ライフサイエンスコーパス: aminoacylated tRNA

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1 ongation factors 1A and 2 and A site-cognate aminoacylated tRNA.

2 ranslational resources, namely ribosomes and aminoacylated tRNAs.

3 eukaryotic elongation factors 1A and 2, and aminoacylated tRNAs.

4 ed by 70S ribosomes programmed with mRNA and aminoacylated tRNAs.

5 on of amino acids via synthetically prepared aminoacylated tRNAs.

6 ext of the kinetic proofreading mechanism of aminoacylated tRNA (aa-tRNA) selection.

7 a 2.3- to 4.2-fold decrease in the level of aminoacylated tRNAs and a >2-fold decrease in growth rat

8 aternary complex consisting of Msn5, RanGTP, aminoacylated tRNA, and Tef1/2.

9 denosine towards a beta-strand, such that an aminoacylated tRNA at this position would be sterically

10 loped that directly measures the fraction of aminoacylated tRNA by following amino acid attachment to

11 ng to dramatic reductions in the fraction of aminoacylated tRNAs, cessation of protein synthesis and

12 rentially assembles with RanGTP and spliced, aminoacylated tRNAs, documenting its role in tRNA nuclea

13 presence of the heterologous aaRSs, and the aminoacylated tRNAs function efficiently in suppression

14 e or puromycin, which inhibit utilization of aminoacylated tRNA in cells; and 3) in cells having a te

15 In the other conformation, presumptive aminoacylated tRNA is bound only by the anticodon, the a

16 cating that much of the binding affinity for aminoacylated tRNA is derived from interaction with the

17 stalled ribosomes and discriminates against aminoacylated tRNAs is missing.

18 a strong (70-75%) reduction in the level of aminoacylated tRNA(Leu(UUR)) and a decrease in mitochond

19 To determine if the decreased fraction of aminoacylated tRNA(Leu(UUR)) in A3243G mutant cells was

20 lso results in a decrease in the fraction of aminoacylated tRNA(Leu(UUR)).

21 In addition to raising aminoacylated tRNA levels, the absence of editing lowere

22 ained limited primarily to canonical RNA, 3'-aminoacylated tRNAs, nucleobase-modified RNAs, and 5'-ca

23 diting-defective strain, increased levels of aminoacylated tRNA(Phe) led to continued synthesis of th

24 n the absence of editing, cellular levels of aminoacylated tRNA(Phe) were elevated during amino acid

25 cid starvation is sensed by depletion of the aminoacylated tRNA pools, and this results in accumulati

26 the repair of the genome, while ARSs provide aminoacylated tRNA precursors for protein synthesis.

27 ha [eEF1A]) aids the specificity of Msn5 for aminoacylated tRNAs to form a quaternary complex consist

28 (aaPGSs) are membrane proteins that utilize aminoacylated tRNAs to modify membrane lipids with amino

29 ion and dissociation rates of deacylated and aminoacylated tRNAs to the A-site and P-site of E. coli

30 thereby facilitating efficient re-export of aminoacylated tRNAs to the cytoplasm.

31 actor 1A (eEF1A; EF-Tu in bacteria) delivers aminoacylated-tRNA to the A-site of the ribosome, wherea

32 icipate in protein translation by presenting aminoacylated-tRNAs to the ribosome.

33 An aminoacylated tRNA was synthesized which was complementa

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