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1 s remaining (often colistin, tigecycline, or aminoglycosides).
2 within 4 d after treatment with a synthetic aminoglycoside.
3 hB gene leads to decreased susceptibility to aminoglycosides.
4 er modifications on glucopyranosyl ring I of aminoglycosides.
5 uct removal with less toxicity than with the aminoglycosides.
6 st in the field of antibacterial amphiphilic aminoglycosides.
7 ensitizes hair cells to the toxic effects of aminoglycosides.
8 fference in inhibitory activity of different Aminoglycosides.
9 of large arteries and its resistance to all aminoglycosides.
10 Most ACSs included vancomycin and aminoglycosides.
11 al for sensors detecting the entire class of aminoglycosides.
12 te profile, including only 4,6-disubstituted aminoglycosides.
13 on of vancomycin without coadministration of aminoglycosides.
14 considering the frequent coadministration of aminoglycosides.
15 (6')lb genes, resulting in susceptibility to aminoglycosides.
16 e same dying hair cell following exposure to aminoglycosides.
17 the presence of nonsense suppressors such as aminoglycosides.
18 All but one infant also received aminoglycosides.
19 monstrated that all members of the bacterial aminoglycoside 2''-phosphotransferase IIIa (APH(2'')) am
20 ween ATP or GTP as the phosphate donor, with aminoglycoside 2''-phosphotransferase IVa (APH(2'')-IVa)
23 ntibiotics, primarily amoxicillin (80%) with aminoglycosides (48%), were prescribed for a median dura
24 el class of potent antibacterial amphiphilic aminoglycosides (AAGs) with significant improved activit
25 bifunctional aminoglycoside-modifying enzyme aminoglycoside acetyltransferase(6')-Ie/aminoglycoside p
28 olding of cytosolic proteins as an effect of aminoglycoside action and reveal that chaperones, chaper
29 inoglycosides shed light on the mechanism of aminoglycosides action as antibiotics, no such data are
31 whose upregulation causes resistance to the aminoglycoside (AG) antibiotic kanamycin A (KAN) in Myco
34 Prior work showed that uptake of ototoxic aminoglycosides (AG) into hair cells requires functional
35 value of a number of antibiotics, including aminoglycosides, against intracellular pathogenic bacter
41 t five classes of antibiotics (beta-lactams, aminoglycosides, amphenicols, sulfonamides, and tetracyc
43 our findings establish N1MS as a nonototoxic aminoglycoside and support targeted modification as a pr
44 patients is well tolerated, combined use of aminoglycoside and the non-toxic adjuvant L-arginine as
45 to oxidative stress, increased resistance to aminoglycosides and cationic antimicrobial peptides, and
46 ey are generally resistant to metronidazole, aminoglycosides and ciprofloxacin with L. acidophilus be
47 sistance to third generation cephalosporins, aminoglycosides and fluoroquinolones was moderately asso
52 ostatic interaction energies between various aminoglycosides and their binding sites correlate with e
54 tions and its per-ring contributions between aminoglycosides and their primary rRNA binding site.
55 litude of electrostatic interactions between aminoglycosides and their rRNA targets to introduce amin
57 rapy with broad-spectrum beta-lactams and/or aminoglycosides and/or fluoroquinolones was started.
58 ncluding sulfonamides, fluoroquinolones, and aminoglycosides), and higher diversity in both genotype
59 combination antibiotic therapy including an aminoglycoside, and early indwelling catheter removal).
60 fections, but it also reduced cephalosporin, aminoglycoside, and vancomycin exposure and reduced the
62 of heat shock proteins (HSPs) inhibits both aminoglycoside- and cisplatin-induced hair cell death an
63 boxamide, 1 (ORC-001), as protective against aminoglycoside antibiotic (AGA)-induced hair cell death.
64 ANG's nuclear translocation by neomycin, an aminoglycoside antibiotic (not G418-neomicin), resulted
66 555A>G predisposes to hearing loss following aminoglycoside antibiotic exposure in an idiosyncratic d
70 ng the efficacy of PTC124 with the classical aminoglycoside antibiotic read-through agent geneticin (
74 ted that bactericidal antibiotics, including aminoglycoside antibiotics (AGAs), and toxic small molec
75 ma membrane, and increased susceptibility to aminoglycoside antibiotics and cationic antimicrobials.
77 saccharide Pel, which protects bacteria from aminoglycoside antibiotics and contributes to biofilm ar
81 almost half of a century, we have known that aminoglycoside antibiotics corrupt ribosomes, causing tr
84 l subunit RNA of the bacterial ribosome, the aminoglycoside antibiotics inhibit protein synthesis, ca
86 aration of a series of four analogues of the aminoglycoside antibiotics neomycin and paromomycin is d
88 an improved understanding of how amphiphilic aminoglycoside antibiotics that bind to negatively charg
89 ility to fluoroquinolone, cephalosporin, and aminoglycoside antibiotics using disk diffusion assays.
90 romising avenue for the development of novel aminoglycoside antibiotics with improved efficacy and re
91 ues, such as hyperosmolarity and presence of aminoglycoside antibiotics, (ii) narrowed their metaboli
92 sh lateral line hair cells after exposure to aminoglycoside antibiotics, a well characterized hair ce
93 sses of ototoxic drugs are cisplatin and the aminoglycoside antibiotics, both of which are toxic to m
94 on-derived kinase that confers resistance to aminoglycoside antibiotics, in Escherichia coli under se
95 ays a significant role in resistance against aminoglycoside antibiotics, is controlled by a translati
106 es for understanding the structural basis of aminoglycoside-aptamer recognition highlighted by the SE
108 COL7A1, and previous studies have shown that aminoglycosides are able to overcome RDEB PTC mutations
113 horylation of 4,5-disubstituted and atypical aminoglycosides are negligible and thus these antibiotic
118 chaperonin expression sensitized bacteria to aminoglycosides as measured by reduced minimum inhibitor
119 itro screening of linear polyamine-based and aminoglycoside-based polymer libraries identified severa
121 ibitory concentrations of an investigational aminoglycoside, belonged to multi-locus sequence type 94
122 gnificantly contributed to the resistance to aminoglycosides, beta-lactams, and macrolides observed i
128 bility, base stacking, and conformation upon aminoglycoside binding to the human cytoplasmic helix69
129 human mitochondrial and E. coli helix69 upon aminoglycoside binding, as compared with human cytoplasm
130 ncapsulated RI promotes the protection of an aminoglycoside-binding RNA E-AB sensor up to 6 h, enabli
131 at 3.3- to 3.7-A resolution, reveal multiple aminoglycoside-binding sites within the large and small
133 methyltransferases confer resistance to most aminoglycosides, but discriminating their activity from
134 resistant to rifampin, fluoroquinolones, or aminoglycosides, but for which Sanger sequencing found n
135 mework for further development of less toxic aminoglycosides by hypothesis-driven chemical synthesis.
136 that antibacterial activity and toxicity of aminoglycosides can be dissected from their suppression
139 strate clinical benefits of beta lactam plus aminoglycoside combination therapy compared to beta lact
140 , Dutch guidelines recommend beta-lactam and aminoglycoside combination therapy or carbapenem monothe
142 rategies synthesized were monotherapy versus aminoglycoside-containing combination therapy; antipseud
143 ensitizes hair cells to the toxic effects of aminoglycosides, contrasting with current models of exci
147 r rational design of new, and more specific, aminoglycoside derivatives as potential therapeutic agen
154 engers conferred superior protection against aminoglycoside exposure compared with identical, untarge
155 lly inherited hearing loss in the absence of aminoglycoside exposure or any other clinical features (
160 antibiotic therapy with a beta-lactam and an aminoglycoside for the treatment of gram-negative bacter
161 ribosomal A site: Geneticin (G418), a potent aminoglycoside for the treatment of leishmaniasis at a 2
162 se of the guanidinylated ligand, but the two aminoglycoside fragments seem to interfere with its acco
163 reviously exposed to long-term macrolides or aminoglycosides, further indicating cross-infection.
164 liver regulates Se metabolism, we tested the aminoglycosides G418 and gentamicin in hepatoma cell lin
166 inst eight antibiotic classes (beta-lactams, aminoglycosides, glycopeptides, chloramphenicols, tetrac
170 to inactivate an unusually broad spectrum of aminoglycosides, including 4,6- and 4,5-disubstituted an
171 asis; however the molecular details by which aminoglycosides induce their deleterious effect on Leish
172 Ca(2+) homeostasis play an essential role in aminoglycoside-induced hair cell death, and indicate sev
179 vide structural and functional insights into aminoglycoside-induced impacts on the eukaryotic ribosom
182 s into the structural elements important for aminoglycoside inhibitory activities and selectivity for
187 cal gentamicin, a mixture of several related aminoglycosides, is a frequently used antibiotic in huma
188 of the 4,6-disubstituted 2-deoxystreptamine aminoglycoside kanamycin B led to improved selectivity f
189 illin and penicillin), quinolone (enoxacin), aminoglycoside (kanamycin and neomycin), and polykeptide
190 oside 2''-phosphotransferase IIIa (APH(2'')) aminoglycoside kinase family are unique in their ability
191 that ATP is the canonical phosphate donor in aminoglycoside kinases and protein kinases, it was recen
193 members of the APH(2'') subfamily and other aminoglycoside kinases, rationalize the different substr
194 g templates are conserved in other bacterial aminoglycoside kinases, whereas in the structurally rela
195 inding that apramycin, a structurally unique aminoglycoside licensed for veterinary use, shows little
196 ion of oritavancin with other agents such as aminoglycosides may offer promise and deserves further i
198 anosine lesions, whereas the cytotoxicity of aminoglycosides might additionally result from mistransl
200 ycosides and their rRNA targets to introduce aminoglycoside modifications that would enhance their bi
202 ere investigated further for the presence of aminoglycoside-modifying enzyme genes using multiplex PC
203 t discriminating their activity from that of aminoglycoside-modifying enzymes (AMEs) is challenging u
204 problems, we engineered Pentobra, a peptide-aminoglycoside molecule that has multiple mechanisms of
205 present crystal structures of two different aminoglycoside molecules bound to a model of the Leishma
206 ry of three dialkyl derivatives of the small aminoglycoside neamine active against susceptible and re
207 philic 3',6-dialkyl derivatives of the small aminoglycoside neamine as broad spectrum antibacterial a
208 ization of such Janus compounds with a small aminoglycoside, neamine, and its guanidinylated analogue
209 trum antibiotics, or with the gut-restricted aminoglycoside neomycin alone, accelerated phagocyte tur
210 4'-O-glycosylation blocking the action of 4'-aminoglycoside nucleotidyl transferases by the use of re
211 orylation through a family of enzymes called aminoglycoside O-phosphotransferases (APHs) is a major m
213 ngs suggest that the interfering activity of aminoglycosides on selenoprotein biosynthesis can be sev
214 ide an acceptable alternative to intravenous aminoglycosides or long courses of tetracyclines where c
223 zyme aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2'')-Ia possesses an N
224 zyme aminoglycoside acetyltransferase(6')-Ie/aminoglycoside phosphotransferase(2'')-Ia, or AAC(6')-Ie
225 a putative kinase belonging to the family of aminoglycoside phosphotransferases suggested that AGXT2L
226 '')-Ia domain of this enzyme is unique among aminoglycoside phosphotransferases, having the ability t
227 We performed a dose-ranging study with the aminoglycoside plazomicin against Pseudomonas aeruginosa
229 Our data indicate that 4'-O-substituted aminoglycosides possess increased selectivity towards ba
230 group from SAM is transferred to Cbl and the aminoglycoside product during the course of the reaction
232 f tetracycline, multidrug, erythromycin, and aminoglycoside resistance genes were discovered in these
233 min, bacitracin, vancomycin, beta-lactam and aminoglycoside resistance genes were the top seven most
235 C(6')-Ie/APH(2'')-Ia, is the major source of aminoglycoside resistance in gram-positive bacterial pat
236 subspecies and determining the macrolide and aminoglycoside resistance levels of 50 Mycobacterium abs
238 nd "not cured." Strong biofilm formation and aminoglycoside resistance were associated with a "not-cu
239 ntly lower during SDD compared with SOD; for aminoglycoside resistance, average prevalence was 5.6% (
242 cluding the extended-spectrum ss-lactam- and aminoglycoside-resistance genes, were identified in the
243 0S recognition by the novel plasmid-mediated aminoglycoside-resistance rRNA methyltransferase A (NpmA
244 new molecular framework for the activity of aminoglycoside-resistance rRNA methyltransferases that m
245 te and preferable in treating non-high-level aminoglycoside-resistant E faecalis infective endocardit
246 entions the prevalence of rectal carriage of aminoglycoside-resistant gram-negative bacteria increase
250 ructed the aspherical electron density of 12 aminoglycoside-RNA complexes from the atomic parameters
251 s and PCA loading factors revealed trends in aminoglycoside:RNA recognition, including the importance
252 he first systematic development of the novel aminoglycoside (S)-11 exhibiting similar in vitro and ex
253 natural or semisynthetic pseudodisaccharide aminoglycoside scaffolds containing an equatorial amine
256 es of the bacterial ribosome in complex with aminoglycosides shed light on the mechanism of aminoglyc
259 bNOS-deficient strains gained resistance to aminoglycosides, suggesting that the role of bNOS in ant
261 In the search for antimicrobial amphiphilic aminoglycosides targeting bacterial membranes, we report
263 AAS and aerobic systems especially reduced aminoglycoside, tetracycline, and beta-lactam ARG levels
264 ugs in known classes such as new quinolones, aminoglycosides, tetracyclines, and beta-lactams have be
265 ng protein synthesis inhibitors (macrolides, aminoglycosides, tetracyclines, lincosamides, and chlora
266 emonstrate that streptomycin, a bactericidal aminoglycoside that increases ribosomal mistranslation,
267 have identified highly charged compounds or aminoglycosides that commonly have modest selectivity.
268 tions in the drug-binding site, resulting in aminoglycosides that interact poorly with the drug-bindi
270 st on the effects of short-course adjunctive aminoglycoside therapy in sepsis patients with organ fai
272 rifampicin, fluoroquinolones and injectable aminoglycosides, they would be suitable for treating man
275 e strong and differential binding ability of aminoglycosides to RNA structures can be used to classif
276 ination with selection for resistance to the aminoglycoside tobramycin, the aac(6')-Ie/aph(2'')-Ia ge
277 le vectors, derived from naturally occurring aminoglycoside tobramycin, was prepared using improved s
284 ncy (aOR = 2.4; 95% CI = 1.0-5.8; P = .046), aminoglycoside use (aOR = 4.7; 95% CI = 2.2-9.8; P < .00
285 e; 95% confidence interval [CI], 0.99-1.21), aminoglycoside use (OR, 2.33; 95% CI, 1.17-4.57), resist
287 ical gatifloxacin, prophylaxis using topical aminoglycoside was ineffective (OR, 1.97; CI, 1.17-3.31)
291 , gyrA (ofloxacin/fluoroquinolone), and rrs (aminoglycosides)-were amplified and sequenced, and resul
293 APH(2'')-Ia phosphorylates 4,6-disubstituted aminoglycosides with high efficiency (k(cat)/K(m) = 10(5
294 ototoxicity, and therefore we synthesized 9 aminoglycosides with modifications based on biophysical
296 and cocaethylene with similar affinities and aminoglycosides with similar or higher affinities in a m
298 ra combines the potent ribosomal activity of aminoglycosides with the bacteria-selective membrane-per
300 EX rounds were toggled against four pairs of aminoglycosides with the goal of isolating reagents that
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