ライフサイエンスコーパス: amphiregulin

1 f Ras in response to constitutively produced amphiregulin.

2 n of 2 crucial growth factors, TGF-alpha and amphiregulin.

3 oter and thereby suppressed the induction of amphiregulin.

4 f the growth factors regenerating gene I and amphiregulin.

5 perplasia by the cAMP-dependent induction of amphiregulin.

6 he SCID mouse is mediated, in large part, by amphiregulin.

7 the mechanism by which tobacco smoke induces amphiregulin.

8 , and AREG, which codes for the EGFR ligand, amphiregulin.

9 e H55a#1 contained a library insert encoding amphiregulin.

10 with a >/= 3 h delay relative to HB-EGF and amphiregulin.

11 sue repair, including IL-7, Ccl2, Ptgs2, and Amphiregulin.

12 2 expression of IL-5 and IL-13 and increased amphiregulin.

13 avage of TGF-alpha, heparin-binding EGF, and amphiregulin.

14 ed by administration of the lung ILC product amphiregulin.

15 n the shedding rate of any ligand, including amphiregulin.

16 HT of human stroke are described, including amphiregulin, a growth factor that regulates matrix meta

17 roteinase (ADAM) 17) to cleave transmembrane amphiregulin, a ligand for the epidermal growth factor r

18 Recently, elevated levels of amphiregulin, a ligand of the EGFR, were found in the or

19 (H)2), but not other T cell subsets, express amphiregulin, a member of the epidermal growth factor (E

20 The major target of WT1 was amphiregulin, a member of the epidermal growth factor fa

21 models of lung tumors in mice, we found that amphiregulin, a member of the epidermal growth factor fa

22 Interestingly, the expression of amphiregulin, a potent mammary epithelial cell growth fa

23 Levels of amphiregulin, a protein that induces mucin production, w

24 yrosine kinase or a neutralizing antibody to amphiregulin abrogated the increase in DNA synthesis med

25 c hyperplasia and suggest that inhibition of amphiregulin activity could be an efficacious therapeuti

26 strogen growth factor receptor (EGFR) ligand amphiregulin acts as an important stage-specific effecto

27 ralizing antibody to EGFR, or an antibody to amphiregulin, an EGFR ligand, also blocked tobacco smoke

28 Amphiregulin, an EGFR ligand, was induced in a TLR4, Cox

29 gnaling, in part, by inducing the release of amphiregulin, an EGFR ligand.

30 ed EGFR signaling by inducing the release of amphiregulin, an EGFR ligand.

31 , and enhances WT1-mediated transcription of Amphiregulin, an endogenous target gene.

32 vealed that PTH stimulates the expression of amphiregulin, an epidermal growth factor (EGF)-like liga

33 ed transmembrane molecule: the precursor for amphiregulin, an epidermal growth factor-related molecul

34 fter stimulation with heparin-binding EGF or amphiregulin and alters the rate of recruitment of the a

35 dermal growth factor receptor (Egfr) ligands amphiregulin and beta-cellulin, as well as Egfr and phos

36 aplasia (MUCIN5AC and MUCIN6), and increased amphiregulin and Egfr activity.

37 a, and Wnt10b, as well as Egf family ligands amphiregulin and epigen.

38 ription of HB-EGF (epidermal growth factor), amphiregulin and epiregulin, resulting in autocrine acti

39 bited with neutralization antibodies against amphiregulin and HB-EGF, the heparin-binding growth fact

40 NA levels of two other EGF receptor ligands, amphiregulin and heparin binding-EGF, however, in the sk

41 CE-deficient cells increased the shedding of amphiregulin and heparin-binding EGF (HB-EGF) proteins.

42 Amphiregulin and heparin-binding EGF-like growth factor

43 show that during infection, the EGFR ligands amphiregulin and heparin-binding EGF-like growth factor

44 The binding of amphiregulin and its homolog, heparin-binding epidermal

45 igh gene expression levels of epiregulin and amphiregulin and patients with wild-type K-ras are more

46 ss both transforming growth factor alpha and amphiregulin and require autocrine signaling through the

47 The ability of tobacco smoke to induce amphiregulin and thereby enhance DNA synthesis is likely

48 Interestingly, unlike amphiregulin and TNFRI, full-length intercellular adhesi

49 endent release of the endogenous EGFR ligand amphiregulin and transactivation of the EGFR.

50 m by which TS activated EGFR, the release of amphiregulin and transforming growth factor alpha, two l

51 markedly induced the expression of mRNAs for amphiregulin and transforming growth factor alpha.

52 Serial serum samples were measured for amphiregulin and transforming growth factor-alpha (TGFal

53 the epidermal growth factor receptor ligand amphiregulin and tumor necrosis factor receptor I (TNFRI

54 release of the endogenous ADAM17 substrates, amphiregulin and tumor necrosis factor-alpha, metallopro

55 evels of two ectopic EGFR ligands (HBEGF and amphiregulin) and the FGFR2(IIIb) receptor ligand KGF, f

56 dermal growth factor family members, epigen, amphiregulin, and betacellulin.

57 recognized HB-EGF as well as the EGFR ligand amphiregulin, and bound specifically to human HB-EGF, bu

58 owth factors TGF-alpha, heparin binding-EGF, amphiregulin, and EGF receptor tyrosine phosphorylation

59 l into two major groups as follows: (i) EGF, amphiregulin, and EPR; and (ii) betacellulin, TGFalpha,

60 ression of transforming growth factor-alpha, amphiregulin, and gastrin; and activation of extracellul

61 h factor vascular endothelial growth factor, amphiregulin, and glucose metabolism-involved gene insul

62 tor (EGF), transforming growth factor alpha, amphiregulin, and heparin-binding EGF in regenerating li

63 piregulin, transforming growth factor alpha, amphiregulin, and heparin-binding EGF-like growth factor

64 r, Wnt, Hh, transforming growth factor beta, amphiregulin, and hepatocyte growth factor) to their res

65 sulting in increased secretion of TGF-alpha, amphiregulin, and heregulin.

66 tor receptors (eg, hepatocyte growth factor, amphiregulin, and insulin-like growth factor 1 receptor)

67 genes revealed that caveolin 1, caveolin 2, amphiregulin, and melanoma growth stimulatory activity a

68 s effect allows plasma components, including amphiregulin, and other mitogens to enter the CSF and pr

69 These results define an amphiregulin- and ErbB1-dependent mechanism by which aut

70 tor, AG1478, 2) neutralizing HB-EGF, but not amphiregulin, antibodies, heparin, or CM197, and 3) phar

71 The anti-amphiregulin antibody reduced epidermal thickness of tra

72 nd we also demonstrated enhanced shedding of amphiregulin (AR) and heparin-binding (HB)-EGF upon rest

73 ic polypeptide-expressing metaplasia (SPEM), amphiregulin (AR) and transforming growth factor-alpha-d

74 Amphiregulin (AR) autocrine loops have been associated w

75 Dysregulated amphiregulin (AR) expression and EGR receptor (EGFR) act

76 in the ectodomain to release several soluble amphiregulin (AR) forms.

77 Overexpression of amphiregulin (AR) has been linked to psoriasis in mouse

78 Biosynthesis and processing of amphiregulin (AR) have been investigated in human colore

79 embryonic lungs synthesized and responded to amphiregulin (AR) in a different fashion.

80 ha synergistically induces the expression of amphiregulin (AR) in colon cancer cells.

81 Amphiregulin (AR) involvement in liver fibrogenesis and

82 Amphiregulin (AR) is a heparin-binding, heparin-inhibite

83 pidermal growth factor (EGF) receptor ligand amphiregulin (AR) is reported to be an 84-amino acid res

84 We previously determined that loss of amphiregulin (AR) promotes SPEM induced by acute oxyntic

85 a saline extract of tobacco smoke stimulated amphiregulin (AR) transcription resulting in increased a

86 Targeted mice lacking functional EGF or amphiregulin (AR) were derived and bred to the TGFalpha-

87 We hypothesized that amphiregulin (AR), a keratinocyte autocrine growth facto

88 This study investigated whether amphiregulin (AR), a ligand of the epidermal growth fact

89 Here we report that the expression of amphiregulin (AR), a member of the epidermal growth fact

90 e A pathway, which induced the expression of amphiregulin (AR), an epidermal growth factor family mem

91 in-binding epidermal growth factor (EGF) and amphiregulin (AR), and activation of the EGF receptor an

92 protein, and mRNA transcripts for TGFalpha, amphiregulin (AR), and heparin-binding EGF-like growth f

93 es EGFR ligands heparin-binding (HB)-EGF and amphiregulin (AR), and reduces betacellulin mRNA levels.

94 ting hormone (FSH) and the EGF-like peptide, amphiregulin (AR), are potent inducers of maturation in

95 ming growth factor (TGF)-alpha, but not with amphiregulin (AR), betacellulin (BTC) or epiregulin (EPR

96 actor (TGF)-alpha, heprin-ding (HB)-EGF, and amphiregulin (AR), have been shown to stimulate events a

97 pidermal growth factor (EGF) family hormones amphiregulin (AR), transforming growth factor-alpha (TGF

98 epidermal growth factor-like growth factor, amphiregulin (AR), which was not expressed by untreated

99 tors, and by neutralizing antibodies against amphiregulin (AR).

100 at include epidermal growth factor (EGF) and amphiregulin (AR).

101 cascades in response to the ligands EGF and amphiregulin (AR).

102 RTs in EGFR recycling after stimulation with amphiregulin (AR).

103 ficking and signaling after stimulation with amphiregulin (AR).

104 sforming growth factor alpha (TGF alpha) and amphiregulin are delivered to the basolateral surface of

105 gh levels of the EGFR ligands epiregulin and amphiregulin are more likely to have disease control wit

106 sine kinase (DDR1) and the ErbB1 receptor of amphiregulin are, for example, required for ductal branc

107 genes repressed by BRCA1, we have identified amphiregulin (AREG) and early growth response-1 (EGR1).

108 dermal growth factor receptor (EGFR) ligands amphiregulin (AREG) and epiregulin (EREG), and systemic

109 dermal growth factor receptor (EGFR) ligands amphiregulin (AREG) and epiregulin (EREG).

110 ving ectodomain shedding of the EGFR ligands amphiregulin (AREG) and TGF-alpha, which rely upon the c

111 is study evaluated the diagnostic utility of amphiregulin (AREG) as a pancreatic cyst fluid biomarker

112 idermal growth factor receptor (EGFR) ligand Amphiregulin (AREG) by co-activating the transcription f

113 ermal growth factor (EGF)-like growth factor amphiregulin (AREG) engages EGFR on Treg cells and, in d

114 se fragment complementation imaging studies, amphiregulin (AREG) functioned as a partial agonist, ind

115 The EGFR ligand amphiregulin (AREG) has been implicated as an important

116 here is a large body of literature regarding amphiregulin (AREG) in human cancer, most knowledge focu

117 with IL-33, expression of the growth factor amphiregulin (AREG) is a dominant functional signature o

118 Amphiregulin (AREG) is an important regulator of cellula

119 rian and lung cancer patients and found that amphiregulin (AREG) is the most abundant and generalized

120 how that silencing of the EGF-related factor amphiregulin (AREG) markedly inhibits the expansion of h

121 ession of EGFR ligands epiregulin (EREG) and amphiregulin (AREG) may correlate with EGFR-targeted the

122 epidermal growth factor (EGF)-like molecule Amphiregulin (AREG) might be a critical component of typ

123 Amphiregulin (AREG) was by far the most abundant EGFR li

124 e epidermal growth factor (EGF)-like protein amphiregulin (AREG) was highly expressed in ExeR cells b

125 owth factor 7, hepatocyte growth factor, and amphiregulin (AREG) were elevated in the extracellular e

126 study shows that AGR2 induces expression of amphiregulin (AREG), a growth promoting EGFR ligand.

127 Amphiregulin (AREG), an epidermal growth factor receptor

128 K by derepressing miR-200 targets, including amphiregulin (AREG), betacellulin (BTC), and the transcr

129 th factor receptor (EGFR) pathway, including amphiregulin (AREG), epiregulin (EREG), and ectodomain c

130 ubstrates TNF-alpha, TNFR1-alpha, TGF-alpha, amphiregulin (AREG), HB-EGF and IL-6Ralpha, from IGROV1-

131 factor (EGF)-like growth factors, including Amphiregulin (AREG), heparin-binding EGF (HB-EGF), and t

132 ligands including EGF, TGF-alpha (TGFalpha), amphiregulin (AREG), heparin-binding EGF-like growth fac

133 -mediated silencing of one of these ligands, amphiregulin (AREG), results in keratinocyte growth arre

134 alpha to regulate directly the expression of amphiregulin (Areg), the progesterone receptor (Pgr) and

135 evealed that the ADAM17 proteolytic targets, amphiregulin (AREG), transforming growth factor alpha (T

136 ratinocytes (KCs) is strongly dependent upon amphiregulin (AREG), whereas blockade of heparin-binding

137 growth factor receptor (EGFR) and its ligand amphiregulin (AREG), which generally must be cleaved fro

138 axis leads to production of the EGFR ligand amphiregulin (AREG).

139 Our findings implicate amphiregulin as a critical mediator of the estrogen resp

140 elated evidence led to the identification of amphiregulin as a major autocrine factor for keratinocyt

141 HER2 induced the EGFR ligands TGF-alpha and amphiregulin at the mRNA and protein levels.

142 s a cause of sustained expression of uterine amphiregulin before the initiation of implantation.

143 Moreover, blockade of amphiregulin bioactivity using a neutralizing polyclonal

144 n addition to TGF-alpha release, GRP induced amphiregulin, but not EGF, secretion into HNSCC cell cul

145 We also demonstrate that amphiregulin, but not epiregulin, partially compensates

146 )] markedly inhibited elaboration of soluble amphiregulin by NHKs.

147 Amphiregulin cleavage by pervanadate occurred in the abs

148 combination of F115 and Y123 determined the amphiregulin cross-reactivity and that F115 accounted fo

149 that the addition of recombinant epiregulin, amphiregulin, CX3CL1, and interleukin-11 significantly e

150 Furthermore, T cell-restricted amphiregulin deficiency resulted in markedly delayed lun

151 e epithelial cell proliferation, and lack of amphiregulin delayed expulsion of the nematode Trichuris

152 am as well as downstream of ErbB1 to promote amphiregulin-dependent autocrine stimulation of NHKs and

153 pressor gene, a transcriptional activator of amphiregulin, did not parallel amphiregulin transcript l

154 Amphiregulin does not interact with NKD2 and retains its

155 ding of transforming growth factor alpha and amphiregulin does not require ADAM17, even though ADAM17

156 iated proteins appear to act as cofactors in amphiregulin-driven mitogenesis mediated by the epiderma

157 The in vivo expression profile of amphiregulin during fetal kidney development mirrors the

158 Results link HDM, IL-17A, amphiregulin, EGFR and GM-CSF in a mechanistic pathway i

159 signaling cascade of GRP-Src-PI3-K-PDK1-TACE-amphiregulin-EGFR with multiple points of interaction, t

160 epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin.

161 bFGF, IL-8, and ANGPTL-2), as well as ErbB (amphiregulin, epiregulin, and neuregulins) and TGF-ss, w

162 pha, heparin-binding EGF-like growth factor, amphiregulin, epiregulin, betacellulin, or heregulin bet

163 echanisms: protection from fatal immunity by amphiregulin expression and augmentation of antileukemic

164 ting mucin production, through regulation of amphiregulin expression and collagen deposition.

165 naling via IL-33 induces type 2 cytokine and amphiregulin expression, and increases ILC2 migration.

166 or-beta signaling, the extracellular matrix, amphiregulin expression, and the growth hormone/insulin-

167 n transforming growth factor (TGF)-alpha and amphiregulin expression.

168 Amphiregulin, follistatin, and inhibin-beta-A and epireg

169 lar smooth muscle cells, particularly COX-2, amphiregulin, follistatin, inhibin-beta-A, and CYR61.

170 mutant mice suggests a compensatory role of amphiregulin for uterine loss of HB-EGF, preventing comp

171 th factor receptor (EGFR) and of its ligand, amphiregulin, for the formation of a signaling complex b

172 emonstrate that PTH increases the release of amphiregulin from osteoblastic cells, which acts on the

173 nes, the connective tissue growth factor and amphiregulin genes.

174 -binding EGF-like growth factor (HB-EGF) and amphiregulin genes.

175 nscripts encoding epithelial growth factors (amphiregulin, Gro-1, Gro-2).

176 Overexpression of amphiregulin has been shown to induce psoriasiform chang

177 Therefore, amphiregulin has been suggested as a target for anti-pso

178 nds including epidermal growth factor (EGF), amphiregulin, heparin-binding EGF and beta-cellulin.

179 In addition, three ErbB1 ligand transcripts (amphiregulin, heparin-binding epidermal growth factor-li

180 as well as transforming growth factor-alpha, amphiregulin, heparin-binding epidermal growth factor-li

181 ) ligands (transforming growth factor-alpha, amphiregulin, heregulin, heparin binding EGF-like ligand

182 stromal lymphopoietin, and the growth factor amphiregulin in a human bronchial epithelial cell line.

183 In this study, we investigated the role of amphiregulin in breast cancer cell proliferation using h

184 tating cleavage and release of TGF-alpha and amphiregulin in HNSCC.

185 ional psoriatic epidermis, the importance of amphiregulin in hyperproliferative skin diseases has bee

186 binding EGF-like growth factor (HB-EGF); and amphiregulin in NHBECs, and when administered exogenousl

187 r, these data indicate an important role for amphiregulin in psoriatic hyperplasia and suggest that i

188 ls, suggesting that another factor regulates amphiregulin in SUM-149PT.

189 Our data confirm the importance of amphiregulin in the etiology of breast cancer.

190 Amphiregulin, in contrast, enables normal ductal develop

191 not transforming growth factor (TGF)alpha or amphiregulin, in young adult mouse colon cells and ADAM1

192 e secretion of EGF family ligands, including amphiregulin, independent of metalloprotease a disintegr

193 terminal differentiation in adult breast and amphiregulin is critical to normal embryonic breast deve

194 Following from the observation that amphiregulin is overexpressed in lesional psoriatic epid

195 Amphiregulin is the most abundantly expressed EGFR ligan

196 trate that selective Treg cell deficiency in amphiregulin leads to severe acute lung damage and decre

197 Furthermore, amphiregulin levels were suppressed in patients treated

198 tion, resulting in impaired IL-5, IL-13, and amphiregulin levels, despite undiminished numbers of Th2

199 er EGFR ligands EGF, heparin-binding EGF, or amphiregulin, mediates SP-induced EGFR transactivation.

200 actor, transforming growth factor-alpha, and amphiregulin mRNA and protein in lesional psoriasis comp

201 nscription resulting in increased amounts of amphiregulin mRNA and protein.

202 9, an EP2-specific agonist, strongly induced amphiregulin mRNA levels in a protein kinase A-dependent

203 ly, TCN enhanced the expression of c-fos and amphiregulin mRNA.

204 genomic responses, since both calcitonin and amphiregulin mRNAs were increased after progesterone tre

205 hat release of activated HB-EGF (but neither amphiregulin nor EGF) occured after wounding.

206 Mice deficient in either amphiregulin or epiregulin, two EGFR ligands, display de

207 induces expression of either the EGFR ligand amphiregulin or the transcription factor CDX2, only the

208 ncentration that neutralized the function of amphiregulin, or antibodies against TGFalpha or HB-EGF a

209 tivity, high levels of ERBB2 (P = 0.036) and amphiregulin (P = 0.026) predicted sensitivity to lapati

210 GM-CSF production also required amphiregulin, p38 MAPK signalling and protease/TACE acti

211 t the cytoplasmic carboxy-terminal domain of amphiregulin plays an important role in regulating autoc

212 In this study, the role of the amphiregulin precursor (pro-AR) cytoplasmic domain in th

213 h factor receptor (EGFR) phosphorylation and amphiregulin production were examined by Western blot an

214 s showed that IGF-1 transactivation required amphiregulin production, whereas LPA was dependent on mu

215 inhibited NHK proliferation, migration, and amphiregulin production.

216 The WT1(-KTS) isoform binds directly to the amphiregulin promoter, resulting in potent transcription

217 -dependent transcriptional activation of the amphiregulin promoter.

218 Through the YAP1 target, Amphiregulin, Ras activates the endogenous EGFR pathway,

219 dermal growth factor and 10-fold increase in amphiregulin, respectively) in HELUs compared with TDLUs

220 Pharmacologic regulation of amphiregulin's expression and receptor signaling may eve

221 by the epidermal growth factor receptor, but amphiregulin's immunolocalization to keratinocyte nuclei

222 TGF-alpha and amphiregulin secretion by GRP stimulation also was inhib

223 0 and ADAM17, reduces in vitro HER-2/neu and amphiregulin shedding, confirming that it interferes wit

224 Two transgenic mouse models (amphiregulin, STAT-3) were reported that have features o

225 -Leuk1 cells with tobacco smoke or exogenous amphiregulin stimulated DNA synthesis.

226 cific pattern of WT1 itself, and recombinant Amphiregulin stimulates epithelial branching in organ cu

227 e observation of normal induction of uterine amphiregulin surrounding the blastocyst at the time of a

228 ytes secrete soluble EGFR ligands (including amphiregulin) that are processed from membrane-bound pro

229 The binding of amphiregulin to EGFR then stimulates proliferation of lu

230 ne encoding keratin 14 promoter-driven human amphiregulin to the basal epidermis of mice.

231 activator of amphiregulin, did not parallel amphiregulin transcript levels, suggesting that another

232 SUM-149PT and H55a#1 cells overexpressed amphiregulin transcripts, and secreted moderate EGF-like

233 PRIP-deficient glands expressed increased amphiregulin, transforming growth factor-alpha, and beta

234 on that regulates release of the EGFR ligand amphiregulin upon GRP treatment.

235 Amphiregulin was enriched in ERalpha-positive human brea

236 lonal antibody capable of neutralizing human amphiregulin was examined for anti-proliferative effects

237 nsforming growth factor-alpha (TGFalpha), or amphiregulin we have shown that only the anti-TGFalpha a

238 GF-alpha), heparin binding-EGF (HB-EGF), and amphiregulin were analyzed for their ability to mediate

239 itogenic on 32D.E4 cells, whereas HB-EGF and amphiregulin were inactive.

240 (EGF), transforming growth factor alpha, and amphiregulin were used to identify roles for these EGF r

241 uscle Treg cells expressed the growth factor Amphiregulin, which acted directly on muscle satellite c

242 EGF receptor stimulation by TGF-alpha and/or amphiregulin, which are known to be elevated in psoriati