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1 KSHV-infected cells, which binds through its amino terminal domain.
2 f a conserved triple serine motif within the amino-terminal domain.
3 nd stability of the intrinsically disordered amino-terminal domain.
4 e open reading frame (ORF) within the common amino-terminal domain.
5 fs, referred to as LR1 and LR2, in the EBNA1 amino-terminal domain.
6 responsible for substrate specificity in the amino-terminal domain.
7 Down-regulation of TBK1 requires the amino-terminal domain.
8 diated crosslinking of annexin-1 through its amino-terminal domain.
9 glutathione to the APS reduction site on the amino-terminal domain.
10 de and one within the variable region of the amino-terminal domain.
11 f a basic amino acid (HKH) motif on the Cx40 amino-terminal domain.
12 uman GLI2 mutants, now containing the entire amino-terminal domain.
13 n the positively charged residues within the amino-terminal domain.
14 ins 6 and 7 functionally cooperated with the amino-terminal domain.
15 nded domain and papain-like proteases by its amino-terminal domain.
16 y bioinformatics and mutagenesis in the TGB1 amino-terminal domain.
17 be an essential triple-arginine motif in the amino-terminal domain.
18 mainly contributed by the residues from the amino-terminal domain.
19 t the interface between the GluN1 and GluN2B amino-terminal domains.
20 may stem from differential regulation by the amino-terminal domains.
21 n-heparin-binding regions of the fibronectin amino-terminal domains.
22 panning domain to productively interact with amino-terminal domains.
23 separation of the two dimeric extracellular amino-terminal domains.
24 -hybrid assay through their highly conserved amino-terminal domains.
25 specific core-type binding sites whereas the amino-terminal domain (1-70) is responsible for cooperat
26 n constructs have revealed the importance of amino-terminal domain (46-290) for memory suppression wh
27 receptor (AR) is recruited by ELK1, via its amino-terminal domain (A/B), as a transcriptional co-act
30 a negative charge substitution (N2E) in the amino terminal domain allow unequivocal separation of th
31 recombinant fragments encoding the utrophin amino-terminal domain alone or in combination with vario
33 ing cross-over between the twofold symmetric amino terminal domain and a twofold symmetric ligand bin
35 s of activity that reside between the GluN2C amino terminal domain and the GluN2C agonist binding dom
36 ccurs between the extracellular zinc-binding amino terminal domain and the glutamate-binding domain o
37 dicted from the primary sequence of P3H1: an amino-terminal domain and a carboxyl-terminal domain cor
39 , uncharged linker between the lethal factor amino-terminal domain and diphtheria toxin A chain exped
41 e report the crystal structure of the capsid amino-terminal domain and examine the self-association p
43 ecular interaction mediated by Arg-61 in the amino-terminal domain and Glu-255 in the carboxyl-termin
44 omains were found to face the cytoplasm (the amino-terminal domain and loops B and D), and the other
45 monomeric nucleocapsid (N) proteins with its amino-terminal domain and positions them for assembly in
46 sponses through disruption or removal of the amino-terminal domain and relief of Zn(2+) inhibition.
48 is an enhanced binding affinity between the amino-terminal domain and the CaM-binding sequence of th
49 tion of new contact interactions between the amino-terminal domain and the CaM-binding sequence that
50 rine protease motif (GDSGSP) in the secreted amino-terminal domain, and the predicted peptide shows m
51 o acid (HKH) motif at positions 15-17 on the amino terminal domain are essential for this inhibitory
52 r identified the juxtamembrane region of its amino-terminal domain as the region of covalent attachme
53 of isolated water-soluble ligand-binding and amino-terminal domains, as well as solving the first cry
55 cocrystallization of this molecule with the amino terminal domain (ATD) of the hmGlu2 receptor prote
56 g through the entire molecule composed of an amino terminal domain (ATD), a ligand-binding domain (LB
59 uN2A-GluN2D chimeric subunits implicates the amino-terminal domain (ATD) as a strong determinant of a
60 of modulator compounds to the extracellular amino-terminal domain (ATD) distinct from the L-glutamat
61 gulated by binding of small compounds to the amino-terminal domain (ATD) in a subtype-specific manner
65 olutionarily distinct structural domains: an amino-terminal domain (ATD), a ligand-binding domain (LB
71 In the absence of Ro, the GluN2A and GluN2B amino-terminal domains (ATDs) adopt "closed" and "open"
72 itive homo- and hetero-dimerization of their amino-terminal domains (ATDs) is a key step controlling
75 were explored using a homology model of the amino-terminal domain based on a crystal structure of an
76 perties of Int appear to be intrinsic to the amino-terminal domain because the phenotype of L64A was
77 r nucleoprotein complexes that form when its amino-terminal domain binds to arm-type DNA sequences th
79 enhances the transcriptional activity of the amino-terminal domain by increasing the alpha-helical co
80 Our results indicate that ligand binding to amino-terminal domains can alter the behavior of synapti
81 NAP) have shown that the conformation of the amino-terminal domain changes substantially between the
82 ermine, an allosteric potentiator, opens the amino-terminal domain cleft of both the GluN2B subunit a
83 ncident replacement of the deduced cytosolic amino-terminal domain CoaT(N) with ZiaA(N) (in ziaR-(p)
86 COP9 signalosome, eIF3) or MPN (Mpr1, Pad1, amino-terminal) domains constitute the structural core o
89 chinery depends on the integrity of both the amino-terminal domain, containing a number of putative R
92 s and found that only the construct with the amino-terminal domain deleted, Hsp93-DeltaN, had reduced
93 and binding of allosteric modulators to the amino-terminal domain determine the open probability of
94 , binds at the interface of the GluN1/GluN2B amino terminal domain dimer by an induced-fit mechanism.
96 -associated protein and demonstrate that its amino-terminal domain disengages p53 from Numb, triggeri
97 ompartment was mediated by its profilin-like amino-terminal domain, even in the absence of protein pr
98 ging charge or polarity), while those in the amino-terminal domains exhibited neither a preponderance
99 rmore, the Arabidopsis HDR contains an extra amino-terminal domain following the transit peptide that
100 rix protein Megator requires its coiled-coil amino-terminal domain for spindle matrix localization, s
102 spectroscopy that the Escherichia coli NusG amino-terminal domain forms a complex with the acidic re
103 how allosteric inhibitors, acting within the amino terminal domain, further stabilize the LBD layer.
104 40 (Cx40) gap junctions, and two cytoplasmic amino-terminal domain glutamate residues are essential f
105 ress the problem, we generated the GPIbalpha amino terminal domain (GPIbalpha-N) fully sulfated on th
106 Pairwise comparisons between Kunitz and amino-terminal domain groups demonstrated that dN was co
108 This region of the protein includes the amino-terminal domain I as well as the subsequent linker
110 demonstrated that phosphorylation within the amino-terminal domain I is essential for transcription,
111 In correlation, a series of deletions in the amino-terminal domain impair nuclear as well as cytoplas
112 the interface of the ligand binding and the amino terminal domains in a homology model of GluN1/GluN
113 ny unresolved issues include the role of the amino-terminal domain in AMPA receptor signaling and the
114 and 349-402 for synaptic suppression, while amino-terminal domains including NLS1 are dispensable.
115 r the suppression of axonal branching, while amino-terminal domains including NLS1 are dispensable.
116 by determining the solution structure of its amino-terminal domain (Int(N), residues Met1 to Leu64) i
117 d and twisted fashion through interdigitated amino-terminal domain interactions, form a kinked centra
118 inal DNA binding domain and a less conserved amino-terminal domain involved in binding small-molecule
119 y interaction between carboxyl and hexameric amino terminal domains is shown to generate the curvatur
123 with the inner envelope membrane through its amino-terminal domain is important for the functions of
124 rR with only one active site cysteine in the amino-terminal domain is inactivated at rates comparable
130 binds to m(6)A-containing mRNA, whereas the amino-terminal domain is responsible for the localizatio
131 which encodes a 21-amino-acid insert in the amino-terminal domain, is a key determinant of GluN1/Glu
132 length hTDP-43, but not a mutant lacking its amino-terminal domain, led to progressive loss of ommati
133 ls when the lethal factor (LF) binds via its amino-terminal domain, LF(N), to oligomeric forms of act
135 actin helix at the pointed end, whereas the amino-terminal domain may bind to only one actin subunit
137 DG-like TNKS-interacting motifs in the EBNA1 amino-terminal domain mediated binding with the ankyrin
138 employing recombinant human mGlu2/3 receptor amino terminal domains, molecular modeling, and site-dir
139 the potential LPS-binding site(s) within the amino-terminal domain, mutations were introduced into C1
140 merlin truncation mutants with impaired GST-amino-terminal domain (N-term or NTD)/GST-carboxy-termin
141 , PrP(Sc) We examined the role of the PrP(c) amino-terminal domain (N-terminal domain [NTD], amino ac
142 m rabbits immunized with the non-collagenous amino-terminal domain (NC1) of human type VII collagen,
143 rate that plasmin can cleave the native NR2A amino-terminal domain (NR2A(ATD)), removing the function
144 r with each protomer containing an L30e-like amino-terminal domain (NTD) and a SPOUT methyltransferas
145 re clearly define the roles of the HTLV-1 CA amino-terminal domain (NTD) and CA CTD in particle bioge
146 a methionine residue at the junction of the amino-terminal domain (NTD) and the carboxy-terminal dom
148 mitotic CDK, Clb2/Cdc28, binds tightly to an amino-terminal domain (NTD) of Cdc6, and that Cdc6 in th
149 tains a proteolytically processed 38-residue amino-terminal domain (NTD) that is essential for basal-
150 g motifs and an approximately 200-amino acid amino-terminal domain (NTD) with known functions includi
151 e we identify missense mutations in Hsp104's amino-terminal domain (NTD), which is conserved among Hs
153 has additional cellular targets besides the amino terminal domain of clathrin and thus cannot be use
154 r of the interaction of amphiphysin with the amino terminal domain of clathrin, and shown to inhibit
155 e residues, E9 and E13, from the cytoplasmic amino terminal domain of Cx40 with the corresponding lys
158 We created a series of mutants within the amino terminal domain of GluN1 that change patient antib
159 udies have added S1PR2 as a receptor for the amino terminal domain of Nogo-A, and have demonstrated s
162 tedly, the structural similarity between the amino-terminal domain of 10-formyltetrahydrofolate dehyd
166 the virulent strain H37Rv, in contrast, the amino-terminal domain of annexin-1 was removed by proteo
167 creasing the conformational stability of the amino-terminal domain of apoE increased aggregation rate
169 endoplasmic reticulum, lysines in the short amino-terminal domain of BST2 are ubiquitinated by K5, r
171 cysteine binding motif within helix A in the amino-terminal domain of calmodulin (CaM) that permits t
172 ructural changes that selectively modify the amino-terminal domain of CaM from those that modulate th
174 egion of natural peptide ligands bind to the amino-terminal domain of class B GPCRs, how their biolog
178 ween the Cu(+)-metallochaperone Atx1 and the amino-terminal domain of Cu(+)-transporter PacS(N) detec
181 edicted to code for a protein containing the amino-terminal domain of DNAJB1, a homolog of the molecu
182 ne-distal immunoglobulin-variable (IgV)-like amino-terminal domain of each is crucial to these intera
183 ely weak protein-protein complex between the amino-terminal domain of enzyme I and the phosphocarrier
186 nteraction was disrupted by mutations in the amino-terminal domain of Gag3, which is predicted to lie
192 we have solved the crystal structure of the amino-terminal domain of human Su(fu)(27-268) at 2.65 A
194 and also show that a potential alpha-helical amino-terminal domain of LANA was important for HIF-1alp
195 erent clones contained parts of the Q/N-rich amino-terminal domain of Mca1p/Yca1p with the Sup35 part
196 ineered a partially humanized variant of the amino-terminal domain of mouse apoE (T61R mouse apoE) to
197 lex nucleated by the binding of Nam1p to the amino-terminal domain of mtRNA polymerase (Rpo41p).
198 tment on a recombinant fusion protein of the amino-terminal domain of NR2B revealed that tPA-mediated
199 n of intermolecular interactions between the amino-terminal domain of one protomer and the linker reg
200 lage-associated protein is homologous to the amino-terminal domain of P3H1 and also contains four CXX
201 human homologue of RNF5 associates with the amino-terminal domain of paxillin, resulting in its ubiq
203 olated mutations in the poorly characterized amino-terminal domain of PerA which affect its ability t
206 ligand, and in this study we found that the amino-terminal domain of Rns does not form homodimers in
207 We determined the x-ray structure of the amino-terminal domain of SAS-6 from zebrafish, and we sh
209 f human Shh, showing that a highly conserved amino-terminal domain of Shh is important for the format
211 ngly disrupting binding, indicating that the amino-terminal domain of Su(fu) likely impacts Gli bindi
212 t the structure is remarkably similar to the amino-terminal domain of the alpharetrovirus, avian leuk
213 e use budding yeast to show that a conserved amino-terminal domain of the Dpb2 subunit of Pol epsilon
214 e conferred by the lid region located in the amino-terminal domain of the enzymes, whereas surprising
215 in CHO cells, we show that the cleft of the amino-terminal domain of the GluN2B subunit, which has a
223 alpha/beta induction, but also implicate the amino-terminal domain of the protein in this function.
226 to a three-dimensional homology model of the amino-terminal domain of the rho1 GABA(C) receptor, they
228 its located two regions in the extracellular amino-terminal domain of the subunit: the E loop (a loop
230 Understanding of the conformation of the amino-terminal domain of these receptors has been substa
231 ized for the cysteine-rich, disulfide-bonded amino-terminal domain of these receptors, detailed insig
232 pite recent solution of the structure of the amino-terminal domain of this receptor and that of sever
236 alysis of the chimeras demonstrated that the amino-terminal domain of Vpx is important for the enhanc
242 udied high-affinity interactions between the amino-terminal domains of GluA2 and GluA3 AMPA receptors
249 -RAG2 heterotetramer is 'Y-shaped', with the amino-terminal domains of the two RAG1 chains forming an
250 nd-binding cleft within the disulfide-bonded amino-terminal domains of these receptors, with the pept
251 n contrast, substitution of either the GLUT4 amino-terminal domain or the large cytoplasmic loop betw
253 a more extensive set of interactions in the amino-terminal domain plays some role in the actions of
254 It spans both ribosomal subunits with its amino-terminal domain positioned adjacent to the aminoac
257 members and may help to orient the receptor amino-terminal domain relative to its helical bundle reg
258 nteraction and cell-to-cell movement and the amino-terminal domain required for importin-alpha intera
259 crystal structure at 2.4 A resolution of the amino-terminal domain (residues 30-340) of human symplek
260 owledge of the structure and function of the amino-terminal domains reviewed here may enable targetin
261 served proteins that are characterized by an amino-terminal domain rich in leucine residues followed
263 tization is accompanied by disruption of the amino-terminal domain tetramer in AMPA, but not kainate,
264 , the detailed conformational changes in the amino-terminal domain that accompany ATP binding, and th
265 r family members such as Cre and Flp, has an amino-terminal domain that binds "arm-type" DNA sequence
266 rminal ends of the Gli proteins and a unique amino-terminal domain that binds the carboxy-terminal ta
267 imals are structurally conserved and have an amino-terminal domain that functions in transport and a
268 dyad protease, with the Lys recruited to the amino-terminal domain that is itself not present in most
269 ding sites located within the noncollagenous amino-terminal domain that may play a role in the functi
271 ydrogenase domain, but rather depends on the amino-terminal domain that recruits PXDLS containing tar
272 oint mutation in AtTPS6 encoding a conserved amino-terminal domain, thought to catalyze trehalose-6-p
273 ring-shaped hexameric self-assemblies via an amino-terminal domain through its phosphorylation or lig
274 of the N-methyl-d-aspartate (NMDA) receptor amino terminal domain to explore the binding mode of mul
275 DNA binding protein that binds via its small amino-terminal domain to high affinity arm-type DNA site
276 of helix A associated with activation of the amino-terminal domain to promote high-affinity binding t
279 ter to its binding site in the extracellular amino-terminal domain triggers structural changes in dis
280 In a proposed model for AMPAR assembly, the amino-terminal domain underlies the formation of a dimer
283 dence that the inherent conformations of the amino-terminal domains vary based on the subunit and mat
284 e demonstrate that peptides corresponding to amino terminal domains VI and V of netrin-1 repel migrat
287 (125) within the same region of the receptor amino-terminal domain was identified as the site of labe
289 Three APC isoforms that differ in their amino-terminal domains were evaluated by gene transfer e
291 s heavily glycosylated domains to expose the amino-terminal domain, which is a ligand for NPC1 and re
292 es with differing specificities and that the amino-terminal domain, which is unique to this class of
293 resolve the crystal structure of ACF7's NT (amino-terminal) domain, which mediates F-actin interacti
294 28 AtCHX genes after revision consists of an amino-terminal domain with 10 to 12 transmembrane spans
296 ylation by PAC-1 requires association of its amino-terminal domain with ERK2 that results in catalyti
298 These data suggest that interactions of the amino-terminal domain with the rest of the PrP(c) molecu
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