ライフサイエンスコーパス: amino group

1 diminishing the leaving group ability of the amino group.

2 of the hydrogen bond involving the exocyclic amino group.

3 uitin carboxy terminus and a substrate lysyl amino group.

4 (II) coordinated by His33 and the N-terminal amino group.

5 abstraction of the proton from the exocyclic amino group.

6 nd histamine without affecting the 1 degrees amino group.

7 tive silylation at the C-H bond gamma to the amino group.

8 the pocket, and they all lack the anchoring amino group.

9 idue Gly1 becomes trimethylated on the alpha-amino group.

10 r leaves no chemical residue on the reactive amino group.

11 ith a neutral imidazole and an ionized alpha-amino group.

12 rogen bond acceptor and endocyclic secondary amino group.

13 ed by an N-terminal Tyr bearing a free alpha-amino group.

14 r (1)pisigma* driven N-H bond fission on the amino group.

15 ehydes that carry a protected beta- or gamma-amino group.

16 -histidine binds better as the neutral alpha-amino group.

17 y amines and donating a hydrogen bond to one amino group.

18 ia electrochemical oxidation of its terminal amino-group.

19 -poly(ethylene glycol) (DAPEG) with terminal amino groups.

20 g and 4-ring MDA was determined to be on the amino groups.

21 substrates containing primary and secondary amino groups.

22 the rather different reactivities of the two amino groups.

23 imethylate all the N-terminal and side chain amino groups.

24 almost entirely by the presence of purine 2-amino groups.

25 es rapidly with the distance of the terminal amino groups.

26 h free bases: hydroxymethylation of cytosine amino groups.

27 related well with their increasing number of amino groups.

28 inal dialkoxylation with the migration of an amino group (1a,b, 2a-i, 3a,b, and 4) in IBD, whereas wi

29 mocysteine (HCys) belonging to the thiol and amino groups, 2,3-naphthalenedicarboxaldehyde (NDA) can

30 logy on the system, the concentration of the amino groups (5, 10, 20, and 30 mol%) and the cross-link

31 prepare a drug-linker incorporating a basic amino group adjacent to the maleimide, positioned to pro

32 to exhibit a positive relation to increasing amino groups (AEMA).

33 d for some HEW, the regeneration of the free amino groups after loss was observed as a function of ti

34 the thio-alkyl linkers of positively charged amino groups, AMBnTbetaCD, demonstrated significantly st

35 erlayer vertical hydrogen bonding between an amino group and a carboxylic acid group.

36 calization of the first cation to the single amino group and destabilization of the second protonatio

37 mine side chain and the distance between the amino group and each catechol hydroxyl.

38 ong the CHN hydrogen bond, which produces an amino group and initiates polymerization to form a dimer

39 tive to the precise placement of the epsilon-amino group and relatively tolerant of alterations to th

40 This utilizes the amino group and side chain of the N-terminal His residue

41 is behaviour seem to be related to the alpha-amino group and the other functional groups (mainly amin

42 new strategy to modify the lysine's epsilon-amino group and the protein's N-terminal, based on the f

43 l Asp reduces the basicity of the N-terminal amino group and, as hence, its charge, by approximately

44 e ion pairs between lysine side-chain NH3(+) amino groups and DNA phosphate groups at the molecular i

45 served, whereas the distance between the two amino groups and the hydrophobic aryl alkyne moiety can

46 s into the pores through coordination to the amino groups, and the resulting MOF is an efficient phot

47 somers can vary depending on the position of amino groups, and the resulting protonation sites play a

48 R(1) = -H, -CH(3)] covalently bonded to the amino group are esterified with various para-substituted

49 In particular, amino groups are dynamic components of nucleic acids tha

50 First, the alpha-hydroxyl and amino groups are protected with simple protecting groups

51 oselectively without affecting the 1 degrees amino groups (aromatic and aliphatic) of 5-aminoindole,

52 of a readily removable nosyl (Ns) protected amino group as the directing group is a crucial practica

53 tic amino substitution and lateral aliphatic amino groups as electron donors.

54 rbamoyl moieties (R7) were appended on the 7-amino group, as well as a para-methoxy group inserted on

55 gases require a mechanism to deprotonate the amino group at physiological pH to produce an effective

56 isubstituted derivatives bearing a methyl or amino group at position 2, were prepared, and the biolog

57 Protein can be preconjugated via an amino group at the 3' end of a synthetic DNA molecule, s

58 In particular, a free amino group at the 5 position with an ethoxycarbonyl gro

59 Introducing an amino group at the C(3) position of the cholate componen

60 However, an amino group at the meta position results in a PPG with b

61 ivileged biphenyl-2-ylphosphine with a basic amino group at the rarely explored 3' position, the deri

62 embrane-mimetics with the positively charged amino groups being close to the micelle surface and ther

63 ere were marked differences in the levels of amino groups between all heated WPI solutions when measu

64 s, with low signal intensities observed from amino groups but none from biological tissue.

65 d that the PRNTase domain recognizes the C-2-amino group, but not the C-6-oxo group, N-1-hydrogen, or

66 ted chrysenes bearing four aryl, alkynyl, or amino groups by means of the Suzuki, Sonogashira, or Buc

67 emonstrate that the measurement of available amino groups by the OPA method is less impacted than by

68 Herein, we demonstrate that an ortho amino group can also facilitate benzylic C-O bond cleava

69 bread and the significant reduction of free amino groups confirm the presence of interactions betwee

70 ugar amino acids in the presence of a second amino group connected to the carbohydrate core, share st

71 the quantitative metabolite profiling of an amino group containing drug (levothyroxine) and its meta

72 The highest alpha-amino group content was observed in gelatin extracted at

73 Based on free amino groups content measurement, it was found that lact

74 ms in the wild-type protein, suggesting that amino group coordination is absent in the two-nitrogen c

75 Amino group coordination was probed through the creation

76 nwhile, purine nucleosides with an exocyclic amino group could be obtained easily by simple reduction

77 asurement of the rotation rate of individual amino groups could give insight into the dynamic process

78 The amount of free amino groups decreased, with an increase in rate of loss

79 a reduction in the number of available free amino groups, decreased tryptophan intrinsic fluorescenc

80 selective and took place exclusively at the amino group despite the presence of the alcohol function

81 o monitor the changes in the content of free amino groups during postharvest wheat and flour maturati

82 ween reducing sugars and compounds with free amino groups during thermal processing of foods.

83 In particular, the lysine side-chain amino groups exhibited only small changes in the order p

84 The mimic for the n-terminal amino group exhibits a measured binding affinity for 18C

85 his purpose, dimethylation of the N-terminal amino group followed by dimethylation of lysines was use

86 e acceptor ubiquitin and positions its alpha-amino group for nucleophilic attack on the E3 approximat

87 BCAT2 catalyses the transfer of the amino group from branched-chain amino acids to alpha-ket

88 that catalyze the reversible addition of an amino group from glutamate to pyruvate, yielding alanine

89 DNA variants, respectively, remove or add an amino group from the DNA minor groove, with correspondin

90 ss spectrometry analysis by blocking peptide amino groups from isotopic/isobaric labeling and changin

91 The final amino-group-functionalized, linker-equipped antigen was

92 luble fractions had higher (P </= 0.05) free amino groups, GABA content, antioxidant and angiotensin

93 By modifying amino-groups, glycation interferes with folding of prote

94 aphene oxide (GO) and GO functionalized with amino groups (GONH2) on 15 immune cell populations, inte

95 Strongly basic amino groups had low oral absorption in vivo.

96 the Thr-gamma positions, the pKA of the Thr1 amino group has been measured to be 6.3 and hence deprot

97 nucleophilicity more than introduction of an amino group, if one takes into account that hydrazine ha

98 mine is chosen as a mimic for the n-terminal amino group, imidazole and 4-methylimidazole are chosen

99 in the linker of (2R,7R)-2 or at the primary amino group in 17 resulted in high affinity Y4R radiolig

100 mono- and dimethylate, respectively, the N6 amino group in 23S rRNA nucleotide A2058.

101 ing based on electrochemical oxidation of an amino group in acidic media.

102 Cyclitols having an amino group in an alpha configuration at a position equi

103 tion from the Tyr phenol ring and N-terminal amino group in combination with hydrogen-atom transfer f

104 The presence of the free amino group in enamines could be further used for synthe

105 nal alanine could be methylated on its alpha-amino group in human cells, with trimethylation being th

106 However, owing to the basicity of the -amino group in lysine, this strategy generates a number

107 ond DKA branch of bifunctional DKAs, and the amino group in position 7 of quinolinone ring combined w

108 etween Glu-142 O(epsilon2) and the substrate amino group in positioning the substrate with the correc

109 were overcome by Teoc protection of the beta-amino group in the assembly of 3 and Boc-MOM protection

110 sugar acetyltransferases that modify the C-4 amino group in the bacillosamine or perosamine biosynthe

111 [(3)H]Propionylation of one amino group in the linker of (2R,7R)-2 or at the primary

112 orms an intra-residue hydrogen bond with the amino group in the N4 position.

113 s substituted with an equatorial hydroxyl or amino group in the newly formed ring are considerably mo

114 bly of 3 and Boc-MOM protection of the alpha-amino group in the synthesis of 2, enabling the efficien

115 ort for the importance of the exocyclic N(2)-amino group in this reaction was provided by an experime

116 he alphaAsn249, alphaAsn258, and alphaLys352 amino groups in alpha-tubulin, which supported the forma

117 quantify the rotational dynamics of guanine amino groups in G-quadruplex nucleic acids.

118 In this novel biosensor matrix, amino groups in HKCN were used for the enzyme immobiliza

119 nges attributable to the involvement of free amino groups in Maillard-type reactions were inhibited b

120 eals a distinct approach to install aromatic amino groups in metabolites and raises questions about t

121 es four major steps: (i) acetylation of free amino groups in paCOS using a deuterated reagent; (ii) l

122 surface of the graphite were cross-linked to amino groups in the enzyme so as to attach glucose oxida

123 We have reacted accessible amino groups in the enzyme with bifunctional cross-linki

124 Initially, the importance of secondary amino groups in the polyamine chain was studied by the s

125 It is well-established that secondary amino groups in the polyamine moiety of these toxins are

126 no-1,2,4-oxadiazole, which has nitramino and amino groups in the same building block.

127 oxidized due to the presence of phenolic and amino groups in their structures.

128 The content of free amino groups increased during postharvest wheat and flou

129 Acetylation of lysine -amino groups influences many cellular processes and has

130 ydroxyl group in the natural substrate by an amino group is a promising strategy for inhibition becau

131 lic acid, or amine when an electron-donating amino group is at the meta position, as demonstrated in

132 trategy (a net reductive process in which an amino group is installed at a site remote from the origi

133 g M residue is cleaved and the exposed alpha-amino group is mono-, di-, or trimethylated by NRMT, a r

134 Therefore, a free amino group is not required for uphill transport as prev

135 However, if the C4 amino group is replaced with a hydroxy group (to give TD

136 N-Terminal methylation of free alpha-amino groups is a post-translational modification of pro

137 ri-substituted naphthalenes having different amino groups is described.

138 lenediamine derivatives, in which one of the amino groups is part of an urea functional group, has be

139 water-dispersible, few-layer h-BN containing amino groups is presented.

140 ous thin-film that is functionalized with an amino-group is directly applied on the resonant sensor,

141 Its replacement by an amino group led to decreased activity.

142 ore and replacement or substitution of the 2-amino group led to loss of antimalarial activity.

143 and 14.5 kDa; however, the reduction of free amino group levels and the increase in chromatogram area

144 These results suggest that the n-terminal amino group may compete with the Lys side chains for 18C

145 into proximity for the radical-mediated 1,2-amino group migration.

146 , theory suggests that binding to n-terminal amino group mimic is weaker than that to all of the Lys

147 Initially, amino group modified gold nanoparticles (AuNPs) were cov

148 , the introduction of additional hydroxy and amino groups mostly cancelled the inhibitory effect, whi

149 xygen atoms of the carboxylate group and the amino group (mu3 coordination), whereas at lower coverag

150 st, the unmethylated cytosine's exocyclic N4 amino group (NH2) and its ring carbon C5 atom hydrogen b

151 erization of aniline increases the number of amino groups (-NH2) for antibody immobilization.

152 th a cage surface bearing positively charged amino groups (-NH3(+)) and directly compare it with a si

153 ile transfer of primary (-NH2) and secondary amino groups (-NHR) to heteroaryl- as well as arylcuprat

154 capacities between 0.44 and 1.01 accessible amino groups/nm(2) membrane are achieved.

155 rotected (S)-valine was first coupled to the amino group of (S)-m-triisopropylsilyloxyphenylalanine t

156 l-CoA synthetases by acetylating the epsilon-amino group of a conserved, catalytic lysine residue.

157 PLP forms a Schiff base with the -amino group of a lysine residue of PLP-dependent enzymes

158 ized, of which NatA will acetylate the alpha-amino group of a number of nonmethionine amino-terminal

159 This mixed anhydride is attacked by the -amino group of a specific lysine present on a highly con

160 tide purine, hydrogen replaces the exocyclic amino group of A.

161 DNA can form a covalent adduct with the N(6)-amino group of adenine residues on the opposing strand.

162 DFT calculations revealed that the tertiary amino group of AM reacts with the phenol compounds under

163 Methylation of the 8-amino group of ammosamide B was an exception, resulting

164 tudy that the proteasome can use the epsilon-amino group of an N-terminal lysine residue in transpept

165 upling the carboxyl group of 3b and the free amino group of arylated diazeniumdiolated piperazine 4.

166 f FNP undergoes nucleophilic substitution by amino group of biomolecule and results in its covalent i

167 intrinsic interactions between the cationic amino group of chitosan and iodide ions.

168 residue was connected to the exocyclic N(6)-amino group of dA.

169 ribose adduct attached to the exocyclic N(2)-amino group of dG.

170 threonine is amide-linked to the side chain amino group of diaminopimelic acid within the peptidogly

171 The amino group of DTBA enables its isolation by cation-exch

172 subsequent imidazolinylation of the epsilon-amino group of each lysine, peptides with highly basic s

173 mutant and a specific surface lysine epsilon-amino group of ErbB2, leading to near quantitative cross

174 arly shows the crucial role of the exocyclic amino group of G in sequence-specific recognition.

175 e SLC5 family, interacts with the main chain amino group of G444, capping the alpha-helix of transmem

176 ed that carbamate functionalization of the 4-amino group of gemcitabine significantly reduced (>23-fo

177 hancing the nucleophilicity of the attacking amino group of glucosamine 1-phosphate.

178 tivation, can react with the exocyclic N (2) amino group of guanine to generate four stereoisomeric B

179 er of a methyl group from SAM to the epsilon-amino group of histone H3K36.

180 f pyridoxal phosphate, transfers the primary amino group of l-Glu to C-4'' of UDP-4-keto-6-deoxy-d-Gl

181 Here, we show that ALD1 transfers the alpha-amino group of l-Lys to acceptor oxoacids.

182 Acetylation of the epsilon-amino group of Lys-40 of alpha-tubulin marks stable micr

183 tonated donor, which is probably the epsilon-amino group of Lys-96 or a water molecule in its vicinit

184 ncy of conRl-B for NR2B, whereas the epsilon-amino group of Lys8 contributed to discrimination in blo

185 n that reversible acetylation of the epsilon-amino group of lysine provides an additional means of mo

186 nd ubiquitination both modify the varepsilon-amino group of lysine residues, we investigated whether

187 linked to target proteins at the varepsilon-amino group of lysine residues.

188 ary amines such as the N-terminus or epsilon-amino group of lysine.

189 but also other acyl groups from the epsilon-amino group of lysines in histones and other substrate p

190 o determine the pKa for the N-terminal alpha-amino group of methionine1 of ubiquitin for the first ti

191 ranslational modification in which the alpha amino group of mono-l-glutamine is covalently linked to

192 m product that can react with the peripheral amino group of purine bases generating bulky DNA adducts

193 , and Asp277 on deprotonation of the epsilon-amino group of reactive Lys12 for direct attack of the a

194 l modification of both Lys-773 and the alpha-amino group of Ser-764.

195 e keto group of the alpha-keto acid, and the amino group of the amino acid.

196 ive addition of an acetyl group to the alpha-amino group of the amino-terminal amino acid of proteins

197 sm whereby E27 specifically recognizes the 2-amino group of the bound substrate and toggles the relea

198 that the l-conformation and protonated alpha-amino group of the first residue were critical for N-deg

199 ilic aliphatic chain attached on the epsilon-amino group of the lysine mycobactin core, which is tran

200 ion of the Ap aldehyde residue with the N(2)-amino group of the opposing guanine residue in 5'-CAp se

201 nt I most likely interacts with the terminal amino group of the substrate side chain.

202 t point II bind the C(alpha) carboxylate and amino group of the substrates, respectively.

203 th 1 and 2 to ascertain the influence of the amino group of this FLP-catalyzed transformation.

204 s provides strong evidence that the terminal amino group of Thr1 serves as the base in the first step

205 dition with the pKa-perturbed Lys-15 epsilon-amino group of TTR.

206 an acetyl moiety from acetyl-CoA to the C-4 amino group of UDP-d-viosamine.

207 carboxy terminus of ubiquitin to the epsilon-amino group of, in most cases, a lysine of the substrate

208 nd to -SO3H-modified alumina via the primary amino groups of both GS moieties.

209 -isothiocyanate (FITC) was conjugated to the amino groups of bovine serum albumin (BSA).

210 PEF caused a decrease in available free amino groups of BSA in presence and absence of MGO, sugg

211 he pattern of acetylation suggested that the amino groups of chitosan and the polar residues Glu-16 a

212 It reacts with exocyclic amino groups of DNA nucleobases and forms adducts/lesion

213 i of proteins/peptides and at the side chain amino groups of lysine and arginine residues.

214 Ubc9 catalyzes the conjugation of SUMOs to -amino groups of lysine residues in target proteins.

215 the attachment of a polyubiquitin chain to -amino groups of lysine residues.

216 orophore was selectively transferred between amino groups of lysines that reside within ~10 A at the

217 e1 is capable of arginylating not only alpha-amino groups of N-terminal residues but also gamma-carbo

218 results in the amide bond formation between amino groups of PANI and COOH groups of anti-Cab.

219 In contrast, the pKa of N-terminal alpha-amino groups of proteins can vary significantly, with re

220 e-mediated catabolism of thiocyanate to free amino groups of proteins.

221 e moieties were prepared by derivatizing the amino groups of the dendrimer with 4-carboxy-benzenesulf

222 Pluronic P85 attached randomly to the lysine amino groups of the hormone.

223 The content of free amino groups of wheat flour was analysed immediately aft

224 cross-links via reaction with the exocyclic amino group on a nearby 2-deoxyguanosine or 2-deoxyadeno

225 Amino group on anti-EpCAM antibody was covalently bound

226 is revealed that Scabin labels the exocyclic amino group on guanine bases in either single-stranded o

227 complexes containing base analogs that the 2-amino group on guanine is the primary molecular determin

228 Due to the presence of a primary amino group on its side chain, lysine is particularly pr

229 s at low energy, which produces high-density amino group on the SiNx surface within a short duration

230 The presence of a suitably protected p-amino group on the styrene moiety could be exploited, af

231 ttom-up strategy employs labeling of primary amino groups on peptide level.

232 igonucleotides have been developed that bear amino groups on the sugar or base.

233 anes were chemically derivatized to generate amino groups on the surface maintaining their pysico-opt

234 t introduction of multiple electron-donating amino groups onto a simple o-(phenylazo)aniline platform

235 play a reactive functionality (either a free amino group or carboxylic acid moiety) for further bioco

236 ologs having the chirality center nearby the amino group or the aromatic ring.

237 With a higher number of amino groups per silane molecule increased loading capac

238 ifferent aminosilanes with one, two or three amino groups per silane molecule, namely 3-aminopropyltr

239 Alkylation of the 4-amino group preferentially improves the activity against

240 ssess the increased content of unsubstituted amino groups present in thermally stressed and autoclave

241 nitro groups to amines; in theory, the only amino groups present will have originally been nitro gro

242 or the fluorescent state upon removal of the amino group, present in guanine but absent in hypoxanthi

243 ar arrangement by acetylating the N-terminal amino group prior to electrochemical oxidation and cleav

244 Whereas the amino groups proved to be critical to its inhibitory act

245 he highest pKa values ever reported for this amino group, providing a rational for the observed need

246 conditions, SOF4 reliably seeks out primary amino groups [R-NH2 ] and becomes permanently anchored v

247 Initially, amino groups react with reducing carbohydrates, yielding

248 H was determined based on the amount of free amino groups released.

249 nd hydrogen-bond interactions in restraining amino-group rotation.

250 h systems lowers the basicity of the pushing amino-group(s) and increases the basicity of the pulling

251 itrogen bases containing one or more pushing amino-group(s) directly linked to a pulling cyano, imino

252 tential indicate that reactions involving an amino group should occur more easily for the 3-amino- th

253 a covalent postsynthetic modification at the amino group sites within the MOF.

254 roups, which through hydrogen bonding to the amino group successfully overrode steric effects and dir

255 yzing the covalent modification of aliphatic amino groups, such as the lysine (Lys) side chain, by nu

256 O with a diazonium salt bearing a protonated amino group that can further immobilize gold nanoparticl

257 the functionality at the surface; revealing amino groups that are utilized to bind biomolecules in t

258 Lysine contains two amino groups that theoretically may both participate in

259 Among the four protecting groups of the o-amino group, the o-nitro protecting group is the only ch

260 With increasing number of amino groups, the compounds tend to form hydrogen bonds,

261 poration in melanoidins and are inhibited by amino groups through Maillard reaction.

262 es of ubiquitin, or via its N-terminal alpha-amino group to build linear ubiquitin chains.

263 Therefore, the ability of the N-terminal amino group to compete for 18C6 complexation is best for

264 ation reagent, which oxidizes the N-terminal amino group to provide a uniquely reactive aldehyde or k

265 g a proton transfer from the carboxyl to the amino group to provide the corresponding alkylammonium i

266 d 1,4-nucleophilic additions of the aromatic amino group to quinones resulting in imine and anilinoqu

267 Glucose spontaneously reacts with hemoglobin amino groups to produce unstable Schiff base complexes t

268 The role of the amino group twisting ability in the BODIPY photophysics

269 on of the olefin on the face proximal to the amino group under hydrogen-bonded direction from the in

270 ium(II)-aryl complex and a weak base, lysine amino groups underwent C-N bond formation at room temper

271 selective acylation of the l-ornithine alpha-amino group using activated succinimidyl esters.

272 ily, which does not contain the highly basic amino group usually present in other sigma1R ligands, sh

273 ondensation (SVAC), (ii) installation of the amino group via aza-Michael addition/elimination, and cr

274 3-acetal, stereospecific introduction of the amino group via the azide, and resolution of a racemic c

275 n iodocinnabarinic acid diester in which the amino group was masked with two Boc substituents, a Cu(I

276 erence was observed depending on whether the amino group was substituted by a phenyl or an alkyl (usu

277 synthesized by CcTAM revealed that the alpha-amino group was transferred to Cbeta of the phenylpropan

278 The reduction in the remaining free amino groups was about 5% at a(w) 0.50 and 6% at a(w) 0.

279 tion 8 poly(amido amine) dendrimer with 1024 amino groups was labeled with an azide group, and then,

280 A significant increase in free amino groups was observed in TBs with a dose-response ef

281 h different amino acids containing secondary amino groups was tested under simulated in-vitro conditi

282 d arginines, bearing spacers with a terminal amino group, were incorporated into the peptides by stan

283 depends to some extent on the nature of the amino group, whereas the reactivity has been shown to be

284 tively introduced by phenolic groups than by amino groups which have been much more commonly used so

285 and 50, rather than modifying the N-terminal amino group, which is instead alphaN-acetylated in cells

286 deprotonation of thiol/selenol moiety by the amino group, which not only increases the strength of ha

287 Such oligomers carry free amino groups, which are positively charged at neutral pH

288 multiple positive charges derived from basic amino groups, which contribute to poor bioavailability,

289 reduce the negative inductive effect of the amino group while simultaneously activating the carboxyl

290 ith aryl groups in the alpha-position to the amino group, while (2-methylcyclopropyl)ethanone gives a

291 BS was limited, with slight changes in free amino groups, while GABA, total phenolic compounds and a

292 ter reagent (SPAER), and those peptides with amino groups will be selectively and covalently captured

293 This was demonstrated by replacing the amino group with a more basic guanidine one while mainta

294 ion C4 of the benzene ring to substitute the amino group with an hydroxyl group.

295 ltryptophan occurs at Calpha rather than the amino group with NosL Y90A and replacing the substrate a

296 actions of these products or the reaction of amino groups with other reactive substances (e.g. alpha-

297 o, one, two (cis and trans), three, and four amino groups, with the remaining para substituents carbo

298 through isopeptide bonds at a lysine epsilon-amino group within a specific amino acid sequence.

299 le reaction between aldoses (or ketoses) and amino groups yielding relatively stable Amadori (or Heyn

300 um ion stabilized by the electron-donating 4-amino group yields the final cross-linked product with h