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1 ensitive aminopeptidase (PSA, cytosol alanyl aminopeptidase).
2 manganese as co-factor, including the BB0366 aminopeptidase.
3 1, but lacked the canalicular marker leucine aminopeptidase.
4 designing effective inhibitors of methionine aminopeptidase.
5 lated aminopeptidase (IRAP), a transmembrane aminopeptidase.
6 trometry identified the protease as aspartyl aminopeptidase.
7 anic chemistry of DNPEP and other M18 family aminopeptidases.
8 f preferred amino acid cleavage by cytosolic aminopeptidases.
9 ding over 200 cleavages of blood proteins by aminopeptidases.
10 n of the substrate specificity of individual aminopeptidases.
11 ed by hydrolysis to amino acids by cytosolic aminopeptidases.
12 se as selective inhibitors for this group of aminopeptidases.
13 cursor peptides by the endoplasmic reticulum aminopeptidase 1 (ERAP1) and ERAP2 is an important event
15 mily of M1 aminopeptidases, consisting of ER aminopeptidase 1 (ERAP1), ER aminopeptidase 2 (ERAP2), a
16 ow-activity variant of endoplasmic reticulum aminopeptidase 1 (ERAP1), Hap10, is associated with the
17 hin the aminopeptidase endoplasmic reticulum aminopeptidase 1 (ERAP1), which is essential for trimmin
19 ses the aggregation of the premature form of aminopeptidase 1 (prApe1) in cytosol and its sequestrati
20 association of ERAP1 (endoplasmic reticulum aminopeptidase 1) with ankylosing spondylitis (AS), whic
22 llular aminopeptidases endoplasmic reticulum aminopeptidases 1 and 2 (ERAP1 and ERAP2), and as well a
23 ast to cytosolic peptidases, silencing of ER aminopeptidases 1 and 2 strongly impaired pp65(495-503)-
25 ates, we determined crystal structures of ER aminopeptidase 2 (ERAP2) in complex with a substrate ana
26 onsisting of ER aminopeptidase 1 (ERAP1), ER aminopeptidase 2 (ERAP2), and insulin-regulated aminopep
27 n the present study we found that methionine aminopeptidase 2 (MetAP2), a critical component of the t
28 459P mirrored those of endoplasmic reticulum aminopeptidase 2, a human enzyme with proline in the var
31 he in vitro catalytic activity of methionine aminopeptidase-2 (MetAP2) are effective in blocking angi
34 ors of the human metalloprotease, methionine aminopeptidase-2 (MetAP2), identified a potent class of
36 al and cytosolic splice variants of X-prolyl aminopeptidase 3, can cause nephronophthisis-like ciliop
39 ral renin-angiotensin system, zinc-dependent aminopeptidase A (APA) up-regulates blood pressure by sp
40 tamylcyclotransferase (gamma-GCT) as well as aminopeptidase A (APA), which are overexpressed in renal
44 e II/III of development, while inhibitors of aminopeptidase A, dopamine beta-hydroxylase, and the int
45 studies support the existence of protective aminopeptidase A-Ang III-Ang II type 2 receptor and ACE2
48 ates the omega-end of LTA4, distant from the aminopeptidase active site, thus providing a molecular b
51 hough sparing the enzyme's anti-inflammatory aminopeptidase activity (i.e., degradation and inactivat
53 ne product possesses previously unrecognized aminopeptidase activity but no carboxy- or endopeptidase
55 potent leukocyte activating agent, while the aminopeptidase activity cleaves and inactivates the chem
56 ated for their ability to detect beta-alanyl aminopeptidase activity in bacteria known to hydrolyze b
57 all yield and were selective for beta-alanyl aminopeptidase activity in bacteria, producing a lighter
58 acological inhibition of puromycin-sensitive aminopeptidase activity in cell lines permissive for IBD
59 e biological contributions made by the LTA4H aminopeptidase activity in CS-induced emphysema, we expo
66 pment of COPD, selectively inhibited LTA(4)H aminopeptidase activity, which led to the accumulation o
78 we report the structure of insulin-regulated aminopeptidase, an enzyme that prepares antigenic epitop
82 (495-503) epitope presentation after leucine aminopeptidase and tripeptidyl peptidase II knockdown.
83 degraded by the cytosolic peptidases leucine aminopeptidase and tripeptidyl peptidase II, as evidence
87 c cleavage events associated with methionine aminopeptidases and signal peptide peptidases, as well a
88 DUF4424 domain and individual domains of M1 aminopeptidases and tricorn proteases, which form massiv
89 hree unknown proteins that are homologous to aminopeptidases and xylanases or that contain a putative
91 seen in the active-site cavity of methionine aminopeptidase, and at least one of the metal ions is di
92 kin (IL)-6, insulin (INS), alanyl (membrane) aminopeptidase (ANPEP), and IL-10 were observed in the P
95 e vascular receptors--alpha(v) integrins and aminopeptidases--are accessible through the circulation
97 roteins such as GLUT4 and insulin-responsive aminopeptidase, as well as six proteins not previously r
98 ading complex, and the endoplasmic reticulum aminopeptidase associated with Ag processing (ERAAP) are
99 es in mice lacking the endoplasmic reticulum aminopeptidase associated with Ag processing (ERAAP).
100 in the endoplasmic reticulum (ER) by the ER aminopeptidase associated with Ag processing (ERAAP).
101 in the absence of the endoplasmic reticulum aminopeptidase associated with Ag processing (ERAAP).
102 s, TAP, and endoplasmic reticulum-associated aminopeptidase associated with Ag processing, but not ta
104 are trimmed to appropriate length by the ER aminopeptidase associated with antigen processing (ERAAP
105 peptides for MHC I are customized by the ER aminopeptidase associated with antigen processing and by
107 Additionally, with prolyl oligopeptidase and aminopeptidase B we identified two new Ag processing mac
108 ming of N-extended peptides into epitopes by aminopeptidases before loading onto MHC class I molecule
111 atin F in different immune cell types is the aminopeptidase cathepsin C, which regulates the activati
120 Single nucleotide polymorphisms within the aminopeptidase endoplasmic reticulum aminopeptidase 1 (E
127 trimming process overall and of the major ER aminopeptidase ERAP1 in particular is not well understoo
130 Members of the oxytocinase subfamily of M1 aminopeptidases (ERAP1, ERAP2, and IRAP) play important
132 together, these results indicate that the M1 aminopeptidase family is a divergent family with three s
135 , in the reaction mechanism of the methionyl aminopeptidase from Escherichia coli ( EcMetAP-I), the H
141 eady-state kinetic studies revealed that the aminopeptidase has broad activity, with a preference for
143 the variable residue in the S1 subsite of M1-aminopeptidases have facilitated the evolution of new sp
147 essing the enzymatic activities of the LTA4H aminopeptidase in lung tissues and accumulating PGP and
150 hese peptides can subsequently be trimmed by aminopeptidases in the cytosol and/or the endoplasmic re
155 er, these results support the development of aminopeptidase inhibitors as novel chemotherapeutics dir
156 inhibitors (e.g., for Polo-like kinase 1 and aminopeptidase), inhibitors of mutated isocitrate dehydr
157 RAP1, which encodes an endoplasmic reticulum aminopeptidase involved in peptide trimming before HLA c
160 Peptide inhibitors of insulin-regulated aminopeptidase (IRAP) enhance fear avoidance and spatial
163 and ERAP2), and as well as insulin-regulated aminopeptidase (IRAP) process antigenic epitope precurso
165 a glucose transporter, and insulin-regulated aminopeptidase (IRAP), a transmembrane aminopeptidase.
166 oss-presented peptides by insulin-responsive aminopeptidase (IRAP), an enzyme localized in a regulate
167 n of GSV cargos, GLUT4 and insulin-regulated aminopeptidase (IRAP), and ACBD3 was required for intrac
169 s nonpeptide inhibitors of insulin-regulated aminopeptidase (IRAP), have previously been shown to enh
170 nopeptidase 2 (ERAP2), and insulin-regulated aminopeptidase (IRAP), plays critical roles in the gener
171 gen was transported across insulin-regulated aminopeptidase (IRAP)-positive early and late endosomes;
174 enzymatic digestion using microsomal alanyl aminopeptidase is combined with MS characterization.
179 from P. menziesii, whereas potential leucine aminopeptidase (LA) activity was significantly lower for
180 sequencing, conventional methods for leucine aminopeptidase (LAP) and pyrrolidonyl arylamidase (PYR)
184 re crossed to mice lacking another cytosolic aminopeptidase, leucine aminopeptidase, the resulting BH
186 available for dimetalated enzyme, methionine aminopeptidase likely functions as a monometalated enzym
190 trated by screening 12,000 compounds against aminopeptidase M in 384-well microtiter plates with Z fa
194 y enhancing cleavage of alpha1 by methionine aminopeptidase (MAP), resulting in acetylation of the N-
196 These studies show that a bestatin-sensitive aminopeptidase may be critical for the hydrolysis of exo
201 N-terminal-modifying enzymes like Methionine aminopeptidase (MetAP), and the signal recognition parti
204 N-terminal methionine removed by methionine aminopeptidases (MetAP1 and MetAP2) prior to action.
206 erative activity and target human methionine aminopeptidases (MetAPs) for their cellular effects.
208 lar characterization of an Anopheles gambiae aminopeptidase N (AgAPN1) as the predominant jacalin tar
210 t Phe(3) is a key residue for neprilysin and aminopeptidase N (AP-N) ectoenkephalinase inhibition.
217 of this family that has been well studied is aminopeptidase N (APN), a multifunctional protease known
223 cificity of human, pig, and rat orthologs of aminopeptidase N (CD13), a highly conserved cell surface
227 The viruses used the human entry receptor aminopeptidase N and replicated in human hepatoma cells,
230 EMV binds to a heavily glycosylated receptor aminopeptidase N in the pea aphid gut and is transcytose
233 r with the lack of receptor functionality of aminopeptidase N proteins might account for some of the
234 d hydrophobic character for the S1 pocket of aminopeptidase N that is conserved with aminopeptidase N
236 We have recently demonstrated that CD13 (aminopeptidase N) expressed by nonmalignant host cells o
239 ular adhesion molecule 1 (ICAM-1), anti-LG3, aminopeptidase N, CXCL9, endothelin-1, and gelsolin.
240 f a receptor protein in the aphid gut called aminopeptidase N, which is responsible for entry of the
242 d with differential alteration of two midgut aminopeptidases N, APN1 and APN6, conferred by a trans-r
243 ta-glucosidase (carbon-cycling) and l-leucin aminopeptidase (nitrogen-cycling), was reduced following
248 Overexpression of human insulin-responsive aminopeptidase/oxytocinase rescued all apm1 phenotypes,
249 dase, angiotensin-I-converting enzyme (ACE), aminopeptidase P (APP), and carboxypeptidase N/M (CPN)]
251 se P (PfAPP) shares with mammalian cytosolic aminopeptidase P a three-domain, homodimeric organizatio
253 Plasmodium falciparum expresses a homolog of aminopeptidase P during its asexual intraerythrocytic cy
256 ed by this system is an exoprotease, leucine aminopeptidase (PA-LAP), which is coexpressed with sever
258 hia coli was nearly entirely dependent on an aminopeptidase, PepN, expression of PepN in periplasm al
259 idue valine 459 in the Plasmodium falciparum aminopeptidase PfA-M1 and of three substitutions of the
260 Here we present evidence that an M1-family aminopeptidase, PfA-M1, has been recruited to specialize
262 te Plasmodium falciparum employs two metallo-aminopeptidases, PfA-M1 and PfA-M17, which are essential
263 ed one of the extracellular enzymes (leucine aminopeptidase), pointing to a specific nanoparticle eff
264 ction of residues that are less cleavable by aminopeptidases predominantly at N-flanking sites, leadi
265 The partially purified enzyme as well as the aminopeptidases present in crude extract cleaved prefere
268 r-fold increase in vasopressinase, a cystine aminopeptidase produced by placental trophoblasts, which
269 aminopeptidase, the resulting BH(-/-)leucine aminopeptidase(-/-) progeny show a selective increase in
271 zyme have suggested that puromycin-sensitive aminopeptidase (PSA) plays a role in creating and destro
272 ngle aminopeptidase, the puromycin-sensitive aminopeptidase (PSA, cytosol alanyl aminopeptidase).
275 variation in domestic cats as Transmembrane aminopeptidase Q (Taqpep), which encodes a membrane-boun
276 e active fractions, and recombinant aspartyl aminopeptidase recapitulated the cleavage pattern observ
277 nflammation is established, changes to LTA4H aminopeptidase remain, even in the absence of ongoing ci
278 nts of beta-casein with elastase and leucine aminopeptidase revealed the release of BCM-7 by competit
280 ins participating in chitin utilization, two aminopeptidases, TagA-related protein, cytolysin, RbmC,
282 Dipeptidyl peptidase I (DPPI) is a cysteine aminopeptidase that can activate several serine protease
286 egradation at neutral pH was due to a single aminopeptidase, the puromycin-sensitive aminopeptidase (
287 ng another cytosolic aminopeptidase, leucine aminopeptidase, the resulting BH(-/-)leucine aminopeptid
288 amily of metalloproteases called M17 leucine aminopeptidases, the preferred substrate for the T. dent
289 to T cells, such peptides must be trimmed by aminopeptidases to the proper size (typically 8-10 resid
290 of action of the orally available methionine aminopeptidase type 2 inhibitor, [(1R)-1-carbamoyl-2-met
291 PPI-2458, a potent irreversible methionine aminopeptidase type 2 inhibitor, was administered orally
294 found that these enzymes are genuine Xaa-Pro aminopeptidases, which hydrolyze peptides with proline a
295 a membrane, detected using insulin-regulated aminopeptidase with a pH-sensitive GFP tag (pHluorin), p
296 ymes is a self-compartmentalizing tetrameric aminopeptidase with a preference for cysteine and hydrop
297 tidase N from Escherichia coli is a M1 class aminopeptidase with the active-site region related to th
298 t (4MDM) that selectively augments the LTA4H aminopeptidase without affecting the bioproduction of le
300 ch, which can be applied in principle to all aminopeptidases, yields useful information for the desig
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