ライフサイエンスコーパス: amino acid substitution

1 hich self-assembly was abolished by a single amino acid substitution.

2 This was subsequently blocked by a bulky amino acid substitution.

3 elic TUBB2B mutation, resulting in a p.R390Q amino acid substitution.

4 the Galpha:RGS protein pair based on single amino acid substitutions.

5 a mechanism supported by the effects of Nun amino acid substitutions.

6 ated the structural and functional impact of amino acid substitutions.

7 d by saturation mutagenesis optimization and amino acid substitutions.

8 rate, or the catalytic water do not tolerate amino acid substitutions.

9 a library encoding all 9,595 possible single-amino acid substitutions.

10 vage preference would require relatively few amino acid substitutions.

11 of protein evolution focused on the rates of amino acid substitutions.

12 ence of more virulent viral variants through amino acid substitutions.

13 n populations that result in specific single amino acid substitutions.

14 mplying a non-linear nature of influences of amino acid substitutions.

15 es between the codons result in conservative amino acid substitutions.

16 proaches exist for predicting the effects of amino acid substitutions.

17 nal ophthalmoplegia generate T251I and P587L amino acid substitutions.

18 an be genetically separated through targeted amino acid substitutions.

19 enicillin-binding proteins (PBPs), with many amino acid substitutions.

20 activation because trimming the Phe by small amino acid substitutions abolished alphaLbeta2 binding w

21 XP substrates confirming that the introduced amino acid substitution abolishes ClpXP activity.

22 s landscapes that survey the impact of every amino acid substitution across the entire protein-protei

23 G2019S, the most common amino acid substitution activates the kinase two- to thr

24 These amino acid substitutions affect well-conserved residues

25 unique NOTCH1 mutations, including 3 de novo amino acid substitutions, all within the ligand-binding

26 peptides and identified that one of the key amino acid substitutions also selectively modulates the

27 All the mutations, four amino acid substitutions, an intragenic deletion, and a

28 We conducted a series of amino acid substitution analyses and identified S1777, i

29 head subdomain, which is highly tolerant of amino acid substitutions and continual addition of glyco

30 Mutations that result in amino acid substitutions and frameshift mutations were a

31 ins can switch bg preference with single DL1 amino acid substitutions, and can coexpress functionally

32 ain in production was attributed to just two amino acid substitutions, and it was isolated after two

33 s little evidence of selection on beneficial amino acid substitutions, and that the domestication bot

34 nown biophysical and evolutionary trends for amino-acid substitutions, and could thus recapitulate kn

35 A Leu to Ala amino acid substitution approximately 10 A from the Cd(2

36 tions and estimate that approximately 50% of amino acid substitutions are positively selected but tha

37 nked glycosylation site is mutated by single-amino-acid substitution are highly attenuated and nonlet

38 Here, we identified NA amino acid substitutions associated with NAI resistance

39 ntiation by CMPI, but not by NS9283, whereas amino acid substitution at alpha4His-116, a known determ

40 13025 strain because of an alanine-to-valine amino acid substitution at residue 188 in NS1.

41 Amino acid substitution at the cleavage site resulted in

42 Amino acid substitutions at (137)TP(138) altered loop C

43 lateral (rHb (betaE6V/alphaH50Q)) or double amino acid substitutions at both the putative axial and

44 Biochemical analysis confirmed that amino acid substitutions at essential positions decrease

45 surface glycoprotein hemagglutinin (HA), and amino acid substitutions at exposed epitope sites in HA

46 A key finding is that rates of amino acid substitutions at exposed sites in the capsid

47 w such changes were attributable to parallel amino acid substitutions at key residues.

48 igomerization state of mutated proteins with amino acid substitutions at multiple putative oligomeriz

49 at the pathology in these patients is due to amino acid substitutions at positions 206, 281, and 284

50 polar N-terminal extensions and non-natural amino acid substitutions at positions 4 and 9.

51 We also show that amino acid substitutions at residues known to interact w

52 4+1 and O3+4+7) are nearly fixed for several amino acid substitutions at the Atpalpha gene that have

53 by comparing recombinant viruses possessing amino acid substitutions at the GP shedding site.

54 Engineered amino acid substitutions at the inhibitor interface bloc

55 We introduced amino acid substitutions at the NS3/4A site to alter the

56 Novel recombinants of Hb S with single amino acid substitutions at the putative axial (recombin

57 lucidating the antigenic effects of specific amino acid substitutions at these sites in swine H3 IAV

58 ominant-negative mechanism for the action of amino acid substitutions at this highly conserved glutam

59 Amino acid substitutions at this polymerase region can i

60 follows: experimentally evaluated effects of amino acid substitutions at toggle positions are binary,

61 A single amino acid substitution-based adaptive coevolution of th

62 specific divergence, we estimate that 31% of amino acid substitutions between Heliconius species are

63 We highlight shared amino acid substitutions between this set of RASopathy m

64 e that vaccination directed at tumor-encoded amino acid substitutions broadens the antigenic breadth

65 a 3-fold decrease occurs in the case of the amino acid substitution C592G.

66 Thus, a single amino acid substitution can significantly alter the AAV

67 Moreover, the location of amino acid substitutions causing the bypass phenotype on

68 cripts, the mechanisms by which these single amino acid substitutions change gene expression remain c

69 tudy the molecular consequences of 16 single amino acid substitutions, classified as pathogenic, in t

70 Disease-associated amino acid substitutions cluster in regions adjacent to

71 All four pathogenic amino acid substitutions cluster within the AAA(+) domai

72 ll six cases showed missense mutations, with amino acid substitutions clustering at positions 33 to 4

73 Semaglutide has two amino acid substitutions compared to human GLP-1 (Aib(8)

74 g in vitro drug screening, we identified 211 amino-acid substitutions conferring resistance to ruxoli

75 This simple switch in mechanism by a single amino acid substitution could potentially generate a lar

76 nfectivity of B virus isolates with a single amino acid substitution (D122N) in the IgV-core of the g

77 Specific amino acid substitutions designed to slacken interaction

78 Y223C amino acid substitution destabilizes AgrC-AgrA interacti

79 Amino acid substitutions disrupting these contacts impin

80 One association appears to be driven by an amino acid substitution encoded in EXO1.

81 variants comprised from conservative single amino acid substitution events.

82 A single amino acid substitution evolved together with this regul

83 physiological CDC45 transcripts, as well as amino acid substitutions expected to result in partial l

84 emonstrated that a MACV strain with a single amino acid substitution (F438I) in the transmembrane dom

85 e screened a library containing all possible amino acid substitutions for LF-binding site to find var

86 Although an amino acid substitution from aspartic acid to alanine at

87 including more than 70% of DIPGs, harbor an amino acid substitution from lysine (K) to methionine (M

88 ost mammals, humans differ at two functional amino acid substitutions from chimpanzees, bonobos and g

89 populations possessed mutations that caused amino acid substitutions from ClO2-labile to ClO2-stable

90 enerated by breeding combinations of natural amino-acid substitutions from the cyclic into the linear

91 Indeed, this single amino acid substitution (G-->V) at a residue invariant i

92 ns carried hly mutations leading to a single amino acid substitution (G299V) or a premature stop codo

93 due to a target-site mutation conferring an amino acid substitution (G4946E), located within the tra

94 f the missense polymorphism resulting in the amino acid substitution Glu326Lys.

95 e same parental stock and differ by a single amino acid substitution (H1047R) caused by a single nucl

96 ption of the SpoIIQ LytM domain via a single amino acid substitution (H120S) impairs engulfment diffe

97 ons affect amino acids for which alternative amino acid substitutions have been reported to cause the

98 tructural assessment predicted that the five amino acid substitutions have damaging effects on DNA bi

99 static potential allowed the impact of known amino acid substitutions (HLA-B*07:02 R79G, R82L, G83R)

100 Two amino acid substitutions I138M and I139M retard the form

101 the mutations found in ChAc patients causes amino acids substitution I2771R which affects the locali

102 The three amino acid substitutions impacted the protein level of T

103 monstrate that a change as small as a single amino acid substitution in a FAD enzyme might result in

104 Li1 short fiber mutant as a single Gly65Val amino acid substitution in a polymerization domain of an

105 n autosomal recessive mutation leading to an amino acid substitution in a WD40 domain of the highly c

106 idopsis thaliana accession Cvi-0 to a single amino acid substitution in MITOGEN-ACTIVATED PROTEIN (MA

107 manashi/166/1998 viruses containing a single amino acid substitution in NA generated by reverse genet

108 Both mutations cause a single amino acid substitution in one OPR repeat.

109 Such ability was restored by a single amino acid substitution in position 186 (K186E) that res

110 A single amino acid substitution in that domain abolished the int

111 We identified a homozygous COL6A2 p.D871N amino acid substitution in the C-terminal C2 A-domain.

112 This mutation causes an amino acid substitution in the calcium-binding motif of

113 ific domain-domain interactions via targeted amino acid substitution in the catalytic site of the C-t

114 loid wheat accessions revealed that a single amino acid substitution in the DNA-binding domain gave r

115 o evolution also revealed that just a single amino acid substitution in the envelope can confer subst

116 ogether, the study demonstrates how a single amino acid substitution in the histidine kinase receptor

117 This same amino acid substitution in the homologous but distinct m

118 gineered in both TRPV1 orthologs by a single amino acid substitution in the N-terminal ankyrin-repeat

119 Thus, a single amino acid substitution in the regulatory domain (the te

120 nd host cell binding were linked to an A300V amino acid substitution in the strain JGS1076 CPB varian

121 An amino acid substitution in the WD40 repeats of RFWD3 (I6

122 ZIKV infectivity was enhanced by this amino acid substitution in the ZIKV FSS13025 strain in m

123 owever, we found higher levels of convergent amino acid substitutions in a control set of terrestrial

124 We report here that amino acid substitutions in a thrombopoietin receptor (M

125 recruitment, by different effects of single amino acid substitutions in ACKR3 on arrestin in respons

126 rus replication and the high fitness cost of amino acid substitutions in capsids to HIV-1 infectivity

127 We use single amino acid substitutions in DAXX that abrogate formation

128 Subsequent amino acid substitutions in duplicated daughter genes se

129 s and characterized the genetic lineages and amino acid substitutions in each gene segment identified

130 Together, these findings demonstrate that amino acid substitutions in Fn-binding repeat-9 can sign

131 le genetic elements (plasmids and phages) or amino acid substitutions in global regulators was identi

132 Many amino acid substitutions in GPIHBP1's Ly6 domain that ab

133 ls harbored low-frequency mutations encoding amino acid substitutions in HA antigenic sites at or nea

134 Many amino acid substitutions in highly pathogenic H5N1 avian

135 and growth selection approach, we identified amino acid substitutions in human and mouse Ctr2 protein

136 ing sequences identified widespread parallel amino acid substitutions in marine mammals; however, the

137 Here, we report that five amino acid substitutions in PA (V44I, V127A, C241Y, A343

138 Amino acid substitutions in PhoQ's cytoplasmic domain hi

139 The locations of many of the amino acid substitutions in Pol delta resemble those of

140 nvestigate antimutator mutations that encode amino acid substitutions in Pol delta that suppress this

141 This allowed amino acid substitutions in rabbit PrP and accurate anal

142 Amino acid substitutions in Rpb9 or Rpb1 that disrupt pr

143 n, but binding affinities were influenced by amino acid substitutions in the adjacent SH3 domain.

144 netic analysis for one of the most prevalent amino acid substitutions in the age-related maculopathy

145 Amino acid substitutions in the amino terminus, or delet

146 associate with relapsing disease, including amino acid substitutions in the atovaquone-binding regio

147 Several amino acid substitutions in the AtPP2CA active site, inc

148 d-targeting inhibitor PF74 requires multiple amino acid substitutions in the binding pocket of the CA

149 Single amino acid substitutions in the C-terminal membrane loca

150 All RV-A strains show high rates of amino acid substitutions in the capsid proteins at expos

151 mangabeys (SIVsm) clone SIVsmE543-3 acquired amino acid substitutions in the capsid that overcame TRI

152 ype (wt) BoNT/A1 in that it incorporates two amino acid substitutions in the catalytic domain of the

153 Here, we identified 4 amino acid substitutions in the cytoplasmic tail of vira

154 focal leukoencephalopathy (PML) carry single amino acid substitutions in the domain of the VP1 capsid

155 These data revealed that specific amino acid substitutions in the EBOV GP have increased t

156 Indeed, we found that recently evolved amino acid substitutions in the GDH2 allosteric domain c

157 igenic drift mediated by the accumulation of amino acid substitutions in the hemagglutinin (HA) prote

158 Amino acid substitutions in the hemagglutinin protein ca

159 Amino acid substitutions in the hemagglutinin protein ca

160 nimals depends on single prion protein (PrP) amino acid substitutions in the host, but the agent's mo

161 Amino acid substitutions in the large subunit that could

162 nt scoring methods for weighting the type of amino acid substitutions in the linear and non-linear mo

163 y-defective, compound-dependent mutants with amino acid substitutions in the major homology region (M

164 promised due to antigenic drift arising from amino acid substitutions in the major influenza virus an

165 (ad) of BoNT/C1 through rationally designed amino acid substitutions in the metalloprotease domain o

166 Amino acid substitutions in the NA glycoprotein of influ

167 proximately DPB1*04:01 haplotype and certain amino acid substitutions in the recipient P1 peptide-bin

168 Here we report a comprehensive study of amino acid substitutions in the retinal-binding pocket o

169 culture-adapted (TC) PoSaV has two conserved amino acid substitutions in the RNA-dependent RNA polyme

170 rtebrates, H. platirhinos lacks the adaptive amino acid substitutions in the skeletal muscle sodium c

171 tance to PF74 is complex, requiring multiple amino acid substitutions in the viral CA protein.

172 LDL) receptor (LDLR) mRNA did not reveal any amino acid substitutions in this cell line, HPAF-II cell

173 s, whereas specificity is achieved by subtle amino acid substitutions in variable residues.

174 everse-genetics system, we identified that 4 amino acid substitutions in VP1 (residues 178, 289, 324,

175 We discovered that 4 amino acid substitutions in VP1 (residues 178, 289, 324,

176 Here, we identified single amino acid substitutions in Vps13 (vacuolar protein sort

177 The two amino acid substitutions in XylR enhance xylose utilizat

178 We demonstrate that a single amino-acid substitution in a banana lectin, replacing hi

179 Here we identified a two-amino-acid substitution in RORgammat (RORgammat(M)) that

180 llography and modelling, to identify limited amino-acid substitutions in Cry51Aa2 that increase insec

181 nally equivalent SNP in Oprm1 with a similar amino acid substitution, in extended (4 h) SA sessions.

182 Genes with the highest rates of amino acid substitutions included many cell wall protein

183 Conversely, we demonstrate that several amino acid substitutions (including His, Phe, Pro, Trp,

184 inst a majority of NS3 resistance-associated amino acid substitutions, including the highly prevalent

185 ssociation of gp120 with the virion and that amino acid substitution increased the amount of dissocia

186 rotein homology modelling suggests that four amino acid substitutions inferred to be under positive s

187 the functional effect of single or multiple amino acid substitutions, insertions and deletions using

188 uPA(-/-)) or uPAR (uPAR(-/-)) or with a four-amino acid substitution into the growth factor domain of

189 Here, by introducing two amino acid substitutions into the beta scorpion toxin Ts

190 Upon introducing these amino acid substitutions into the E. coli D-lactate prod

191 nhibition, ETV6 variants were generated with amino acid substitutions introduced along the solvent ex

192 predicting changes in protein stability upon amino acid substitution is a much sought after goal.

193 , but this activity was restored by a single amino acid substitution (K186E), which was responsible f

194 e EGFR Ab matuzumab (H425 wt) by introducing amino acid substitutions K326A/E333A (H425 mt).

195 Amino acid substitutions K599E and T601M conferred no ga

196 both ALA1 and ALA2 was abolished by a single amino acid substitution known to inactivate the flippase

197 he authentic JEV SA14-14-2 (E) protein, with amino acid substitutions L107F, E138K, I176V, T177A, E24

198 HR1 mutants encode an FHR-1 protein with two amino acid substitutions, L290S and A296V, converting th

199 ring increased ZNRF3 binding upon RSPO4 with amino acid substitutions L56F, I58L, and I63M enhanced i

200 5' UTR (5'-UTR-T39A), the capsid (C) protein amino acid substitution L66S (C-L66S), and the complete

201 The amino acid substitutions lie in two highly conserved loo

202 For amino acid substitutions located at the protein surface,

203 An amino acid substitution, lysine to glutamine, at positio

204 amD depletion were partly reversed by single-amino-acid substitutions mapping within the beta-barrel

205 te the power of our method, we construct two amino acid substitution matrices from the prediction sta

206 Universal amino acid substitution matrices such as Blosum62 are us

207 dition to sequence information into specific amino acid substitution matrices, the sequence matching

208 ic prediction method relies on the choice of amino acids substitution matrices.

209 using Rates of Evolution) algorithm with an amino acid substitution matrix in a dynamic scoring func

210 rate based approach coupled to the BLOSUM62 amino acid substitution matrix in inferring protein doma

211 When default amino acid substitution matrix in the Psi-blast algorith

212 Amino acid substitution mutations within a PMS2 C-termin

213 Amino acid substitution mutations within the correspondi

214 We show that single amino acid substitutions near the receptor binding site

215 urified remodeled nitrogenase containing two amino acid substitutions near the site of its FeMo cofac

216 DGAT variants were then designed to include amino acid substitutions observed in promising C. americ

217 We find that unique amino acid substitutions occur at sites under positive s

218 cell immunity directed against tumor-encoded amino acid substitutions occurs in some melanoma patient

219 g information as a guide to introduce single amino acid substitutions of nine different residues on t

220 Here we show that amino acid substitutions of residues near the tip of the

221 Although amino acid substitutions of residues surrounding Arg-508

222 erating a panel of mutant viruses containing amino acid substitutions of the residues lining this por

223 eterozygous mutations in ALDH18A1 leading to amino acid substitutions of the same highly conserved re

224 tional scan of hMOF Lys-274 reveals that all amino acid substitutions of this residue are able to bin

225 em to quantify the impact of disease-causing amino acid substitutions on catalytic activity, metal bi

226 provided in-depth insights on the effects of amino acid substitutions on IL-8 protein structure, func

227 We investigated the effect of amino acid substitutions on propensity of the completely

228 Amino acid substitutions on the exterior surface of the

229 one (D137L) or two (D137L/G126R) stabilizing amino acid substitutions on the mechanical behavior of r

230 Different amino acid substitutions on the same motif resulted in o

231 the effect of the shaker-1 mutation, a R502P amino acid substitution, on the motor function is unclea

232 ealed that some escape mutants possessing an amino acid substitution other than K166Q showed superior

233 gave the greatest oil increase contained 14 amino acid substitutions out of a total of 504 (97% sequ

234 nonsense variant or c.164G>A that encodes an amino acid substitution p.Arg55His, but also affects spl

235 as identified in the patient, predicting the amino acid substitution p.His586Pro in the desmoplakin p

236 ely a c.526C > T substitution leading to the amino acid substitution p.L176F in the guanylate cyclase

237 = 1.3 x 10(-15); odds ratio [OR] = 9.4) with amino acid substitution p.V95A on the risk haplotype har

238 x syndrome, associated with distinct de novo amino acid substitutions (p.Glu117Val and p.Glu117Gly) a

239 -3 that had been engineered to contain the 4 amino acid substitutions present in gp41 of SIVsm804E.

240 on/function produced by readthrough-mediated amino acid substitutions prevented a significant functio

241 Here, amino acid substitutions previously identified to affect

242 ting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to li

243 the same missense mutation, which led to an amino acid substitution (R171W) in the MSN four-point-on

244 We find that the blue trait maps to a single amino acid substitution (R644W) in an uncharacterized po

245 We detected comparable accelerated amino acid substitution rates in FIS2 and MEA but not in

246 Protein modeling of the 4 highly conserved amino acid substitutions, residing in both head and tail

247 The HA amino acid substitutions responsible for switching the a

248 arrier protein and even conservative peptide amino acid substitutions resulted in a complete loss of

249 6-P-specific enzyme was started by a single amino acid substitution resulting in negative selection

250 lysis of the two iNK TCR types with a single amino acid substitution revealed that the staining inten

251 t prepared cyanobacterial ChlB variants with amino acid substitution(s) to mimic ChlB translated from

252 guishable from eIF4E1a by a set of conserved amino acid substitutions, several of which are located n

253 We used an unbiased D-amino acid substitution strategy to determine structure-

254 These amino acid substitutions subdivided both the conformatio

255 ne indica population, we identified a double amino acid substitution (T102I+P106S [TIPS]) in the 5-en

256 C3277A causes amino acid substitution T860N in the protease 2A(pro) cl

257 We have updated the environment-specific amino-acid substitution tables based on the current expa

258 etic enzyme from IPMDH results from a single amino acid substitution that alters substrate specificit

259 utants were designed to contain every single amino acid substitution that distinguishes rabbit recomb

260 lation is most likely attributed to a single amino acid substitution that leads to different OsHMA4 t

261 In this study, we demonstrate that an amino acid substitution that mimics insulin-mediated pho

262 bitor 1A (SERPINA1) gene leading to a single amino acid substitution that results in an unfolded prot

263 We then identify multiple novel amino acid substitutions that are likely to have contrib

264 tagenesis" assay and identified a cluster of amino acid substitutions that confer a WRAD-dependent ga

265 ith NAI resistance have been identified, the amino acid substitutions that confer multidrug resistanc

266 We identified nine single amino acid substitutions that could not complement the c

267 the earliest reported isolate and introduced amino acid substitutions that defined viral lineages.

268 n, to express the RSV F glycoprotein bearing amino acid substitutions that increase its stability in

269 effective in producing a mutant with only 3 amino acid substitutions that maintained the same fold a

270 ity to compare the effects of two dissimilar amino acid substitutions that produce a similar phenotyp

271 Oncogenic KRAS mutations introduce discrete amino acid substitutions that reduce intrinsic Ras GTPas

272 While amino acid substitutions that result in escape from CD8(

273 sgenic mice that express human PrP with four amino acid substitutions that result in expression of Pr

274 Here we report two additional amino acid substitutions that significantly shift the re

275 aracterized identified a number of candidate amino acid substitutions that will aid in advancing engi

276 ling the fragment crystallizable domain with amino-acid substitutions that promote binding to Fcgamma

277 To evaluate the contribution of each amino acid substitution to shaping the dynamic conformat

278 l possessing the human equivalent nucleotide/amino acid substitution to study social affiliation and

279 Single amino acid substitutions to benenodin-1 generate peptide

280 3D modelling suggests that only three key amino acid substitutions (Trp --> Pro, Gly --> Ser and A

281 re we show that a naturally occurring single amino acid substitution (tyrosine to cysteine) at positi

282 The five PA amino acid substitutions V44I, V127A, C241Y, A343T, and

283 A particular construct, harboring amino acid substitutions W871T, W875D, and V878T (FPII.2

284 ity was lost in synthetic peptides harboring amino acid substitutions W871T, W875D, and V878T in FPII

285 A Glu-217-Gln amino acid substitution was found to confer high Rca act

286 Gradual accumulation of nucleotide and amino acid substitutions was observed in the hemagglutin

287 fied mutations (two premature stops and five amino acid substitutions) was studied in vitro, using im

288 By constructing specific amino-acid substitutions, we demonstrate that the prefer

289 Six amino acid substitutions were detected in 5 patients.

290 Fourteen amino acid substitutions were introduced into the NA of

291 Out of 86 variants of p145, seven amino acid substitutions were selected and made the basi

292 finding indicates that some of the numerous amino acid substitutions were selected to restore a viab

293 ative genomic analyses found that convergent amino acid substitutions were widespread throughout the

294 Resistance to C1 was conferred by a single amino acid substitution within the compound-binding site

295 calculated for nearly every possible single amino acid substitution within this fragment.

296 rain Brescia (BICv) was used to evaluate how amino acid substitutions within FPII may affect replicat

297 We identified 37 amino acid substitutions within the NA gene, 16 of which

298 tive mutations included exon 3 deletions and amino acid substitutions within the ss-TRCP binding site

299 We report that a narrow spectrum of amino-acid substitutions within the transactivation doma

300 We previously reported that an amino acid substitution, Y704A, near the 2-fold interfac