ライフサイエンスコーパス: amyloid precursor

1 model of AD; Tg19959 mice express the human amyloid precursor gene (APP) with 2 familial AD mutation

2 pidly detecting small molecules that bind to amyloid precursors, identifying the interacting protein

3 Amyloid precursor-like protein 1 (APLP1) is a transmembr

4 The amyloid precursor-like protein 1 (APLP1) is a type I tra

5 Amyloid precursor-like protein 2 (APLP2) and sortilin we

6 human Kunitz protease inhibitor domains from amyloid precursor-like protein 2 (APLP2), bikunin, hepat

7 exchanged for its homologous domain from the amyloid precursor-like protein 2.

8 d Swedish and Indiana mutations of the human amyloid precursor protein (APP mice) and WT mice.

9 kidney cells bearing the Swedish mutation of amyloid precursor protein (APP(sw) HEK cells) as a cellu

10 set Alzheimer's disease-causing mutations in amyloid precursor protein (APP(Swe)) and presenilin 1 (P

11 owed significant amounts of beta-amyloid and amyloid precursor protein (APP) aggregates in the cortex

12 Previous studies have demonstrated that amyloid precursor protein (APP) and Abeta levels can be

13 SorLA interacts directly with the amyloid precursor protein (APP) and affects the processi

14 Processing of the amyloid precursor protein (APP) and APP-like protein 2 (

15 eavage product of the ubiquitously expressed amyloid precursor protein (APP) and is able to self-asso

16 We determined that full-length amyloid precursor protein (APP) and its beta-C-terminal

17 Amyloid precursor protein (APP) and its cleavage product

18 beta-Amyloid precursor protein (APP) and its cleaved products

19 Amyloid precursor protein (APP) and its extracellular do

20 ha-, beta-, and gamma-secretases, cleave the amyloid precursor protein (APP) and modulate beta-amyloi

21 uitin aggregates and increased expression of amyloid precursor protein (APP) and phosphorylated tau (

22 Here, we show that amyloid precursor protein (APP) and presenilin 1 (PS1) d

23 ysosomal cysteine protease that cleaves both amyloid precursor protein (APP) and tau, mediating the a

24 The amyloid precursor protein (APP) and the APP-like protein

25 beta due to a change in the approximation of amyloid precursor protein (APP) and the beta-site APP cl

26 l invasion and colonization by destabilizing amyloid precursor protein (APP) and ZNF395 transcripts,

27 Overexpression and/or abnormal cleavage of amyloid precursor protein (APP) are linked to Alzheimer'

28 es whether C-terminal fragments (CTF) of the amyloid precursor protein (APP) are present in cerebrosp

29 ally neurotoxic Abeta fragments derived from amyloid precursor protein (APP) at synapses may be a key

30 Cleavage of amyloid precursor protein (APP) by BACE-1 (beta-site APP

31 generated during sequential cleavage of the amyloid precursor protein (APP) by beta- and gamma-secre

32 ta (Abeta) peptide, derived from cleavage of amyloid precursor protein (APP) by beta- and gamma-secre

33 and are formed by sequential cleavage of the amyloid precursor protein (APP) by beta-secretase (BACE)

34 eta is generated by a sequential cleavage of amyloid precursor protein (APP) by beta-secretase 1 (BAC

35 ides derived from sequential cleavage of the amyloid precursor protein (APP) by beta-site APP cleavin

36 tion of Abeta peptide from the processing of amyloid precursor protein (APP) by clipping enzymes (bet

37 ovel regulation of proteolytic processing of amyloid precursor protein (APP) by DISC1, a major risk f

38 Cleavage of the amyloid precursor protein (APP) by gamma-secretase is a

39 Processing of the amyloid precursor protein (APP) by gamma-secretase resul

40 mer's disease results from processing of the amyloid precursor protein (APP) by secretases.

41 Proteolytic processing of amyloid precursor protein (APP) C-terminal fragments (CT

42 dels of Alzheimer's disease suggest that the amyloid precursor protein (APP) can cause changes in syn

43 Prior work suggests that amyloid precursor protein (APP) can function as a proinf

44 APP/PS1 Tg mice, the critical molecules for amyloid precursor protein (APP) cleavage and signaling p

45 icits in AD.SIGNIFICANCE STATEMENT beta-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1

46 beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1

47 beta-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1

48 Amyloid precursor protein (APP) derivative beta-amyloid

49 The two de novo CNVs (an amyloid precursor protein (APP) duplication and a BACE2

50 d beta-peptide (Abeta) species generated via amyloid precursor protein (APP) endoproteolysis and clea

51 reviously that the Alzheimer-associated beta-amyloid precursor protein (APP) facilitates neuronal iro

52 Members of the amyloid precursor protein (APP) family participate in ma

53 's disease (AD) brain and the requirement of amyloid precursor protein (APP) for these effects.

54 EG recordings in tet-off mice overexpressing amyloid precursor protein (APP) from birth display frequ

55 haracterized by increases in DNA content and amyloid precursor protein (APP) gene copy number.

56 nsmembrane synaptic protein belonging to the amyloid precursor protein (APP) gene family.

57 Pathogenic mutations in the amyloid precursor protein (APP) gene have been described

58 his hypothesis derives from mutations in the amyloid precursor protein (APP) gene.

59 Proteolytic cleavage of the amyloid precursor protein (APP) generates beta-amyloid (

60 The amyloid precursor protein (APP) harbors physiological ro

61 ng evidence suggests that the copper-binding amyloid precursor protein (APP) has an essential synapti

62 Activation of nonamyloidogenic processing of amyloid precursor protein (APP) has been hypothesized to

63 p family proteins.SIGNIFICANCE STATEMENT The amyloid precursor protein (App) has been intensively stu

64 The amyloid precursor protein (APP) has garnered considerabl

65 The amyloid precursor protein (APP) has long been appreciate

66 The function of the amyloid precursor protein (APP) in brain health remains

67 ion of amyloid-beta (Abeta) derived from the amyloid precursor protein (APP) in the brain is thought

68 yloid beta (Abeta) peptides originating from amyloid precursor protein (APP) in the endosomal-lysosom

69 ecretase (BACE1) initiates processing of the amyloid precursor protein (APP) into Abeta peptides, whi

70 retase is responsible for the proteolysis of amyloid precursor protein (APP) into short, aggregation-

71 a growing body of evidence suggests that the amyloid precursor protein (APP) intracellular C-terminal

72 Here we report that the amyloid precursor protein (APP) intracellular domain (AI

73 retase component, the enzyme responsible for amyloid precursor protein (APP) intramembraneous cleavag

74 Amyloid precursor protein (APP) is a key player in Alzhe

75 The amyloid precursor protein (APP) is a widely expressed ty

76 The amyloid precursor protein (APP) is an integral membrane

77 The amyloid precursor protein (APP) is an ubiquitously expre

78 associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by beta-secre

79 Here, we reveal that the membrane-associated amyloid precursor protein (APP) is highly expressed in m

80 The beta-amyloid precursor protein (APP) is involved in Alzheimer

81 Amyloid precursor protein (APP) is involved in the patho

82 nce of earlier complications occurring while amyloid precursor protein (APP) is trafficking through t

83 nked mutations in Presenilins (PSEN) and the amyloid precursor protein (APP) lead to production of lo

84 Proteolysis of the amyloid precursor protein (APP) liberates various fragme

85 ACH) and presenilin (PSH) hypotheses and the amyloid precursor protein (APP) matrix approach (AMA), o

86 Endocytic sorting of amyloid precursor protein (APP) mediated by the vacuolar

87 For these cohorts, amyloid precursor protein (APP) metabolism, synaptic mar

88 Amyloid precursor protein (APP) metabolites (amyloid-bet

89 beta-secretase 1 (BACE-1) and BACE-1-cleaved amyloid precursor protein (APP) metabolites (secreted AP

90 -targeted replacement mice with mutant human amyloid precursor protein (APP) mice.

91 ients harboring the London familial AD (fAD) amyloid precursor protein (APP) mutation (V717I).

92 death: 50.0 +/- 8.6 years) with mutations in amyloid precursor protein (APP) or presenilin 1 (PSEN1),

93 The beta-amyloid precursor protein (APP) plays a central role in

94 Amyloid precursor protein (App) plays a crucial role in

95 ly involvement of endosomes and lysosomes in amyloid precursor protein (APP) processing and clearance

96 D) as it results directly in the decrease of amyloid precursor protein (APP) processing through the b

97 of APOE varepsilon3/4 allele exhibit altered amyloid precursor protein (APP) processing, abnormally i

98 of the unfolded protein response and altered amyloid precursor protein (APP) processing.

99 Aberrant cleavage of the amyloid precursor protein (APP) results in aggregation o

100 and Abeta42 secretion, and the amount of the amyloid precursor protein (APP) secreted at the cell sur

101 Compelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer's disease (

102 mplicated a pathway involving binding of the Amyloid Precursor Protein (APP) to Death Receptor 6 (DR6

103 enic mouse model expressing a mutant form of amyloid precursor protein (APP) to distinguish the impac

104 ns of alpha-syn-containing preparations into amyloid precursor protein (APP) transgenic mice (express

105 hat Abeta pathology and neuroinflammation in amyloid precursor protein (APP) transgenic mice are wors

106 Here, we report that cAMP controls amyloid precursor protein (APP) translation and Abeta le

107 Amyloid precursor protein (APP) undergoes post-translati

108 Amyloid precursor protein (APP) was originally identifie

109 ng studies revealed that the dynamics of the amyloid precursor protein (APP) were significantly impai

110 in, and scyllo-inositol, in cells expressing amyloid precursor protein (APP) with the Osaka (E693Delt

111 The amyloid precursor protein (APP), a key player in Alzheim

112 te products in the brain, possibly including amyloid precursor protein (APP), a marker of DAI.

113 in 4 (CNTN4) or one of its binding partners, amyloid precursor protein (APP), a subset of direction-s

114 transport of the Alzheimer's disease-related amyloid precursor protein (APP), although neuronal morph

115 nerated by the proteolytic processing of the amyloid precursor protein (APP), and alterations to this

116 laques resulting from abnormal processing of amyloid precursor protein (APP), and presence of neurofi

117 eferring to an interaction between DISC1 and amyloid precursor protein (APP), and to an association o

118 Amyloid precursor protein (APP), encoded on Hsa21, funct

119 a-peptide (Abeta), a cleavage product of the amyloid precursor protein (APP), exerts detrimental effe

120 erated through sequential proteolysis of the amyloid precursor protein (APP), first by the action of

121 oid-beta generation from its precursor, beta-amyloid precursor protein (APP), in a competitive manner

122 tide, a metabolite of sequential cleavage of amyloid precursor protein (APP), is a critical step in t

123 ition of amyloid-beta peptides, derived from amyloid precursor protein (APP), is a neuropathological

124 proteins linked to familial AD (FAD), mutant amyloid precursor protein (APP), or APP and presenilin (

125 eta), derived from proteolytic processing of amyloid precursor protein (APP), play a central role in

126 and fully penetrant pathogenic mutations in amyloid precursor protein (APP), presenilin 1 and 2 (PSE

127 The amyloid precursor protein (APP), primarily known as the

128 er impregnation and immunohistochemistry for amyloid precursor protein (APP), respectively.

129 ) peptide because of increased processing of amyloid precursor protein (APP), resulting in loss of sy

130 Missense mutations in alanine 673 of the amyloid precursor protein (APP), which corresponds to th

131 ilar to that of transgenic mice that express amyloid precursor protein (APP), which is duplicated in

132 tween these conditions may be constituted by amyloid precursor protein (APP), which plays a pivotal r

133 idue protein produced by the cleavage of the amyloid precursor protein (APP), which subsequently aggr

134 The amyloid precursor protein (APP), whose mutations cause A

135 The amyloid precursor protein (APP), whose mutations cause f

136 The protease beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1

137 The beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (beta-

138 udies implicate death receptor 6 (DR6) in an amyloid precursor protein (APP)-dependent pathway regula

139 rt the generation of Abeta-peptides from the amyloid precursor protein (APP).

140 metabolism of the Alzheimer disease-related amyloid precursor protein (APP).

141 ase, which can be caused by mutations in the amyloid precursor protein (APP).

142 protein and in the cleaved fragments of the amyloid precursor protein (APP).

143 endocytosis and proteolytic cleavage of the amyloid precursor protein (APP).

144 anied by an increase in the levels of mature amyloid precursor protein (APP).

145 mma-secretase cleavage of the membrane-bound amyloid precursor protein (APP).

146 eady shown for oAbeta, also oTau can bind to amyloid precursor protein (APP).

147 drogen bond strengths in the TM helix of the amyloid precursor protein (APP).

148 x Virus strikingly overlaps with that of the amyloid precursor protein (APP).

149 Using the amyloid precursor protein (APP)/presenilin 1 (PS1) trans

150 Here, we examined the impact of CXCR3 in the amyloid precursor protein (APP)/presenilin 1 (PS1) trans

151 ne beta-hydroxylase (DBH) knockout mice with amyloid precursor protein (APP)/presenilin-1 (PS1) mice

152 Here we discovered that, in amyloid precursor protein (APP)/presenilin-1 (PS1) mice

153 well as an Alzheimer's disease mouse model, amyloid precursor protein (APP)/PSEN1dE9(+/-) (PS1) that

154 We have previously shown that the fly amyloid precursor protein (APPL) is required for memory

155 TgF344-AD) expressing disease-causing mutant amyloid precursor protein (APPsw) and presenilin-1 (PS1D

156 criptomic changes in control and mutant beta-amyloid precursor protein (APPSw,Ind) transgenic mice du

157 SY5Y neuroblastoma cells expressing the beta-amyloid precursor protein (betaAPP) harboring the famili

158 The 99 amino acid C-terminal fragment of amyloid precursor protein (C99), consisting of a single

159 ocampal neurons and in mice expressing human amyloid precursor protein (hAPP mice), a model for famil

160 compared transgenic mice that express human amyloid precursor protein (hAPP) and patients with mild

161 humans with AD, aging mice expressing human amyloid precursor protein (hAPP) showed increased levels

162 cking in the axon of AD-related mutant human amyloid precursor protein (hAPP) transgenic (Tg) mouse n

163 e mortality and network dysfunction in human amyloid precursor protein (hAPP) transgenic mice, which

164 tors, in the brains of AD patients and human amyloid precursor protein (hAPP) transgenic mice.

165 malities in transgenic mice expressing human amyloid precursor protein (hAPP).

166 he AD mouse model carrying human mutation of amyloid precursor protein (mhAPP) expressing human Abeta

167 Here, we have uncovered a role for soluble amyloid precursor protein (sAPP) as a vascular niche sig

168 soluble metabolites alpha and beta (soluble amyloid precursor protein (sAPP)alpha, sAPPbeta) and two

169 ), gamma-secretase, soluble Abeta42, soluble amyloid precursor protein (sAPP)beta, sAPPalpha, glial-d

170 nsgenic mice expressing mutated forms of the amyloid precursor protein (Tg2576 mice).

171 (+/-)) in a mouse model of familial AD (FAD; amyloid precursor protein [APP]/presenilin 1 [PS1]) amel

172 odel of AD (transgenic mice expressing human amyloid precursor protein [hAPP]) and patients in the ea

173 hese observations, anterogradely transported amyloid precursor protein accumulated in ligated sciatic

174 ion on transmembrane proteins other than the amyloid precursor protein affects the nervous system is

175 Sarm1(-/-) mice developed fewer beta-amyloid precursor protein aggregates in axons of the cor

176 Amyloid precursor protein and endosomal-lysosomal dysfun

177 It binds to the C terminus of the Abeta amyloid precursor protein and is involved in regulating

178 C-terminal domain (residues 672-770) of the amyloid precursor protein and is the immediate precursor

179 Alzheimer's disease we used a double mutant amyloid precursor protein and presenilin 1 (APPswe/PSEN1

180 Here we report that FAD mutations in beta-amyloid precursor protein and presenilin 1 are able to i

181 expression of human familial AD mutations in amyloid precursor protein and presenilin 1 leads to sens

182 nd transgenic APPPS1 mice (overexpression of amyloid precursor protein and presenilin 1 with Swedish

183 r's disease (AD), mice overexpressing mutant amyloid precursor protein and presenilin-1 (APP/PS1) wer

184 numerous proteins besides ApoER2, including amyloid precursor protein and the synaptic adaptor prote

185 at initiates amyloidogenic processing of the amyloid precursor protein and which is a substrate for t

186 Abeta43, a product of the proteolysis of the amyloid precursor protein APP, is related to Abeta42 by

187 known that mutations in the gene coding for amyloid precursor protein are responsible for autosomal

188 transmembrane aspartyl protease that cleaves amyloid precursor protein at the beta-secretase site to

189 hemistry; white matter showed Abeta and beta-amyloid precursor protein by immunocytochemistry, but no

190 accompanied by a decrease in BACE1-mediated amyloid precursor protein cleavage and amyloid-beta leve

191 hway represses the transcription of the beta-amyloid precursor protein cleaving enzyme (BACE1) via bi

192 sufficient to unleash a global and beta-site amyloid precursor protein cleaving enzyme 1 (bace-1) DNA

193 ide derivative, is a high-affinity beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhi

194 Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a

195 nooxazoline xanthene inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is d

196 sion causes an increase in APP and beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) prot

197 bustly reduces Abeta by inhibiting beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), a k

198 he beta secretase, widely known as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), ini

199 S6K1 levels reduced translation of beta-site amyloid precursor protein cleaving enzyme 1 and tau, two

200 BACE1 (beta site amyloid precursor protein cleaving enzyme 1) is the rate

201 reduced translation of tau and the beta-site amyloid precursor protein cleaving enzyme 1, a key enzym

202 of Group II mGluR in Dutch APP (Alzheimer's amyloid precursor protein E693Q) transgenic mice that ac

203 Although brain amyloid precursor protein expression and amyloid beta pr

204 The amyloid precursor protein family (APP/APLPs) has essenti

205 pressing a shorter FE65 isoform able to bind amyloid precursor protein family members (APP, APLP1, AP

206 s of the Alzheimer's disease (AD)-implicated amyloid precursor protein gene (APP) and comprehensively

207 Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a

208 t over-express the Swedish mutant human beta-amyloid precursor protein gene with G protein-coupled re

209 TgCRND8 (Tg) transgenic mice express human amyloid precursor protein harboring the Swedish and Indi

210 examined [3H]PiB binding and Abeta and beta-amyloid precursor protein immunocytochemistry in autopsy

211 ochemistry for beta-amyloid (Abeta) and beta-amyloid precursor protein in brain tissue were obtained

212 e and monkeys, and accompanied by diminished amyloid precursor protein in monkeys.

213 iple similarities, strengthening the role of amyloid precursor protein in normal brain function and d

214 human induced neurons overexpressing mutant amyloid precursor protein in the background of APOE vare

215 l PDAPP mice, which overexpress mutant human amyloid precursor protein in the brain, exhibit two cryp

216 screpancy is likely due to overexpression of amyloid precursor protein in the transformed cellular mo

217 Overexpression of human amyloid precursor protein in transgenic mice induces hip

218 e of the Alzheimer's disease-associated beta-amyloid precursor protein in vitro and in human embryoni

219 affected brain regions caused by cleavage of amyloid precursor protein into the pathogenic peptide am

220 Here we report that the amyloid precursor protein intracellular domain associate

221 ta42 in nuclear signaling, distinct from the amyloid precursor protein intracellular domain.

222 We report that amyloid precursor protein is crucial for axonal pruning

223 ogy of Alzheimer's disease, it is clear that amyloid precursor protein is expressed in numerous cell

224 umulation of the C-terminal fragments of the amyloid precursor protein is inversely correlated with P

225 Here we demonstrate that amyloid precursor protein is involved in regulating the

226 vine pancreatic trypsin inhibitor (BPTI) and amyloid precursor protein Kunitz protease inhibitor (APP

227 Previous studies have shown that the amyloid precursor protein Kunitz protease inhibitor doma

228 hand, gamma-secretase-mediated processing of amyloid precursor protein leads to the production of amy

229 Both DDT and DDE increase amyloid precursor protein levels, providing mechanistic

230 ) identify novel genetic factors involved in amyloid precursor protein metabolism and (ii) highlight

231 Results: Aged mutant amyloid precursor protein mice with established disease

232 P = .01) and associative memory (P = .02) in amyloid precursor protein mice.

233 The amyloid precursor protein modulates alpha2A-adrenergic r

234 Amyloid precursor protein mutations falling within the a

235 protective in Drosophila models of Ass42 and amyloid precursor protein neurotoxicity.

236 endosomes was coupled with reduced levels of amyloid precursor protein processing and Abeta productio

237 In the latter case, proteins related to amyloid precursor protein processing and secretion are S

238 sosome transport in regulating amyloidogenic amyloid precursor protein processing and support a model

239 These swellings contain high levels of amyloid precursor protein processing enzymes (BACE1 and

240 immunoreactivity without detectably altering amyloid precursor protein processing or extracellular Ab

241 ; however, its role in the processing of the amyloid precursor protein remains unknown.

242 ht chain (NFL), alpha-synuclein (alpha-syn), amyloid precursor protein soluble metabolites alpha and

243 smic reticulum retrograde transport, affects amyloid precursor protein subcellular localization, cell

244 ral transmembrane proteins, most notably the amyloid precursor protein that results in Abeta, a trans

245 efflux by lowering tau protein that traffics amyloid precursor protein to facilitate iron efflux.

246 m for Golgi fragmentation and its effects on amyloid precursor protein trafficking and processing in

247 gomeric Abeta or in slices from mutant human amyloid precursor protein transgenic mice (mhAPP J20).

248 Expression analysis of amyloid precursor protein transgenic mice also revealed

249 dated miRNA data using AD postmortem brains, amyloid precursor protein transgenic mice and AD cell li

250 Starting at 5 months of age, tet-off amyloid precursor protein transgenic mice were treated w

251 creases brain beta-amyloid (Abeta) levels in amyloid precursor protein transgenic mice, but no data a

252 vivo modulates the amyloidotic phenotype of amyloid precursor protein transgenic mice.

253 backbonding on the backbone dynamics of the amyloid precursor protein transmembrane helix.

254 The human systemic amyloid precursor protein transthyretin (TTR) is known t

255 of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway.

256 Increased APP (amyloid precursor protein) processing causes beta-amyloi

257 ovel object recognition test and stained for amyloid precursor protein, a DAI marker.

258 the absence of any changes in the amounts of amyloid precursor protein, amyloid-beta or synaptic prot

259 rane proteins such as EGF, betacellulin, the amyloid precursor protein, and CD23 from cells.

260 generative diseases such as alpha-synuclein, amyloid precursor protein, and tau.

261 at bind a variety of proteins, including the amyloid precursor protein, and that mediate the assembly

262 e result of alterations in expression of the amyloid precursor protein, as confirmed by both immunost

263 Due to the fact that it also cleaves amyloid precursor protein, BACE1 is a therapeutic target

264 havioural signs, astrogliosis, deposition of amyloid precursor protein, synaptic loss and neuronal de

265 e proteolytic fragments of the transmembrane amyloid precursor protein, whereas tau is a brain-specif

266 teins including several, such as tau and the amyloid precursor protein, which are involved in the pat

267 he diversion of the membrane-bound beta-site amyloid precursor protein-(APP) cleaving enzyme (BACE1)

268 ant factors amyloid beta (Abeta) and soluble amyloid precursor protein-alpha (sAPPalpha) and present

269 to measure amyloid beta (Abeta) and soluble amyloid precursor protein-alpha (sAPPalpha), analytes ce

270 The beta-site amyloid precursor protein-cleaving enzyme (BACE1) is the

271 ADE levels of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE-1), ga

272 inistration of an inhibitor of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) on A

273 gical substrate of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1)).

274 Short-term treatment of two human amyloid precursor protein-expressing models, Tg2576 and

275 In Alzheimer amyloid precursor protein-transgenic mice and SH-SY5Y ce

276 Unexpectedly, ablation of CR3 in human amyloid precursor protein-transgenic mice results in dec

277 ations in presenilin 1, presenilin 2, or the amyloid precursor protein.

278 s alpha-secretase of the Alzheimer's disease amyloid precursor protein.

279 imer disease-associated mutations within the amyloid precursor protein.

280 expressing familial AD-linked forms of human amyloid precursor protein.

281 decreased beta-secretase processing of beta-amyloid precursor protein.

282 toma cells to DDT or DDE increased levels of amyloid precursor protein.

283 ype I membrane proteins, including Notch and amyloid precursor protein.

284 undant in neurons and occurs on both tau and amyloid precursor protein.

285 protein, phosphorylated tau 181, and soluble amyloid precursor protein.

286 carboxyl-terminal fragment (betaCTF) of beta-amyloid precursor protein.

287 secretion by elevating alpha-cleavage of the amyloid precursor protein.

288 d with doxycycline (dox) to suppress further amyloid precursor protein/Abeta production, and at the s

289 ells via intracerebroventricular infusion in amyloid precursor protein/presenilin 1 (APP/PS1) double-

290 e effect of CLU on Abeta pathology using the amyloid precursor protein/presenilin 1 (APP/PS1) mouse m

291 content of mitochondrial 5-methylcytosine in amyloid precursor protein/presenilin 1 mice along with A

292 t spines and boutons distant from plaques in amyloid precursor protein/presenilin 1-GFP (APPPS1-GFP)

293 al glutathione (mGSH) depletion in older age amyloid precursor protein/presenilin-1 (APP/PS1) mice.

294 Amyloid precursor protein/tetracycline transactivator mi

295 Down syndrome critical region 1 (DSCR1) and amyloid-precursor protein (APP), proteins upregulated in

296 /Down syndrome critical region 1 (DSCR1) and amyloid-precursor protein (APP), proteins upregulated in

297 One major target has been the beta-site amyloid-precursor-protein-cleaving enzyme 1 (BACE-1), wi

298 Transgenic mouse lines overexpressing amyloid precursor proteins develop cerebral amyloidosis

299 protease complex involved in the cleavage of amyloid precursor proteins that lead to the formation of

300 locate across the outer membrane as unfolded amyloid precursors through a secretion system.