ライフサイエンスコーパス: amphipathic

1 rio cholerae cytolysin/hemolysin (VCC) is an amphipathic 65-kDa beta-pore-forming toxin with a C-term

2 s (NiNLPs) were assembled to incorporate the amphipathic adjuvants monophosphoryl lipid A and cholest

3 DNA damage and repair proteins that contain amphipathic alpha helical domains.

4 The domains form two amphipathic alpha helices separated by a rigid kink, whi

5 s-alpha" amyloid-like architecture, in which amphipathic alpha helices stacked perpendicular to the f

6 nked on each side by an additional solvating amphipathic alpha helix.

7 ponent of dry bee venom, was used as a model amphipathic alpha-helical peptide.

8 Certain amphipathic alpha-helical peptides can functionally mimi

9 -forming cytolysin alpha-toxin (Hla) and the amphipathic alpha-helical phenol-soluble modulin (PSM) p

10 Despite its amphipathic alpha-helical structure, Ctn[1-14] was total

11 cally to the LD surface, contains a discrete amphipathic alpha-helical targeting sequence, and partic

12 teins are disordered in water, but fold into amphipathic alpha-helices at high osmolyte concentration

13 The amphipathic alpha-helices have relatively low stability,

14 re fibrils nor bind lipid surfaces via their amphipathic alpha-helices in a manner typical of apolipo

15 The isolated protein folds into amphipathic alpha-helices in response to increased crowd

16 tant structural motifs formed by two or more amphipathic alpha-helices that twist into a supercoil.

17 al and cell-penetrating peptides (CPPs) form amphipathic alpha-helices when bound to lipid membranes.

18 ealed that helices 6, 7, and 10 are separate amphipathic alpha-helices with a calculated periodicity

19 he propensity of inhibitory peptides to make amphipathic alpha-helices.

20 e viral M2 protein bind membrane and form an amphipathic alpha-helix (AH).

21 at this interaction is mainly mediated by an amphipathic alpha-helix (alpha2), which undergoes a subs

22 nding EF-hands, a linker loop domain with an amphipathic alpha-helix and a C-terminal mitochondrial c

23 ction/association region, which comprises an amphipathic alpha-helix and is distinct from the PP1c in

24 at this sequence (named PMasseq) contains an amphipathic alpha-helix and the FWC signature, which is

25 DN activity all require a putative five-turn amphipathic alpha-helix at the C-terminus of C20orf112,

26 isordered C-terminal domain and an incipient amphipathic alpha-helix contained within it.

27 In conclusion, we have identified an amphipathic alpha-helix in the NCX1 large intracellular

28 (SpoVM(P9A)) to reveal that SpoVM's atypical amphipathic alpha-helix inserts deeply into the membrane

29 phaS), an amyloid protein known to insert an amphipathic alpha-helix into negatively charged phosphol

30 mbrane space are high, the N-terminus of the amphipathic alpha-helix is bound to a cleft in the regul

31 endent appearance of the C-terminal cationic amphipathic alpha-helix is inducible within hours by Sta

32 lcium levels drop, the cleft closes, and the amphipathic alpha-helix is released to bind to the carri

33 to the basic domain, and a carboxy-terminal amphipathic alpha-helix referred to as Helix III.

34 from a random coil at physiological pH to an amphipathic alpha-helix under mildly acidic conditions.

35 We hypothesized that this segment forms an amphipathic alpha-helix whose properties facilitate Cys-

36 residue at position 175, which is part of an amphipathic alpha-helix within the C-terminal region of

37 The availability of apoAI or other amphipathic alpha-helix-rich apoproteins relieves the bu

38 um via a locking pin mechanism involving the amphipathic alpha-helix.

39 dimerization domain of the protein forms an amphipathic alpha-helix.

40 passing the Leu/Ile/Phe-rich domain forms an amphipathic alpha-helix.

41 tures were conserved, including a C-terminal amphipathic alpha-helix.

42 t is capable of participating in an extended amphipathic alpha-helix.

43 xide-coated sensing substrate along with the amphipathic, alpha-helical (AH) peptide-induced structur

44 dly less pronounced to that observed for the amphipathic alpha2, likely reflecting structural plastic

45 enetrating into the lipid droplet matrix and amphipathic amino- and carboxyl (C)-terminal peptides ly

46 s the toxic antimicrobial activities of many amphipathic AMPs and protects them from degradation duri

47 is a key mechanism of killing for cationic, amphipathic AMPs, which may explain why most AMPs requir

48 Further, the two partner helices, both amphipathic and located at the polar-nonpolar interface

49 ed the series of experiments confirming that amphipathic and membrane-permeabilizing properties of CS

50 t residues approximately 198-206 is strongly amphipathic and proposed to anchor the chaperone domain

51 tgun") or targeted profiling of hydrophilic, amphipathic, and hydrophobic constituents of plasma meta

52 We analyze three amphipathic antimicrobial peptides, a class of membrane-

53 m(2) patches of lipid bilayers stabilized by amphipathic belt proteins.

54 ce, which is consistent with the behavior of amphipathic beta-strands.

55 urface (especially helix 4) are cationic and amphipathic, both classic characteristics of antimicrobi

56 stantially enhance the alpha-helicity of the amphipathic C terminus of lacritin.

57 The amphipathic C-helix was sufficient for this localization

58 In particular, the role of the amphipathic C-terminal tail of Atlastin is still unknown

59 The hydrogel was made of amphipathic carboxymethyl-hexanoyl chitosan (CHC), beta-

60 6, which are structural features of cationic amphipathic cell-penetrating peptides.

61 ues were still partly retained, imparting an amphipathic character and explaining its residual antimi

62 surface of the molecule does not display any amphipathic character.

63 suggested that a region named TM1, which has amphipathic characteristics and spans from amino acids 8

64 nd LS3 helical peptides are designed to have amphipathic characteristics that form ion channels in me

65 ia 2 pairs of hydrophobic amino acids and an amphipathic cluster.

66 Adamantyl Gb(3) is an amphipathic competitive inhibitor of VT1/VT2 Gb(3) bindi

67 many structurally dissimilar hydrophobic and amphipathic compounds, including anticancer drugs from c

68 The complex adopts a highly amphipathic conformation that offers clues to antibiotic

69 The amphipathic conformation typical of PMAP-36 was not requ

70 Cationic AMPs typically exhibit an amphipathic conformation, which allows increased interac

71 t bactericidal activity was the cationic and amphipathic COOH-terminus.

72 s based on TP10W, a peptide derived from the amphipathic CPP transportan 10; the second was based on

73 The data suggest that cell uptake of amphipathic CPPs correlates with their adopted alpha-hel

74 s starting from low concentrations; (ii) non-amphipathic CPPs that do not evoke changes at relevant c

75 that CPPs split into two major classes: (i) amphipathic CPPs that modulate the plasma membrane integ

76 Structurally, UCNII has a cationic and amphipathic design that resembles antimicrobial peptides

77 nker region facilitates client binding to an amphipathic docking surface on Hsp33.

78 odulation of gating by lipids, alcohols, and amphipathic drug molecules.

79 an interface and to propose a model for the amphipathic EAS rodlet structure.

80 ment for membrane proteins to be embedded in amphipathic environments such as membranes, lipid vesicl

81 A leading hypothesis proposes that a small amphipathic fragment of APP, the amyloid beta-protein (A

82 tail 'triplex' strand arrangement creates an amphipathic functional topology akin to that of the acti

83 Rigid amphipathic fusion inhibitors (RAFIs) are lipophilic inv

84 nd via insertion of a phosphopeptide into an amphipathic groove of 14-3-3.

85 co-expression and subsequent binding at the amphipathic groove.

86 14-3-3 protein forms a dimer containing two amphipathic grooves that can potentially bind these phos

87 with five portals framed by adjacent helical amphipathic (HA) stretches within the 114-residue loop b

88 oxic activity of 10 analogs of the idealized amphipathic helical 21-mer peptide (KAAKKAA)3, where thr

89 ides by altering the charged residues of the amphipathic helical address were unsuccessful.

90 , we focus on how alpha-helical proteins use amphipathic helical layering and bundling to form modula

91 Synthetic amphipathic helical peptides (SAHPs) designed as apolipo

92 bilizing motifs, which increase retention of amphipathic helical peptides in RP, reduce peptide reten

93 o provide a fundamental understanding of how amphipathic helical peptides interact with each other an

94 We found that interactions of amphipathic helical peptides with a hydrophobic C18 phas

95 y stabilized by the shallow insertion of the amphipathic helical wedges with the BAR domain removed f

96 SDS micelles confirmed the importance of the amphipathic helices (11s --> 11sG --> 11) for antinocice

97 igned to disrupt folding of this region into amphipathic helices (AHs) significantly decreased lipid

98 n AI-alphaE interaction as a cluster of four amphipathic helices (two alphaE and two AI helices) at t

99 Here we show that N-terminal amphipathic helices ahA and ahB in PspA HD1 are function

100 line 25 is involved in sequential use of the amphipathic helices and ahA-IM interaction.

101 moting structural motifs, such as wedge-like amphipathic helices and crescent-shaped BAR domains, are

102 observations of the degree of tubulation by amphipathic helices and variation of the free energy of

103 Furthermore, we show that amphipathic helices are dispensable in forming protein s

104 The amphipathic helices enable PspA to switch from a low-ord

105 actions of the tau MBD are mediated by short amphipathic helices formed within each of the MBD repeat

106 is generic, operating even in the absence of amphipathic helices in the BAR domain, and could in prin

107 curvature generation, for IMDs we find that amphipathic helices inhibit membrane shape transitions,

108 does not occur until endophilin inserts its amphipathic helices into lipid bilayers, supporting an a

109 onstructions, the precise positioning of the amphipathic helices is still ambiguous.

110 imuthal angles are observed, positioning the amphipathic helices of all three peptides with the charg

111 ut, C-in topology, with no evidence that the amphipathic helices of either protein are exposed at the

112 onserved across all HCV isolates, as well as amphipathic helices of many pathogens and apolipoprotein

113 icle size depend on the number and length of amphipathic helices per BAR domain, in accord with theor

114 cement results in a loss of stability of the amphipathic helices TH1-3 and the hydrophobic core helix

115 F-BARs, endophilin N-BARs have N-terminal H0 amphipathic helices that are proposed to interact with o

116 domains, which coordinate membrane-spanning amphipathic helices that form the sugar translocation po

117 vitro via its crescent-shaped dimer and four amphipathic helices that penetrate into membranes as wed

118 termed AD1 and AD2, which fold to form short amphipathic helices upon binding to TAZ1 and TAZ2 wherea

119 Single molecule imaging of eGFP-PspA and its amphipathic helices variants in live Escherichia coli ce

120 Two amphipathic helices within the Naa60 C terminus bind the

121 deling predicts two DNA-binding domains, two amphipathic helices, and an in-plane membrane anchor in

122 d essential elements: DegA, encompassing two amphipathic helices, and DegB, a hydrophobic sequence wi

123 embrane remodelling also requires functional amphipathic helices, predicted to be present in all SNX-

124 n/Rvs (BAR) domain and deep insertion of its amphipathic helices.

125 tes that RemCA folds into a tight hairpin of amphipathic helices.

126 r and aromatic interactions with neighboring amphipathic helices.

127 membrane insertion (also called wedging) of amphipathic helices.

128 Yop1p) and identified a C-terminal conserved amphipathic helix (APH) that, on its own, interacts stro

129 gion in the C terminus containing a putative amphipathic helix (APH).

130 tured peptide, whereas promoter C encodes an amphipathic helix (Kal-C-helix).

131 Similarly, mutation of the RGS4 amphipathic helix (L23D) prevented membrane localization

132 hydrophobic residues to alanines within the amphipathic helix (M2 five-point mutant, or 5PM) reduced

133 ir of positively charged residues within the amphipathic helix (the basic amino acid PI(4,5)P2 pincer

134 nd-binding pocket and by the presence of the amphipathic helix 8.

135 Therefore, the hydrophobic amphipathic helix alpha(0) of NS3 is required for NS3/4A

136 argeting domains within NS4A and also at the amphipathic helix alpha(0) of NS3.

137 -sensitive manner between a membrane-binding amphipathic helix and a soluble degradation-prone segmen

138 sport-competent precursor interacts with the amphipathic helix and amino terminus of functional Tha4

139 n Doa10 yeast degron, Deg1, also contains an amphipathic helix and exhibits 42% amino acid similarity

140 allisation inhibition activity linked to its amphipathic helix and that it enhances the DMSO cryopres

141 eracts with anionic lipid membranes using an amphipathic helix at its unique N-terminus.

142 eal a similar fold to Cu(+)-ATPases, with an amphipathic helix at the membrane interface.

143 etic and biochemical analyses showed that an amphipathic helix at the N terminus functions as the mem

144 The resultant stabilization of the amphipathic helix deep in the bilayer interface facilita

145 our simulations indicate that the C-terminal amphipathic helix does not significantly change the prot

146 uggest that both RGS4 palmitoylation and the amphipathic helix domain are required for optimal plasma

147 Molecular dynamics simulations of an amphipathic helix embedded in a lipid bilayer indicate t

148 The amphipathic helix extends outwards from the ring of tran

149 The hNaa60 protein contains an amphipathic helix following its GNAT domain that may con

150 Both FtsA and SepF use an amphipathic helix for membrane binding.

151 Thus, reversible alphaS amphipathic helix formation and dynamic multimerization

152 alphaS vesicle binding via membrane-induced amphipathic helix formation, and '3K' further enhances t

153 This work deciphers how the CCT regulatory amphipathic helix functions as a silencing device.

154 ics simulations-suggest that alpha-tubulin's amphipathic helix H10 is responsible for peripheral bind

155 Serine scan mutagenesis of the N-Cap amphipathic helix identified Leu-15, Ile-18, and Ile-19

156 ate an essential role in this process for an amphipathic helix in CIDEA, which facilitates embedding

157 her, our results support a model whereby the amphipathic helix in SM N100 attaches reversibly to the

158 Furthermore, we showed that an amphipathic helix in the C-terminal cytosolic tail of RH

159 onsible for causing membrane curvature is an amphipathic helix in the cytoplasmic domain of the prote

160 f FtsZ to the membrane via FtsA's C-terminal amphipathic helix in vitro using Thermotoga maritima pro

161 Contrary to N-BAR domains, where amphipathic helix insertion is known to promote its memb

162 ating that the hydrophobic face of the N-Cap amphipathic helix interacts with a surface-exposed hydro

163 This amphipathic helix is aligned nearly parallel to the memb

164 Our data demonstrate that the N-Cap amphipathic helix is critical for channel stability and

165 fferent M2 domains show that the cytoplasmic amphipathic helix is necessary and sufficient for NGC ge

166 e occupancy of the canonical position of the amphipathic helix is reduced to various extents in many

167 eriphery was reduced, suggesting that the M2 amphipathic helix is required for proper localization in

168 ort a mechanistic model where the C-terminal amphipathic helix is stabilized by an intramolecular sal

169 ependently of these recycling pathways by an amphipathic helix is viable and polarizes spontaneously

170 An amphipathic helix located at the C-terminus of Tts1 is i

171 ions of charged residues located in the TatA amphipathic helix lock TatA in an assembled state, sugge

172 A favorable N-capping arrangement prior to amphipathic helix may result in the highest hydrophobici

173 inal domain that includes a highly conserved amphipathic helix motif and to microtubules through a do

174 r, when the PAS domain is present, the N-Cap amphipathic helix must also be present for channels to t

175 it tunnel, is auto-inhibited by a C-terminal amphipathic helix occluding its hydrophobic binding groo

176 Recently, we showed that the N-terminal amphipathic helix of Arl3, but not that of Arl2, regulat

177 a stepwise model in which the amino-terminal amphipathic helix of GTP-bound Sar1 stably penetrates th

178 The N-terminal amphipathic helix of NS5A bound specifically to PI(4,5)P

179 The interactions between the juxtamembrane amphipathic helix of one monomer and its neighboring mon

180 ein VI-specific antibodies, we show that the amphipathic helix of protein VI contributes to capsid st

181 We show that the amphipathic helix of the adenovirus internal protein VI

182 On calcium binding, an amphipathic helix of the C-terminal domain binds to the

183 endoplasmic reticulum-localizing, N-terminal amphipathic helix of viperin is specifically required fo

184 5 was observed to bind to cardiolipin via an amphipathic helix on its N terminus.

185 G vesicles, the first demonstration that the amphipathic helix on its own is capable of this effect.

186 structures reveal a well-ordered N-terminal amphipathic helix preceding a putative transmembrane hel

187 embrane-binding module, a membrane-inducible amphipathic helix present in a previously undescribed lo

188 l3 and other Arf proteins with an N-terminal amphipathic helix require GTP loading for the interactio

189 5 or residues on the hydrophobic face of the amphipathic helix strongly attenuated palmitoylation and

190 in its cytoplasmic tail a membrane-proximal amphipathic helix that facilitates the scission process

191 We demonstrate that HAfp23 is a new class of amphipathic helix that functions by leveraging the negat

192 n some cases, a BAR domain also possesses an amphipathic helix that inserts into the membrane to indu

193 t C-terminal peptide (containing a conserved amphipathic helix that is a key to HDM function), which

194 anchoring region (residues 710-724) forms an amphipathic helix that is stabilized by the membrane.

195 peptide binds with residues 3-11 forming an amphipathic helix that makes contact with the antibody f

196 s membrane-binding domain with an N-terminal amphipathic helix that senses and generates membrane cur

197 dynamics and circular dichroism revealed an amphipathic helix within this 12-residue region.

198 rved between cholesterol and residues in the amphipathic helix, accounting for cholesterol binding ad

199 res revealed that this domain is a five-turn amphipathic helix, and the invariant tryptophan forms a

200 and M2(21-61), which contains an additional amphipathic helix, are studied.

201 the palmitoylation insertion, containing an amphipathic helix, contributes to the PI-binding pocket

202 ression of a novel, phosphoinositide-binding amphipathic helix, Kalrn promoter usage is expected to a

203 embrane-inserting, curvature-sensing/driving amphipathic helix, the existence and properties of which

204 opathy analysis suggests that it can form an amphipathic helix, which is ideal for lipid membrane int

205 tes with the cell membrane via an N-terminal amphipathic helix, which is necessary for function.

206 hydrophobic targeting signal displaces this amphipathic helix, which then acts as a protective lid o

207 erminal transmembrane (TM) residues, near an amphipathic helix, without requiring a cholesterol recog

208 ropose to include synucleins in the class of amphipathic helix-containing proteins that sense and gen

209 induced by the hydrophobic void beneath the amphipathic helix.

210 and membrane insertion of the M domain as an amphipathic helix.

211 the asymmetric insertion of their N-terminal amphipathic helix.

212 e cytoplasmic membrane by its amino-terminal amphipathic helix.

213 region involved a highly conserved predicted amphipathic helix.

214 n of the lipid headgroup conformation by the amphipathic helix.

215 terminal transmembrane helix and an adjacent amphipathic helix.

216 facilitating membrane insertion of the Arf1 amphipathic helix.

217 Here we describe the stabilization of the amphipathic L4F peptide through fusion to a high molecul

218 An amphipathic lid loop from the nitrilase domain interacts

219 of CCT1, to remove the predicted C-terminal amphipathic lipid binding domain, produced a constitutiv

220 The translocation of the amphipathic lipid II across the cytoplasmic membrane is

221 The intrinsic amphipathic lipid packaging sensor (ALPS) motif within H

222 st sensitive membrane curvature sensors, the Amphipathic Lipid Packing Sensor (ALPS) motif, does not

223 roperties of the Golgi resembles that of the amphipathic lipid-packing sensor (ALPS) motif of GMAP-21

224 Thr-87 is located within an amphipathic lipid-packing sensor (ALPS) motif, which par

225 mes with lipid order-sensitive proteins like amphipathic lipid-packing sensor and alpha-synuclein was

226 rage and metabolism, and it was assumed that amphipathic lipids simply served a passive structural ro

227 We introduce a rationale of helical amphipathic lockers that differentiates autonomously fol

228 We propose that it is the amphipathic locking of interfacing helices prior to bind

229 plexes, we hypothesized that accumulation of amphipathic, long-chain acyl-CoA (LC-CoA) metabolites st

230 Because of the presence of amphipathic LPS molecules, the OM behaves as an effectiv

231 structures of RNase II required the RNase II amphipathic membrane binding domain.

232 t that self-assembled enantiomerically pure, amphipathic metallohelicies inhibited ice growth at just

233 Lipid II is a large amphipathic molecule composed of undecaprenyl diphosphat

234 Lanosterol is an amphipathic molecule enriched in the lens.

235 ulosis, and the extracellular export of this amphipathic molecule likely accounts for the known virul

236 We have screened a library of 96 amphipathic molecules for effects on Abeta(1-42) aggrega

237 rodlets further associate laterally to form amphipathic monolayers.

238 transporters that mediate transport of large amphipathic, mostly anionic molecules across cell membra

239 Oleosin has short amphipathic N- and C-terminal peptides flanking a conser

240 Here we quantitatively demonstrate that the amphipathic N-terminal H0 helix of endophilin is importa

241 romiscuous interactions between endophilin's amphipathic N-terminal helices.

242 tational approaches, we demonstrate that the amphipathic N-terminal helix of MscL acts as a crucial s

243 trum of bactericidal activity resulting from amphipathic nature and membrane-permeabilizing propertie

244 helix and the improvement and extension the amphipathic nature of the alpha-helix.

245 Our working hypothesis posited that the amphipathic nature of the C-terminal alpha-helix (Thr(60

246 This indicates that the amphipathic nature of the C-terminal alpha-helix was dis

247 Based on the amphipathic nature of the critical helix it may probe th

248 diverse polypeptides require them to have an amphipathic nature, and this is achieved by a diverse ra

249 ive channel opening, as the target for these amphipathic neurotoxins.

250 t members of a new class of guanidinium-rich amphipathic oligocarbonates that noncovalently complex,

251 moting its assembly to a water-soluble, less amphipathic oligomer variant with reduced ability to pen

252 binding cassette transporters that transport amphipathic or hydrophobic substrates in a detergent-fre

253 Moreover, we show that the HD1 amphipathic pattern is required to induce membrane dynam

254 estigated the effects of KL(4), a 21-residue amphipathic peptide approximating the overall ratio of p

255 emonstrated that a melittin-derived cationic amphipathic peptide combined with siRNA targeting the p6

256 ports the extensive investigation of a novel amphipathic peptide composed of repeating RALA units cap

257 also called LAH4-A4, a short histidine-rich amphipathic peptide derived from the LAH4 family of DNA

258 WLBU2 is an engineered cationic amphipathic peptide designed to maximize antimicrobial a

259 teraction between SLBs and PEP1, a synthetic amphipathic peptide resembling a segment of the nonstruc

260 termed A-ZIP53 that has a glutamic acid-rich amphipathic peptide sequence attached to N-terminal of b

261 Thus, the amphipathic peptide sequences become available to disrup

262 rmed from equimolar mixtures of enantiomeric amphipathic peptides (L- and D-(FKFE)(2)).

263 on-dependent curvature sensing mechanisms in amphipathic peptides and challenge existing theories of

264 d by H. W. Huang for the interaction between amphipathic peptides and membranes.

265 This phenomenon can be reproduced with amphipathic peptides as short as three amino acids.

266 tatic interactions provided by short, basic, amphipathic peptides can be harnessed to drive RNA bindi

267 invade membranes by exposing hydrophobic or amphipathic peptides generated by a proteolytic maturati

268 In addition to its biological activity, amphipathic peptides such as L4F are likely candidates t

269 universal approach to express many cationic amphipathic peptides that are normally toxic and would k

270 Cationic amphipathic pH responsive peptides possess high in vitro

271 Amphipols (APols) are amphipathic polymers with the ability to substitute dete

272 The ability of amphipathic polypeptides with substantial net positive c

273 the inner leaflet of the OM with a central, amphipathic pore.

274 rface pressure as surface area decreases and amphipathic products transiently accumulate at the lipop

275 My own passion for the unique amphipathic properties of lipids led me to seek other, n

276 cated apolipoprotein A-I, which serves as an amphipathic proteic 'shield' that sequesters the IMP fro

277 n the lipids and the hydrophobic face of the amphipathic protein alpha-helix.

278 ApoA-IV is an amphipathic protein that can emulsify lipids and has bee

279 T(H)17 cell-derived cytokine, is a cationic amphipathic protein that kills extracellular bacteria vi

280 uce both small lipid-associated peptides and amphipathic proteins that allow growth across water:air

281 at lacked helices H8 and H9, indicating that amphipathic rather than hydrophobic helices were the maj

282 veolin scaffolding domain (CSD), a conserved amphipathic region implicated in interactions with signa

283 positively charged residues, and an adjacent amphipathic region that can bind membranes in either a d

284 hin the conduction pathway framed by helical amphipathic regions (termed membrane-associated (MA) hel

285 gical activity was diminished, indicating an amphipathic requirement for activity in cells.

286 man thrombopoietin receptor (TpoR), a unique amphipathic RWQFP motif separates the transmembrane (TM)

287 The rationale offers structurally balanced amphipathic scaffolds to advance the exploitation of fun

288 It is composed of a 17-amino-acid amphipathic segment (Htt17), an amyloidogenic segment of

289 on rate constant for a construct lacking the amphipathic segment helix 0 (H0).

290 uncation study indicated that the C-terminal amphipathic segments of NTM14 interacts with the Mbeta s

291 Given the impact of amphipathic small molecules on bilayer properties such a

292 s corresponding to the membrane interacting, amphipathic stem region of the dengue virus envelope (E)

293 ne tract flanked by an N-terminal 17-residue amphipathic stretch (N17) and a C-terminal 38-residue pr

294 Specifically, a seventeen-residue amphipathic stretch (N17) that is directly N-terminal to

295 atm (Tatm3x) with an elongated alpha-helical amphipathic structure enhances transduction activity and

296 tion, as determined by NMR, showed that this amphipathic structure matches the polar/apolar interface

297 d inside the structure and shielded by eight amphipathic surface helices.

298 inding site in TAP1 to the polar face of the amphipathic TM helix TM9 and identify key residues that

299 hich involves formation of an intermolecular amphipathic two- or three- strand antiparallel beta shee

300 metry for the qualitative detection of model amphipathic viral peptide on a screen-printed electrode.