ライフサイエンスコーパス: amygdalar

1 Based on recent findings of amygdalar abnormalities in Parkinson's disease, we hypot

2 In GAD, we find evidence of an intra-amygdalar abnormality and engagement of a compensatory f

3 g was associated with increased striatal and amygdalar activation in the anticipation of losses, and

4 In addition, the relative amount of amygdalar activation observed appeared to be related to

5 tion of IM has the opposite effect, allowing amygdalar activation of autonomic structures and emotion

6 Fasting amygdalar activation was negatively associated with full

7 Bilateral amygdalar activation was significantly greater during co

8 Perceived stress was associated with amygdalar activity (r=0.56; p=0.0485), arterial inflamma

9 The association between amygdalar activity and cardiovascular disease events see

10 Relations between amygdalar activity and cardiovascular disease events wer

11 Alterations in amygdalar activity and structure accompany various mood-

12 at not all fear instances lead to heightened amygdalar activity and, instead, point to roles of the a

13 t is resolved through top-down inhibition of amygdalar activity by the rostral cingulate cortex.

14 f glucocorticoid hormones and the heightened amygdalar activity have been implicated in the emergence

15 tivity to subsequent cardiovascular disease, amygdalar activity independently and robustly predicted

16 We conclude that amygdalar activity influences olfactory processing as ea

17 Amygdalar activity is involved partly via a path that in

18 ndings suggest that the growing dominance of amygdalar activity over the hippocampus during and even

19 Amygdalar activity was associated with increased bone-ma

20 who underwent psychometric analysis (n=13), amygdalar activity was significantly associated with art

21 lysed the relation between perceived stress, amygdalar activity, arterial inflammation, and C-reactiv

22 Amygdalar activity, bone-marrow activity, and arterial i

23 These results suggest that the heightened amygdalar activity, but not the elevated level of cortic

24 anterior cingulate in ways that would dampen amygdalar activity.

25 y a simultaneous and correlated reduction of amygdalar activity.

26 sing of emotional faces can be influenced by amygdalar activity.

27 levels but also a reduction in cortical and amygdalar anandamide.

28 cally organized projections between distinct amygdalar and BST subnuclei.

29 G neurons may supply afferents essential for amygdalar and cingulothalamic TIA and for avoidance lear

30 et of rapamycin complex 1 (mTORC1) in select amygdalar and cortical regions in rats, resulting in inc

31 Relationships between amygdalar and hippocampal volumes and BIS measures in PG

32 This linkage of amygdalar and LC output to primary sensory signaling may

33 e, we evaluate how cortico-striatal, cortico-amygdalar, and amygdalo-striatal projections control ext

34 of age were used to measure total cerebral, amygdalar, and hippocampal volumes.

35 d cingulate, striatal, temporal, hippocampal/amygdalar, and insular regions in the CU group compared

36 laying flight had more activity in cortical, amygdalar, and striatal motor areas, the dorsolateral po

37 yburide binding in numerous hypothalamic and amygdalar areas of both DR- and DIO-prone rats with litt

38 projections supply information that supports amygdalar associative processes underlying acquisition o

39 minative TIA in the MGm via basolateral (BL) amygdalar axonal projections to the auditory cortex.

40 from gustatory cortical (GC) and basolateral amygdalar (BLA) neural ensembles as awake, behaving rats

41 ects revealed different patterns of gaze and amygdalar BOLD changes in ASD and NT: Individuals with A

42 mygdalae, suggesting the importance of extra-amygdalar brain structures.

43 Absolute and normalized left amygdalar CBF changes tended to correlate positively wit

44 with euphoria had greater increases in left amygdalar CBF.

45 Labeled amygdalar cells occurred ipsilateral and contralateral t

46 hypothalamic paraventricular nucleus and the amygdalar central nucleus compared with wild-type.

47 e results may correspond to hypothalamic and amygdalar changes in the human condition and suggest tha

48 these nuclei participate as components of an amygdalar circuit to drive cocaine-seeking behavior prod

49 Our findings were anatomically specific to amygdalar circuitry in that individual differences in so

50 Conditioned neuropeptide levels in amygdalar circuits may act as a reversible "gain control

51 and social behaviors, many of which involve amygdalar circuits, are hallmarks of adolescence in many

52 hown to be critical regulatory components of amygdalar circuits, which control appropriate fear respo

53 hypothesized that neurons in the basolateral amygdalar complex (BLA) (lateral and basal nuclei) suppo

54 of whether NMDA receptors in the basolateral amygdalar complex (BLA) are critically involved in the e

55 imulation of ventral PAG and the basolateral amygdalar complex (BLA) evoked freezing and/or ultrasoni

56 ve long-term potentiation in the basolateral amygdalar complex (BLC).

57 The amygdalar complex is a medial temporal lobe structure in

58 'Amygdala' and 'amygdalar complex' are terms that now refer to a highly

59 e proposed teleost homologs of the mammalian amygdalar complex, hippocampus, striatum, preoptic area,

60 proposed teleost homologues of the mammalian amygdalar complex, hippocampus, striatum, preoptic area,

61 n GABA efflux in the basolateral and central amygdalar complexes.

62 mediates the association between prefrontal-amygdalar connectivity and elevated anxiety.

63 ala function across species and implicate an amygdalar contribution to both acquisition and extinctio

64 The critical period of the amygdalar contribution to stress effects on hippocampal

65 These data provide evidence of amygdalar control of stress-induced metabolic activation

66 become impaired from abnormal expression of amygdalar corticotropin-releasing hormone (CRH) and/or C

67 In our study, we have assessed levels of amygdalar CRF and CRF-BP mRNA in Fischer 344 rats of 4,

68 There were no significant differences in amygdalar CRF gene expression between stressed and handl

69 Associated with amygdalar CRF is a 37 kDa binding protein (CRF-BP) which

70 implications for understanding how discrete amygdalar CRF pathways modulate longer-lasting fear in a

71 ts of restraint associated with decreases in amygdalar CRF-BP gene expression.

72 The changes in amygdalar CRF-BP observed may be secondary to the known

73 avioral effects of exogenously applied intra-amygdalar CRF.

74 Higher amygdalar Crhr1 expression was negatively correlated wit

75 tylation of histone H3, c-Fos induction, and amygdalar-dependent taste aversion learning is constrain

76 ese results provide additional evidence that amygdalar development is implicated in the behavioral im

77 Amygdalar development is poorly understood.

78 tress hyperresponsiveness, perhaps driven by amygdalar disinhibition of the PVN.

79 ats, associated with prefrontal cortical and amygdalar dysfunction.

80 adly characterize anxiety-like behaviors and amygdalar eCB clearance enzymes in msP versus nonselecte

81 constitutive upregulation in CRF systems on amygdalar eCB function and persistent anxiety-like effec

82 f CRF systems induces maladaptive changes in amygdalar eCB signaling.

83 However, although the importance of this amygdalar expression in emotion-related behavior and the

84 nhanced HPA axis inhibition, whereas reduced amygdalar expression predicts impaired stress excitation

85 xious phenotype accompanied by elevations in amygdalar FAAH activity and reduced dialysate N-arachido

86 genitors to the structures that comprise the amygdalar fear circuit including the central (CA), later

87 these findings identify the BNST as an extra-amygdalar fear circuit structure important in CO2-evoked

88 or the neuronal components that comprise the amygdalar fear circuit.

89 mechanisms by which chronic stress modulates amygdalar function are not well characterized.

90 y in males are mediated by the modulation of amygdalar function by delta-9-THC and the extent of thes

91 ty disorders, possibly by maintaining normal amygdalar function in the face of chronic stress.

92 otivated behavior, relate to hippocampal and amygdalar function, and link to pathological gambling (P

93 e hippocampus is increased through decreased amygdalar GABAergic inhibition have shown alterations of

94 an fluctuations of corticosterone, increased amygdalar glucocorticoid receptors, decreased time spent

95 (D1+) neurons thought to induce cortical and amygdalar glutamate output.

96 Amygdalar gray matter volume was also investigated with

97 a backward-masking task, which measures the amygdalar hemodynamic response to emotional faces presen

98 rtfMRI-nf training to increase the amygdalar hemodynamic response to positive memories was

99 disorder who are trained to upregulate their amygdalar hemodynamic responses during positive autobiog

100 ietal-occipital GM and significantly reduced amygdalar, hippocampal, insular, temporal, and inferior

101 volume at 3 and 4 years of age, but not left amygdalar, hippocampal, or total cerebral volume, is ass

102 The former depended on an amygdalar-hippocampal network, whereas the latter was su

103 In contrast, amygdalar inactivation blocked this fear-related impairm

104 earning in rabbits trained immediately after amygdalar inactivation confirmed previous results with e

105 he olfactory bulb of the brain revealed that amygdalar inactivation preferentially strengthened the o

106 initiation by mating was prevented by intra-amygdalar infusion of the NMDA receptor antagonist, 2-am

107 algesia were significantly impaired by intra-amygdalar infusions of APV.

108 Intra-amygdalar infusions of Rp-cAMPS made 3 h following react

109 Bilateral intra-amygdalar infusions of the PKA inhibitor Rp-cAMPS (18 mi

110 Furthermore, systemic or central amygdalar inhibition of mTORC1 during reconsolidation di

111 a uniquely one-way excitatory pathway to the amygdalar inhibitory intercalated masses (IM), which inh

112 arboxylic acid enhanced the effects of intra-amygdalar injection of BMI.

113 tors were present at mPFC and insula but not amygdalar inputs in the NAcore.

114 noaminergic systems in the m-PFC, as well as amygdalar integration of behavioral and neuroendocrine c

115 its persistence and that altered hippocampal-amygdalar interaction may contribute to such pathologic

116 rful pathway that targets a special class of amygdalar intercalated mass (IM) inhibitory neurons, who

117 A rather specific population of amygdalar interneurons, the intercalated cells (ITCs), i

118 ) are coexpressed in large subpopulations of amygdalar interneurons.

119 Amygdalar intrinsic inhibitory networks comprise several

120 Increased insular and amygdalar involvement during negative word encoding may

121 The amygdalar involvement in eyeblink conditioning was exami

122 no training trials) was sufficient to reduce amygdalar involvement in response performance.

123 Amygdalar labeling was observed after tracer deposits th

124 Amygdalar lesion/inactivation blocked the UR of dPAG sti

125 l signals were paired with food, control and amygdalar-lesioned rats were able to divide attention an

126 ippocampal slices from stressed animals with amygdalar lesions exhibited normal LTP.

127 Localized amygdalar lesions in humans produce deficits in the reco

128 ial dorsal) thalamic, cingulate cortical, or amygdalar lesions severely impair acquisition, and neuro

129 Amygdalar lesions severely impaired the acquisition of a

130 oning is partially disrupted with unilateral amygdalar lesions, but that the right amygdala has great

131 aze task, and this impairment was blocked by amygdalar lesions.

132 The present study examined the role of amygdalar mAChRs in trace fear conditioning, a paradigm

133 ely supports transient memory, then blocking amygdalar mAChRs should impair trace conditioning, while

134 work for dissecting the functional impact of amygdalar mGluR-plasticity on fear versus anxiety in hea

135 s mood-related disorders, and interestingly, amygdalar morphology and behavior can be altered in anim

136 ning was indicated by the finding that intra-amygdalar muscimol failed to disrupt performance of the

137 Intra-amygdalar muscimol infusion before 60 or 120 conditionin

138 Our results indicate that intra-amygdalar muscimol infusions before uncontrollable restr

139 ical thickness, amygdala volume, and cortico-amygdalar network correlates of externalizing behavior i

140 Fronto-amygdalar networks are implicated in childhood psychiatr

141 Together, these results suggest that the amygdalar neuronal activity during stress, but not short

142 rontal cortical, medial dorsal thalamic, and amygdalar neuronal response profiles and learning-relate

143 Here it is shown that amygdalar neurons are also involved in learning to avoid

144 leus of the amygdala was given to inactivate amygdalar neurons at each of three stages of acquisition

145 In contrast, smaller amygdalar neurons directed to pOFC expressed VGLUT1 foun

146 tracked the Ca(2+) dynamics of ensembles of amygdalar neurons during fear learning and extinction ov

147 ent study investigated the role of intrinsic amygdalar neurons in mediating stress effects on the hip

148 ern in the 3-week-old animals, and damage to amygdalar neurons increased progressively with age.

149 These results suggested that amygdalar neurons induce discriminative TIA in the MGm v

150 differentiation and functional maturation of amygdalar neurons involved in cholinergic-regulated emot

151 , the photoactivation of paAIP2 expressed in amygdalar neurons of mice during an inhibitory avoidance

152 Larger amygdalar neurons projected to MDmc and expressed the ve

153 Lateral amygdalar neurons showed gradual development of discrimi

154 he lesions abolished the sensory response of amygdalar neurons, and they attenuated (but did not elim

155 l and REM sleep suggests that alterations in amygdalar neurotransmission may be involved in the chang

156 ults are consistent with the hypothesis that amygdalar NMDA receptors participate in normal synaptic

157 heric lateralization of mGluR5 modulation of amygdalar nociceptive processing.

158 Baseline levels of amygdalar Nor-1 and GR mRNA were higher in the WKYs comp

159 o DMI are strain dependent and that elevated amygdalar Nor-1 expression can contribute to depressive

160 ve behavior of WKYs in the FST and decreased amygdalar Nor-1 mRNA levels without affecting GR mRNA le

161 ordings were also made in the lateral and BL amygdalar nuclei and in the cingulate cortex.

162 cally expressed in medial subpallium-derived amygdalar nuclei from early developmental stages to adul

163 Other Lhx proteins mark neurons in amygdalar nuclei implicated in defense.

164 However, the specific role of these amygdalar nuclei in predator odor-induced fear memory is

165 basal forebrain, in the septum, and in some amygdalar nuclei in the adult rodent brain.

166 and in the anterior basolateral and lateral amygdalar nuclei in the brains of the conditioned-fear g

167 nd centromedial amygdala (CMA) are two major amygdalar nuclei that contribute to distinct functions v

168 e rooted in altered development of disparate amygdalar nuclei that subserve different social function

169 iverse groups of interneurons populate these amygdalar nuclei, and as predicted our data support the

170 ex innervated mostly the basolateral and CeM amygdalar nuclei, poised to activate CeM for autonomic a

171 lls serve specialized functions within human amygdalar nuclei.

172 solateral, posterior basomedial, and lateral amygdalar nuclei; to the paraventricular and medial medi

173 IP+ interneurons in the anterior basolateral amygdalar nucleus (BLa) by SOM+ axon terminals.

174 roscopic study revealed that the basolateral amygdalar nucleus (BLa) contains a network of parvalbumi

175 eurotransmission in the anterior basolateral amygdalar nucleus (BLa) mediated by the M1 receptor (M1R

176 the anterior subdivision of the basolateral amygdalar nucleus (BLa) of the rat using electron micros

177 Similar to other species, the central amygdalar nucleus (CAmy), anterior hypothalamus, paraven

178 which inhibit the medial part of the central amygdalar nucleus (CeM).

179 l caudoputamen (CP) and anterior basolateral amygdalar nucleus - areas presumably modulating somatomo

180 st, it densely innervates the medial central amygdalar nucleus and the subcommissural zone and caudal

181 The possible role of the lateral central amygdalar nucleus in circuitry mediating conditioned emo

182 uron and glia numbers in the rat basolateral amygdalar nucleus was undertaken in male and female hood

183 The PMv is heavily targeted by the medial amygdalar nucleus, and we used lesion and immediate-earl

184 , central autonomic control network (central amygdalar nucleus, BST anterolateral group, descending p

185 : central autonomic control network (central amygdalar nucleus, descending hypothalamic paraventricul

186 ; central autonomic control network (central amygdalar nucleus, descending paraventricular nucleus, a

187 ), central autonomic control system (central amygdalar nucleus, dorsal lateral hypothalamic area, ven

188 ), nucleus of the solitary tract and central amygdalar nucleus, other refeeding activated regions wer

189 l substantia innominata and adjacent central amygdalar nucleus, retrorubral area, and lateral parabra

190 ateral septal nucleus, posterior basolateral amygdalar nucleus, supramammillary nucleus, and nucleus

191 ns, caudal substantia innominata and central amygdalar nucleus, thalamic paraventricular nucleus, hyp

192 i project topographically back to the medial amygdalar nucleus, to the adjacent lateral septal nucleu

193 ral autonomic structures such as the central amygdalar nucleus, which is implicated as a stress-relat

194 terneurons from the rat anterior basolateral amygdalar nucleus.

195 pographically ordered inputs from the medial amygdalar nucleus.

196 lly and in the cortical amygdala and lateral amygdalar nucleus.

197 lamic area; parasubthalamic nucleus; central amygdalar nucleus; area postrema; and nucleus of the sol

198 c nuclei; lateral hypothalamic area; central amygdalar nucleus; parasubthalamic nucleus; ventral post

199 ies as a function of IQ, total cerebral, and amygdalar or hippocampal volumes.

200 nput: More recent studies of hippocampal and amygdalar or prefrontal cortical afferents suggest that

201 creases in frontocortical cytokines, but not amygdalar or striatal markers.

202 Obese humans also show greater striatal, amygdalar, orbitofrontal cortex, and somatosensory regio

203 e anterior cingulate cortex innervates other amygdalar parts, activating circuits to help avoid dange

204 esonance Imaging-based techniques to examine amygdalar pathology in these patients.

205 se findings identify the subcortical pulvino-amygdalar pathway as a relevant precursor of a mature aP

206 The amygdalar pathway formed unusual synapses close to cell

207 Among inhibitory neurons, the amygdalar pathway innervated preferentially the neuroche

208 The robust amygdalar pathway provides a mechanism for rapid shiftin

209 lower fractional anisotropy in auditory and amygdalar pathways but not prefrontal cortex.

210 s in addition to pOFC, it is unknown whether amygdalar pathways in MDmc innervate pOFC-bound neurons.

211 d transitional cortex that together with the amygdalar/periamygdalar region may subserve functions of

212 Here we assessed whether amygdalar PKA is required for the reconsolidation of an

213 and time limited and critically depends upon amygdalar PKA.

214 rment of memory reconsolidation dependent on amygdalar PKA.

215 of emotional modulation and suggest that non-amygdalar processes contribute to the emotional modulati

216 G nucleus and suggest that distinct forms of amygdalar processes induce TIA in the MG nucleus and cin

217 These results define the time period wherein amygdalar processes initiate TIA in the MG nucleus and s

218 Thus, amygdalar processing at the outset of training is necess

219 ese data highlight an essential role for the amygdalar projection to the ventral striatum in aversive

220 Extra-amygdalar projections from the BMA are divided into asce

221 in other layers, suggesting that the robust amygdalar projections may also activate neurons in layer

222 In the rat, we found that activation of amygdalar protein kinase A (PKA) was sufficient to enhan

223 These results indicate that amygdalar PVB-IR neurons can be subdivided into at least

224 indicate that the synaptology of basolateral amygdalar pyramidal cells is remarkably similar to that

225 hat the HR infant phenotype predicts greater amygdalar reactivity to novel faces almost two decades l

226 was found in young subjects in the piriform/amygdalar region and in the orbitofrontal cortex and in

227 ng, subsequently ceding fear memory to extra-amygdalar regions.

228 rior cingulate, bilateral insular, and right amygdalar regions.

229 ory-motor cortex, medial frontal cortex, and amygdalar regions.

230 hether the previously reported dysfunctional amygdalar response patterns in ASD support an active avo

231 During the backward-masking task, amygdalar responses increased while viewing masked happy

232 othesis was obtained by a demonstration that amygdalar responses predict expression-specific neural a

233 tive memories was associated with changes in amygdalar responses to happy and sad faces and improved

234 thesized to be due, in part, to variation in amygdalar responses to novelty.

235 This study addressed the amygdalar role in mediation of discriminative instrument

236 muscimol had become ineffective indicated an amygdalar role in the establishment of acquisition-relev

237 This study tested whether amygdalar rtfMRI-nf also changes emotional processing of

238 These results may suggest that amygdalar rtfMRI-nf training alters responses to emotion

239 ompleted two rtfMRI-nf sessions (18 received amygdalar rtfMRI-nf, 16 received control parietal rtfMRI

240 Based on these findings, we suggest that the amygdalar signaling of fear influences the stability of

241 42; P = .009) hippocampal subfields and left amygdalar (simple slope, -34.62; standard error, 12.74;

242 ting from reduced hippocampal, but increased amygdalar, size and function.

243 olarization-evoked release of [(3)H]-NE from amygdalar slices of mice, which were trained to recogniz

244 of PV interneurons by individual PNs in rat amygdalar slices.

245 led axon terminals, most likely arising from amygdalar sources, are positioned dually to affect LC fu

246 Moreover, anxiogenesis and amygdalar spinogenesis are also triggered by chronic str

247 We found that amygdalar stimulation reliably evoked distress behaviors

248 received either corticosterone injection or amygdalar stimulation.

249 tems and little is known with regards to how amygdalar stress systems change with aging.

250 ical thickness, amygdala volume, and cortico-amygdalar structural networks were examined using first-

251 d neuroplasticity, contributes to changes in amygdalar structure and function following chronic stres

252 All of the stress-induced changes in amygdalar structure and function were absent in mice def

253 cy for parasite cysts to be more abundant in amygdalar structures than those found in other regions o

254 pression have often examined hippocampal and amygdalar structures, since they are two key structures

255 tly observed retrograde labeling in a single amygdalar subdivision, the magnocellular subdivision of

256 functional contributions for these different amygdalar subregions in reward-processing and motivation

257 rms of PIT have been studied at the level of amygdalar subregions in rodents, it is still unknown whe

258 t results show a double dissociation between amygdalar subsystems that control food consumption by ap

259 These amygdalar synapses in pOFC exceeded in size and speciali

260 ons that interface with distinct striatal or amygdalar targets.

261 We found that amygdalar terminations innervated labeled neurons in MDm

262 eatening faces activated circuitry including amygdalar, thalamic, and brainstem regions, known in hum

263 It is hypothesized that amygdalar training-induced neuronal plasticity in the in

264 dition there was a positive correlation with amygdalar Type I orexin receptor (Orx1) mRNA and depress

265 tromedial prefrontal and increasing extended amygdalar-ventral striatal activity correlated highly wi

266 score and left middle temporal thickness and amygdalar volume (Pone-tailed=0.026, 0.019 and 0.003, re

267 Larger right amygdalar volume also was predictive of poorer social an

268 previous findings of reduced hippocampal and amygdalar volume among heavy cannabis users, and suggest

269 The relationship between amygdalar volume and mental health, driven by emotional

270 Larger right amygdalar volume at 3 and 4 years of age, but not left a

271 Reductions in hippocampal and amygdalar volume that putatively reflect dendritic atrop

272 Larger right amygdalar volume was associated with more severe social

273 re were no group by genotype interactions on amygdalar volume.

274 bolites were associated with hippocampal and amygdalar volume.

275 This study compared hippocampal and amygdalar volumes (potential CD intermediate phenotypes)

276 iving in poverty and reduced hippocampal and amygdalar volumes in adulthood.

277 tant factors associated with hippocampal and amygdalar volumes in depression.

278 as to examine differences in hippocampal and amygdalar volumes in patients with depression subtypes r

279 anxiety were associated with increased right amygdalar volumes in patients with FND.

280 tudies have not investigated hippocampal and amygdalar volumes in PG and their relationships to BIS/B

281 ngs of relatively diminished hippocampal and amygdalar volumes in PG individuals resonate with findin

282 ly correlated with left hippocampal and left amygdalar volumes in PG individuals.

283 ging was used to measure the hippocampal and amygdalar volumes of 60 chimpanzees (Pan troglodytes).

284 us, and CA3 hippocampal subfields as well as amygdalar volumes were assessed using magnetic resonance

285 icipants were aged 25 years, hippocampal and amygdalar volumes were measured using magnetic resonance

286 To examine hippocampal and amygdalar volumes, all participants underwent structural

287 es did not detect significant differences in amygdalar volumes, surface analyses indicated the presen

288 gyrus and CA3 hippocampal subfields and left amygdalar volumes.

289 Visual assessment and amygdalar volumetry were performed on oblique coronal T2

290 8 upregulation, indicating that cortical and amygdalar zif-268 expression during REM sleep is under h