ライフサイエンスコーパス: amyloid beta precursor protein

1 that overexpress a mutated form of the human amyloid-beta precursor protein.

2 rocessing of both the Notch receptor and the amyloid-beta precursor protein.

3 nal cell lines engineered to overexpress the amyloid-beta precursor protein.

4 myloid precursor protein (APP), better named amyloid-beta precursor protein (A(beta)PP), by secretase

5 e core genes were connected to APP (encoding amyloid beta precursor protein), a major player in Alzhe

6 cessing of the familial disease gene product amyloid beta precursor protein (AbetaPP) by beta- and ga

7 brain show alterations in the processing of amyloid beta precursor protein (AbetaPP), including incr

8 Transgenic mice expressing mutant forms of amyloid-beta precursor protein (AbetaPP) and presenilin-

9 LH did not alter amyloid-beta precursor protein (AbetaPP) expression but

10 The amyloid-beta precursor protein (AbetaPP) is a ubiquitous

11 the overexpression of a mutated cDNA of the amyloid-beta precursor protein (AbetaPP) or by knock-in

12 muscle fibers we also studied the effect of amyloid-beta precursor protein (AbetaPP) overexpression

13 orms of Alzheimer's disease (AD) encodes the amyloid-beta precursor protein (AbetaPP) substitution mu

14 ysical interaction of the ER chaperones with amyloid-beta precursor protein (AbetaPP) was studied by

15 We also found no accumulation of amyloid-beta precursor protein after several months of i

16 Intracellular accumulation of amyloid-beta precursor protein, amyloid-beta, and amyloi

17 NCT and PS1 play important roles in binding amyloid beta precursor proteins and modulating PS1 catal

18 se-associated amyloid-beta peptides from the amyloid-beta precursor protein and in releasing the tran

19 Abnormal accumulations of the amyloid-beta precursor protein and of its proteolytic fr

20 ich coexpress mutated human presenilin 1 and amyloid-beta precursor protein) and 30 wild-type mice ag

21 protein expression, that Histone 1 Family 2, amyloid beta precursor protein, and E-cadherin are usefu

22 ntified a caspase-3 cleavage site within the amyloid-beta precursor protein, and a caspase-3 cleavage

23 increased transcription and accumulation of amyloid-beta precursor protein, and accumulation of its

24 a is generated by sequential cleavage of the amyloid beta precursor protein (APP) by beta- and gamma-

25 Mutations in amyloid beta precursor protein (APP) gene alter APP proc

26 cts of mutations in the BRI2 (ITM2b) and the amyloid beta precursor protein (APP) genes support the h

27 he familial Alzheimer's disease gene product amyloid beta precursor protein (APP) is sequentially pro

28 Mice transgenic for an amyloid beta precursor protein (APP) mini-gene driven by

29 All other mutations at this site of amyloid beta precursor protein (APP) reduced C99 generat

30 iP) that catalyzes the final cleavage of the amyloid beta precursor protein (APP) to release the amyl

31 human form of one of these candidate genes, amyloid beta precursor protein (APP), displayed enhanced

32 dependent C-terminal cleavage product of the amyloid beta precursor protein (APP), Fe65, and Tip60, i

33 essed the effects of isoflurane on beta-site amyloid beta precursor protein (APP)-cleaving enzyme (BA

34 nerated by the proteolytic processing of the amyloid beta precursor protein (APP).

35 hen tartrate (Posiphen), lowers secreted (s) amyloid-beta precursor protein (APP) alpha and -beta, am

36 s to a significant decrease in intracellular amyloid-beta precursor protein (APP) and extracellular A

37 Proteolytic processing of the amyloid-beta precursor protein (APP) and generation of a

38 ng number of membrane proteins including the amyloid-beta precursor protein (APP) and Notch.

39 nic (Tg) mice overexpressing mutant forms of amyloid-beta precursor protein (APP) and presenilin 1 (P

40 three Mints bind to the cytoplasmic tail of amyloid-beta precursor protein (APP) and presenilins and

41 LR11 interacts with the amyloid-beta precursor protein (APP) and regulates APP t

42 al cell cultures secrete exosomes containing amyloid-beta precursor protein (APP) and the APP-process

43 The transmembrane protein amyloid-beta precursor protein (APP) and the vesicle-ass

44 P-1, which in turn enhances transcription of amyloid-beta precursor protein (APP) and thereby increas

45 Phosphorylation of amyloid-beta precursor protein (APP) at Thr(668) is a no

46 ghboring cells that express normal levels of amyloid-beta precursor protein (APP) but show redistribu

47 Cleavage of amyloid-beta precursor protein (APP) by alpha-,beta-, an

48 Site-specific proteolysis of the amyloid-beta precursor protein (APP) by BACE 1 and gamma

49 stigate the production of Abeta11-40/42 from amyloid-beta precursor protein (APP) by beta-site APP-cl

50 Cleavage of amyloid-beta precursor protein (APP) by site-specific pr

51 Amyloid-beta precursor protein (APP) forms a transcripti

52 Although mutations in the amyloid-beta precursor protein (APP) gene are known to c

53 Abeta is a fragment of amyloid-beta precursor protein (APP) generated in neuron

54 al to the gamma-secretase proteolysis of the amyloid-beta precursor protein (APP) involved in Alzheim

55 Abnormal phosphorylation of amyloid-beta precursor protein (APP) is a pathologic fea

56 Amyloid-beta precursor protein (APP) is well studied for

57 required for the penultimate cleavage of the amyloid-beta precursor protein (APP) leading to the gene

58 5LO did not induce any significant change in amyloid-beta precursor protein (APP) levels and processi

59 As reported in an earlier article, the amyloid-beta precursor protein (APP) region is strongly

60 loidogenic amyloid-beta peptide (Abeta) from amyloid-beta precursor protein (APP) requires cleavage b

61 le in Alzheimer disease, is derived from the amyloid-beta precursor protein (APP) through consecutive

62 and inhibits cerebral amyloid deposition in amyloid-beta precursor protein (APP) transgenic mice.

63 re we use Tg2576 mice, which express a human amyloid-beta precursor protein (APP) variant linked to A

64 ng synaptophysin, neurofilament H (NF-H) and amyloid-beta precursor protein (APP) were performed to e

65 n human and mouse leads to downregulation of amyloid-beta precursor protein (APP), a known neuronal m

66 Amyloid-beta precursor protein (APP), a type I membrane

67 The amyloid-beta precursor protein (APP), a type I transmemb

68 Amyloid-beta precursor protein (APP), a widely expressed

69 uce any change in the steady state levels of amyloid-beta precursor protein (APP), BACE1 or ADAM10.

70 oidogenic fragments (ie, C99 and Abeta) from amyloid-beta precursor protein (APP), crucial factors ca

71 Mutations in the genes encoding amyloid-beta precursor protein (APP), presenilin 1 (PS1)

72 P cleavage enzyme 1 (BACE1) that cleaves the amyloid-beta precursor protein (APP), which is abundant

73 peptides derived from the processing of the amyloid-beta precursor protein (APP).

74 4-kDa peptide generated via cleavage of the amyloid-beta precursor protein (APP).

75 s are neuronal adaptor proteins that bind to amyloid-beta precursor protein (APP).

76 s generated by proteolytic processing of the amyloid-beta precursor protein (APP).

77 nd in the brains of Alzheimer's patients and amyloid-beta precursor protein (APP)/PS1 transgenic mice

78 aneuronal accumulation of metabolites of the amyloid-beta-precursor protein (APP) is neurotoxic.

79 FAD has also been linked to mutations in the amyloid beta precursor protein (beta PP), and the presen

80 The Alzheimer's amyloid-beta precursor protein (betaAPP) is a type 1 mem

81 ch is derived from proteolysis of the larger amyloid-beta precursor protein (betaAPP), seems to be an

82 pregulated in MDA-MB-231) and GREB1, S100A8, amyloid beta precursor protein, claudin 3 and cadherin 1

83 is required for intramembrane proteolysis of amyloid-beta precursor protein, contributing to the path

84 amyloid-beta precursor protein or C-terminal amyloid-beta precursor protein fragments.

85 disease, both caused by a duplication of the amyloid-beta precursor protein gene (APP; termed APP(Dp)

86 sport proteins JNK-interacting protein 1 and amyloid beta precursor protein in the brains and spinal

87 Binding of antithrombin and the amyloid beta-precursor protein Kunitz domain inhibitor (

88 siology of Alzheimer disease (AD), including amyloid-beta precursor protein metabolism, Tau phosphory

89 r order Abeta structures but not full-length amyloid-beta precursor protein or C-terminal amyloid-bet

90 , including transgenic mice expressing human amyloid-beta precursor protein, presenilin 1, and tau mu

91 Unexpectedly, C83, the major endogenous amyloid-beta precursor protein substrate of gamma-secret

92 f the Alzheimer's disease hallmark gene APP (amyloid-beta precursor protein) to the beta-site-cleavin

93 expression and secretase-cleaved products of amyloid-beta precursor protein were not affected by sucr

94 basic hypothesis is that over-expression of amyloid-beta precursor protein within aging muscle fiber