ライフサイエンスコーパス: amygdala

1 al regions (external capsule, claustrum, and amygdala).

2 ting from the rpSTS, via the raSTS, into the amygdala.

3 omically consistent with the BNST toward the amygdala.

4 pallium and to part of the mammalian pallial amygdala.

5 atory synaptic activity in both the mPFC and amygdala.

6 and dose-response latency for targeting the amygdala.

7 trophy in right ventral mid-insula and right amygdala.

8 n binding sites in coronal brain sections of amygdala.

9 x (PFC), nucleus accumbens, hippocampus, and amygdala.

10 ate neurons that project to the striatum and amygdala.

11 immunodensity in the central nucleus of the amygdala.

12 posteromedial cortex (PMC), hippocampus, and amygdala.

13 ith differential expression of miRNAs in the amygdala.

14 of stress and chronic pain pathways via the amygdala.

15 dely throughout the forebrain, including the amygdala.

16 y and cataplexy is reduced by lesions of the amygdala.

17 y in the basal and lateral subregions of the amygdala.

18 lis, a key component of the central extended amygdala.

19 tion in the prefrontal cortex, striatum, and amygdala.

20 h interactions with the ventral striatum and amygdala.

21 well as with the chemosensory and basomedial amygdala.

22 telencephalon is comparable to the mammalian amygdala.

23 tructed, CS presentations in the human right amygdala.

24 l synaptic efficacy under the control of the amygdala.

25 les showed preferential recruitment of basal amygdala.

26 ting from the rpSTS, via the raSTS, into the amygdala.

27 ere weakly correlated to the activity in the amygdala.

28 e projection neurons in the central extended amygdala.

29 campus, medial prefrontal cortex (mPFC), and amygdala.

30 ace in the striatum and are regulated by the amygdala.

31 on in the PFC at inputs from the basolateral amygdala.

32 ions, including the orbitofrontal cortex and amygdala.

33 These data indicate amygdala 2-AG signalling mechanisms promote resilience t

34 Recent work suggests that the amygdala, a brain area important for processing emotion,

35 nt study elucidates one circuit by which the amygdala, a critical structure for emotional learning, v

36 ffects on the brain, less is known about the amygdala, a key brain area involved in the neural circui

37 eta oscillations between V2L and basolateral amygdala, a physiological correlate of successful recall

38 o date, we add new knowledge about bilateral amygdala, accumbens, and hippocampus reductions in ADHD.

39 nits and their correlation with task-induced amygdala activation revealed distinct functional profile

40 ta-9-THC induced anxiety and modulated right amygdala activation while processing fear.

41 in a city has been associated with increased amygdala activity in a stress paradigm, and being brough

42 connectivity analysis confirmed that reduced amygdala activity was not merely an indirect consequence

43 e-dependent dynamic balance between BNST and amygdala activity.

44 ine (NE) administration into the basolateral amygdala after training on an inhibitory avoidance discr

45 g is mediated by synapse-specific LTP in the amygdala, allowing animals to discriminate stimuli that

46 the structure-function relationship between amygdala anatomical substructures, supporting the use of

47 We investigated reactivity of the amygdala and cortical areas to repeated threat presentat

48 Evidence for circadian SST expression in the amygdala and disrupted circadian rhythms and rhythmic pe

49 l stimuli in multiple brain areas, including amygdala and fronto-limbic regions, compared with placeb

50 We used direct recordings in the amygdala and hippocampus from human epilepsy patients to

51 ethyl-D-aspartate receptor plasticity in the amygdala and how this system could contribute to disorde

52 nous administration of T rapidly potentiates amygdala and hypothalamus responses to angry facial expr

53 e modulation of developmental factors in the amygdala and hypothalamus, underpinned by a systems-wide

54 ain regions for social behavior, such as the amygdala and insula.

55 ppocampus (VH) projects to both the mPFC and amygdala and is recruited in context-dependent control o

56 These findings show that the amygdala and LC state actively determines which sensory

57 ter radial distance (thickness) of the right amygdala and left thalamus, and localized increases and

58 erences in the a priori regions of interest (amygdala and midbrain) revealed a significant difference

59 enotype and messenger RNA levels of Ppm1f in amygdala and mPFC in male mice and in mPFC of female mic

60 d colocalization with CAMK2G were altered in amygdala and mPFC of male mice.

61 s with crossed surgical disconnection of the amygdala and OFC did not.

62 , we recorded the activity of neurons in the amygdala and orbitofrontal cortex (OFC) of monkeys durin

63 ns (for example, the locus coeruleus, medial amygdala and paraventricular nucleus), implicating a pro

64 Positive connectivity between amygdala and posterior middle cingulate cortex was found

65 The amygdala and prefrontal cortex (PFC) appear to have crit

66 higher average levels of activity within the amygdala and regions of PFC known a priori to be involve

67 sful life events showed hyperactivity of the amygdala and several regions across the brain.

68 localized with miR-144-3p in the basolateral amygdala and showed functional downregulation following

69 enhances low-frequency coupling between the amygdala and the hippocampus.

70 ect output to the medial part of the central amygdala and the hypothalamic 'aggression area', suggest

71 onal and structural connectivity between the amygdala and the prefrontal systems may contribute to th

72 differences in FC were observed between the amygdala and ventral PFC (VPFC), dorsolateral PFC (DLPFC

73 Corticolimbic pathways connecting the amygdala and ventral prefrontal cortex (vPFC) are linked

74 , and connectivity between, the hippocampus, amygdala and ventromedial PFC during conditioning.

75 vCA1 neurons projected to both the mPFC and amygdala and were recruited preferentially during contex

76 , globus pallidus, putamen, hippocampus, and amygdala) and homeostatic (hypothalamus) food motivation

77 f cortical (motor cortex, insula, cingulate, amygdala) and sub-cortical (putamen, thalamus, globus pa

78 n (striatum, prefrontal cortex, hippocampus, amygdala, and bed nucleus of the stria terminalis).

79 Reduced forebrain, hippocampus, striatum, amygdala, and cortical volume were also observed.

80 abnormalities in frontal and temporal lobes, amygdala, and insula are less consistent.

81 tructural abnormalities of the frontal lobe, amygdala, and insula.

82 xhibited significantly decreased mid-insula, amygdala, and orbitofrontal activity while attending to

83 ject to NAc, prefrontal cortex, the extended amygdala, and other forebrain regions but less than 10%

84 urons, compromises prefrontal control of the amygdala, and sets off a general alarm system as seen in

85 ty between the nucleus accumbens (NAcc), the amygdala, and the medial prefrontal cortex (mPFC), which

86 ocial behavior: the nucleus accumbens (NAc), amygdala, and ventral tegmental area.

87 ng anatomically defined ROIs in the caudate, amygdala, and visual cortex, we developed a classifier b

88 ased structural connectivity in centromedial amygdala-anterior vmPFC white matter was associated with

89 composition of GABAA receptors in the human amygdala are lacking.

90 rtex (OFC), medial frontal cortex (MFC), and amygdala are thought to underlie several psychiatric con

91 , this study establishes the medial extended amygdala as a major neural substrate regulating the swit

92 ies of CU traits have typically examined the amygdala as a unitary structure.

93 ols (<18 years old) and (b) decreases in the amygdala as people with ASD age into adulthood, a phenom

94 ippocampal, and parahippocampal cortices and amygdala, as well as lower NAA:Cr and Cho:Cr ratios (reg

95 eurons modulate the activity of the mPFC and amygdala at the synaptic level has not been determined p

96 performed patch-clamp recordings from basal amygdala (BA) neurons in brain slices from mice with cha

97 The authors used amygdala-based connectivity during a threat-attention ta

98 cal response was evaluated, and pretreatment amygdala-based connectivity profiles were compared among

99 Task-related amygdala-based functional connectivity was assessed.

100 rs, which were mainly observed in the medial amygdala/bed nucleus of the stria terminalis to lateral

101 dbrain) revealed a significant difference in amygdala binding between controls and remitters (P = 0.0

102 These results suggest 5-HTT amygdala binding should be examined further, in conjunct

103 nadjusted), where remitters had an 11% lower amygdala binding than controls.

104 reatment had lower pretreatment midbrain and amygdala binding than healthy volunteers.

105 gate causal contributions of the basolateral amygdala (BLA) and orbitofrontal cortex (OFC) in rats to

106 connections with neurons in the basolateral amygdala (BLA) at neonatal to adult developmental stages

107 The basolateral amygdala (BLA) contributes to emotion-related behaviors

108 st, inhibitory Gi-DREADDs in the basolateral amygdala (BLA) impaired the acquisition of both conditio

109 The basolateral amygdala (BLA) integrates sensory input from cortical an

110 aling.SIGNIFICANCE STATEMENT The basolateral amygdala (BLA) is a key structure of the fear circuit.

111 ownstream structures such as the basolateral amygdala (BLA) or nucleus accumbens (NAc).

112 The basolateral amygdala (BLA) sends excitatory projections to the nucle

113 prefrontal cortex (mPFC) or the basolateral amygdala (BLA) to examine the effects of beta-adrenocept

114 Within the basolateral amygdala (BLA), LAC did not reduce, but slightly enhance

115 ly control PCs projecting to the basolateral amygdala (BLAPC) compared to those projecting to contral

116 hift in behavioural sensitivity to fear, and amygdala BOLD responses were modulated by both fear and

117 tion did occur during early conditioning and amygdala BOLD signaling was unaffected in these patients

118 or cingulate cortex, insula cortex, and left amygdala, brain regions involved in valuation, emotion r

119 um gives rise not only to all of the pallial amygdala but also to the olfactory cortex, which hithert

120 ated neural activation patterns in the right amygdala (but not in other fear-related regions) that di

121 lly, childhood maltreatment levels predicted amygdala, but not BNST, hyperactivity during shock antic

122 TS) projecting into dorsal subregions of the amygdala, but whether this same pathway exists in humans

123 OFC to IM exceeded all other pathways to the amygdala by density and size and proportion of large and

124 SIGNIFICANCE STATEMENT The modulation of the amygdala by serotonin (5-HT) is important for emotional

125 These results show that the amygdala can initiate endogenous memory prioritization p

126 t subcortical structures (nucleus accumbens, amygdala, caudate, hippocampus, pallidum, putamen, thala

127 Decreased amygdala CBF correlated with reduced depressive symptoms

128 drinking.SIGNIFICANCE STATEMENT The central amygdala (CeA) plays a critical role in the development

129 Aergic neurons of the central nucleus of the amygdala (CeA) target brainstem regions known to regulat

130 ecting neurons in the central nucleus of the amygdala (CeA) that produce the neuropeptide corticotrop

131 nsported dye from the central nucleus of the amygdala (CeA) to identify CeA-projecting nucleus of the

132 BLA neurons project to the central amygdala (CeA), which also participates in negative and

133 ss system dysfunction, including the central amygdala (CeA).

134 o assess: (1) whether the circuit connecting amygdala, CEA, and DA cells follows CEA intrinsic organi

135 little is known about the maturation of mPFC-amygdala circuitry.

136 gulated triangular sensory-prefrontal-cortex-amygdala circuitry: intrinsic sensory hyperactivity and

137 through which midbrain 5-HT neurons modulate amygdala circuits could be pivotal in understanding emot

138 neurons in the dorsal raphe nuclei modulate amygdala circuits.

139 In fact, PPI can reveal how inter-regional amygdala communications change dynamically depending on

140 rpSTS, right anterior STS (raSTS), and right amygdala, compared with TBS delivered over the vertex.

141 new detailed map of the pigeon's arcopallium/amygdala complex and compare the receptor architecture o

142 in entry site for sensory information to the amygdala complex, and local plasticity in excitatory bas

143 These changes in amygdala connectional patters characterize the dynamic s

144 right amygdala volume and stronger bilateral amygdala connectivity to brain regions involved in senso

145 Irritability and/or anxiety influenced amygdala connectivity to the prefrontal and temporal cor

146 born right amygdala volume and stronger left amygdala connectivity were in turn associated with lower

147 r amygdala lesions strongly suggest that the amygdala contributes to the ability to learn stimulus-re

148 either the orbitofrontal cortex (OFC) or the amygdala could learn an action-outcome task, they could

149 volumes of the accumbens (Cohen's d=-0.15), amygdala (d=-0.19), caudate (d=-0.11), hippocampus (d=-0

150 ed amygdala-VPFC FC and SZ had reductions in amygdala-dACC FC.

151 rossed surgical disconnection of OFC and the amygdala did not.

152 Although the amygdala does not directly project to the olfactory bulb

153 emonstrated increased synchronicity with the amygdala during breathlessness.

154 e dorsal hippocampus or basal nucleus of the amygdala enhanced context fear without affecting tone fe

155 mygdalae (d = -0.11, p = .025), although the amygdala finding did not survive a significance level th

156 It has been postulated that the amygdala first receives visual input via a rapid subcort

157 the hippocampus is conveyed to the mPFC and amygdala for contextual fear conditioning.

158 iculus, pulvinar nucleus of the thalamus and amygdala) for the same stimuli seen freely or with the g

159 The amygdala from 32 postmortem human brains (7-46 years of

160 sults also demonstrate an important role for amygdala function as a mediator of this relationship at

161 Though subregion-specific anomalies in amygdala function have been suggested in CU pathophysiol

162 nd anxiety through effects on threat-related amygdala function, a risk pathway specific to women.

163 iable biomarker of individual differences in amygdala function.

164 l frontal, and right cerebellum regions; and amygdala functional connectivity to the left ventral and

165 synaptic suppression at ventral hippocampal-amygdala glutamatergic synapses and amygdala-specific 2-

166 ological studies revealed 2-AG modulation of amygdala glutamatergic transmission as a key synaptic co

167 ecific component of this pathway - i.e., the amygdala - has been shown to be abnormally activated in

168 Patients with depression show blunted amygdala hemodynamic activity to positive stimuli, inclu

169 rtfMRI-nf training to increase the amygdala hemodynamic response to positive memories signi

170 urochemical metabolism across regions of the amygdala, hippocampus, frontal cortex, and hypothalamus.

171 tromedial prefrontal cortex (vmPFC), insula, amygdala, hypothalamus, and periaqueductal gray emerge a

172 accompanied by lesions of the contralateral amygdala impede goal-directed response selection, implic

173 These data support a role of the amygdala in recovery from depression.

174 pathways and their postsynaptic sites in the amygdala in rhesus monkeys, we found that the anterior c

175 to the amygdala (proper) and to the extended amygdala in the rat.

176 resting-state functional connectivity of the amygdala in traumatized humans.

177 its low spatial frequency information to the amygdala independently of the cortex, and yet the direct

178 erior cingulate, frontoinsula, striatum, and amygdala, indicating that degeneration of these regions

179 itatory responses in both the mPFC and basal amygdala, indicating that they could convey contextual i

180 reat processes associated with dysfunctional amygdala-insula connectivity that are not targeted by CB

181 be most effective for patients with abnormal amygdala-insula connectivity.

182 sociation between the coverage of forest and amygdala integrity.

183 functional dissociation between the BNST and amygdala is however controversial, and human evidence sc

184 idence suggest that 5-HT transmission in the amygdala is implicated in the susceptibility and drug tr

185 , after a trace-to-delay update session, the amygdala is now required for extinction of the updated m

186 The basolateral amygdala is the main entry site for sensory information

187 in dendritic spines of the adult rat lateral amygdala (LA) during consolidation of aversive pavlovian

188 long-term potentiation (LTP) in the lateral amygdala (LA) plays an essential role in auditory fear c

189 ic neurons within the lateral nucleus of the amygdala (LA).

190 ferent approaches: behavioural analysis of 3 amygdala lesion patients, neuroimaging of 19 healthy adu

191 Lorazepam and amygdala lesions reduced loss adaptation in the primary

192 First, amygdala lesions slowed the acquisition and use of stimu

193 hanges in behavior and neural activity after amygdala lesions strongly suggest that the amygdala cont

194 sence of the hormone oxytocin in the central amygdala makes a mother rat willing to put her life in d

195 en serotonergic control of CRF levels in the amygdala may contribute to the transition from moderate

196 probe how coordination between the BNST and amygdala may regulate responses during shock anticipatio

197 The amygdala may, therefore, play a central role in RL.

198 CRS-induced structural remodeling of medial amygdala (MeA) stellate neurons.

199 rtex (OFC), medial frontal cortex (MFC), and amygdala mediate stimulus-reward learning, but the mecha

200 CIC activity in the hypothalamus and medial amygdala modulates social interactions.

201 Therefore, OFC and the amygdala must interact functionally to mediate adaptive

202 ntrinsic network (referred to as the "medial amygdala network") that supports social functioning.

203 ger intrinsic connectivity within the medial amygdala network.

204 ypes can powerfully regulate the activity in amygdala networks predominantly via their perisomatic sy

205 Prior research shows that amygdala neurons are active during cataplexy and cataple

206 ecific roles served by activity of different amygdala neurons at different times during learning is p

207 suggest mechanistic roles for Crh-expressing amygdala neurons in emotional deficits portending major

208 behavioral modules and suggest that central amygdala neurons instruct predatory hunting across jawed

209 Persistent activity of hippocampal and amygdala neurons was stimulus-specific, formed stable at

210 In the amygdala, neurons expressing SST play an important role

211 tral, basolateral, and lateral nuclei of the amygdala nonetheless strongly suppressed odor-evoked act

212 iles consistent with the neurobiology of the amygdala nuclei.

213 SST-IR neurons were decreased in the lateral amygdala nucleus in BD (Nt, p = .003) and SZ (Nt, p = .0

214 n releasing factor receptor 2 (CrfR2) in the amygdala of males subjected to CUS during adolescence, b

215 etic and chemogenetic stimulation of central amygdala of mice elicited predatory-like attacks upon bo

216 Decreased SST-IR neurons in the amygdala of patients with SZ and BD, interpreted here as

217 ape in the hypothalamus, frontal cortex, and amygdala of socially challenged mice over time.

218 en in the infralimbic cortex and basolateral amygdala of stress-susceptible male mice after remote me

219 noreactive (IR) neurons are decreased in the amygdala of subjects with SZ and BD.

220 The findings suggest that interactions among amygdala, OFC, and MFC contribute to learning about stim

221 These findings demonstrate that amygdala-OFC interactions are necessary for choices amon

222 5.09 to -2.99; p<0.0001) than did those with amygdala-only TDP-43 (n=6, -1.78%, -3.04 to -0.55; p=0.0

223 The central nucleus (CeA) serves major amygdala output functions and can generate emotional-aff

224 increased the alcohol-related signal in the amygdala (P=0.01) and modulated the food-related signal

225 However, how the central amygdala participates in such a learning process remains

226 s consistent with the existence of a cortico-amygdala pathway in humans for processing face informati

227 e consistent with the existence of a cortico-amygdala pathway in humans for processing face informati

228 xtual information through the VH-mPFC and VH-amygdala pathways.

229 BLA contributes to neuropathic-pain-related amygdala plasticity by driving synaptic excitation of Ce

230 sing the medial prefrontal cortex (mPFC) and amygdala plays important roles in developmentally regula

231 , dual retrograde injections into the IC and amygdala plus corpus striatum as well into the IC and au

232 Among attempters, reductions in amygdala-prefrontal functional connectivity may be assoc

233 d local plasticity in excitatory basolateral amygdala principal neurons is considered to be crucial f

234 ogether, our results indicate that the human amygdala processes both the degree of emotion in facial

235 emotion shown and that these two aspects of amygdala processing can be most clearly distinguished at

236 An amygdala-projecting ensemble promoted aversive learning,

237 erentially innervate and suppress long-range amygdala-projecting pyramidal cells.

238 hal bites on prey, was mediated by a central amygdala projection to the reticular formation in the br

239 attern of distribution of 5-HT fibers to the amygdala (proper) and to the extended amygdala in the ra

240 analysis showed that increased centromedial amygdala-rACC functional connectivity was associated wit

241 s are consistent with reduced threat-related amygdala reactivity in WS and suggest that common variat

242 Studies suggest that exaggerated amygdala reactivity is a vulnerability factor for posttr

243 uently demonstrate that greater increases in amygdala reactivity moderate the association between a p

244 th increased depression severity and reduced amygdala reactivity to salient outcomes.

245 Amygdala reactivity was also inversely associated with d

246 Amygdala reactivity, but not habituation, 5 to 12 weeks

247 al anxiety predicts decreased threat-related amygdala reactivity, which mediates an association betwe

248 nucleotide polymorphisms and threat-related amygdala reactivity, which represents a robust brain phe

249 anxiety, predicted decreased threat-related amygdala reactivity.

250 In addition, lesions of the amygdala reduce cataplexy.

251 The amygdala regulates responses to rewarding stimuli and co

252 and subiculum, could be targets for treating amygdala-related disorders.

253 interact with neurons, but their role in the amygdala remains largely unknown.

254 ve ingredient of cannabis, on anxiety and on amygdala response while processing fearful stimuli were

255 The results link hyperactive amygdala responses and regions critical for top-down emo

256 Functional neuroimaging data showed that amygdala responses tracked the valence of surprised faci

257 n RNA, given into the central nucleus of the amygdala reversed CES-induced anhedonia without influenc

258 Twelve participants in the amygdala rtfMRI-nf group, compared with only two in the

259 In participants receiving amygdala rtfMRI-nf, the percent of positive specific mem

260 y studies have hypothesized to depend on the amygdala's interactions with memory systems.

261 tral, basolateral, and lateral nuclei of the amygdala selectively strengthened the weakest olfactory

262 44-3p, robustly expressed in the basolateral amygdala, showed specific extinction-induced, but not fe

263 pocampal-amygdala glutamatergic synapses and amygdala-specific 2-AG depletion impairs successful adap

264 neurons, BLA stellate neurons or in lateral amygdala stellate neurons.

265 Amygdala stimulation elicited no subjective emotional re

266 We additionally examined whether perturbed amygdala subregional connectivity coincides with altered

267 between avian and mammalian arcopallial and amygdala subregions is poorly understood.

268 latent inhibition and fear extinction in the amygdala, suggesting a critical role for RIN1 in prevent

269 atients revealed higher activity in the left amygdala than female patients.

270 (ACo) is a chemosensory area of the cortical amygdala that receives afferent projections from both th

271 patterns particularly within regions of the amygdala, the hippocampus and the ventral hypothalamus.

272 ased fear processing and memory in the right amygdala, thereby making a direct link between human and

273 r also projects directly to the striatum and amygdala, these results establish the pulvinar nucleus a

274 whole-cell patch clamp analysis of the basal amygdala to CeA projections showed that alcohol consumpt

275 Here we show that basolateral amygdala to orbitofrontal cortex projections are require

276 rticotropin-releasing factor output from the amygdala to the anterior hypothalamus and then the later

277 investigated the causal contribution of the amygdala to the development of neuronal activity in maca

278 positively modulate connectivity of the left amygdala to the posterior thalamus in male but not femal

279 issue and test the sensitivity of the human amygdala to valence values specifically, we measured the

280 frontal cortex, hippocampus, and basolateral amygdala) to identify imaging predictors of response and

281 d clinical improvement, as did more positive amygdala-to-ventromedial prefrontal cortex connectivity.

282 fMRI data from both sexes, showing that the amygdala tracks these consensus valence values.

283 s between orbitofrontal cortex (OFC) and the amygdala underlie several mental health disorders, often

284 beta2/3, and gamma2 was studied in the human amygdala using immunohistochemistry.

285 arity to investigate the organization of the amygdala using resting state functional magnetic resonan

286 , and that these effects are mediated by the amygdala, ventromedial prefrontal cortex, and striatum.

287 pressed excitatory synapses from basolateral amygdala via A1 adenosine receptor activation and enhanc

288 from the lateral subdivision of the central amygdala via A2A receptor activation.

289 e characterized developmental changes of the amygdala-vmPFC subregion functional and structural conne

290 s prospectively associated with larger right amygdala volume and stronger bilateral amygdala connecti

291 Larger newborn right amygdala volume and stronger left amygdala connectivity

292 Many studies report smaller hippocampal and amygdala volumes in posttraumatic stress disorder (PTSD)

293 lyses demonstrated that MDD showed decreased amygdala-VPFC FC and SZ had reductions in amygdala-dACC

294 association between trait anxiety and right amygdala-vPFC pathway FA was strongest in women carrying

295 Amygdala-vPFC pathway fractional anisotropy (FA) from 66

296 Activations in the right anterior insula and amygdala were markedly reduced when participants receive

297 ession; rather, both the hippocampus and the amygdala were targeted by a top-down inhibitory control

298 toms) was hyperactivation of the hippocampus/amygdala, when controlling for baseline psychotic-like e

299 within the parabrachial nucleus and central amygdala, which constitute part of the 'emergency circui

300 t with time, engram cells in the basolateral amygdala, which were necessary for fear memory, were mai