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1 catalyzed condensation of two molecules of 5-aminolevulinic acid.
2 applying protoporphyrin IX or its precursor aminolevulinic acid.
3 nsed with succinyl coenzyme A to yield delta-aminolevulinic acid.
4 linically approved PSs porfimer sodium and 5-aminolevulinic acid.
5 xpress rabbit GAPDH in the presence of delta-aminolevulinic acid.
6 tachlorbiphenyl, an inducer of CYP1A2, and 5-aminolevulinic acid.
7 d heme b when expressed in the presence of 5-aminolevulinic acid.
8 ides 2.4.1 which catalyze the formation of 5-aminolevulinic acid.
9 , which was intensified by pretreatment with aminolevulinic acid.
10 ic labeling with [2-14C]glycine or delta-[3H]aminolevulinic acid ([3H]ALA) was used to investigate he
11 Cells were incubated with PpIX pro-drug 5-aminolevulinic acid (5-ALA) at 0, 1, 2, 3, and 4 mM for
13 (PpIX), which is endogenously derived from 5-aminolevulinic acid (5-ALA) or its derivatives, is a pro
16 croneedles for improved dermal delivery of 5-aminolevulinic acid (5-ALA), which naturally gets conver
17 cal, oral, or parenteral administration of 5-aminolevulinic acid, a precursor for heme biosynthesis.
18 us studies revealed periodic fluctuations of aminolevulinic acid, a precursor of heme, indicating tha
19 r deferoxamine and the porphyrin precursor 5-aminolevulinic acid (ALA) (mimicking intracellular proto
23 B-synthase activities and elevated urinary 5-aminolevulinic acid (ALA) and porphobilinogen (PBG), the
24 ion of the neurotoxic porphyrin precursors 5-aminolevulinic acid (ALA) and porphobilinogen (PBG), whi
28 ubations arms, either 10-minute or 20-minute aminolevulinic acid (ALA) incubation times, after pretre
34 cteria, the heme and chlorophyll precursor 5-aminolevulinic acid (ALA) is formed from glutamate in a
35 Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) is increasingly employed for s
41 utants defective in the genes encoding delta-aminolevulinic acid (ALA) synthase and ferrochelatase, e
42 nscripts for the two committed enzymes for 5-aminolevulinic acid (ALA) synthesis despite the marked i
44 ollowing photosensitization by administering aminolevulinic acid (ALA) to induce the accumulation of
45 increased ability to convert the precursor 5-aminolevulinic acid (ALA) to PPIX appeared to reinforce
46 of regulated heme synthesis was achieved by aminolevulinic acid (ALA) treatment of mice or cultured
48 lyzes the condensation of two molecules of 5-aminolevulinic acid (ALA), an essential step in tetrapyr
49 e common precursor to all tetrapyrroles is 5-aminolevulinic acid (ALA), and in Rhodobacter sphaeroide
50 synthesize the tetrapyrrole precursor, delta-aminolevulinic acid (ALA), from glutamate by means of a
51 ith the first committed heme precursor alpha-aminolevulinic acid (ALA), generates high levels of PP-I
52 ies to help clarify the roles of heme, delta-aminolevulinic acid (ALA), hemA, and hemM in Escherichia
53 es can be potently stimulated by exogenous 5-aminolevulinic acid (ALA), resulting in accumulation of
55 ice in a 129S6/SvEvTac background were fed 5-aminolevulinic acid (ALA), which results in hepatic URO
61 herapy, mediated by exogenously administered aminolevulinic acid (ALA-PDT), followed by exposure to a
64 tes with aminolevulinic acid plus red light, aminolevulinic acid alone, light alone, and untreated co
65 been shown to have higher specificity than 5-aminolevulinic acid and can possibly play a complementar
66 ifests a defect in the biosynthesis of delta-aminolevulinic acid and displays reduced levels of downs
68 en approved for systemic administration, and aminolevulinic acid and methyl aminolevulinate have been
70 utant has a reduced capacity to synthesize 5-aminolevulinic acid and reduced CHLM activity compared w
71 PCT: wild-type mice treated with iron, delta-aminolevulinic acid, and polychlorinated biphenyls; and
72 ation into heme from its precursor 5-[(13)C4]aminolevulinic acid, and this assay confirmed that de no
74 27, and contributes to feedback-control of 5-aminolevulinic acid biosynthesis, the rate-limiting step
75 d, unexpectedly, that it is the enzyme delta-aminolevulinic acid dehydratase (ALA-D) and that it does
76 ALAD gene (chromosome 9q34) codes for delta-aminolevulinic acid dehydratase (ALAD) (E.C. 4.2.1.24).
77 encoding the haem biosynthesis enzyme delta-aminolevulinic acid dehydratase (ALAD) is normally repre
78 ms and its potential modification by a delta-aminolevulinic acid dehydratase (ALAD) polymorphism.
81 endent transcriptional co-regulator of delta-aminolevulinic acid dehydratase (Alad), but not 5-aminol
82 TX)), and the K59N polymorphism in the delta-aminolevulinic acid dehydratase gene, ALAD, were measure
83 d for use in the clinical diagnosis of delta-aminolevulinic acid dehydratase-deficient porphyria, a r
87 in and cefadroxil, the antineoplastics delta-aminolevulinic acid (delta-ALA) and bestatin, and the ne
88 y of UVA alone and in combination with delta-aminolevulinic acid (delta-ALA), a precursor of the intr
90 oplasts by feeding these chloroplasts with 5-aminolevulinic acid, determined the relative levels of G
91 , the rate-limiting enzyme upstream of delta-aminolevulinic acid export, failed to restore heme level
95 an and given drinking water containing delta-aminolevulinic acid for 21 days, hepatic porphyrins accu
96 an but not rat liver, maximal rates of delta-aminolevulinic acid formation required addition to the i
98 plication of the photosensitizer precursor 5-aminolevulinic acid has therapeutic implications for the
99 fter 3 h of incubation in the heme precursor aminolevulinic acid hexylester, EMT6 cells accumulated a
100 LECTION Only randomized PDT trials that used aminolevulinic acid hydrochloride ormethyl aminolevulina
103 zoporphyrin derivative monoacid ring A and 5-aminolevulinic acid-induced protoporphyrin IX, were stud
104 as show the direct in vitro conversion of 5-aminolevulinic acid into cobyrinic acid using a mixture
105 2) The incorporation of radioactive delta-aminolevulinic acid into heme A is reduced in yah1 ts bu
108 eased synthesis of glutamate semialdehyde, 5-aminolevulinic acid, magnesium-porphyrins, and chlorophy
109 photodynamic therapy using topical methyl 5-aminolevulinic acid (MAL) for actinic keratoses (AKs) is
110 respond adequately to PDT with methyl-delta-aminolevulinic acid (MAL-PDT) and the tumors acquire an
111 With this model, we demonstrated that 5-aminolevulinic acid-mediated sonodynamic therapy (ALA-SD
112 by favoring low-activity oligomers, while 5-aminolevulinic acid, Mg(2+), or K(+) stabilized high-act
113 oxybenzoic acid (3,4-AHBA), and a cyclized 5-aminolevulinic acid moiety, 2-amino-3-hydroxycyclopent-2
114 loenzyme catalyzes the condensation of two 5-aminolevulinic acid molecules to form the tetrapyrrole p
115 ad activity peak (pH 7-8.5), with a K(m) for aminolevulinic acid of approximately 150 microM and spec
116 nin contents and de-represses synthesis of 5-aminolevulinic acid of tetrapyrrole metabolism in darkne
121 ge of the hyperkeratotic lesions followed by aminolevulinic acid photodynamic therapy (PDT) 1 to 2 we
122 e skin inflammation occurs following topical aminolevulinic acid-photodynamic therapy (ALA-PDT), but
127 e on the back was treated in four sites with aminolevulinic acid plus red light, aminolevulinic acid
128 ignificant clearance of inflammatory acne by aminolevulinic acid plus red light, for at least 20 wk a
129 heme synthesis pathway by facilitating delta-aminolevulinic acid production or export from the mitoch
131 nt of tumor-specific fluorophores, such as 5-aminolevulinic acid, real-time microscopic visualization
135 d enzymatic assays indicate that erythroid 5-aminolevulinic acid synthase (Alas2) is decreased in hem
137 to a deletion in the gene that encodes delta-aminolevulinic acid synthase (HEM1), resulted in decreas
138 tors that induce the expression of hepatic 5-aminolevulinic acid synthase 1 (ALAS1) result in the acc
140 ate-limiting enzyme in heme synthesis, delta-aminolevulinic acid synthase 2 (ALAS2), was significantl
142 These knock-out parasite lines, lacking 5-aminolevulinic acid synthase and/or ferrochelatase (FC),
144 whereby increased cellular heme regulates 5-aminolevulinic acid synthase is by decreasing the stabil
145 nase, and heme (200 nM); (c) Repression of 5-aminolevulinic acid synthase mRNA levels by zinc mesopor
146 a decrease in cellular heme might increase 5-aminolevulinic acid synthase mRNA stability and whether
148 eroxamine; (b) This increased stability of 5-aminolevulinic acid synthase mRNA was reversed by the ad
149 mium mesoporphyrin significantly decreased 5-aminolevulinic acid synthase mRNA without increasing hem
150 heme-like, effect of zinc mesoporphyrin on 5-aminolevulinic acid synthase mRNA; (d) Among the several
153 In conjunction with the dark repression of 5-aminolevulinic acid synthesis, GUN4 phosphorylation mini
155 y of low levels of activity of hepatic delta-aminolevulinic acid synthetase have been studied, compar
156 yl-CoA generation was more labile than delta-aminolevulinic acid synthetase under these conditions.
158 de isozymes that catalyze the formation of 5-aminolevulinic acid, the first step in the biosynthesis
159 ness for 14 days, upon the addition of delta-aminolevulinic acid, the level of magnesium-protoporphyr
161 ALA-D is about as active in converting delta-aminolevulinic acid to porphobilinogen and as Zn2+-depen
164 rthermore, we show that the heme precursor 5-aminolevulinic acid, which is used as an antimicrobial a
165 -5-aminolevulinic acid is an ester form of 5-aminolevulinic acid with improved uptake by tumor cells.
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