amino acid residues.

20 s a prolonged N terminus and consists of 344 amino acid residues.

21 ences of the two isozymes only differ at six amino acid residues.

22 opterins, is stabilized by conserved anionic amino acid residues.

23 hemical property and occurrence frequency of amino acid residues.

24 sites links receptor activation to specific amino acid residues.

25 to codons encoding evolutionarily conserved amino acid residues.

26 l and yet accounts for 90 of the toxin's 387 amino acid residues.

27 i.e., peptides 1 and 2), each composed of 10 amino acid residues.

28 heme oxidations must occur through mediating amino acid residues.

29 sequons containing and/or flanked by acidic amino acid residues.

30 further by assessing the role of individual amino acid residues.

31 n of 3D structures as contact networks among amino-acid residues.

32 umber of truncated PEX5 molecules comprising amino acid residues 1-197 than full-length PEX5 molecule

33 ragments or an N-terminal gelsolin fragment (amino acid residues 1-70) in the presence of TRAIL impai

34 the N terminus of human pro-EMAP II protein (amino acid residues 1-70) that can form specific strip-l

35 in (NP) acquires the critical human-adaptive amino acid residues 100I/V, 283P, and 313Y.

36 urons, we developed a pff species labeled at amino acid residue 114 with the environmentally insensit

37 in a substitution of cysteine by tyrosine at amino acid residue 1156 (C1156Y).

38 e interaction region in BB0238 spans only 11 amino acids, residues 120-130.

39 ydrolase domain in the alpha-helical region (amino acid residues 126 to 173).

40 d of HPV-18 L1 with insertions of HPV-33 L2 (amino acid residues 17 to 36; L1 DE loop) and HPV-58 L2

41 amined a putative cell entry region of TcdB (amino acid residues 1753-1851) for short sequences that

42 pl-dependent processing site in ActA between amino acid residues 207 to 238.

43 at the interaction region in BB0323 requires amino acid residues 22-200, suggesting that the binding

44 ystal structure led to the identification of amino acid residue 24 in the floor of the putative bindi

45 Envelope protein was found to correspond to amino acid residues 250 to 270.

46 n essential E1A transforming domain spanning amino acid residues 26 to 35 which also interacted with

47 Amino acid residues 28 to 39 of the N-terminal membrane-

48 ra- and intermolecular cross-linking between amino acid residues 3 and 28, as well as intra- and inte

49 ese results imply a gate is situated between amino acid residues 337 and 344 along TM6, encompassing

50 e of the mutation hotspots (corresponding to amino acid residues 3778-4201) that contains a number of

51 Five highly represented signature amino acid residues (37A, 95K, 224N, and 242N in the M1

52 Deletion of 11 amino acids (residues 50 to 60 or residues 110 to 120) p

53 esidues 17 to 36; L1 DE loop) and HPV-58 L2 (amino acid residues 56 to 75; L1 C terminus).

54 We observed that epitopes within amino acid residues 64 to 81 and 163 to 170 and a C-term

55 tion method, mutations at seven different M1 amino acids (residue 73, 94, 135, 136, or 138 or a doubl

56 Instead, we found that amino acid residue 9 in the N-terminal mitochondrial tar

57 nto the mitochondrial matrix and showed that amino acid residue 9 is a determinant of mitochondrial i

58 to infer insertion-energy profiles for each amino acid residue across the membrane, and quantified t

59 The conservation of relevant amino acid residues across all ETS TFs indicates that th

60 attention has been given to the mutation of amino acid residues along the proton translocating D-cha

61 omers containing mixtures of alpha- and beta-amino acid residues ("alpha/beta-peptides") can mimic th

62 ng oligomers containing both alpha- and beta-amino acid residues ("alpha/beta-peptides") that mimic s

63 We found that amino acid residues alpha4Gly-41, alpha4Lys-64, and alph

64 these diverse myomixer orthologs reveals key amino acid residues and a minimal fusogenic peptide moti

65 nvolves protein electrostatics between basic amino acid residues and acidic lipids such as phosphoino

66 -directed mutagenesis to substitute specific amino acid residues and computational analyses to elucid

67 h of these mutations affect highly conserved amino acid residues and impair key catalytic functions o

68 val leaves the positions of all coordinating amino acid residues and most nearby water molecules larg

69 ment of alpha-helix propensities for d-alpha-amino acid residues and propensities of residues with no

70 itonin is a peptide hormone consisting of 32 amino acid residues and the calcitonin receptor is a Cla

71 h the mutations occurred at highly conserved amino acid residues and were absent in the normal popula

72 gular prism-with the largest containing >700 amino-acid residues and measuring 11 nm in diameter.

73 in the pedigree, affected a highly conserved amino acid residue, and was predicted to be deleterious

74 blic databases, both affect highly conserved amino acid residues, and both are predicted to be damagi

75 helix propensities among proteinogenic alpha-amino acid residues, and quantitative comparison with pr

76 of two amino acids (Met and Trp), all other amino acid residues are each encoded by multiple, so-cal

77 sa in the studied families, and the affected amino acid residues are evolutionarily conserved.

78 sults show that interactions between charged amino acid residues are important both to directly stabi

79 Several amino acid residues are important for the transport acti

80 (Mentha spicata L.) were used to infer which amino acid residues are in close proximity to the substr

81 Segments of 20-40 amino acid residues are placed with an average precision

82 As many as twenty-one amino-acid residues are engaged in ligand interactions w

83 >T (p.Arg258Trp) mutations involve conserved amino acid residues, are located within the cofactor bin

84 he chemical environment of >20% of the total amino acid residues, as revealed by their NMR chemical-s

85 Furthermore, to identify the amino acid residues associated with the low-pH resistanc

86 A transporter subfamily all contain an extra amino acid residue at or near a conserved glycine in tra

87 horylated at Ser 264 (S264), the penultimate amino acid residue at the C terminus.

88 Furthermore, we demonstrate that the amino acid residues at positions 249, 309, and 339 of th

89 ly analyzed the transfer free energies of 20 amino acid residues at the center of the lipid bilayer o

90 Our study maps the important ISD11 amino acid residues belonging to putative helix 1 (Phe-4

91 2 and basigin is stabilized through multiple amino acid residues, but Gly-171 and Leu-175 of P2 were

92 wn that divergence of a very small number of amino acid residues can account for the cold temperature

93 Changes in particular gp41 HR1 amino acid residues can apparently affect the relative s

94 de knowledge-base by confirming that beta(3)-amino acid residues can serve as effective structural mi

95 Induction of YjhX (85 amino acid residues) causes cell-growth arrest resulting

96 o unambiguously model the side chains of the amino acid residues comprising loop III in domain IV of

97 Structure-based mutations of key amino-acid residues confirm drug binding at both sites.

98 e the effects of mutating Lys-300 of NhaA to amino acid residues containing side chains of different

99 These results delineate the role of amino acid residues contributing to the alpha4:alpha4 su

100 ructMAn analyzes the spatial location of the amino acid residue corresponding to nsSNVs in the three-

101 us with a mutated PIMMS2 allele reveals that amino acid residues corresponding to the putative subtil

102 The p.Lys163Glu substitution altered an amino acid residue critical for TBX18-DNA interaction, r

103 e complex revealed that Be is coordinated by amino acid residues derived from the HLA-DP2 beta-chain

104 To identify which specific amino acid residues determine high or low susceptibility

105 insight into the large structural and subtle amino acid residue differences that lead to unique activ

106 Our results show that proton transport from amino acid residue E286 to both the pump loading site (P

107 onstructed eight internal deletions of 40-60 amino acid residues each, spanning the amino-terminal ha

108 es HA and BMP2, which contained highly basic amino acid residues either at the N-terminus (BMP2) or C

109 ceptor, regardless of conservation of the gD amino acid residues essential for HSV-1 entry via HVEM.

110 Using deletions and specific amino acid residue exchanges, we identified critical det

111 The majority of the positively selected amino acid residues fall on the alpha-helix and beta-she

112 l for SOD2 interactions, we substituted each amino acid residue for alanine or more conservative resi

113 erogeneous glycans may be bound to different amino acid residues, forming multiple types of protein g

114 caffold establishing favorable contacts with amino acid residues from the active site.

115 uires Mg(2+) cations, is catalyzed mainly by amino acid residues from the N-terminal domain.

116 Oct1 cleaved eight amino acid residues from the N-terminal region of Prx1 i

117 e number of exopeptidases that cleave single amino acid residues from the N-terminus of peptide subst

118 insecticidal peptide toxin consisting of 35 amino acid residues from the spider Heriaeus melloteei (

119 pitope recognized by this antibody comprises amino-acid residues from two adjacent protomers of HA.

120 s van der Waals contacts with side chains of amino acid residues Glu169(EL2), His264(EL3), Leu267(7.3

121 ellular glycosylated domain of Msb2 (100-900 amino acid residues) had a new and unexpected role in re

122 bryos, but the functional role of individual amino acid residues has been unclear because of technica

123 This loop, comprising 11-amino-acid residues, has been shown to be crucial for su

124 Convergent substitutions at the same amino acid residue have evolved at least five times acro

125 mino acid residues or ring-constrained gamma-amino acid residues have been reported to adopt 12-helic

126 Whereas several amino acid residues have been shown to contribute to ext

127 pe-specific usage of public TCRs, defined as amino acid residue-identical TRB sequences that occur in

128 Mutagenesis further revealed a conserved amino acid residue implicated in reprotonation.

129 In order to identify additional amino acid residues important for acetyltransferase acti

130 This same amino acid residue in EKC viruses shows evidence for pos

131 a variety of aromatic side chains at the aza-amino acid residue in the 4-position.

132 alysis is observed upon changing the achiral amino acid residue in the catalyst (at the i+2 position)

133 through a mechanism dependent on a specific amino acid residue in the HCV NS5A protein.

134 entified mutation affects a highly conserved amino acid residue in the zinc finger domain of ZNHIT3.

135 em, we demonstrate that substitution of four amino acid residues in a bacterial lanosterol synthase e

136 By replacing key amino acid residues in AmTrac we constructed a set of du

137 An analysis of amino acid residues in and around the OEC has identified

138 error because the random appearance of other amino acid residues in close proximity to trypsin cleava

139 ne the involvement of individual S4S5 and S6 amino acid residues in dynamic binding, we studied S4S5

140 Structure-guided alterations of amino acid residues in FePYR1 generated ABA receptor var

141 Ten amino acid residues in Gag correlated with lopinavir EC5

142 Finally, unique amino acid residues in HCV E2 could explain these outlie

143 n of the side chain of Arg-389 with opposing amino acid residues in helix 1.

144 nts with substitutions across nine different amino acid residues in hemagglutinin including seven tha

145 tivity in vitro and in vivo To determine the amino acid residues in hsp70 that are critical for SOD2

146 istidines protonated and if other titratable amino acid residues in lieu of the histidines could bind

147 nisms of this coupling, we mutated conserved amino acid residues in membrane helices H and I.

148 Examination of these amino acid residues in more natural accessions revealed

149 In this study, we identify amino acid residues in NA that contribute to viral repli

150 ns were missense variants predicted to alter amino acid residues in or near the S5 and S6 pore-formin

151 cagon-like peptide-1 (GLP-1) containing beta-amino acid residues in place of native alpha residues at

152 alyzed enrichment in free amino acids and in amino acid residues in protein during a 24-h pulse and 4

153 anding, and the role(s) played by individual amino acid residues in recognition, binding and subseque

154 mutations clustered within a region of nine amino acid residues in the aligned protein sequences (P

155 ty profile elucidate the roles of individual amino acid residues in the binding of ATR inhibitors, of

156 with neutralizing maternal IgG that targets amino acid residues in the C-terminal region of the V3 l

157 Results from mutating the critical amino acid residues in the disputed transmembrane (TM) r

158 Five critical amino acid residues in the E2 domain primarily are invol

159 r 3beta-groups are closer to the hydrophilic amino acid residues in the entrance of the ligand-bindin

160 t Glu(446) and Arg(447) cooperate with other amino acid residues in the GERAMT-binding site for prope

161 Changes in particular amino acid residues in the gp41 HR1 region decreased the

162 However, deletions of amino acid residues in the hydrophobic portion of the si

163 l mutations caused substitution of conserved amino acid residues in the kinase domain and impaired ki

164 The conserved amino acid residues in the loop interacting with CoA wer

165 Five highly represented amino acid residues in the M1 and M2 proteins derived fr

166 nds between the compound and the surrounding amino acid residues in the receptor ligand-binding pocke

167 e mutations, heb1 and heb3, change conserved amino acid residues in the regulatory H-NOX domains of G

168 d identical clusters of receptor-interacting amino acid residues in the VP2 protein, a major determin

169 d A despite possessing a number of different amino acid residues in their combining sites.

170 expression of CCHFV NSs, which contains 150 amino acid residues, in CCHFV-infected cells.

171 mar, i.e. the arrangement and frequencies of amino acid residues, in known antimicrobial peptide sequ

172 re PTS1 domains and position-specific single amino acid residues, including residues upstream of the

173 of the asymmetric C(alpha)-atom of the alpha-amino acid residue influences the left- or right-handed

174 These observations suggested that amino acid residues involved in integrin-fibronectin bin

175 he ribosome, as well as to identify the Gib2 amino acid residues involved in ribosome binding.

176 ent ionization (i.e., on average, every 10th amino acid residue is negatively charged).

177 ability to localize phosphosites to specific amino acid residues is crucial to translating phosphopro

178 oat protein recognition motif or its contact amino acid residues is deleterious for viral assembly.

179 Clostridium difficile TcdB (2366 amino acid residues) is an intracellular bacterial toxin

180 d CBP acetylate Mastermind-like 1 (Maml1) on amino acid residues K188 and K189 to recruit NACK to the

181 Mutations of these amino acid residues lead to reduced selectivity properti

182 These mutations recurrently affect specific amino acid residues, leading to perturbed normal splice

183 er order conformational changes occur on the amino-acid residue level.

184 changes of protein G'e at the molecular and amino acid residue levels in solution by using nanoESI-

185 changes of Abeta1-42 at subregional and even amino-acid-residue levels to be revealed.

186 icular substrate specificity is conferred by amino acid residues lining their substrate pocket that d

187 hich is connected to the calpain via the 600-amino acid residue Linker.

188 ide chains at the so-called P1 position, the amino acid residue located directly N-terminal to the sc

189 B, and CLEC18C are almost identical, several amino acid residues located in the C-type lectin-like do

190 We confirmed that amino acid residues making contact with the ligand in th

191 The amino acid residues modulating HDAC1 subcellular localiz

192 In so doing, SdhE likely orients amino acid residues near the dicarboxylate and FAD bindi

193 l method available for the conversion of one amino acid residue of a given protein into another.

194 we examined the importance of the N-terminal amino acid residue of RNase H in the early life cycle of

195 t of the internal degrees of freedom in each amino acid residue of VVD on its overall dynamics by app

196 Amino acid residues of APOBEC3A that are known to be req

197 Epigenetic modifications of specific amino acid residues of core histones and their isoforms

198 The 36 amino acid residues of DSP are sufficient to bind to int

199 irus (HCV) comprises the first 27 N-terminal amino acid residues of E2.

200 teins of GLUT5 and GLUT7, here we identified amino acid residues of GLUT5 that define its substrate s

201 Studies in yeast with mutants at two amino acid residues of hENT1 (L442I, L442T, M33A, M33A/L

202 permeation was probed by replacing them with amino acid residues of increasing side chain volume.

203 ar function by reversibly oxidising specific amino acid residues of key target proteins.

204 NRC-1was used to express the N-terminal 199 amino acid residues of mBPI fused to the GVNP GvpC prote

205 A subset of the amino acid residues of membrane proteins interact with t

206 Punctual mutations of amino acid residues of MNEI, a single chain derivative o

207 Solvent exposure of amino acid residues of proteins plays an important role

208 Furthermore, we analyzed the relevance of amino acid residues of the active quintet of conserved r

209 1091kJmol(-1) to withstand the disruption of amino acid residues of the enzyme binding site.

210 a truncated GluTR lacking the 29 N-terminal amino acid residues of the mature protein.

211 Mutational studies indicate that amino acid residues of two short regions within the NusG

212 ndences to a large extent are set by charged amino-acid residues of the extracellular linkers of the

213 as greater oxidative modifications occur for amino-acid residues of the IgG-binding domains I and II.

214 , which electrostatically affect the charged amino-acid residues of the voltage sensor S4.

215 incorporated into HDL, was used to identify amino acid residues on PON1 that directly interact with

216 s spec-based fragment analysis confirmed key amino acid residues on ROCK that are phosphorylated by S

217 ement of alpha-amino acid residues with beta-amino acid residues on susceptibility to proteolysis and

218 Site-specific grafting of dendrons to amino acid residues on the exterior of the alpha-helical

219 hat involve distinct and conserved ionizable amino acid residues, one a glutamate, and the other an a

220 e majority of these products comprised three amino acid residues or more.

221 Peptide foldamers containing either gamma(4)-amino acid residues or ring-constrained gamma-amino acid

222 *-) or QA(*-) The identification of specific amino acid residues oxidized by reactive oxygen species

223 n, c.567 G > A, affecting a highly conserved amino acid residue (p.Gly189Arg) of the MRM2 protein.

224 t bridges between different types of charged amino-acid residue pairs on alpha-helix folding.

225 aspartic proteases from other origins, basic amino acid residues, particularly lysine, were found to

226 radation and mass spectrometry revealed a 63 amino acid residue peptide with 4 disulphide bonds that

227 t amyloid polypeptide (IAPP) or amylin, a 37-amino acid residue peptide, is produced in pancreatic be

228 te specificity is controlled by one specific amino acid residue positioned at the entrance to the cat

229 Six amino acid residues potentially important for cold activ

230 -guided mutagenesis in macrophages highlight amino acid residues potentially involved in recognition

231 Structural adjustments of individual amino acid residues predictably control both the assembl

232 re we computationally identify second-sphere amino acid residues predicted to influence the freedom o

233 uorescent spectroscopy, we demonstrated that amino acid residues predicted to participate in Fe(II)-b

234 e-directed mutagenesis studies indicate that amino acid residues predisposing VH1-46 Abs to Dsg3 reac

235 e of the tryptophan (Trp) and tyrosine (Tyr) amino acid residues present in the leuprolide nonapeptid

236 Due to ionizable amino acid residues present on the solvent-exposed surfa

237 ite-directed mutagenesis identified the core amino acid residues required for KEAP1-mediated degradat

238 ence of known human proteins sharing the key amino acid residues required for recognition by the TCR,

239 er-aided substrate-coenzyme docking, the key amino acid residues responsible for binding the phosphat

240 We have identified four amino acid residues responsible for this lack of sensiti

241 hanging one of the three calpain active-site amino acid residues results in the same phenotype as del

242 n the central gate with a positively charged amino acid residue reverses the ion selectivity and prod

243 Modified amino-acid residue(s) can be identified by proteolytic c

244 we found that hMPV M2-1 is phosphorylated at amino acid residues S57 and S60.

245 saccharide in Ca(2+)-independent manner, and amino acid residues Ser/Arg(339) and Asp/Asn(421) in CTL

246 Mutation of amino acid residues Ser67(2.65), Glu169(EL2), and His264

247 The evolutionary conservation of amino acid residue serine 15 in yeast hexokinases and it

248 blast activation protein), resulting in a 12-amino-acid residue shorter form.

249 ansported peptides were found to contain 3-4 amino acid residues showing strong ACE inhibition.

250 In step 2, based on conservation of amino acid residues, stability analysis, structural supe

251 We further determined that a single amino acid residue substitution in NY1682 hemagglutinin

252 n this study, several BnaDGAT1 variants with amino acid residue substitutions in PTMD9 were character

253 rized the mechanisms by which these critical amino acid residue substitutions increased the misfoldin

254 ously revealed that one of the regions where amino acid residue substitutions lead to higher performa

255 gnment and further biochemical analysis, the amino acid residue substitutions that conferred increase

256 When amino acid residue substitutions that increased BnaDGAT1

257 Key amino acid residue substitutions were identified that ma

258 f the BnaDGAT1 variants were affected by the amino acid residue substitutions, and a new kinetic mode

259 of the pKa values of ion-coordinating acidic amino acid residues suggested that the face-specific pH

260 tatic effects of non-conserved and conserved amino acid residues surrounding the rhodopsin chromophor

261 eoxyribozymes are general with regard to the amino acid residues surrounding the tyrosine, while othe

262 In this study, we identified amino acid residues targeted by potentially protective m

263 ic screen in planta, we identify a conserved amino acid residue that determines product specificity i

264 ftware called Xenophile, the identity of the amino acid residue that was adducted can be established,

265 but not in Culicoides cells due to a single amino acid residue that, most likely, leads to rapid and

266 entity of a CRM, the protein target, and the amino acid residues that are modified to be rapidly esta

267 lar interface and identified a unique set of amino acid residues that determined its affinity.

268 Next, we identified a number of specific amino acid residues that greatly diminish the VCC potenc

269 nes, we were able to pinpoint three specific amino acid residues that may be driving the change in th

270 Amino acid residues that mediate this allosteric mechani

271 and transport assays, we identified several amino acid residues that play important roles in antimic

272 mation by interacting directly with specific amino acid residues that resulted in changes in gluten p

273 This is a tetrameric membrane protein of 97 amino-acid residues that has multiple functions, among t

274 prediction targets with sizes from 44 to 595 amino acid residues, the average size being 251 residues

275 egatively charged DNA and positively charged amino acid residues, the translocation speed of DNA can

276 vered that the agonist could mobilize nearby amino acid residues to act as molecular switches for the

277 riterpenoid synthesis and reveals diagnostic amino acid residues to differentiate between sterol and

278 ge equilibria to measure the propensities of amino acid residues to participate in helical secondary

279 on contributions by tryptophan and tyrosine amino acid residues to the antioxidant capacity of SPH f

280 omomeric receptors, linked previously to two amino acid residues, Tyr-454 and Arg-461, in its ligand

281 allele knock-in of the most commonly mutated amino acid residue, tyrosine 537, in the estrogen-respon

282 Two amino acid residues unique to gamma-8 determined this se

283 A photocaged cysteine amino acid residue was genetically introduced into a hig

284 ol, an aryl olefin, an alpha substituent, or amino acid residues was carried out to generate the desi

285 that involves just 7-8 out of a total of 148 amino acid residues was clearly detected.

286 cently, by precision mapping on all possible amino acid residues, we identified histone serine ADPr m

287 Hydroxylated peptides of 15 and 27 amino acid residues were also able to trigger cell degra

288 Key amino acid residues were validated with site-directed mu

289 oviding a positive charge at the substituted amino acid residue, were associated with poor survival (

290 the adhesin consists of the receptor-binding amino acid residues which are involved in a specific int

291 dechain hydrogen bonds, XSuLT annotates each amino acid residue with residue depth, chain and ligand

292 of broadly distributed replacement of alpha-amino acid residues with beta-amino acid residues on sus

293 ctions between polypeptide chains containing amino acid residues with opposite absolute configuration

294 Seeking amino acid residues with unique roles at the protein-pro

295 Amino-acid residues with high pKa are seldom considered

296 Substitution of a single amino acid residue within the degenerin region of betaEN

297 ective structural mimics of homologous alpha-amino acid residues within a natural tertiary fold, whic

298 ense or small in-frame deletions that affect amino acid residues within or adjacent to the protein's

299 Replacement of critical amino acid residues within the FP radically alters how i

300 ange radical transport (RT) through aromatic amino acid residues (Y122 left arrow over right arrow [W