ライフサイエンスコーパス: amyloid beta-protein

1 s effect is exacerbated with the addition of amyloid beta protein.

2 ole in Alzheimer's disease by generating the amyloid beta protein.

3 d by diffusible oligomeric assemblies of the amyloid beta protein.

4 (LVFFAEDVGSNK), a tryptic fragment from the amyloid beta-protein.

5 ipoprotein E4, amyloid precursor protein and amyloid beta-protein.

6 mbrane protein involved in the production of amyloid beta-protein.

7 ta-sheet secondary structure in a 42-residue amyloid beta-protein.

8 aved products, Notch intracellular domain or amyloid-beta protein.

9 ys by which hypoperfusion influenced tau and amyloid-beta proteins.

10 rval: 0.64-0.83) and for cerebrospinal fluid amyloid beta protein 1-42 was 0.685 (95% confidence inte

11 an score 7.6 +/- 5.3 for cerebrospinal fluid amyloid beta protein 1-42).

12 nergy landscapes and relative stabilities of amyloid-beta protein (1-40) in the monomer and all of it

13 abilities of amyloid-beta protein (1-42) and amyloid-beta protein (1-40) in their monomeric and oligo

14 nergy landscapes and relative stabilities of amyloid-beta protein (1-42) and amyloid-beta protein (1-

15 Amyloid beta protein (A beta) accumulates in the brains

16 The deposition of amyloid beta-protein (A beta or beta A4) is a key featur

17 ogical folding and oligomer formation of the amyloid beta-protein (A beta) are widely perceived as ce

18 Assembly of monomeric amyloid beta-protein (A beta) into oligomeric structures

19 Cerebral deposition of amyloid beta-protein (A beta) is believed to play a key

20 Amyloid beta-protein (A beta) is the main constituent of

21 the beta- and gamma-secretases generate the amyloid beta-protein (A beta), which plays a central rol

22 The accumulation of fibrillar amyloid-beta protein (A beta) in cerebral blood vessels,

23 ing soluble aggregation intermediates of the amyloid-beta protein (A beta), as well as the ongoing gr

24 e 1 transmembrane protein, gives rise to the amyloid beta-protein, a neurotoxic peptide postulated to

25 Accumulation of amyloid beta protein (Abeta) aggregates is hypothesized

26 ng the deposition of amyloidogenic proteins, amyloid beta protein (Abeta) and amylin (islet amyloid p

27 ers involved in Alzheimer's disease (AD) are amyloid beta protein (Abeta) and apolipoprotein E (apoE)

28 Interaction between aggregates of amyloid beta protein (Abeta) and membranes has been hypo

29 Direct immunization with amyloid beta protein (Abeta) and passive transfer of ant

30 Cerebral microvascular amyloid beta protein (Abeta) deposition and associated n

31 Amyloid beta protein (Abeta) deposition in the brain is

32 (APP695SWE) develop Alzheimer's disease-like amyloid beta protein (Abeta) deposits by 8 to 10 months

33 e progress in defining a pathogenic role for amyloid beta protein (Abeta) in Alzheimer's disease, ora

34 e data support a central pathogenic role for amyloid beta protein (Abeta) in Alzheimer's disease, the

35 acterized by the progressive accumulation of amyloid beta protein (Abeta) in areas of the brain servi

36 the progressive deposition of the 42-residue amyloid beta protein (Abeta) in brain regions serving me

37 uction and clearance of the self-aggregating amyloid beta protein (Abeta) in brain regions serving me

38 s characterised in part by the deposition of amyloid beta protein (Abeta) in the brain.

39 The accumulation of amyloid beta protein (Abeta) in the Tg2576 mouse model o

40 (AD) maintains that the accumulation of the amyloid beta protein (Abeta) is a critical event in dise

41 The aggregation of amyloid beta protein (Abeta) is a fundamental pathogenic

42 odents suggest that soluble oligomers of the amyloid beta protein (Abeta) may discretely interfere wi

43 ic hallmarks of Alzheimer's disease (AD) are amyloid beta protein (Abeta) plaques and neurofibrillary

44 indings suggest that oligomeric forms of the amyloid beta protein (Abeta) play a critical role in Alz

45 APP at minor Asp(1) site to generate C99 for amyloid beta protein (Abeta) production, and predominant

46 Deposition of amyloid beta protein (Abeta) to form neuritic plaques in

47 en developed to study the pathophysiology of amyloid beta protein (Abeta) toxicity, which is thought

48 Amyloid beta protein (Abeta), a relevant risk factor in

49 heimer's disease (AD) is the accumulation of amyloid beta protein (Abeta), a small peptide derived fr

50 Cerebral deposition of the amyloid beta protein (Abeta), an invariant feature of Al

51 is associated with elevated brain levels of amyloid beta protein (Abeta), particularly neurotoxic Ab

52 Amyloid beta protein (Abeta), the principal component of

53 rated that the TNFR1 cascade is required for amyloid beta protein (Abeta)-induced neuronal death.

54 of tau appears to be a downstream effect of amyloid beta protein (Abeta).

55 gamma-secretase cleavage that generates the amyloid beta protein (Abeta).

56 ive stress and the accumulation of fibrillar amyloid beta proteins (Abeta) in senile plaques througho

57 Amyloid fibrils, large ordered aggregates of amyloid beta proteins (Abeta), are clinical hallmarks of

58 c differences in structural dynamics between amyloid beta-protein (Abeta) 40 and Abeta42 appear to un

59 The C-terminus of amyloid beta-protein (Abeta) 42 plays an important role

60 ubstrates of insulin-degrading enzyme (IDE), amyloid beta-protein (Abeta) and insulin, are critically

61 urther cleaved by gamma-secretase to produce amyloid beta-protein (Abeta) and p3, respectively.

62 Increased production and deposition of amyloid beta-protein (Abeta) are believed to be key path

63 Proteases that degrade the amyloid beta-protein (Abeta) are important regulators of

64 Oligomeric forms of amyloid beta-protein (Abeta) are key neurotoxins in Alzh

65 e to suggest that ABri and the AD-associated amyloid beta-protein (Abeta) are molecular equivalents t

66 Amyloid beta-protein (Abeta) assembly into toxic oligome

67 easing evidence supports the hypothesis that amyloid beta-protein (Abeta) assembly is a key pathogeni

68 Amyloid beta-protein (Abeta) assembly is hypothesized to

69 Cerebral vascular amyloid beta-protein (Abeta) deposition, also known as c

70 Amyloid beta-protein (Abeta) fibril assembly is a defini

71 ved by Lowe et al. to simultaneously enhance amyloid beta-protein (Abeta) fibrillogenesis and decreas

72 The deposition of amyloid beta-protein (Abeta) fibrils into plaques within

73 hioflavin T associated with freshly extended amyloid beta-protein (Abeta) fibrils.

74 In Alzheimer's disease (AD), the amyloid beta-protein (Abeta) forms neurotoxic oligomers.

75 cts of isoflurane on apoptosis are linked to amyloid beta-protein (Abeta) generation and aggregation.

76 loid precursor protein (APP) processing, and amyloid beta-protein (Abeta) generation in H4 human neur

77 the structural and assembly dynamics of the amyloid beta-protein (Abeta) has direct relevance to the

78 Oligomeric assemblies of the amyloid beta-protein (Abeta) have been implicated in the

79 esenilin 1 (PS1) decreases the production of amyloid beta-protein (Abeta) identified the presenilins

80 e suggests that the accumulation of cerebral amyloid beta-protein (Abeta) in Alzheimer's disease (AD)

81 The assembly and deposition of amyloid beta-protein (Abeta) in brain is a key pathologi

82 ntia that involves progressive deposition of amyloid beta-protein (Abeta) in brain regions important

83 The accumulation of amyloid beta-protein (Abeta) in brain regions serving me

84 ggregation of Alzheimer's disease-associated amyloid beta-protein (Abeta) in cultured cells.

85 The causes of cerebral accumulation of amyloid beta-protein (Abeta) in most cases of Alzheimer'

86 Deposits of amyloid beta-protein (Abeta) in neuritic plaques and cer

87 Accumulation of amyloid beta-protein (Abeta) in neurons has been demonst

88 Deposition of fibrillar amyloid beta-protein (Abeta) in the brain is a prominent

89 ed ACE has been reported to cleave synthetic amyloid beta-protein (Abeta) in vitro.

90 We have recently reported that fibrillar amyloid beta-protein (Abeta) inhibits the proteolytic ac

91 Accumulation of amyloid beta-protein (Abeta) into brain parenchymal plaq

92 Assembly of the amyloid beta-protein (Abeta) into neurotoxic oligomers a

93 ests that the folding and aggregation of the amyloid beta-protein (Abeta) into oligomers is a key pat

94 Cerebrovascular deposition of amyloid beta-protein (Abeta) is a common pathological fe

95 Oligomerization of the amyloid beta-protein (Abeta) is a seminal event in Alzhe

96 The amyloid beta-protein (Abeta) is a seminal neuropathic ag

97 Progressive cerebral accumulation of amyloid beta-protein (Abeta) is an early and invariant f

98 Amyloid beta-protein (Abeta) is central to the pathology

99 cture of the 21-30 fragment of the Alzheimer amyloid beta-protein (Abeta) is investigated by replica-

100 (gamma-secretase) that cleave APP to release amyloid beta-protein (Abeta) is likely to be presenilin.

101 c oligomeric and fibrillar structures by the amyloid beta-protein (Abeta) is linked to Alzheimer's di

102 Amyloid beta-protein (Abeta) is linked to neuronal injur

103 Amyloid beta-protein (Abeta) is present in soluble form

104 ented LTP inhibition by soluble oligomers of amyloid beta-protein (Abeta) isolated from AD cortex.

105 port on the plasticity-disrupting effects of amyloid beta-protein (Abeta) isolated from Alzheimer's d

106 (AD) is age-dependent, brain accumulation of amyloid beta-protein (Abeta) leading to Abeta self-assoc

107 Using Tg2576 mice, which model AD-type amyloid beta-protein (Abeta) neuropathology, we tested w

108 The final proteolytic step to generate the amyloid beta-protein (Abeta) of Alzheimer's disease (AD)

109 The roles of metal ions in promoting amyloid beta-protein (Abeta) oligomerization associated

110 Strong evidence exists for a central role of amyloid beta-protein (Abeta) oligomers in the pathogenes

111 Amyloid beta-protein (Abeta) oligomers may be the proxim

112 Amyloid beta-protein (Abeta) oligomers may be the proxim

113 assay using antibodies that are specific for amyloid beta-protein (Abeta) oligomers with sub-femtomol

114 Soluble amyloid beta-protein (Abeta) oligomers, the main neuroto

115 Oligomers of amyloid beta-protein (Abeta) play a central role in the

116 evidence suggests that soluble assemblies of amyloid beta-protein (Abeta) play an important role in t

117 The 40-42 residue amyloid beta-protein (Abeta) plays a central role in the

118 treating Alzheimer's disease (AD), in which amyloid beta-protein (Abeta) plays a key pathogenic role

119 many type I membrane proteins, including the amyloid beta-protein (Abeta) precursor (APP) and the Not

120 many type I membrane proteins, including the amyloid beta-protein (Abeta) precursor (APP) and the Not

121 Mutations in the amyloid beta-protein (Abeta) precursor gene cause autoso

122 In Alzheimer's disease (AD), amyloid beta-protein (Abeta) self-assembles into toxic o

123 Amyloid beta-protein (Abeta) self-assembly is linked str

124 One of the earliest events in amyloid beta-protein (Abeta) self-association is nucleat

125 Amyloid beta-protein (Abeta) sequence length variants wi

126 We used amyloid beta-protein (Abeta) to further explore the bind

127 euronal cell surface receptor that regulates amyloid beta-protein (Abeta) trafficking into the cell.

128 Until recently, naturally occurring amyloid beta-protein (Abeta) variants were believed to b

129 Cerebrovascular accumulation of amyloid beta-protein (Abeta), a condition known as cereb

130 gamma-Secretase generates amyloid beta-protein (Abeta), a pathogenic molecule in A

131 that oligomers of the 42-residue form of the amyloid beta-protein (Abeta), Abeta42, play a critical r

132 Amyloid plaques, composed of the amyloid beta-protein (Abeta), are hallmark neuropatholog

133 TP) can be inhibited by soluble oligomers of amyloid beta-protein (Abeta), but the synaptic elements

134 in Alzheimer's disease, soluble oligomers of amyloid beta-protein (Abeta), have been complicated by t

135 IDE) in mice causes accumulation of cerebral amyloid beta-protein (Abeta), hyperinsulinemia, and gluc

136 hat a small amphipathic fragment of APP, the amyloid beta-protein (Abeta), self-associates to form so

137 APP is the precursor to the amyloid beta-protein (Abeta), the 38-43-amino acid resid

138 Amyloid beta-protein (Abeta), the major component of cer

139 Numerous studies have now shown that the amyloid beta-protein (Abeta), the principal component of

140 the amyloid precursor protein (APP) produces amyloid beta-protein (Abeta), the probable causative age

141 The amyloid beta-protein (Abeta), which accumulates abnormal

142 Importantly, amyloid beta-protein (Abeta)-induced neuronal compromise

143 relevant peptides, including insulin and the amyloid beta-protein (Abeta).

144 his association may impact the production of amyloid beta-protein (Abeta).

145 ated with formation of fibrillar deposits of amyloid beta-protein (Abeta).

146 f synaptic plasticity by Alzheimer's disease amyloid beta-protein (Abeta).

147 eta40 are the two primary alloforms of human amyloid beta-protein (Abeta).

148 se (AD) contain large deposits of aggregated amyloid beta-protein (Abeta).

149 imate pathologic agents are oligomers of the amyloid beta-protein (Abeta).

150 D) is linked to the aberrant assembly of the amyloid beta-protein (Abeta).

151 id fibrils formed from long fragments of the amyloid beta-protein (Abeta-protein), the monomers are a

152 Insoluble fibrillar plaques of amyloid beta-proteins (Abeta) and neurofibrillary deposi

153 neurodegeneration associated with deposited amyloid-beta protein (Abeta) aggregates in the brains of

154 While amyloid-beta protein (Abeta) aggregation into insoluble

155 cides with the accumulation of extracellular amyloid-beta protein (Abeta) and intraneuronal tau aggre

156 ctive in inducing an immune response against amyloid-beta protein (Abeta) and reducing brain Abeta lo

157 Brain accumulation of the amyloid-beta protein (Abeta) and synapse loss are neurop

158 dies have determined that fibrillar forms of amyloid-beta protein (Abeta) comprise the characteristic

159 loid hypothesis suggests that the process of amyloid-beta protein (Abeta) fibrillogenesis is responsi

160 myloid precursor protein (APP), and increase amyloid-beta protein (Abeta) generation.

161 ggests water-soluble, non-fibrillar forms of amyloid-beta protein (Abeta) have important roles in Alz

162 able evidence supports a causal role for the amyloid-beta protein (Abeta) in AD, a direct link betwee

163 Deposition of fibrillar amyloid-beta protein (Abeta) in senile plaques and in th

164 The aggregation of amyloid-beta protein (Abeta) in vivo is a critical patho

165 The oligomerization of the amyloid-beta protein (Abeta) is an important event in Al

166 Production of amyloid-beta protein (Abeta) is initiated by a beta-secr

167 Amyloid-beta protein (Abeta) is thought to play an impor

168 We extracted soluble amyloid-beta protein (Abeta) oligomers directly from the

169 Specific mutations within the amyloid-beta protein (Abeta) peptide have been identifie

170 protein (APP) and its pathogenic by-product amyloid-beta protein (Abeta) play central roles in Alzhe

171 that interaction of CypD with mitochondrial amyloid-beta protein (Abeta) potentiates mitochondrial,

172 The amyloid-beta protein (Abeta) protein plays a pivotal rol

173 de hypothesis," linking self-assembly of the amyloid-beta protein (Abeta) to the pathogenesis of Alzh

174 Here, we show that amyloid-beta protein (Abeta), a major component of plaqu

175 The final step in the generation of the amyloid-beta protein (Abeta), implicated in the etiology

176 croglia are activated by aggregated forms of amyloid-beta protein (Abeta), usually demonstrated in vi

177 generate various polypeptides, including the amyloid-beta protein (Abeta), which forms amyloid plaque

178 amma-secretases results in generation of the amyloid-beta protein (Abeta), which is characteristicall

179 cumulation of amyloid plaques containing the amyloid-beta protein (Abeta).

180 ociated with pathological assembly states of amyloid-beta protein (Abeta).

181 The amount of amyloid beta protein, Abeta(42(43)), but not Abeta(40,)

182 (ELISA) to measure plasma concentrations of amyloid beta proteins Abeta40 and Abeta42 among 55 adult

183 brils formed by the Arctic variant (E22G) of amyloid-beta protein (Abeta40(ARC)) as well as the effec

184 however, it is the shorter and more soluble amyloid beta protein, Abeta40, that predominates.

185 lower the level of the 42-amino-acid form of amyloid beta protein (Abeta42) in a human H4 cell line.

186 Plasma amyloid beta protein (Abeta42) levels and late onset Alz

187 Using plasma amyloid beta protein (Abeta42) levels as an intermediate

188 Amyloid beta protein (AbetaP) is the major constituent o

189 Here, we show that soluble amyloid beta protein accelerates amyloid precursor prote

190 h with CLR01 resulted in a decrease in brain amyloid beta protein aggregates, hyperphosphorylated tau

191 lyphenolic extract can significantly inhibit amyloid beta-protein aggregation into high-molecular-wei

192 embly of the two predominant disease-related amyloid beta-protein alloforms, Abeta40 and Abeta42.

193 cline in the absence of neurodegeneration or amyloid-beta protein amyloidosis.

194 oteins including TAR DNA-binding protein 43, amyloid beta protein and alpha-synuclein.

195 f multiple amyloidogenic proteins, including amyloid beta protein and tau, by disrupting key interact

196 caused by toxic oligomers and aggregates of amyloid beta protein and the microtubule-associated prot

197 anes are known to promote the aggregation of amyloid beta proteins and fibril formation.

198 ecursor protein (APP) processing and affects amyloid beta-protein and APP secretion and APP-c-termina

199 opment of in vivo imaging probes targeted to amyloid beta protein, and one agent is already available

200 id membranes promote beta-sheet formation by amyloid beta-proteins, and they suggest a possible role

201 Cerebral amyloid beta-protein angiopathy (CAA) is a key pathologi

202 Although the amyloid-beta protein associated with the Alzheimer's dis

203 eurons are defective in apoptosis induced by amyloid-beta protein but not by staurosporine or trophic

204 how that BSB binds not only to extracellular amyloid beta protein, but also many intracellular lesion

205 The aggregation properties of amyloid beta proteins can be strongly affected by single

206 surface LRP immunoreactivity in response to amyloid beta-protein challenge was associated with incre

207 glish and the Tottori, the mutations produce amyloid beta-proteins containing amino acid substitution

208 or protein may be another mechanism by which amyloid beta protein contributes to synapse loss and neu

209 ent transgenic mouse models suggest that the amyloid beta-protein contributes to memory loss in Alzhe

210 In vivo, the levels of soluble amyloid beta protein correlated with caspase-cleaved fra

211 ectron microscopy in a preparation of seeded amyloid beta protein fibrils that formed at relatively l

212 ion of peptide self-assembly pathways in the amyloid-beta protein fragment Abeta(25-35) by two amyloi

213 s, such as angiotensin I (Agt I) and [Gln11]-amyloid-beta-protein fragment 1-16 (A beta(1-16)), the o

214 ce gamma-secretase can specifically generate amyloid beta-protein from an APP substrate and similarly

215 Progressive accumulation of the amyloid beta protein in extracellular plaques is a neuro

216 in the islet and brain (amyloid derived from amyloid beta protein in the brain in Alzheimer disease a

217 Moreover, levels of amyloid beta protein in the brains of treated mice did n

218 as potential contributory factors, including amyloid beta-protein in Alzheimer's disease, tau in fron

219 s were performed in C6 cells challenged with amyloid beta-protein in the presence or absence of activ

220 hemical basis for oxidative damage caused by amyloid-beta protein in AD.

221 ntia, increase cell death, and deposition of amyloid-beta proteins in Alzheimer's disease brains.

222 oxicity induced by the 42-residue isoform of amyloid beta protein, including approximately 80% inhibi

223 These findings suggest that soluble amyloid beta protein-induced multimerization of the amyl

224 ence that a defined molecular species of the amyloid-beta protein interferes with cognitive function.

225 haracterized by the self-assembly of tau and amyloid beta proteins into oligomers and fibrils.

226 The accumulation of amyloid-beta protein into plaques is a characteristic fe

227 Fragment 11-25 of the amyloid beta protein involved in Alzheimer's disease (Ab

228 dogenic effects of oxidative lipid damage on amyloid beta proteins is demonstrated and the mechanism

229 seed the formation of fibrils by unmodified amyloid beta proteins is enhanced.

230 gests that the aggregation and deposition of amyloid-beta protein is an initiating event in Alzheimer

231 We applied these methods to a number of the amyloid-beta protein isoforms of Abeta40 and Abeta42 and

232 etase cleavage of the mutant C99 to generate amyloid beta protein, leading to recessively inherited A

233 WT mice presented a significant increase in amyloid beta protein levels, a hallmark of AD.

234 in on learning and memory are independent of amyloid beta protein levels.

235 aptic preservation and reduction in cerebral amyloid-beta protein levels and astrogliosis (P < 0.001

236 airment and a 2-3-fold increase in insoluble amyloid-beta protein levels and deposition in the brain.

237 acellular amyloid deposits and intracellular amyloid beta protein may activate caspases, leading to c

238 nges, taken together with toxic insults from amyloid-beta protein, may underlie the observed neuronal

239 SIGNIFICANCE STATEMENT: Oligomers of amyloid beta-protein (oAbeta) are tought to play an impo

240 Soluble oligomers of amyloid beta-protein (oAbeta) isolated from the brains o

241 Elevated cerebral levels of amyloid beta-protein occur universally in Alzheimer's di

242 amma-secretase, critical to the formation of amyloid-beta protein, on membrane thickness and lipid co

243 rticularly vulnerable to early deposition of amyloid beta-protein, one of the hallmark pathologies of

244 However, for the amyloid beta-protein peptide (Abeta), thought to be the

245 ionship of APP-CTFgamma to the production of amyloid beta protein peptides is not known, we conclude

246 inal to the scissile bonds for production of amyloid beta protein peptides.

247 Processing of the amyloid beta protein precursor (A beta PP) by the beta a

248 he familial Alzheimer's disease gene product amyloid beta protein precursor (A beta PP) is sequential

249 Proteolytic processing of amyloid beta protein precursor (AbetaPP) generates pepti

250 ) is genetically linked to the processing of amyloid beta protein precursor (AbetaPP).

251 eta1-40 or Abeta1-42 in the absence of human amyloid beta protein precursor (APP) overexpression.

252 were then tested in acute dosing studies in amyloid beta protein precursor (APP) transgenic mice, an

253 en shown to influence limited proteolysis of amyloid beta protein precursor (APP), Notch and ErbB4, a

254 ease-causing mutations in the genes encoding amyloid beta protein precursor and presenilins, raising

255 d not affect the amyloidogenic processing of amyloid beta protein precursor.

256 ed increase in the levels of cell-associated amyloid beta-protein precursor (AbetaPP) and cell death.

257 The amyloid beta-protein precursor (AbetaPP) is best known a

258 The amyloid beta-protein precursor (AbetaPP) is best recogni

259 vidence suggests that dysregulated levels of amyloid beta-protein precursor (APP) and its catabolites

260 rous type I membrane proteins, including the amyloid beta-protein precursor (APP) and the Notch recep

261 se A beta is produced from the processing of amyloid beta-protein precursor (APP) by beta- and gamma-

262 Sequential cleavages of the amyloid beta-protein precursor (APP) by the beta- and ga

263 idation of the proteolytic processing of the amyloid beta-protein precursor (APP) has revealed that o

264 ated with Alzheimer disease, is derived from amyloid beta-protein precursor (APP) through sequential

265 es the amyloid beta-peptide (Abeta) from the amyloid beta-protein precursor (APP).

266 , the Abeta parent molecule protease nexin-2/amyloid beta-protein precursor (PN-2/AbetaPP), which is

267 Both caspase-cleaved amyloid beta-protein precursor and activated caspase-9 w

268 nal presenilins and cleaves substrates (e.g. amyloid beta-protein precursor and Notch) with very loos

269 I integral membrane proteins, including the amyloid beta-protein precursor and the Notch receptor, a

270 I integral membrane proteins, including the amyloid beta-protein precursor and the Notch receptor.

271 ns of a variety of substrates, including the amyloid beta-protein precursor and the Notch receptor.

272 resses human vasculotropic Dutch/Iowa mutant amyloid beta-protein precursor in brain.

273 nd able to produce amyloid beta-peptides and amyloid beta-protein precursor intracellular domain.

274 is of a variety of substrates, including the amyloid beta-protein precursor of Alzheimer's disease an

275 al factor for optimal transcription from the amyloid beta-protein precursor promoter.

276 peptide inhibitors and designed to mimic the amyloid beta-protein precursor substrate bind specifical

277 Here we show that amyloid beta-protein precursor was proteolytically cleav

278 ate the possibility that caspase cleavage of amyloid beta-protein precursor with the generation of C3

279 mice, an AD mouse model overexpressing human amyloid beta-protein precursor with the Swedish double m

280 agulant protein, an aprotinin mutant (6L15), amyloid beta-protein precursor, or tissue factor pathway

281 ical beta-secretase cleavage site within the amyloid beta-protein precursor.

282 the Kunitz-type protease inhibitor domain of amyloid beta-protein precursor.

283 The amyloid-beta protein precursor (AbetaPP) is a type I tra

284 own to attenuate amyloidogenic processing of amyloid-beta protein precursor (APP) in cell culture stu

285 Amyloid-beta protein precursor intracellular domain-asso

286 The amyloid-beta protein precursor, a type 1 transmembrane p

287 P cleaving enzyme 1 (BACE1) is essential for amyloid beta protein production.

288 99 amino acids, and measured the effects on amyloid-beta protein production and Notch signaling, res

289 Amyloid beta proteins spontaneously form fibrils in vitr

290 loid precursor protein to generate the toxic amyloid beta protein, the major component of plaques in

291 important to understand factors that induce amyloid beta-proteins to adopt this conformation.

292 ocytic receptor conferred protection against amyloid beta-protein toxicity in the presence of activat

293 y protects neurons from oxidative stress and amyloid beta-protein toxicity, and conditional deletion

294 otein receptor-related protein (LRP) against amyloid beta-protein toxicity, studies were performed in

295 th presenilin 1, increased susceptibility to amyloid beta-protein toxicity.

296 , also protects against oxidative stress and amyloid beta-protein toxicity.

297 se, lactate, pyruvate, glutamate and tau and amyloid-beta proteins, were measured every 1-2 h in the

298 2-nonenal modifies the three His residues in amyloid beta proteins, which increases their membrane af

299 ta-amyloid precursor protein (APP) generates amyloid beta-protein, which can assemble into oligomers

300 ease is a dense plaque composed of fibrillar amyloid beta-proteins with a characteristic and well-ord