ライフサイエンスコーパス: amino alcohol

1 on ligands bearing a chiral binaphthyl-based amino alcohol.

2 dily hydrolyzed to an oxazolidin-2-one or an amino alcohol.

3 esis of a family of bicyclic fluorinated 1,3-amino alcohols.

4 vailable two- and three-carbon Cbz-protected amino alcohols.

5 used for enantioselective sensing of chiral amino alcohols.

6 lled convergent elaboration of protected 1,5-amino alcohols.

7 n be used to prepare enantiopure N-aryl beta-amino alcohols.

8 ore conveniently, from the corresponding 1,2-amino alcohols.

9 in synthesizing pharmaceutical compounds and amino alcohols.

10 ymmetric synthesis of both syn- and anti-1,3-amino alcohols.

11 pha- and beta-amino acids, beta-lactams, and amino alcohols.

12 ghtforward access to either syn- or anti-1,2-amino alcohols.

13 lyzed heterocyclization reactions of allenic amino alcohols.

14 in a modular fashion, from readily available amino alcohols.

15 paration of anti-alpha-(difluoromethyl)-beta-amino alcohols.

16 the highly enantioselective synthesis of 1,2-amino alcohols.

17 can be enantioselectively quenched by chiral amino alcohols.

18 synthesized from K(2)PtCl(4) and appropriate amino alcohols.

19 efficiently and enantioselectively by chiral amino alcohols.

20 or protonated amino acid esters, amines, and amino alcohols.

21 e of phosphocholine and other phosphorylated amino alcohols.

22 zolines, which are precursors of unsaturated amino alcohols.

23 tereoselective reduction to syn- or anti-1,3-amino alcohols.

24 htforward approach to prepare chiral vicinal amino alcohols.

25 d total concentration of a variety of chiral amino alcohols.

26 pulated to yield highly enantioenriched free amino alcohols.

27 2-iodo-1-naphthoic acid and enantiopure beta-amino alcohols.

28 ces between the two single hydrocarbon chain amino-alcohols.

29 c propargylation provides homopropargyl beta-amino alcohol 1 with high regio- and diastereoselectivit

30 This route was used to prepare amino alcohol 1, the core portion of the HIV protease in

31 catalyst systems derived from a multidentate amino alcohol (1).

32 ng causes of the selectivity for three gamma-amino alcohols, 1, 2, and 3.

33 The cis-decalin based gamma-amino alcohols, 1-5, were synthesized, resolved, and emp

34 the salicaldimine complex 11 and the derived amino alcohol 12 with 94% ee overall.

35 and allylation at the alpha-carbon to yield amino alcohol 17, which is similar to a hydride migratio

36 Amino alcohol 2-MAP was prepared from its trans isomer 2

37 Two-dimensional NMR was used to characterize amino alcohol 2-MAP, and NOE was used to confirm its rel

38 Amino alcohols 2-MAP and 3-MAP were also found to be use

39 Regioisomeric amino alcohols 2-MAP and 3-MAP, even though they were pr

40 The protected amino-alcohol ((2R,3R,4R,5R)-5-amino-2,3:4,6-diisopropyl

41 Amino alcohol 3-MAP was synthesized by converting (+)-no

42 nene, was converted to the two regioisomeric amino alcohols 3-MAP and 2-MAP in very good yield and ex

43 involving regioisomeric, pseudo-enantiomeric amino alcohols 3-MAP and 2-MAP.

44 dditions to aldehydes promoted by the chiral amino alcohol 415, but this process was not catalytic ye

45 1,3-Anti amino alcohols 5(a)-18(a) are obtained with high diaster

46 Polymer-supported amino alcohols 5a-c have been evaluated as catalytic lig

47 bromide to ester 4 and converted to pyrrolyl amino alcohol 7 by olefin oxidation and Paal-Knorr conde

48 A new series of alkenyl amino alcohol (AAA) ionizable lipid nanoparticles (LNPs)

49 selective formation of the corresponding syn-amino alcohol adduct 3.

50 s to the formation of the corresponding anti-amino alcohol adduct 4 with high stereoselectivity.

51 The strategy employs a variety of amino alcohols/amines and proceeds with 6 + 4/6 + 5 and

52 l aziridine building blocks with an array of amino alcohols/amines in a modular one-pot, sequential p

53 eric composition of chiral amines, diamines, amino alcohols, amino acids, and alpha-hydroxy carboxyli

54 ctionalization of aliphatic C-H bonds within amino alcohols, an important class of small molecule.

55 molecular hydrogen bonding between the bound amino alcohol and the proximate N-oxide group.

56 This was reduced to the primary amino alcohol and was converted to the morpholino group

57 Oxazaborolidines made from chiral amino alcohols and 6-tosyl-1-hexenylboronic acid were tr

58 ations of this catalyst for the synthesis of amino alcohols and a one-pot procedure for indole synthe

59 activity is exploited to convert alkyls into amino alcohols and allylic amines.

60 s to produce chiral alpha-hydroxy acids, 1,2-amino alcohols and alpha-amino acids, respectively.

61 nd concentration of unprotected amino acids, amino alcohols and amines.

62 pplied to more challenging compounds, namely amino alcohols and diastereomers possessing more than on

63 ides and cyclic nitrones derived from chiral amino alcohols and glyoxylic acid is reported.

64 backbone substituted N,N-bisubstituted beta-amino alcohols and isolated via flash column chromatogra

65 ore undergoes rapid condensation with chiral amino alcohols and subsequent asymmetric transformation

66 enamides toward the synthesis of cis vicinal amino alcohols and tetrasubstituted alpha-borylamido com

67 n of the nitro alcohols to the corresponding amino alcohols and their subsequent conversion to enanti

68 -fluoroacetoxylated products, 1,3-diols, 1,3-amino alcohols, and 1,3-diamines.

69 pid determination of the ee value of amines, amino alcohols, and amino acid esters.

70 analysis of unprotected amino acids, amines, amino alcohols, and carboxylic acids in aqueous solution

71 e configurations of erythro and threo diols, amino alcohols, and diamines is reported.

72 Access to substituted amines, amino alcohols, and diamines is thereby made possible in

73 by their conversion to gamma-lactams, delta-amino alcohols, and hydrolysis products in high yields w

74 A series of amino alcohol- and diamino-cis-decalins were synthesized

75 Besides anti-beta-amino alcohols, anti-2-amino-1,3-diols and anti-3-amino-

76 Enantiopure beta-amino alcohols are converted into N-hydroxyethylamides,

77 The amino alcohols are efficiently transformed to protected

78 xample that species generated from the (beta-amino alcohol)(arene)RuCl (II) catalytic precursor can s

79 was used to study the reactivity of a (beta-amino alcohol)(arene)RuCl transfer hydrogenation catalyt

80 By using natural and non-natural amino alcohols as "side chains" for the proline derivati

81 The usefulness of norephedrine-derived beta-amino alcohols as catalysts for the enantioselective alk

82 Employment of tethered optically active amino alcohols as pronucleophiles allowed for efficient

83 mount and the enantiomeric excess of several amino alcohols at micromolar concentrations is reported.

84 emistry of a variety of chiral 1,2-diols and amino alcohols at room temperature with no chemical deri

85 As a result, from a single amino alcohol auxiliary, both enantiomers of key P-stere

86 eproducibility of GCC-IRMS determinations of amino alcohols averaged SD(613C) = 0.25 +/- 0.19%.

87 of compounds with 2, 3, or 4 carbon diol or amino alcohol backbones and oleoyl or palmitoleoyl acyl

88 In the presence of enantioenriched amino alcohol-based catalysts, ArZnBu adds to aldehydes

89 (CaR) resulted in the identification of the amino alcohol-based hit 2 (IC(50) = 11 microM).

90 We have identified an amino-alcohol carbazole (N-CBZ) as a PfHsp90-selective i

91 carbonyls has been accomplished using a new amino alcohol catalyst in the presence of electron-rich

92 pM, third-generation) contains an open-chain amino alcohol cation with two asymmetric carbons.

93 ase method for the preparation of C-terminal amino-alcohol-containing peptides using activated Wang r

94 Opening of representative epoxides with 1,2-amino alcohols delivered the amino diols.

95 nonpolar amino acids to their corresponding amino alcohols, demonstrate a GC strategy to produce acc

96 ransformation to convert a relatively simple amino alcohol derivative to the functionalized core of t

97 furnished medicinally important N-aryl beta-amino alcohol derivatives in moderate to good yields.

98 ediated amidation of unactivated esters with amino alcohol derivatives is reported.

99 n efficient sequence of reactions, the above amino alcohol derivatives were subsequently transformed

100 nt C-C bond-forming step, furnishing syn 1,2-amino alcohol derivatives with excellent levels of diast

101 It can also provide amino alcohol derivatives with regio- and stereochemical

102 wide range of amino lactones as well as 1,2-amino alcohol derivatives.

103 beta-amino acids and their corresponding 1,3-amino alcohol derivatives.

104 dines in this reaction afforded N-aryl gamma-amino alcohol derivatives.

105 This circumvents the necessity to synthesize amino alcohols derived from (-)-nopinone, which in turn

106 diastereomers accessed by ring-opening of an amino alcohol-derived cyclic sulfamidate.

107 lectively to produce either the syn- or anti-amino alcohol diastereomer.

108 pure epoxides (ee, 99%) and N-protected beta-amino alcohols (ee, 99%) with quantitative yield in 16 h

109 -methyl-2-imidazolecarboxaldehyde and chiral amino alcohols followed by reduction is key to the desig

110 e synthesis of five- or six-membered lactone amino alcohols, followed by incorporation of the require

111 he basicity of the hydroxyl group of the CF3 amino alcohol formed.

112 dual purpose of installing the necessary 1,2-amino alcohol functionality as well as providing an effi

113 o-Mannich reaction to introduce the syn-beta-amino alcohol functionality of conduramine E and ring-cl

114 doxorubicin, reacts with formaldehyde at its amino alcohol functionality to produce a conjugate, Epid

115 well as the linker chain containing the beta-amino alcohol functionality.

116 Reduction of the resulting N-Boc amino alcohols furnished hygrolines and pseudohygrolines

117 ethyl (Dde) in place of Z protection on the amino alcohol has allowed us to introduce cationic amino

118 e Ts group, and subsequent formation of beta-amino alcohols have also been developed.

119 A commercially available collection of beta-amino alcohols have been converted to their correspondin

120 a range of cyclic allylic amines and vicinal amino alcohols have been prepared stereoselectively and,

121 The amino alcohol head group of the sphingosine backbone is

122 es an unusual four-electron oxidation of the amino alcohol histidinol via the histidinaldehyde interm

123 atalyzed reaction of 4 and 5 to give the syn-amino alcohol in excellent yield and very high diastereo

124 on a surface and spraying a solution of beta-amino alcohol in methanol, two unique transient intermed

125 These compounds can be prepared from beta-amino alcohols in enantiomerically pure form through a t

126 yl aldimines provides 1,2-disubstituted beta-amino alcohols in good yields (73-98%) and with high dia

127 ver Pd/C furnished syn-1,2-disubstituted-1,3-amino alcohols in high yields (82-90%) with moderate to

128 precursors in the synthesis of protected 1,2-amino alcohols in high yields and diastereoselectivities

129 ersion of catalytically incompatible primary amino alcohols into hindered secondary amines that are c

130 vised, and the enantiopurity of the starting amino alcohol is retained in the aziridine product.

131 The formation of chiral poly 1,3-amino alcohols is also demonstrated.

132 y enamines to generate 1,2-disubstituted-1,3-amino alcohols is also outlined.

133 reparation of diastereo- and enantiopure 1,2-amino alcohols is also realized using this catalytic sys

134 tuted morpholines from enantiomerically pure amino alcohols is described.

135 ic amines, aromatic amines, amino acids, and amino alcohols is described.

136 hesis of complex aminocyclopentitols and 1,2-amino alcohols is discussed.

137 en-bond complexes between the dendrimers and amino alcohols is proposed to account for the fluorescen

138 igand does not require optically pure biaryl amino alcohols, its synthesis is significantly shorter a

139 tions in the presence of chiral diamines and amino alcohols led to the enantioselective allylation of

140 Aminolysis of the latter entity with an amino alcohol liberates a thiol that reacts with an acry

141 t-hand side aromatic moieties as well as the amino alcohol linker region.

142 by an elemental analyzer coupled to IRMS and amino alcohols measured by GCC-IRMS was delta613C = 0.14

143 dihydropyran-2-one to the C-2, C-3 trans-1,2-amino alcohol moiety as present in ezoaminuroic acid.

144 e organocatalyst featuring a chiral diphenyl amino alcohol moiety instead derived its preferred (R)-a

145 f a catalyst derived from an enantioenriched amino alcohol (morpholino isoborneol, MIB).

146 c C-H amination reaction en route to syn-1,3-amino alcohol motifs is reported.

147 e highly selective synthesis of anti-vicinal amino alcohol natural products.

148 phosphine ligand, Pd(II) and a chiral amine, amino alcohol or amino acid gen-erates characteristic UV

149 ,1-b]thiazol-5(6H)-ones was synthesized from amino alcohols or amino thiols and keto acids.

150 amic probes designed to rapidly bind amines, amino alcohols, or amino acids and to translate this bin

151 -epi-hyacinthacine B3 from a common anti-1,2-amino alcohol precursor is described.

152 he preparation of several functionalized 1,3-amino alcohol precursors.

153 zation-oxidation reaction of a Boc-protected amino alcohol, prepared from 3-butynol, which led to the

154 Either syn- or anti-amino alcohol products can be obtained by the appropriat

155 on oxidation reaction, to afford substituted amino alcohol products.

156 establishing a route to enantioenriched 1,3-amino alcohol products.

157 Specifically, we synthesized these amino-alcohol products using sequential, copper-hydride-

158 a route to all possible stereoisomers of the amino-alcohol products, which contain up to three contig

159 alysts generated the desired library of beta-amino alcohols rapidly and efficiently.

160 hons where N-benzyloxycarbonyl (Z) protected amino alcohols replace the cyanoethyl group.

161 The amino alcohol residue of the coupling product 4 was oxid

162 neumococci appears to be the role that these amino alcohol residues play in a pneumococcal immune eva

163 transformation to optically active diol and amino alcohol scaffolds.

164 The systematic variation of the 4-position amino alcohol side chain led to analogues that maintaine

165 re a subgroup of glycolipids that contain an amino alcohol sphingoid base linked to sugars.

166 ved using biphasic conditions for a range of amino alcohol starting materials.

167 TC undergo stoichiometric reactions with the amino alcohol substrates to afford ureas and cyclic carb

168 ngle conformation upon condensation with two amino alcohol substrates.

169 on-peptide small molecule PCNA inhibitor, T2 amino alcohol (T2AA), a T3 derivative that lacks thyroid

170 ein box (PIP-Box) interactions, including T2 amino alcohol (T2AA), inhibit translesion DNA synthesis.

171 of a carboxylic acid functionality into the amino alcohol template led to the identification of 12 w

172 Ring-opening of the isoxazolidines gives amino alcohols that can be converted to 1,3-oxazines, re

173 des can be reduced to beta-substituted-gamma-amino alcohols, the major diastereomer of which can be i

174 ]-catalyzed oxidative N-heterocyclization of amino alcohol to form the key amide bond.

175 environmentally friendly method to transform amino alcohols to amino acid salts using just basic wate

176 ysis for amino acids and their corresponding amino alcohols to evaluate any possible isotopic fractio

177 e deoxofluoro-arylsulfinylation of diols and amino alcohols to give fluoroalkyl arylsulfinates and ar

178 ereospecific conversion of syn- and anti-1,2-amino alcohols to their respective syn- and anti-1,2-imi

179 [reaction: see text] Amino alcohols undergo W(CO)(6)-catalyzed oxidative carb

180 e case of adequately substituted enantiopure amino alcohols, up to 95:5 of diastereoisomeric excess w

181 -5,6-dihydro-1,3-oxazines, precursors of 1,3-amino alcohols, using the palladium-catalyzed cyclizatio

182 rescence of 1 can be effectively quenched by amino alcohols via H-bonding with the binaphthol moietie

183 The resulting amino alcohol was alkylated and then deoxygenated using

184 This amino alcohol was formed faster, but its subsequent dehy

185 substituted anti-alpha-(difluoromethyl)-beta-amino alcohol was further elaborated to form (2S,3R)-dif

186 GC separation of a mixture of the six amino alcohols was achieved using a thick stationary-pha

187 highly enantioenriched N-(2-ethylamino)-beta-amino alcohols was developed.

188 n of fluorinated alpha-bromoenones with beta-amino alcohols was elaborated.

189 ral information from small readily available amino alcohols was employed to control relative and abso

190 (fluorenylmethoxy)carbonyl (Fmoc) protected amino alcohols was found to load rapidly and efficiently

191 reaction with ambident nucleophiles such as amino alcohols was highly selective and took place exclu

192 lel to the reaction paths for simple amines, amino alcohols were converted into hydroxy sulfinyl amid

193 lected examples of 1,2-, 1,3-, 1,4-, and 1,5-amino alcohols were converted to the ureas in good to ex

194 sessing N-3 side chains derived from various amino alcohols were designed and synthesized as potent h

195 The requisite amino alcohols were either commercially available (DBFOX

196 These amino alcohols were employed as chiral auxiliaries in th

197 A range of 1-allenyl-2-amino alcohols were obtained with excellent regioselecti

198 Enantioenriched beta-functionalized-gamma-amino alcohols were produced from simple achiral enals i

199 Enantiomerically pure anti-beta-amino alcohols were synthesized from optically pure alph

200 studies was derived from chiral, nonracemic amino alcohols which, themselves, were prepared from ami

201 (13)CN yielded the corresponding diprotected amino alcohol, which was readily converted to 32.

202 ino ketone product with Zn(BH4)2 gives a 1,3-amino alcohol with modest diastereoselectivity.

203 mides, which furnished chiral amines or beta-amino alcohols with 94-->99% ee.

204 es affords epoxy-diols and N-protected epoxy-amino alcohols with excellent enantio- and diastereosele

205 process readily affords synthetically useful amino alcohols with excellent selectivity (dr up to > 20

206 ducts from reaction of simpler vicinal trans-amino alcohols with formaldehyde.

207 nes provided the corresponding (2S,3R)-alpha-amino alcohols with good-to-excellent diastereoselectivi

208 F, leading to a remarkable chiral sensor for amino alcohols with greatly enhanced sensitivity and ena

209 approach for the expeditious construction of amino alcohols with high levels of chemo-, regio-, diast

210 reduced predictably and selectively to anti-amino alcohols with LiAlH(O-t-Bu)3 in ethanol at -78 deg

211 no ketones can be reduced selectively to syn-amino alcohols with LiAlH(O-t-Bu)3 in THF at -5 degrees

212 1 was quenched by four chiral amino alcohols with unprecedentedly high Stern-Volmer co

213 cyclic amines via efficient chlorination of amino alcohols with use of SOCl(2) has been developed.

214 ane and LiBHEt(3) provides syn- and anti-1,3-amino alcohols with very high diastereomeric ratios.

215 es, readily available from the corresponding amino alcohols, yield enantioenriched keto-polyheterocyc