ライフサイエンスコーパス: amyloid beta-protein precursor

1 d not affect the amyloidogenic processing of amyloid beta protein precursor.

2 ical beta-secretase cleavage site within the amyloid beta-protein precursor.

3 the Kunitz-type protease inhibitor domain of amyloid beta-protein precursor.

4 Processing of the amyloid beta protein precursor (A beta PP) by the beta a

5 he familial Alzheimer's disease gene product amyloid beta protein precursor (A beta PP) is sequential

6 or IXa and Factor XIa (ie, protease nexin-2/ amyloid beta-protein precursor, A beta PP) in the organi

7 The amyloid-beta protein precursor, a type 1 transmembrane p

8 Proteolytic processing of amyloid beta protein precursor (AbetaPP) generates pepti

9 ) is genetically linked to the processing of amyloid beta protein precursor (AbetaPP).

10 ed increase in the levels of cell-associated amyloid beta-protein precursor (AbetaPP) and cell death.

11 The amyloid beta-protein precursor (AbetaPP) is best known a

12 The amyloid beta-protein precursor (AbetaPP) is best recogni

13 The amyloid-beta protein precursor (AbetaPP) is a type I tra

14 ease-causing mutations in the genes encoding amyloid beta protein precursor and presenilins, raising

15 Both caspase-cleaved amyloid beta-protein precursor and activated caspase-9 w

16 nal presenilins and cleaves substrates (e.g. amyloid beta-protein precursor and Notch) with very loos

17 I integral membrane proteins, including the amyloid beta-protein precursor and the Notch receptor, a

18 ns of a variety of substrates, including the amyloid beta-protein precursor and the Notch receptor.

19 I integral membrane proteins, including the amyloid beta-protein precursor and the Notch receptor.

20 eta1-40 or Abeta1-42 in the absence of human amyloid beta protein precursor (APP) overexpression.

21 were then tested in acute dosing studies in amyloid beta protein precursor (APP) transgenic mice, an

22 en shown to influence limited proteolysis of amyloid beta protein precursor (APP), Notch and ErbB4, a

23 se cleaved carboxyl-terminal fragment of the amyloid beta protein precursor (APP).

24 vidence suggests that dysregulated levels of amyloid beta-protein precursor (APP) and its catabolites

25 rous type I membrane proteins, including the amyloid beta-protein precursor (APP) and the Notch recep

26 se A beta is produced from the processing of amyloid beta-protein precursor (APP) by beta- and gamma-

27 Sequential cleavages of the amyloid beta-protein precursor (APP) by the beta- and ga

28 protein (Abeta) is released from the larger amyloid beta-protein precursor (APP) by unidentified enz

29 Protease nexin-2 (PN-2), a soluble form of amyloid beta-protein precursor (APP) containing a Kunin

30 The promoter of the amyloid beta-protein precursor (APP) gene directs high l

31 nic mouse models that coexpress human PS and amyloid beta-protein precursor (APP) genes and analyzed

32 idation of the proteolytic processing of the amyloid beta-protein precursor (APP) has revealed that o

33 e presenilin 1 (PS1), presenilin 2 (PS2) and amyloid beta-protein precursor (APP) mutations linked to

34 ated with Alzheimer disease, is derived from amyloid beta-protein precursor (APP) through sequential

35 es the amyloid beta-peptide (Abeta) from the amyloid beta-protein precursor (APP).

36 own to attenuate amyloidogenic processing of amyloid-beta protein precursor (APP) in cell culture stu

37 rge proteins collectively referred to as the amyloid beta protein precursor (betaAPP).

38 The amyloid beta-protein precursor gives rise to the amyloid

39 ther LRP ligands, APOE and APP (encoding the amyloid beta-protein precursor), have now all been genet

40 resses human vasculotropic Dutch/Iowa mutant amyloid beta-protein precursor in brain.

41 nd able to produce amyloid beta-peptides and amyloid beta-protein precursor intracellular domain.

42 Amyloid-beta protein precursor intracellular domain-asso

43 is of a variety of substrates, including the amyloid beta-protein precursor of Alzheimer's disease an

44 agulant protein, an aprotinin mutant (6L15), amyloid beta-protein precursor, or tissue factor pathway

45 , the Abeta parent molecule protease nexin-2/amyloid beta-protein precursor (PN-2/AbetaPP), which is

46 The TATA-less human amyloid beta-protein precursor promoter contains an init

47 al factor for optimal transcription from the amyloid beta-protein precursor promoter.

48 peptide inhibitors and designed to mimic the amyloid beta-protein precursor substrate bind specifical

49 s of presenilin familial AD mutations on the amyloid beta-protein precursor, the presenilins themselv

50 Here we show that amyloid beta-protein precursor was proteolytically cleav

51 ate the possibility that caspase cleavage of amyloid beta-protein precursor with the generation of C3

52 mice, an AD mouse model overexpressing human amyloid beta-protein precursor with the Swedish double m