ライフサイエンスコーパス: amino-terminal region

1 the carboxyl-terminal region) and Dact1 (the amino-terminal region).

2 inding of AbetaPP through its cysteine-rich, amino-terminal region.

3 y inhibit HIV-1 entry by binding to the gp41 amino-terminal region.

4 aminase family characterized by their unique amino-terminal region.

5 nct to RGSZ1 that encodes a newly identified amino-terminal region.

6 s 1 to 380 of HCF-1 as well as an additional amino-terminal region.

7 otyrosine binding domain and Tyr(146) at the amino-terminal region.

8 irectly with the plasma membrane through its amino-terminal region.

9 main, but also possesses an extremely acidic amino-terminal region.

10 site is formed by parts of the extracellular amino-terminal region.

11 new signal peptide sequence with an extended amino-terminal region.

12 ding) sites, many of which are located in an amino-terminal region.

13 ent modification of cysteine residues in the amino-terminal region.

14 d that the mass difference originated in the amino-terminal region.

15 ized in plant cells is located in the MAN2B1 amino-terminal region.

16 inal region, and can form homodimers via its amino-terminal region.

17 n of a 17-amino-acid segment from within the amino-terminal region.

18 SSAV infection of E36 cells lies within its amino-terminal region.

19 bstitutions were introduced in the conserved amino-terminal region.

20 by using galectin-3 mutants with a truncated amino-terminal region.

21 ssociated proteins MTA1 and MTA2 through the amino-terminal region.

22 bunit interactions involving a non-conserved amino-terminal region.

23 that are presented within its highly acidic amino-terminal region.

24 gion and the other located within its unique amino-terminal region.

25 at a highly conserved K residue in the RAG1 amino-terminal region.

26 ugh the 30-amino acid stretch comprising the amino-terminal region.

27 mbled into disulfide-linked multimers by the amino-terminal regions.

28 ue of DeltaF508 dependent folding defects in amino-terminal regions.

29 e giant helical HEAT repeat domains in their amino-terminal regions.

30 ibition of the RNAp by Gp2 also involves the amino terminal region 1 domain of the RNAp promoter spec

31 pregulating these viral promoters, while the amino-terminal region (435 amino acids) exhibited little

32 F-2alpha kinases, PEK contains a distinctive amino-terminal region 550 residues in length.

33 to the following peptide regions of rat C5a: amino-terminal region (A), residues 1-16; middle region

34 the Drosophila E74/human Elf-1 subfamily, an amino-terminal region (A-region or Pointed domain) homol

35 n the loops was roughly equal to that of the amino-terminal region, a domain considered less importan

36 binding domain, while the second maps to the amino-terminal region (aa 1 to 85) common to both IE2 86

37 nsive sequence homologies in the DNA-binding amino-terminal regions (about 50 residues).

38 r localization signal resides in a conserved amino-terminal region adjacent to the DNA binding domain

39 tivation functions (AFs)--one located in the amino-terminal region (AF-1) and the second located in t

40 inds filamentous actin (F-actin) through its amino terminal region (amino acids 1-66, N66).

41 Here, we show that the amino-terminal region (amino acids 1-450) of CBP specifi

42 ween cysteine residues at position 35 in the amino-terminal region and 481 in the carboxyl-terminal r

43 mbrane proteins are comprised of a divergent amino-terminal region and a very homologous carboxyl-ter

44 ese include residues in the highly conserved amino-terminal region and basic residues in the D1 and E

45 m alternatively spliced mRNAs, that share an amino-terminal region and differ in the carboxy-terminal

46 the reciprocal chimeras, indicated that the amino-terminal region and extracellular loops 1 and 2 of

47 rs from that of p70alpha in the noncatalytic amino-terminal region and in the carboxyl-terminal tail,

48 li-1 and Fli-1 interact with CBP through its amino-terminal region and inhibit the CBP-dependent tran

49 e third allele contains two deletions in the amino-terminal region and is a null allele.

50 The heme-binding domain of Shp is in the amino-terminal region and is functionally active by itse

51 he channel distant in primary structure, the amino-terminal region and the carboxyl-terminal region c

52 Coexpression in the same cells of the amino-terminal region and the disulfide-rich carboxyl-te

53 he relative juxtaposition of the hydrophobic amino-terminal region and the opening to the catalytic c

54 with PDE4D5, one associated with its extreme amino-terminal region and the other located within the c

55 a novel cysteine-rich domain residing in the amino-terminal region and two LIM domains with regular s

56 potential nuclear localization signal in the amino-terminal region, and five putative transmembrane d

57 Amino-terminal regions appear to modulate thyroid hormon

58 oxyl-terminal transactivation domains, their amino-terminal regions are completely divergent.

59 le metabolites (most likely depending on the amino-terminal region around the highly conserved cystei

60 amphipathic (&agr;)-helical domains in their amino-terminal regions, as described originally for Bear

61 that specifically cleaved A beta 1-40 in the amino terminal region between Arg5 and His6.

62 mKsr-1 or its carboxy-terminal, but not its amino-terminal region, blocked serum-induced DNA synthes

63 LigA and LigB are conserved at the amino-terminal region but are variable at the carboxyl-t

64 Brk DNA binding activity was localized to an amino-terminal region containing a putative homeodomain.

65 The amino-terminal regions containing the RING-CH domain of

66 The amino-terminal region contains an eag domain, which is c

67 The amino-terminal region contains the hallmarks of a serine

68 e C terminus of SNAP-25, as well as from the amino-terminal region decreased binding to Gbeta(1)gamma

69 dues (K6, K7, K13, Y14, R17, and Y18) in the amino-terminal region decreased cell growth; the Y14 mut

70 Transgenic mice with amino-terminal regions deleted remained healthy at >400

71 old, consistent with the hypothesis that the amino-terminal region, disordered in the crystal structu

72 ass B GPCRs, how their biologically critical amino-terminal regions dock to the receptor is unclear.

73 e hp55 gamma protein is composed of a unique amino terminal region followed by a proline-rich motif a

74 ntains one Src homology (SH) 3 domain in its amino-terminal region followed by a region containing bi

75 3 requires its own zinc finger motifs and an amino-terminal region for its X association.

76 The amino-terminal region forms a tight dimerization domain

77 Salpalpha lacks the amino-terminal region found in Sam68, and has only a sin

78 as proSAAS (named after four residues in the amino terminal region) has many attractive properties.

79 says used to probe the role of the sigma(54) amino terminal region I in activation.

80 The amino-terminal Region I activation domain together with

81 phenotype of RA336 is shared with mutants in amino-terminal Region I sequences.

82 r motifs in X chromosome recognition and the amino-terminal region in interactions with other dosage

83 Despite the consistent inclusion of the MLL amino-terminal region in leukemia oncoproteins, little i

84 c, demonstrating that ICP27 contains a large amino-terminal region, including its RGG box RNA binding

85 Recent research has shown that the amino terminal region is important for enzyme activity,

86 tion and 2) domain-specific folding of apoBs amino-terminal region is required to initiate MTP-depend

87 Here, the amino-terminal region is shown to down-regulate binding

88 large cytosolic loop (Gly354-Lys712) and the amino-terminal regions (Met1-Asp162) of the SERCA1-ATPas

89 y cells localized proteoglycan binding to an amino-terminal region near the proline-rich domain.

90 The amino-terminal region (NTR) regulates the timing of kelc

91 membrane association of AtCPK2, and that the amino terminal region of AtCPK2 is sufficient for correc

92 ty with a mAb specific for an epitope in the amino terminal region of C(H)2, suggesting that the conf

93 ant of human Tip60, which interacts with the amino terminal region of cPLA(2).

94 idues 23 to 43), which lacks homology to the amino terminal region of gonococcal pilB or pneumococcal

95 mouse monoclonal antibody (1A5) against the amino terminal region of human parathyroid hormone-relat

96 binding and possibly other functions in the amino terminal region of Msh6 are important for eukaryot

97 Because the amino terminal region of the gene 4 protein contributes

98 s observed for HLA peptides derived from the amino terminal regions of the proteins, suggesting that

99 lapping peptides spanning the cysteine-rich, amino-terminal region of AbetaPP were used as competitor

100 e retroviral integrase has three domains: an amino-terminal region of about 50 amino acids that conta

101 physically interacts with YB-1 and that the amino-terminal region of Agnoprotein, between residues 1

102 ed that a fractional domain (helix C) in the amino-terminal region of alpha-spectrin (Nalpha region)

103 6K) in one of the KTKEGV-type repeats in the amino-terminal region of alpha-synuclein suggests that t

104 An amino-terminal region of alpha3 chain of type IV collage

105 cipitation analyses showed that the diverged amino-terminal region of Ama1p recognizes both Cdc20p an

106 th gephyrin ascribes a function to the large amino-terminal region of an ATM-related protein and reve

107 Further site-specific mutations in the amino-terminal region of annexin I indicated that Lys-26

108 ies of these mutants indicated that both the amino-terminal region of annexin I spanning residues 26-

109 d monoclonal antibodies directed against the amino-terminal region of apolipoprotein B (apo B).

110 amino acid, carboxyl-terminal domains and an amino-terminal region of approximately 280 amino acids.

111 The two proteins are 29% identical in an amino-terminal region of approximately 340 residues, 39%

112 The amino-terminal region of AtXLG1 contains domains homolog

113 Deletion of this domain allows an amino-terminal region of AvrPtoB (AvrPtoB(1-387)) to be

114 n-independent interaction that mapped to the amino-terminal region of BRCA1 (ca. amino acid 1-300) an

115 as intrinsic HAT activity, which maps to the amino-terminal region of BRCA2.

116 least four myosin-binding motifs within the amino-terminal region of CaD, located between residues 1

117 creened a yeast two-hybrid library using the amino-terminal region of CAP and identified the caveolar

118 The evolutionarily conserved amino-terminal region of Cbl (Cbl-N) binds to phosphoryl

119 This interaction requires the amino-terminal region of CBP as well as the transactivat

120 These data indicate that the amino-terminal region of CCR2 is both necessary and suff

121 several different hydrophilic regions of the amino-terminal region of CD14 are involved in LPS bindin

122 In the absence of caspase 3 cleavage of the amino-terminal region of DFF-45/ICAD by another caspase

123 hereby protein-protein interactions with the amino-terminal region of E2A allow the chimera to act as

124 4F DNA binding activity is encoded within an amino-terminal region of E4F-1 that contains a zinc fing

125 FAC-RED interaction requires the amino-terminal region of FAC and the cytosolic, membrane

126 Mutation of proline residues (Pro2) in the amino-terminal region of FAK blocks direct binding with

127 The amino-terminal region of FAK contains a region of sequen

128 al steps of fibronectin matrix assembly, the amino-terminal region of fibronectin binds to cell surfa

129 RevA bound to the amino-terminal region of fibronectin.

130 by cell surface-binding sites for the 70-kDa amino-terminal region of FN.

131 B, a truncation mutant encompassing only the amino-terminal region of gB (gB(1-460)) was markedly les

132 In this work, we have focused on the amino-terminal region of GLP1, known to be critical for

133 In addition to the SH2 domain, the Pro-rich amino-terminal region of Grb10 was implicated in the reg

134 Here we show that a 361-residue amino-terminal region of HCF is sufficient to bind VP16,

135 ethionine-rich clusters in the extracellular amino-terminal region of hCtr1 that were required for st

136 These results indicate that the amino-terminal region of HDAg is in close contact with t

137 syndrome-associated mutations located in the amino-terminal region of HERG (F29L, N33T, G53R, R56Q, C

138 The amino-terminal region of HERG was recently crystallized

139 Both the basic amino-terminal region of histone H4 and the silent infor

140 ere pS denotes phosphoserine) located in the amino-terminal region of HopQ1.

141 equences to nuclear function of a pathogenic amino-terminal region of htt (httex1p) including aggrega

142 odels of HD, points to the importance of the amino-terminal region of Htt in the disease process.

143 etiological missense variants cluster in the amino-terminal region of human BCL11A, and we demonstrat

144 We have analyzed the role of the amino-terminal region of human TFIIB in transcription in

145 istent with its amino acid identities to the amino-terminal region of human von Willebrand factor, wh

146 ed by expansion of a glutamine repeat in the amino-terminal region of huntingtin.

147 INR-mutated gC promoters was located in the amino-terminal region of ICP4.

148 We show that the amino-terminal region of JAZ10.4 contains a cryptic MYC2

149 ly with domain III of 23 S rRNA; whereas the amino-terminal region of L37ae interacts primarily with

150 ddressed the hypothesis that the hydrophilic amino-terminal region of lambda1, which adopts an extend

151 ne substitution for other lysines within the amino-terminal region of lambda2 identified lysine 190 a

152 The amino-terminal region of LDLR, which consists of seven t

153 In the amino-terminal region of leupaxin there are three short

154 An amino-terminal region of LifA shares homology with the c

155 We find that an amino-terminal region of LIN-10 directs LIN-10 protein l

156 Here, we report the crystal structure of the amino-terminal region of LRP6 and using NMR show that th

157 However, only antibodies to the amino-terminal region of LTBP-1 block transglutaminase-d

158 transglutaminase-reactive domains within the amino-terminal region of LTBP-1S, mutants of LTBP-1S wit

159 The amino-terminal region of MEKK4 has little sequence homol

160 We have further identified the amino-terminal region of menin and the head domain of NM

161 We propose that additional factors bind the amino-terminal region of Met30p and mediate its nuclear

162 ype was suppressed by co-expression with the amino-terminal region of Mi-1.1, suggesting that residue

163 lular signal-regulated kinase; ERK), and the amino-terminal region of mKsr-1.

164 hly conserved Asp9 or Asp10 positions in the amino-terminal region of MSP also resulted in a reduced

165 This ability of the amino-terminal region of mucin to aid in the assembly of

166 as myelinogenic potential, and identify the amino-terminal region of Nogo-A, expressed by oligodendr

167 Interestingly, the isolated amino-terminal region of p27kip1 (p27N), encompassing on

168 ation domain of RelA(p65) interacted with an amino-terminal region of p300 distinct from a carboxyl-t

169 WW domains and a PY motif located within the amino-terminal region of p45.

170 mdm2 directly binds to the amino-terminal region of p53 and targets it for degradat

171 We suggest that the unique amino-terminal region of PDE4D5 allows it to preferentia

172 s spectrometric analysis indicated that this amino-terminal region of PDHc-E1 was protected by PDHc-E

173 ot analysis, one species of which lacked the amino-terminal region of PFM1 and part of the PR domain.

174 rmore, a truncated protein consisting of the amino-terminal region of phospholipase D containing the

175 late fraction depends on the presence of the amino-terminal region of PKCmu including the predicted t

176 The amino-terminal region of Pol32 is essential for damage-i

177 argeting of the precursor is mediated by the amino-terminal region of polyprotein.

178 Plasmids encoding the amino-terminal region of porcine submaxillary mucin were

179 de a series of overlapping peptides from the amino-terminal region of Rac1 and rendered them cell per

180 -BI-mediated cholesterol efflux and that the amino-terminal region of residues 1-165 of apoE is suffi

181 Deletion of the amino-terminal region of REST (Rest(DeltaN) knockout) as

182 These findings suggest that the amino-terminal region of RGS16 may affect the affinity o

183 The amino-terminal region of rhoGDI is unstructured in the a

184 mnant on primary transcripts, resides in the amino-terminal region of RNase E and does not require ot

185 The amino-terminal region of Rsp5 contains three WW domains

186 tion, while increasing the truncation of the amino-terminal region of SecA from 8 to 11 residues resu

187 an important new constraint for docking the amino-terminal region of secretin to its receptor core.

188 The amino-terminal region of serum amyloid A (SAA), the subu

189 We determined that the amino-terminal region of SidE was essential for SidJ-med

190 tion that links the activity of SidJ and the amino-terminal region of SidE, which is required to modu

191 The conserved amino-terminal region of sigma 54 (Region I) contains se

192 eover, an interaction between Spc98p and the amino-terminal region of Spc110p is a critical component

193 Thus, an amino-terminal region of Stn1p is sufficient for its ess

194 SULT2B1, exon 1B encodes for only the unique amino-terminal region of SULT2B1b; however, exon 1A enco

195 Recently, we demonstrated that the amino-terminal region of SUR1 contains 5 transmembrane s

196 The amino-terminal region of Swi1 is dispensable for its nor

197 ajor transactivation domain of NFAT1 and the amino-terminal region of Tat, results in a reciprocal mo

198 s provide the first direct evidence that the amino-terminal region of TBP is important for the format

199 The amino-terminal region of TcpP shows sequence homology to

200 plex at 4.5 angstrom resolution revealed the amino-terminal region of TFIIB, including a loop termed

201 arison to other terpene cyclases revealed an amino-terminal region of the abietadiene synthase, which

202 y the receptor perturbs the structure of the amino-terminal region of the alpha-subunit of Gs and con

203 with assembly defects or truncations in the amino-terminal region of the capsid protein supports the

204 lts indicate that antibodies directed to the amino-terminal region of the catalytic domain of gingipa

205 Ras-GTP and multiple phosphorylations of the amino-terminal region of the catalytic domain.

206 leles contain missense mutations, one in the amino-terminal region of the channel protein and the oth

207 cking the normal tyrosine sulfate-containing amino-terminal region of the coreceptor.

208 s suggest that distinct sequences within the amino-terminal region of the cytoplasmic domain of the r

209 the protein to bind DNA and a domain in the amino-terminal region of the factor.

210 The amino-terminal region of the FANCA protein is required f

211 xplore the importance of the sequence of the amino-terminal region of the gamma-chain to the structur

212 otal of six SN-HPCs for mutations within the amino-terminal region of the gene CTNNB1 (cadherin-assoc

213 had a single amino acid substitution in the amino-terminal region of the glycoprotein (F18L).

214 3 hydrophobic (heptad) repeat located in the amino-terminal region of the gp41 molecule.

215 These results suggest that the amino-terminal region of the gp41 outer-layer alpha-heli

216 agment 1 (S1), with the exception of a short amino-terminal region of the heavy chain, which is absen

217 f seven in vivo phosphorylation sites in the amino-terminal region of the human progesterone receptor

218 er caused by polyglutamine expansions in the amino-terminal region of the huntingtin (Htt) protein.

219 e presence of the passenger mutations to the amino-terminal region of the linker decrease secretion e

220 The amino-terminal region of the low-density lipoprotein rec

221 The amino-terminal region of the membrane-anchored subunit o

222 -associated major epitopes localizing to the amino-terminal region of the molecule.

223 ation resulting from self-association of the amino-terminal region of the molecule.

224 Interestingly, the amino-terminal region of the Nipah virus V protein, whic

225 Previously we found that the amino-terminal region of the NS1 protein of influenza A

226 The amino-terminal region of the phiX174 J protein, which is

227 The amino-terminal region of the protein contains an arginin

228 d helix-to-coil structural transition in the amino-terminal region of the protein is partly responsib

229 hat MLO homooligomerization, mediated by the amino-terminal region of the protein, and carboxyl-termi

230 mutation affecting structural aspects of the amino-terminal region of the protein, and support the co

231 ssembly and suggests a possible role for the amino-terminal region of the protein.

232 e fibers that use contacts from the flexible amino-terminal region of the protein.

233 eir activation potentials were mapped to the amino-terminal region of the proteins, and the poorly tr

234 , at least in part, by the PAS domain in the amino-terminal region of the RsbP phosphatase.

235 evealed conserved amino acid sequences in an amino-terminal region of the Saccharomyces cerevisiae en

236 The amino-terminal region of the structure is well defined a

237 ed a single amphipathic helix located in the amino-terminal region of the third intracellular domain

238 est that an amphipathic helix located in the amino-terminal region of the third intracellular domain

239 cognate G proteins is often dependent on the amino-terminal region of the third intracellular loop.

240 The amino-terminal region of the Vif molecule in human immun

241 Although it has been proposed that an amino-terminal region of the viral matrix (MA, p17Gag) p

242 eptors to G proteins is known to involve the amino-terminal region of their third cytoplasmic loop.

243 We also show that the cytoplasmic amino-terminal region of THIK2 (Nt-THIK2) contains an ar

244 mino-terminal half of secretin and this same amino-terminal region of this receptor, support a key ro

245 Thus, the amino-terminal region of TRbeta1 contains an activation

246 We also demonstrate that the amino-terminal region of tuberin interacts specifically

247 In addition, we propose that the flexible amino-terminal region of Tva plays an important role in

248 The region of STAT2 interaction spans an amino-terminal region of two predicted coiled coils.

249 functions of the protein and a nonconserved amino-terminal region of unknown function.

250 ons affecting the previously uncharacterized amino-terminal region of uORF2 were analyzed in transien

251 The SOCS proteins contain an amino-terminal region of variable length and primary str

252 growth phase, whereas provision of only the amino-terminal region of Vfr comprising the secretion si

253 activity were mapped to two residues in the amino-terminal region of Vif (positions 39F and 48H).

254 The amino-terminal region of ViuP has homology to a lipoprot

255 Then, we show that the amino-terminal region of WRN from amino acid 1 to 388, w

256 By controlled proteolysis, we show that the amino-terminal region of yeast Rad54 is rather unstructu

257 addition, we have identified a domain in the amino-terminal region of YopH that binds to both p130Cas

258 We also demonstrate that the conserved amino-terminal region of ySMN is not required for SMN an

259 modelling and mutagenesis that the globular amino-terminal regions of apoB and MTP are closely relat

260 The proteins share two amino-terminal regions of approximately 100 residues wit

261 on repressor (MITR) shares homology with the amino-terminal regions of HDAC4 and -5, but lacks an HDA

262 We show that the amino-terminal regions of MITR and class II HDACs intera

263 n bacterial copper metallochaperones and the amino-terminal regions of P(1)-type ATPases for metals o

264 Amino-terminal regions of secretin-family peptides conta

265 ins containing segments of the actin-binding amino-terminal regions of the B subunits of V-ATPase, we

266 associated box (KRAB) A and B domains at the amino-terminal regions of the predicted proteins.

267 The amino-terminal regions of these ligands are critical for

268 91%, 58% and 48% identity to the mouse AES, amino-terminal regions of Xenopus ESG1 and Drosophila gr

269 Fusion of various amino-terminal regions of YplA to Escherichia coli alkal

270 deletion of a specific portion of the unique amino-terminal region or specific mutations in the regul

271 aromyces cerevisiae) pol II, the yeast TFIIB amino-terminal region recruits yeast pol II but not huma

272 on repression by Mnt maps to a 13-amino-acid amino-terminal region related to the Sin3 interaction do

273 e Salmonella type III secretion system (SopE amino-terminal region residues 1 to 80 with two copies o

274 6) that connects the first PAS domain to the amino-terminal region (residues 1 to 135).

275 gnated here as INP51, that has carboxyl- and amino-terminal regions similar to mammalian inositol pol

276 ecently had the structures of their isolated amino-terminal regions solved by NMR, yet it remains unc

277 peptide and found that mutations within the amino-terminal region specifically affect the secM trans

278 his enzyme contains arginine residues in the amino-terminal region that are relatively conserved in s

279 Net2p has an amino-terminal region that contains predicted coiled-coi

280 Phytochromes consist of an amino-terminal region that covalently binds a single bil

281 NSF consists of an amino-terminal region that interacts with other componen

282 ivator protein TAF(II)31 binds to p53 at the amino-terminal region that is also required for interact

283 A-dependent RNA polymerase nsP4 possesses an amino-terminal region that is unique to alphaviruses and

284 rds of the protein including a 67 amino-acid amino-terminal region that was previously thought not to

285 nd to arginine residues in the pre-helix and amino-terminal regions that were organized in a triad ar

286 Wnt inhibitors that act by cleaving the Wnt amino-terminal region to inactivate specific Wnt ligands

287 ificant sequence similarity of the resulting amino-terminal region to that of Sulfolobus, and on a si

288 by acting on a specific DNA sequence via its amino-terminal region, to inhibit elongation of DNA repl

289 ts tested except the one containing only the amino-terminal region underwent tyrosine phosphorylation

290 compensated for by a negative charge in the amino-terminal region, upon which the pmf acts.

291 of the biologically important alpha-spectrin amino terminal region was examined by the use of fluores

292 an autonomous transactivation domain in the amino-terminal region was demonstrated by its ability to

293 rated that when the first 19 residues of the amino-terminal region were separated from the rest of CC

294 Several cysteine substitutions along the amino-terminal region were then introduced.

295 eas the IpaD epitopes in the surface-exposed amino-terminal region were unique for the Shigella prote

296 poER2 binding domain of apoE is in the 1-165 amino terminal region, whereas the carboxy terminal 230-

297 Deletion of the amino-terminal region, which contains a putative nuclear

298 ge factor (GEF) for Rho, p115 RhoGEF, has an amino-terminal region with similarity to RGS proteins.

299 roach showed that replacement of the pre-TM1 amino-terminal region with the corresponding P2X2 recept

300 has 46% amino acid sequence identity in its amino-terminal region with the second lipoyl domain of E