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1 g a biologically inert, low-molecular-weight amphiphile.
2 ght of as monodisperse oligomers of a single amphiphile.
3 io-opaque elements encapsulated by synthetic amphiphile.
4 e achiral segment of the fluorescent peptide amphiphile.
5 s an effective and well-accessible colloidal amphiphile.
6 le by adjusting the structure of the polymer amphiphile.
7 rities and to self-assemble like a molecular amphiphile.
8 ecular self-assembly of a perylene monoimide amphiphile.
9 ntetheinyl transferase to generate a peptide amphiphile.
10 coil" and "globule-rod-coil" protein complex amphiphiles.
11 lar geometry, and hydrocarbon content of the amphiphiles.
12 erting the zwitterions into typical cationic amphiphiles.
13 f-assembled cylindrical micelles of cationic amphiphiles.
14 as a topological isomer pair of these shape amphiphiles.
15 ences from those characteristic of molecular amphiphiles.
16 d regulation of membrane protein function by amphiphiles.
17 bbon in supramolecular assemblies of peptide amphiphiles.
18 nded hydrophilic groups, affording polymeric amphiphiles.
19 uble monolayers of nonionic analogues of the amphiphiles.
20 the presence of DNA with the addition of the amphiphiles.
21 tric data on the membrane partition of other amphiphiles.
22 composed of hexagonal- and lamellar-forming amphiphiles.
23 igating the hydrophobic portions of cationic amphiphiles.
24 nanofiber formed by self-assembly of peptide amphiphiles.
25 self-assembling features of these dendritic amphiphiles.
26 can be preserved by using photocrosslinkable amphiphiles.
27 edia exhibit optical responses to biological amphiphiles.
28 e identical electronic properties of all PMI amphiphiles.
29 n of nanomaterials based on aromatic peptide amphiphiles.
31 f planar bilayers that contain two different amphiphiles, a lamellar former and a hexagonal former, w
32 lity, attributed to the unusual shape of the amphiphile: a relatively rigid molecule composed of a la
34 However, we find that anionic and cationic amphiphiles adopt strikingly different structures at liq
35 f a new class of cardanol-derived functional amphiphiles, along with their ability to generate hierar
38 molecular vaccines, through the synthesis of amphiphiles (amph-vaccines) comprising an antigen or adj
41 report here on the self-assembly of peptide amphiphiles and fatty acids driven primarily by anion-pi
42 groups increases the cohesion energy of the amphiphiles and favors the formation of two-dimensional,
43 mphiphiles, which thereby demix from neutral amphiphiles and form spots or rafts within vesicles as w
44 es (Sterosomes) formulated with single-chain amphiphiles and high content of sterols have been develo
45 polar and hydrophobic groups, such as ionic amphiphiles and proteins, is of paramount importance in
46 n vivo correlations that emphasize promising amphiphiles and successful formulation optimization effo
47 cation of an elastin-like protein by peptide amphiphiles and with the capacity to access, and be main
48 alently linked to the hydrophilic end of the amphiphile, and the second molecule is a shorter, nonflu
49 ith prescribed and well-defined densities of amphiphiles, and (iv) require only approximately 200 nL
50 utting of long CNTs in the presence of lipid amphiphiles, and for validation of CNTP incorporation in
51 nditions, these stimuli-responsive molecular amphiphiles are able to assemble into different structur
56 , we report that the same "fragrant" dynamic amphiphiles are ideal to screen for new siRNA transfecti
58 on hybrids, in which perylene diimide (PDI) amphiphiles are noncovalently immobilized onto single wa
61 the aggregates formed in water by head/tail amphiphiles are revisited and discussed from the point o
64 ive phase behaviors of these molecular shape amphiphiles are unique and have not been systematically
66 , we report here the use of isomeric peptide amphiphiles as molecular building blocks to create one-d
67 e, the polymerization of monomers in peptide amphiphile assemblies by a rigid conjugated backbone als
69 that underpin the field of aromatic peptide amphiphile assembly, paving the way to a more rational d
71 possible to draw firm conclusions regarding amphiphile association in solution from crystallographic
72 ar force probes to measure the net effect of amphiphiles, at concentrations often used in biological
74 ated a small library of structurally similar amphiphiles based on poly(2-oxazoline)s and poly(2-oxazi
77 n transmitting the effect of the cooperative amphiphile binding to the i-face as a structural change
78 areful selection of LHGs, different types of amphiphiles (both polymer and small-molecule surfactants
80 govern the self-assembly of aromatic peptide amphiphiles by focusing on four segments, (i) the N-term
82 rooctyl chain attached to a perylene diimide amphiphile can dramatically enhance the strength of supr
84 ssumption that opportunely designed cationic amphiphiles can behave as CD14/MD-2 ligands and therefor
88 s) represent the most recent self-assembling amphiphiles capable of forming monodisperse, stable, and
90 owever, fusion is restored by the lipophilic amphiphile chlorpromazine or by the phospholipase C inhi
91 ctivity relationships were drawn within each amphiphile class, presenting the cellular and animal mod
92 To this end, the use of small molecules, amphiphiles, colloids, and polymers have been investigat
95 of pre-existing vesicles upon an increase in amphiphile concentration either through solvent evaporat
97 echanisms that would lead to increased local amphiphile concentrations is an important aspect of defi
99 supramolecular assemblies of a novel peptide amphiphile containing aldehyde functionality in order to
101 viously we showed that liposomes of cationic amphiphiles containing mannose-mimicking shikimoyl headg
102 repared from polymer-peptide block copolymer amphiphiles containing substrates for protein kinase A,
103 conjugates, small molecule prodrugs, or drug amphiphiles) could involuntarily aggregate, or self-asse
104 lves intercalation of the lipid tails of DNA amphiphiles (CpG motifs for TLR-9 stimulation) into the
106 examined enhanced tumor-specific delivery of amphiphile-CpG, an albumin-binding analog of CpG ODN, fo
109 fferent metals in the porphyrin ring for the amphiphiles described here) in variable proportions.
110 d and synthesized a novel class of glucoside amphiphiles, designated tandem malonate-based glucosides
115 nanoporous network, whereas carboxylic acid amphiphiles do not adopt this nanoporous network due to
116 hydrogen-bonded beta-sheets, and chromophore amphiphiles driven to assemble by pi-orbital overlaps--w
117 e study of enzymatic hydrolysis of polymeric amphiphiles due to the monodispersity and symmetry of th
119 by addition of both zwitterionic and neutral amphiphiles (e.g., diheptanoylphosphatidylcholine or Tri
120 sical properties change upon addition of new amphiphiles (e.g., lipids, alcohols, peptides, or protei
123 means of two supramolecular systems--peptide amphiphiles engaged in hydrogen-bonded beta-sheets, and
124 water as the selective solvent, these shape amphiphiles exhibited versatile self-assembled micellar
126 tives of this maltose-neopentyl glycol (MNG) amphiphile family show favorable behavior relative to co
127 e developed a family of steroid-based facial amphiphiles (FAs) that are structurally distinct from co
130 s knowledge in the design of novel synthetic amphiphiles, formulations, and revolutionary screening a
131 producing a self-assembling aromatic peptide amphiphile from amino acid precursors that temporarily e
132 ynthesis of a homologous series of five such amphiphiles from 14 to 22 carbons-RNHCONHC(CH2CH2CO2H)3,
141 specific interactions between water and the amphiphile head groups, both at the interface and in the
142 imple expedient of mixing slightly different amphiphiles (i.e., different metals in the porphyrin rin
143 eins bind to and interact with the polymeric amphiphiles in both their assembled and monomeric states
144 ecently reported on the activity of cationic amphiphiles in inhibiting TLR4 activation and subsequent
145 measurements were performed on the discotic amphiphiles in mixtures of water and alcohol at temperat
147 nducing properties of the promising cationic amphiphiles in syngeneic C57BL/6J mice under prophylacti
149 eparation protocols to self-assemble peptide amphiphiles in water can result in the formation of diff
152 , we synthesize a series of methanofullerene amphiphiles, including derivatives of C60, C70, and C84,
154 s of 1 nM, measured for PEO-rich bottlebrush amphiphiles, indicated an enhanced thermodynamic stabili
155 he induced circular dichroism signal of this amphiphile, indicating a sterically congested, but stabl
157 hat aggregates of decanoic acid, a prebiotic amphiphile, interact with the bases and sugar found in R
158 drophobic effect drives the self-assembly of amphiphiles into a broad range of micellar, rod-like, bi
160 s, their modified versions, and other single amphiphiles into liposomes, and from block copolymers in
162 stigations on the self-assembly of dendritic amphiphiles into various nanostructures in water on the
165 spontaneous formation of membranes from such amphiphiles is a concentration-dependent process in whic
166 formation of graphene derivatives by natural amphiphiles is essential for elucidating the biological
173 s been drawn between them, organic molecular amphiphiles (MAMs) and inorganic nanoparticle (NP) amphi
174 ness in three-dimensional artificial peptide amphiphile matrices offers a chemical strategy to contro
176 show that the 2D crystallization process in amphiphile membranes can be controlled by modifying the
177 on early Earth and other rocky planets, and amphiphile-mineral interactions in diverse other phenome
178 ows the renormalized bending stiffness of an amphiphile mixture membrane tube in contact with a flat
179 ures formed between tobramycin, DNA, and the amphiphile mixtures and show how interactions between th
180 ing cryogenic electron microscopy, a peptide amphiphile molecule containing aromatic residues was fou
181 eveloped a series of self-assembling peptide amphiphile molecules that transform either isolated from
183 embly of two model series of molecular shape amphiphiles, namely, hydrophilic [60]fullerene (AC(60))
184 y to study the molecular exchange of peptide amphiphile nanofibres, supramolecular systems known to h
186 synthetic cell-free therapy based on peptide amphiphile nanostructures designed to mimic the activity
187 hiles (MAMs) and inorganic nanoparticle (NP) amphiphiles (NPAMs) are significantly different in dimen
196 ssembling dilysine (+2) and carboxylate (-1) amphiphiles of various tail lengths into bilayer membran
197 The solution self-assembly of macromolecular amphiphiles offers an efficient, bottom-up strategy for
200 mixtures of cationic and negative curvature amphiphiles optimized for DNA binding via charge matchin
201 ertion of cone-shaped or inverse cone-shaped amphiphiles or by cholesterol removal switches CD39 to t
203 eport here on a coassembly system of peptide amphiphile (PA) molecules designed to form nanofibers fo
205 ane disruption was integrated into a peptide amphiphile (PA) that self-assembles into bioactive, cyli
206 self-assembly of mixtures of bilayer-forming amphiphiles, particularly phospholipids and micelle-form
207 The predictive powers should extend also to amphiphile partitioning and the kinetics of lipid-monome
210 ramolecular liquid crystal formed by peptide amphiphiles (PAs) that encapsulates cells and growth fac
211 on a set of diacetylene-derivatized peptide amphiphiles (PAs) that react to form conjugated polydiac
212 ilic packing in the self-assembly of peptide-amphiphiles (PAs) was investigated using a series of 26
219 alent ligands within a mixture of polyvalent amphiphiles provides, in principle, a simple mechanism f
222 lf-assembly of molecular and block copolymer amphiphiles represents a well-established route to micel
223 expressed by the minimum volume fraction of amphiphile required to form microemulsion (Phi(ME)), whi
224 e on a proof-of-concept bioconjugate polymer amphiphile, revealed growth and evolution occurring by u
225 inding chemistry to design a new fluorinated amphiphile, RfNTA, using an improved one-step synthesis
226 y grafted with macromolecules ('nanoparticle amphiphiles') robustly self-assemble into a variety of a
227 er membranes composed of simple single-chain amphiphiles seem to be well-suited for a potential role
229 he ability of ionic liquids (ILs) to support amphiphile self-assembly into a range of mesophase struc
230 tructures that are formed, and (iii) how can amphiphile self-assembly materials be used to enhance pr
232 In this review we discuss ionic liquids as amphiphile self-assembly media, and identify trends that
233 To reproducibly engineer the low energy amphiphile self-assembly of materials for the future, we
236 ecent key findings regarding (i) what drives amphiphile self-assembly, (ii) what governs the self-ass
240 ructures obtained from natural and synthetic amphiphiles serve as mimics of biological membranes and
241 uman aortic endothelial cells with exogenous amphiphiles, shown previously in model membranes, and co
243 hese results suggest that optimized cationic amphiphile solutions have the potential to enhance antim
244 antages of cholesterol with those of charged amphiphiles, stabilizing the aligned phase and preventin
245 hat vesicles composed of simple single-chain amphiphiles such as fatty acids, fatty alcohols, and fat
246 his study we systematically examined whether amphiphiles such as indomethacin influence Ras protein n
247 levels and high concentrations of exogenous amphiphiles, suggesting it as a general feature of the o
248 The results reported here show that peptide amphiphile supramolecular systems can be dynamic and tha
250 ithin the same energy landscape, the peptide-amphiphile system forms a thermodynamically favoured pro
252 rylated once more to generate a farnesyl-CoA amphiphile that self-assembles into spherical micelles.
253 in aqueous media produces a bola-type supra-amphiphile that self-assembles to produce higher order m
255 These results demonstrate that only the amphiphile that thinned Ld lipid domains increased beta1
256 his aggregate consists of three inequivalent amphiphiles that assemble to create 3- and 6-fold rotati
257 are designing novel cationic and procationic amphiphiles that can pack, transport, and deliver nuclei
258 rticles are colloidal analogues of molecular amphiphiles that can self-assemble to form diverse supra
259 work is motivated by one class of molecular amphiphiles that change their surfactant properties in r
260 Antimicrobial peptides (AMPs) are cationic amphiphiles that comprise a key component of innate immu
261 ort the crystal structures of several tripod amphiphiles that contain an N-oxide hydrophilic group.
262 s, we prepared a small collection of anionic amphiphiles that could recognize cations by ionpair-pi i
263 d evaluation of a new class of benzothiazole amphiphiles that exhibit a dose-dependent response leadi
264 gating dendritic alkyl chains to DNA creates amphiphiles that exhibit high-affinity (Kd in low nanomo
265 protocell membranes because they are simple amphiphiles that form bilayer membrane vesicles that ret
266 Antimicrobial peptides are small cationic amphiphiles that play an important role in the innate im
268 convert nonstructure forming molecules into amphiphiles that spontaneously assemble into vesicles.
270 intermolecular complexes can exist for this amphiphile, the molecule folds into a unique intramolecu
271 n the dimension mismatch of the two types of amphiphiles, the entanglement of polymer chains, and the
274 ed by rational design in the headgroup of an amphiphile to generate small micelles with enhanced stab
275 The ability to utilize multiple distinct amphiphiles to construct discrete assemblies represents
276 PEG chain induces self-assembly of polymeric amphiphiles to form micrometer-sized vesicles entrapping
277 The presence of zwitterionic and neutral amphiphiles (to which the protein binds weakly) dilutes
278 on of n-alkylated peptide nucleic acids (PNA amphiphiles) to the products, followed by separation wit
283 xtures under the influence of three nonlipid amphiphiles, vitamin E (VE), Triton-X (TX)-100, and benz
285 nd charged oligo(p-phenylene vinylene) (OPV) amphiphiles were fabricated in one step by spin casting
286 tizing perylene monomimide (PMI) chromophore amphiphiles were found to show variation in hydrogen gas
287 or spectroscopic investigation is to form an amphiphile, which is able to disperse the latter at the
288 D in toxicity induced by U18666A, a class II amphiphile, which triggers cell death by impairing the t
289 ns are shown here to crossbridge polyanionic amphiphiles, which thereby demix from neutral amphiphile
293 c function of perylene monoimide chromophore amphiphiles with different alkyl linker lengths separati
295 on (1)H-(13)C HSQC experiments, complexes of amphiphiles with more than 10 different maltooligosaccha
296 dispersities were obtained from bottlebrush amphiphiles with packing parameters of approximately 0.3
297 functionalized polymer to give rise to shape amphiphiles with precisely defined surface chemistry and
298 versus fibers) in a series of simple peptide amphiphiles with the sequence c16-xyL3K3-CO2H where c16
299 hed dendrons make an excellent headgroup for amphiphiles with ultralong, saturated, linear alkyl chai
300 ebiotic synthesis of fatty acids and related amphiphiles would result in dilute solutions well below
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