ライフサイエンスコーパス: amyloid precursor protein

1 ations in presenilin 1, presenilin 2, or the amyloid precursor protein.

2 s alpha-secretase of the Alzheimer's disease amyloid precursor protein.

3 imer disease-associated mutations within the amyloid precursor protein.

4 expressing familial AD-linked forms of human amyloid precursor protein.

5 decreased beta-secretase processing of beta-amyloid precursor protein.

6 toma cells to DDT or DDE increased levels of amyloid precursor protein.

7 ype I membrane proteins, including Notch and amyloid precursor protein.

8 undant in neurons and occurs on both tau and amyloid precursor protein.

9 protein, phosphorylated tau 181, and soluble amyloid precursor protein.

10 carboxyl-terminal fragment (betaCTF) of beta-amyloid precursor protein.

11 secretion by elevating alpha-cleavage of the amyloid precursor protein.

12 ovel object recognition test and stained for amyloid precursor protein, a DAI marker.

13 d with doxycycline (dox) to suppress further amyloid precursor protein/Abeta production, and at the s

14 hese observations, anterogradely transported amyloid precursor protein accumulated in ligated sciatic

15 ion on transmembrane proteins other than the amyloid precursor protein affects the nervous system is

16 Sarm1(-/-) mice developed fewer beta-amyloid precursor protein aggregates in axons of the cor

17 ant factors amyloid beta (Abeta) and soluble amyloid precursor protein-alpha (sAPPalpha) and present

18 to measure amyloid beta (Abeta) and soluble amyloid precursor protein-alpha (sAPPalpha), analytes ce

19 the absence of any changes in the amounts of amyloid precursor protein, amyloid-beta or synaptic prot

20 Amyloid precursor protein and endosomal-lysosomal dysfun

21 It binds to the C terminus of the Abeta amyloid precursor protein and is involved in regulating

22 C-terminal domain (residues 672-770) of the amyloid precursor protein and is the immediate precursor

23 mice expressing abnormal levels or forms of amyloid precursor protein and its presumed, etiopathogen

24 Using SH-SY5Y cells overexpressing wild-type amyloid precursor protein and pharmacological inhibition

25 Alzheimer's disease we used a double mutant amyloid precursor protein and presenilin 1 (APPswe/PSEN1

26 Here we report that FAD mutations in beta-amyloid precursor protein and presenilin 1 are able to i

27 expression of human familial AD mutations in amyloid precursor protein and presenilin 1 leads to sens

28 nd transgenic APPPS1 mice (overexpression of amyloid precursor protein and presenilin 1 with Swedish

29 r's disease (AD), mice overexpressing mutant amyloid precursor protein and presenilin-1 (APP/PS1) wer

30 numerous proteins besides ApoER2, including amyloid precursor protein and the synaptic adaptor prote

31 at initiates amyloidogenic processing of the amyloid precursor protein and which is a substrate for t

32 rane proteins such as EGF, betacellulin, the amyloid precursor protein, and CD23 from cells.

33 generative diseases such as alpha-synuclein, amyloid precursor protein, and tau.

34 at bind a variety of proteins, including the amyloid precursor protein, and that mediate the assembly

35 Abeta43, a product of the proteolysis of the amyloid precursor protein APP, is related to Abeta42 by

36 d Swedish and Indiana mutations of the human amyloid precursor protein (APP mice) and WT mice.

37 kidney cells bearing the Swedish mutation of amyloid precursor protein (APP(sw) HEK cells) as a cellu

38 set Alzheimer's disease-causing mutations in amyloid precursor protein (APP(Swe)) and presenilin 1 (P

39 owed significant amounts of beta-amyloid and amyloid precursor protein (APP) aggregates in the cortex

40 Previous studies have demonstrated that amyloid precursor protein (APP) and Abeta levels can be

41 SorLA interacts directly with the amyloid precursor protein (APP) and affects the processi

42 Processing of the amyloid precursor protein (APP) and APP-like protein 2 (

43 eavage product of the ubiquitously expressed amyloid precursor protein (APP) and is able to self-asso

44 We determined that full-length amyloid precursor protein (APP) and its beta-C-terminal

45 Amyloid precursor protein (APP) and its cleavage product

46 beta-Amyloid precursor protein (APP) and its cleaved products

47 Amyloid precursor protein (APP) and its extracellular do

48 ha-, beta-, and gamma-secretases, cleave the amyloid precursor protein (APP) and modulate beta-amyloi

49 uitin aggregates and increased expression of amyloid precursor protein (APP) and phosphorylated tau (

50 Here, we show that amyloid precursor protein (APP) and presenilin 1 (PS1) d

51 ysosomal cysteine protease that cleaves both amyloid precursor protein (APP) and tau, mediating the a

52 The amyloid precursor protein (APP) and the APP-like protein

53 beta due to a change in the approximation of amyloid precursor protein (APP) and the beta-site APP cl

54 l invasion and colonization by destabilizing amyloid precursor protein (APP) and ZNF395 transcripts,

55 Overexpression and/or abnormal cleavage of amyloid precursor protein (APP) are linked to Alzheimer'

56 es whether C-terminal fragments (CTF) of the amyloid precursor protein (APP) are present in cerebrosp

57 ally neurotoxic Abeta fragments derived from amyloid precursor protein (APP) at synapses may be a key

58 Cleavage of amyloid precursor protein (APP) by BACE-1 (beta-site APP

59 generated during sequential cleavage of the amyloid precursor protein (APP) by beta- and gamma-secre

60 ta (Abeta) peptide, derived from cleavage of amyloid precursor protein (APP) by beta- and gamma-secre

61 and are formed by sequential cleavage of the amyloid precursor protein (APP) by beta-secretase (BACE)

62 eta is generated by a sequential cleavage of amyloid precursor protein (APP) by beta-secretase 1 (BAC

63 ides derived from sequential cleavage of the amyloid precursor protein (APP) by beta-site APP cleavin

64 tion of Abeta peptide from the processing of amyloid precursor protein (APP) by clipping enzymes (bet

65 ovel regulation of proteolytic processing of amyloid precursor protein (APP) by DISC1, a major risk f

66 Cleavage of the amyloid precursor protein (APP) by gamma-secretase is a

67 Processing of the amyloid precursor protein (APP) by gamma-secretase resul

68 mer's disease results from processing of the amyloid precursor protein (APP) by secretases.

69 Proteolytic processing of amyloid precursor protein (APP) C-terminal fragments (CT

70 dels of Alzheimer's disease suggest that the amyloid precursor protein (APP) can cause changes in syn

71 Prior work suggests that amyloid precursor protein (APP) can function as a proinf

72 APP/PS1 Tg mice, the critical molecules for amyloid precursor protein (APP) cleavage and signaling p

73 icits in AD.SIGNIFICANCE STATEMENT beta-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1

74 beta-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1

75 beta-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1

76 Amyloid precursor protein (APP) derivative beta-amyloid

77 The two de novo CNVs (an amyloid precursor protein (APP) duplication and a BACE2

78 d beta-peptide (Abeta) species generated via amyloid precursor protein (APP) endoproteolysis and clea

79 reviously that the Alzheimer-associated beta-amyloid precursor protein (APP) facilitates neuronal iro

80 Members of the amyloid precursor protein (APP) family participate in ma

81 's disease (AD) brain and the requirement of amyloid precursor protein (APP) for these effects.

82 EG recordings in tet-off mice overexpressing amyloid precursor protein (APP) from birth display frequ

83 haracterized by increases in DNA content and amyloid precursor protein (APP) gene copy number.

84 nsmembrane synaptic protein belonging to the amyloid precursor protein (APP) gene family.

85 Pathogenic mutations in the amyloid precursor protein (APP) gene have been described

86 his hypothesis derives from mutations in the amyloid precursor protein (APP) gene.

87 Proteolytic cleavage of the amyloid precursor protein (APP) generates beta-amyloid (

88 The amyloid precursor protein (APP) harbors physiological ro

89 ng evidence suggests that the copper-binding amyloid precursor protein (APP) has an essential synapti

90 Activation of nonamyloidogenic processing of amyloid precursor protein (APP) has been hypothesized to

91 p family proteins.SIGNIFICANCE STATEMENT The amyloid precursor protein (App) has been intensively stu

92 The amyloid precursor protein (APP) has garnered considerabl

93 The amyloid precursor protein (APP) has long been appreciate

94 The function of the amyloid precursor protein (APP) in brain health remains

95 ion of amyloid-beta (Abeta) derived from the amyloid precursor protein (APP) in the brain is thought

96 yloid beta (Abeta) peptides originating from amyloid precursor protein (APP) in the endosomal-lysosom

97 ecretase (BACE1) initiates processing of the amyloid precursor protein (APP) into Abeta peptides, whi

98 retase is responsible for the proteolysis of amyloid precursor protein (APP) into short, aggregation-

99 a growing body of evidence suggests that the amyloid precursor protein (APP) intracellular C-terminal

100 Here we report that the amyloid precursor protein (APP) intracellular domain (AI

101 transcriptional regulatory complex with the amyloid precursor protein (APP) intracellular domain.

102 retase component, the enzyme responsible for amyloid precursor protein (APP) intramembraneous cleavag

103 Amyloid precursor protein (APP) is a key player in Alzhe

104 The amyloid precursor protein (APP) is a widely expressed ty

105 The amyloid precursor protein (APP) is an integral membrane

106 The amyloid precursor protein (APP) is an ubiquitously expre

107 associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by beta-secre

108 Here, we reveal that the membrane-associated amyloid precursor protein (APP) is highly expressed in m

109 The beta-amyloid precursor protein (APP) is involved in Alzheimer

110 Amyloid precursor protein (APP) is involved in the patho

111 nce of earlier complications occurring while amyloid precursor protein (APP) is trafficking through t

112 nked mutations in Presenilins (PSEN) and the amyloid precursor protein (APP) lead to production of lo

113 Proteolysis of the amyloid precursor protein (APP) liberates various fragme

114 ACH) and presenilin (PSH) hypotheses and the amyloid precursor protein (APP) matrix approach (AMA), o

115 Endocytic sorting of amyloid precursor protein (APP) mediated by the vacuolar

116 For these cohorts, amyloid precursor protein (APP) metabolism, synaptic mar

117 Amyloid precursor protein (APP) metabolites (amyloid-bet

118 beta-secretase 1 (BACE-1) and BACE-1-cleaved amyloid precursor protein (APP) metabolites (secreted AP

119 -targeted replacement mice with mutant human amyloid precursor protein (APP) mice.

120 ients harboring the London familial AD (fAD) amyloid precursor protein (APP) mutation (V717I).

121 death: 50.0 +/- 8.6 years) with mutations in amyloid precursor protein (APP) or presenilin 1 (PSEN1),

122 The beta-amyloid precursor protein (APP) plays a central role in

123 Amyloid precursor protein (App) plays a crucial role in

124 ly involvement of endosomes and lysosomes in amyloid precursor protein (APP) processing and clearance

125 D) as it results directly in the decrease of amyloid precursor protein (APP) processing through the b

126 of APOE varepsilon3/4 allele exhibit altered amyloid precursor protein (APP) processing, abnormally i

127 of the unfolded protein response and altered amyloid precursor protein (APP) processing.

128 Aberrant cleavage of the amyloid precursor protein (APP) results in aggregation o

129 and Abeta42 secretion, and the amount of the amyloid precursor protein (APP) secreted at the cell sur

130 Compelling genetic evidence links the amyloid precursor protein (APP) to Alzheimer's disease (

131 mplicated a pathway involving binding of the Amyloid Precursor Protein (APP) to Death Receptor 6 (DR6

132 enic mouse model expressing a mutant form of amyloid precursor protein (APP) to distinguish the impac

133 ns of alpha-syn-containing preparations into amyloid precursor protein (APP) transgenic mice (express

134 hat Abeta pathology and neuroinflammation in amyloid precursor protein (APP) transgenic mice are wors

135 Here, we report that cAMP controls amyloid precursor protein (APP) translation and Abeta le

136 Amyloid precursor protein (APP) undergoes post-translati

137 Amyloid precursor protein (APP) was originally identifie

138 ng studies revealed that the dynamics of the amyloid precursor protein (APP) were significantly impai

139 in, and scyllo-inositol, in cells expressing amyloid precursor protein (APP) with the Osaka (E693Delt

140 The amyloid precursor protein (APP), a key player in Alzheim

141 te products in the brain, possibly including amyloid precursor protein (APP), a marker of DAI.

142 in 4 (CNTN4) or one of its binding partners, amyloid precursor protein (APP), a subset of direction-s

143 Amyloid precursor protein (APP), a transmembrane glycopr

144 transport of the Alzheimer's disease-related amyloid precursor protein (APP), although neuronal morph

145 nerated by the proteolytic processing of the amyloid precursor protein (APP), and alterations to this

146 ta levels, alters cell surface expression of amyloid precursor protein (APP), and improves memory in

147 laques resulting from abnormal processing of amyloid precursor protein (APP), and presence of neurofi

148 eferring to an interaction between DISC1 and amyloid precursor protein (APP), and to an association o

149 Amyloid precursor protein (APP), encoded on Hsa21, funct

150 a-peptide (Abeta), a cleavage product of the amyloid precursor protein (APP), exerts detrimental effe

151 erated through sequential proteolysis of the amyloid precursor protein (APP), first by the action of

152 oid-beta generation from its precursor, beta-amyloid precursor protein (APP), in a competitive manner

153 tide, a metabolite of sequential cleavage of amyloid precursor protein (APP), is a critical step in t

154 ition of amyloid-beta peptides, derived from amyloid precursor protein (APP), is a neuropathological

155 proteins linked to familial AD (FAD), mutant amyloid precursor protein (APP), or APP and presenilin (

156 eta), derived from proteolytic processing of amyloid precursor protein (APP), play a central role in

157 and fully penetrant pathogenic mutations in amyloid precursor protein (APP), presenilin 1 and 2 (PSE

158 The amyloid precursor protein (APP), primarily known as the

159 er impregnation and immunohistochemistry for amyloid precursor protein (APP), respectively.

160 ) peptide because of increased processing of amyloid precursor protein (APP), resulting in loss of sy

161 Missense mutations in alanine 673 of the amyloid precursor protein (APP), which corresponds to th

162 ilar to that of transgenic mice that express amyloid precursor protein (APP), which is duplicated in

163 tween these conditions may be constituted by amyloid precursor protein (APP), which plays a pivotal r

164 idue protein produced by the cleavage of the amyloid precursor protein (APP), which subsequently aggr

165 The amyloid precursor protein (APP), whose mutations cause A

166 The amyloid precursor protein (APP), whose mutations cause f

167 The protease beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (BACE1

168 The beta-site amyloid precursor protein (APP)-cleaving enzyme 1 (beta-

169 udies implicate death receptor 6 (DR6) in an amyloid precursor protein (APP)-dependent pathway regula

170 rt the generation of Abeta-peptides from the amyloid precursor protein (APP).

171 metabolism of the Alzheimer disease-related amyloid precursor protein (APP).

172 ase, which can be caused by mutations in the amyloid precursor protein (APP).

173 protein and in the cleaved fragments of the amyloid precursor protein (APP).

174 endocytosis and proteolytic cleavage of the amyloid precursor protein (APP).

175 anied by an increase in the levels of mature amyloid precursor protein (APP).

176 mma-secretase cleavage of the membrane-bound amyloid precursor protein (APP).

177 eady shown for oAbeta, also oTau can bind to amyloid precursor protein (APP).

178 drogen bond strengths in the TM helix of the amyloid precursor protein (APP).

179 x Virus strikingly overlaps with that of the amyloid precursor protein (APP).

180 Using the amyloid precursor protein (APP)/presenilin 1 (PS1) trans

181 Here, we examined the impact of CXCR3 in the amyloid precursor protein (APP)/presenilin 1 (PS1) trans

182 ne beta-hydroxylase (DBH) knockout mice with amyloid precursor protein (APP)/presenilin-1 (PS1) mice

183 Here we discovered that, in amyloid precursor protein (APP)/presenilin-1 (PS1) mice

184 well as an Alzheimer's disease mouse model, amyloid precursor protein (APP)/PSEN1dE9(+/-) (PS1) that

185 Down syndrome critical region 1 (DSCR1) and amyloid-precursor protein (APP), proteins upregulated in

186 /Down syndrome critical region 1 (DSCR1) and amyloid-precursor protein (APP), proteins upregulated in

187 (+/-)) in a mouse model of familial AD (FAD; amyloid precursor protein [APP]/presenilin 1 [PS1]) amel

188 he diversion of the membrane-bound beta-site amyloid precursor protein-(APP) cleaving enzyme (BACE1)

189 We have previously shown that the fly amyloid precursor protein (APPL) is required for memory

190 TgF344-AD) expressing disease-causing mutant amyloid precursor protein (APPsw) and presenilin-1 (PS1D

191 criptomic changes in control and mutant beta-amyloid precursor protein (APPSw,Ind) transgenic mice du

192 known that mutations in the gene coding for amyloid precursor protein are responsible for autosomal

193 e result of alterations in expression of the amyloid precursor protein, as confirmed by both immunost

194 transmembrane aspartyl protease that cleaves amyloid precursor protein at the beta-secretase site to

195 Due to the fact that it also cleaves amyloid precursor protein, BACE1 is a therapeutic target

196 SY5Y neuroblastoma cells expressing the beta-amyloid precursor protein (betaAPP) harboring the famili

197 hemistry; white matter showed Abeta and beta-amyloid precursor protein by immunocytochemistry, but no

198 The 99 amino acid C-terminal fragment of amyloid precursor protein (C99), consisting of a single

199 accompanied by a decrease in BACE1-mediated amyloid precursor protein cleavage and amyloid-beta leve

200 recently that autophagy was responsible for amyloid precursor protein cleaved C-terminal fragment (A

201 hway represses the transcription of the beta-amyloid precursor protein cleaving enzyme (BACE1) via bi

202 sufficient to unleash a global and beta-site amyloid precursor protein cleaving enzyme 1 (bace-1) DNA

203 ide derivative, is a high-affinity beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhi

204 Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is a

205 nooxazoline xanthene inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) is d

206 sion causes an increase in APP and beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) prot

207 bustly reduces Abeta by inhibiting beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), a k

208 he beta secretase, widely known as beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), ini

209 S6K1 levels reduced translation of beta-site amyloid precursor protein cleaving enzyme 1 and tau, two

210 BACE1 (beta site amyloid precursor protein cleaving enzyme 1) is the rate

211 reduced translation of tau and the beta-site amyloid precursor protein cleaving enzyme 1, a key enzym

212 The beta-site amyloid precursor protein-cleaving enzyme (BACE1) is the

213 ADE levels of beta-site amyloid precursor protein-cleaving enzyme 1 (BACE-1), ga

214 inistration of an inhibitor of the beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1) on A

215 gical substrate of beta-secretase (beta-site amyloid precursor protein-cleaving enzyme 1 (BACE1)).

216 One major target has been the beta-site amyloid-precursor-protein-cleaving enzyme 1 (BACE-1), wi

217 Transgenic mouse lines overexpressing amyloid precursor proteins develop cerebral amyloidosis

218 of Group II mGluR in Dutch APP (Alzheimer's amyloid precursor protein E693Q) transgenic mice that ac

219 Short-term treatment of two human amyloid precursor protein-expressing models, Tg2576 and

220 Although brain amyloid precursor protein expression and amyloid beta pr

221 The amyloid precursor protein family (APP/APLPs) has essenti

222 pressing a shorter FE65 isoform able to bind amyloid precursor protein family members (APP, APLP1, AP

223 s of the Alzheimer's disease (AD)-implicated amyloid precursor protein gene (APP) and comprehensively

224 Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a

225 t over-express the Swedish mutant human beta-amyloid precursor protein gene with G protein-coupled re

226 ocampal neurons and in mice expressing human amyloid precursor protein (hAPP mice), a model for famil

227 compared transgenic mice that express human amyloid precursor protein (hAPP) and patients with mild

228 humans with AD, aging mice expressing human amyloid precursor protein (hAPP) showed increased levels

229 cking in the axon of AD-related mutant human amyloid precursor protein (hAPP) transgenic (Tg) mouse n

230 e mortality and network dysfunction in human amyloid precursor protein (hAPP) transgenic mice, which

231 tors, in the brains of AD patients and human amyloid precursor protein (hAPP) transgenic mice.

232 malities in transgenic mice expressing human amyloid precursor protein (hAPP).

233 odel of AD (transgenic mice expressing human amyloid precursor protein [hAPP]) and patients in the ea

234 TgCRND8 (Tg) transgenic mice express human amyloid precursor protein harboring the Swedish and Indi

235 examined [3H]PiB binding and Abeta and beta-amyloid precursor protein immunocytochemistry in autopsy

236 ochemistry for beta-amyloid (Abeta) and beta-amyloid precursor protein in brain tissue were obtained

237 e and monkeys, and accompanied by diminished amyloid precursor protein in monkeys.

238 iple similarities, strengthening the role of amyloid precursor protein in normal brain function and d

239 human induced neurons overexpressing mutant amyloid precursor protein in the background of APOE vare

240 l PDAPP mice, which overexpress mutant human amyloid precursor protein in the brain, exhibit two cryp

241 screpancy is likely due to overexpression of amyloid precursor protein in the transformed cellular mo

242 es, enhances the amyloidogenic processing of amyloid precursor protein in these organelles and reduce

243 Overexpression of human amyloid precursor protein in transgenic mice induces hip

244 e of the Alzheimer's disease-associated beta-amyloid precursor protein in vitro and in human embryoni

245 affected brain regions caused by cleavage of amyloid precursor protein into the pathogenic peptide am

246 Here we report that the amyloid precursor protein intracellular domain associate

247 ta42 in nuclear signaling, distinct from the amyloid precursor protein intracellular domain.

248 We report that amyloid precursor protein is crucial for axonal pruning

249 ogy of Alzheimer's disease, it is clear that amyloid precursor protein is expressed in numerous cell

250 umulation of the C-terminal fragments of the amyloid precursor protein is inversely correlated with P

251 Here we demonstrate that amyloid precursor protein is involved in regulating the

252 vine pancreatic trypsin inhibitor (BPTI) and amyloid precursor protein Kunitz protease inhibitor (APP

253 Previous studies have shown that the amyloid precursor protein Kunitz protease inhibitor doma

254 hand, gamma-secretase-mediated processing of amyloid precursor protein leads to the production of amy

255 Both DDT and DDE increase amyloid precursor protein levels, providing mechanistic

256 ) identify novel genetic factors involved in amyloid precursor protein metabolism and (ii) highlight

257 he AD mouse model carrying human mutation of amyloid precursor protein (mhAPP) expressing human Abeta

258 Results: Aged mutant amyloid precursor protein mice with established disease

259 P = .01) and associative memory (P = .02) in amyloid precursor protein mice.

260 The amyloid precursor protein modulates alpha2A-adrenergic r

261 Amyloid precursor protein mutations falling within the a

262 protective in Drosophila models of Ass42 and amyloid precursor protein neurotoxicity.

263 ells via intracerebroventricular infusion in amyloid precursor protein/presenilin 1 (APP/PS1) double-

264 e effect of CLU on Abeta pathology using the amyloid precursor protein/presenilin 1 (APP/PS1) mouse m

265 content of mitochondrial 5-methylcytosine in amyloid precursor protein/presenilin 1 mice along with A

266 t spines and boutons distant from plaques in amyloid precursor protein/presenilin 1-GFP (APPPS1-GFP)

267 al glutathione (mGSH) depletion in older age amyloid precursor protein/presenilin-1 (APP/PS1) mice.

268 endosomes was coupled with reduced levels of amyloid precursor protein processing and Abeta productio

269 In the latter case, proteins related to amyloid precursor protein processing and secretion are S

270 sosome transport in regulating amyloidogenic amyloid precursor protein processing and support a model

271 These swellings contain high levels of amyloid precursor protein processing enzymes (BACE1 and

272 immunoreactivity without detectably altering amyloid precursor protein processing or extracellular Ab

273 Increased APP (amyloid precursor protein) processing causes beta-amyloi

274 ; however, its role in the processing of the amyloid precursor protein remains unknown.

275 Here, we have uncovered a role for soluble amyloid precursor protein (sAPP) as a vascular niche sig

276 soluble metabolites alpha and beta (soluble amyloid precursor protein (sAPP)alpha, sAPPbeta) and two

277 ), gamma-secretase, soluble Abeta42, soluble amyloid precursor protein (sAPP)beta, sAPPalpha, glial-d

278 ht chain (NFL), alpha-synuclein (alpha-syn), amyloid precursor protein soluble metabolites alpha and

279 rsor protein in these organelles and reduces amyloid precursor protein sorting to intraluminal vesicl

280 smic reticulum retrograde transport, affects amyloid precursor protein subcellular localization, cell

281 havioural signs, astrogliosis, deposition of amyloid precursor protein, synaptic loss and neuronal de

282 Amyloid precursor protein/tetracycline transactivator mi

283 nsgenic mice expressing mutated forms of the amyloid precursor protein (Tg2576 mice).

284 ral transmembrane proteins, most notably the amyloid precursor protein that results in Abeta, a trans

285 protease complex involved in the cleavage of amyloid precursor proteins that lead to the formation of

286 efflux by lowering tau protein that traffics amyloid precursor protein to facilitate iron efflux.

287 m for Golgi fragmentation and its effects on amyloid precursor protein trafficking and processing in

288 gomeric Abeta or in slices from mutant human amyloid precursor protein transgenic mice (mhAPP J20).

289 Expression analysis of amyloid precursor protein transgenic mice also revealed

290 dated miRNA data using AD postmortem brains, amyloid precursor protein transgenic mice and AD cell li

291 Starting at 5 months of age, tet-off amyloid precursor protein transgenic mice were treated w

292 creases brain beta-amyloid (Abeta) levels in amyloid precursor protein transgenic mice, but no data a

293 vivo modulates the amyloidotic phenotype of amyloid precursor protein transgenic mice.

294 In Alzheimer amyloid precursor protein-transgenic mice and SH-SY5Y ce

295 Unexpectedly, ablation of CR3 in human amyloid precursor protein-transgenic mice results in dec

296 backbonding on the backbone dynamics of the amyloid precursor protein transmembrane helix.

297 The human systemic amyloid precursor protein transthyretin (TTR) is known t

298 of intracellular C-terminal fragments of the amyloid precursor protein via the MVB/lysosomal pathway.

299 e proteolytic fragments of the transmembrane amyloid precursor protein, whereas tau is a brain-specif

300 teins including several, such as tau and the amyloid precursor protein, which are involved in the pat