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1 tal models led to parameter estimate bias in an excess of 1,000% of true values, while the new model
8 on-treatment LDL-C and incident cancer, with an excess of 2.2 (95% confidence interval: 0.7 to 3.6) c
10 t, when the reaction is carried out by using an excess of 3 M equivalents of the Grignard reagent (cl
11 r every 1000 women exposed to this strategy, an excess of 3.5 neonatal deaths occurred, and the risk
12 known bis-alpha-diketone was condensed with an excess of 4-bromo-1,2-diaminobenzene in the presence
13 e the hydrophobic domain of the membrane and an excess of a bicyclo[6.1.0]nonyne (BCN)-cross-linker c
14 0305-treated animals that were co-dosed with an excess of a nontoxic folate-containing analogue, ther
15 onucleotide sequence even in the presence of an excess of a sequence with a single-base-pair mismatch
20 n improvement in the quality of care without an excess of adverse events related to more aggressive m
23 nduced cytidine deaminase (AID) and observed an excess of AID signature mutations in immortalised cel
24 omplished double C-H activation by employing an excess of alkyne, where both annulation and hydroaryl
25 om a functional perspective, we did not find an excess of alleles contributing to height despite bein
26 found that the source of this enrichment was an excess of alleles that increased sensitivity to the e
27 lassemia is characterised by the presence of an excess of alpha-globin chains, which contribute to er
29 icle neutralization lead us to conclude that an excess of ammonium enabled particle formation and gro
30 produce, in a sequential one-pot operation, an excess of any one of four possible diastereoisomers f
31 ever, when the coated samples are exposed to an excess of aqueous electrolyte, an increase in the amo
32 ctive only with electron-rich arenes, unless an excess of arene is used, which limits synthetic appli
34 scade were significantly more likely to have an excess of association signals than expected by chance
35 ys with overlapping genes, and clusters with an excess of association signals were determined by the
38 uNPs] ratio was determined, corresponding to an excess of AuNP surface relative to the molar GSNO amo
42 al lineCPh(pCF3))(CO)2] (6) upon addition of an excess of benzonitrile and by the temperature-depende
43 es HPV27/57, the unusual wart type HPV7, and an excess of Betapapillomavirus types (P = .002), compar
48 wo distinct mutant phenotypes were observed: an excess of buds on the protonema, and abnormal cell di
51 s even lesser degrees of renal compromise to an excess of cardiovascular events in the general popula
52 excess of diabetes or cancers, but there was an excess of cataract surgery (in 3.8% of the participan
58 r, one species (Drosophila sechellia) showed an excess of cis-regulatory divergence that we argue mos
59 -7 subunits was accelerated by co-expressing an excess of ClC-7 subunits carrying an accelerating mut
62 4 equiv of CNAr (Ar = 3,5-Me(2)C(6)H(3)) or an excess of CO in toluene provided excellent yields of
63 divergence across population pairs involving an excess of coding genes with specific molecular functi
64 olumes required for these techniques lead to an excess of coenriched organic or inorganic materials.
66 er specificity, tracers were coinjected with an excess of cold proteins of the same or opposite recep
67 ed connection pruning at later ages, and not an excess of connection formation, underlies the hyperco
70 ed by severe inflammatory symptoms caused by an excess of cytokines, particularly KSHV-encoded viral
71 (2+) on cell cycle progression and show that an excess of cytosolic Mn(2+) alters S-phase transit, in
73 DYRK1A truncating mutations (P=0.00851) and an excess of de novo mutations (P=2.53 x 10(-10)) among
74 lly, WES (n = 18) was very informative, with an excess of de novo mutations identified in genes predi
75 d 91 genes, including 38 new NDD genes, with an excess of de novo mutations or private disruptive mut
77 sed difference in liability and demonstrated an excess of deleterious autosomal copy-number variants
80 mr1 knockout (KO) model are characterized by an excess of dendritic spines, suggesting a deficit in e
84 Thus, simply upon mixing the dendralene and an excess of dienophile at ambient temperature in a comm
85 mechanisms underlying negative responses to an excess of dietary protein, including the causes of th
86 e these models to then identify loci showing an excess of differentiation as a means of identifying p
87 reatment of triphenylphosphine (Ph(3)P) with an excess of diisopropyl azodicarboxylate at 0-25 degree
88 In addition, the reaction of diynols with an excess of dimethyl disulfide in the presence of NBS g
91 se Bicc1-depleted eggs produced embryos with an excess of dorsal-anterior structures and overexpresse
94 to treatment with alemtuzumab but there was an excess of early infection-associated death in this gr
95 R complex to regulate lipid storage and that an excess of ecdysone disrupts the whole process, probab
96 magnitude and timing of the establishment of an excess of effector cells versus targets were found to
97 nti-DM4 B-Fabs and blocking experiments with an excess of either B-Fab or huDS6 were used to determin
100 annel currents from receptors assembled with an excess of either the alpha4 or beta2 subunit, forming
101 oidal stability over a wide range of pHs, to an excess of electrolytes, and in the presence of growth
104 fission is potently inhibited in vitro when an excess of endophilin co-assembles with dynamin around
105 The key property controlling evolvability is an excess of enzymatic activity relative to the strength
107 ard deviations from the genome-wide average: an excess of European ancestry at 1p36 and 14q32, and an
108 with a sex-biased pattern of gene flow with an excess of European male and African female ancestry.
110 However, histopathologic analysis revealed an excess of extracellular matrix in several tissues, in
111 ngly, in some mixture experiments we observe an excess of F plasmid in the early saturation phase tha
113 sts that recent admixture does not result in an excess of false-positive results for neutrality tests
114 L2, showed evidence of reduced diversity and an excess of fixed replacement sites, consistent with a
115 FMRP, particularly as recent studies suggest an excess of FMRP targets among genes implicated in idio
116 e between alpha- and beta-globin chains with an excess of free alpha-globin chains causing ineffectiv
118 (Malus x domestica) trees naturally produce an excess of fruitlets that negatively affect the commer
119 12%) on placebo (p=0.0002) was mainly due to an excess of gastrointestinal adverse effects, and there
123 nts, and among DNA-based movements there was an excess of genes moving onto the X chromosome as well.
124 rosophila and mammals, consistently detected an excess of genes moving out of the X chromosome and ga
125 AS data (the top 5% of SNPs) were tested for an excess of genes spanned by large, rare CNVs in the ch
126 he Drosophila and mouse X chromosomes harbor an excess of genes with female-biased expression after c
127 use many biologically defined gene sets have an excess of genes with longer or shorter gene locus len
128 ed 2,446 ASD-affected families and confirmed an excess of genic deletions and duplications in affecte
131 onditions with low Fe(3+) concentrations and an excess of H(2)O(2) as well as acidic conditions were
134 rmal lifespan, consistent with the idea that an excess of H3K4 trimethylation-a mark associated with
144 though studies of standard models often find an excess of hybrid male sterility factors, we found no
145 ween plasma electrons and aqueous ions yield an excess of hydroxide ions (OH(-)), making the solution
149 d that dysferlinopathy patient biopsies show an excess of immature fibres and therefore investigated
150 retinal connectome govern this computation: an excess of inhibitory inputs over excitatory, with bot
152 reduced estrogen sensitivity by introducing an excess of interaction partners into the receptor/estr
153 2 pg/mL target concentration in samples with an excess of interfering DNA and in a total analysis tim
155 etic, a large lattice constant together with an excess of La can stabilize an antiferromagnetic LaMnO
157 lize iodocyclopropanes involve reaction with an excess of LiCu(n-Bu)(2) to generate the cyclopropyl c
158 termediate that dominates in the presence of an excess of ligand, and (2) transmetalation via an acti
159 variants by in vivo complementation revealed an excess of loss-of-function alleles in individuals wit
160 n is under purifying selection, resulting in an excess of low-frequency variants and a negative corre
161 l baseline spirometry (n = 12,039), we found an excess of lung cancers during screening in the CT arm
163 duplications by retroposition have revealed an excess of male-biased duplicates generated from X chr
165 ppearance that the placenta tends to display an excess of maternally expressed imprinted genes, with
166 d, but paradoxically there is reported to be an excess of MCM DNA replication proteins over the numbe
167 s at high cardiovascular disease risk, found an excess of MIs among patients in the valsartan arm.
168 hows Debye-like behavior at low energies and an excess of modes, or Boson peak, at higher energies.
170 use retrotransposed gene duplicates to show an excess of movement off the An. gambiae X chromosome o
173 monooxygenase from Pseudomonas sp. OX1, with an excess of NO(g) or NO-generators S-nitroso-N-acetyl-D
175 Blocking antigen-expressing tumors with an excess of nonradiolabeled alphaGPC3 resulted in decre
176 rter, a phenotype that could be explained by an excess of nonreducing ends leading to a reinforced xy
179 Altogether, these findings indicate that an excess of NPM-ALK activation and signaling induces ap
181 for overcoming this challenge: (1) employing an excess of one reagent; (2) electronic differentiation
182 ed the respiration rate, which suggests that an excess of oxaloacetate is converted to aspartate and
185 sis, 638 (55%) of 1162 sarcoma probands bore an excess of pathogenic germline variants (combined odds
191 identifying 56 candidate elicitors that have an excess of positively selected residues in a backgroun
192 esults show that in the absence of sec61al1, an excess of precursor cells for the LsDh exit the ventr
193 emarkably, either phenotype can be dominant; an excess of primary keratinocytes leads to activation o
194 eterious autosomal CNVs (p = 7 x 10(-4)) and an excess of private deleterious single-nucleotide varia
195 unding, cells reversibly switch to producing an excess of proliferating daughters until the wound has
196 dney disease (CKD) is designing their diets: an excess of protein leads to the accumulation of uremic
197 f 1213 CHD parent-offspring trios identified an excess of protein-damaging de novo mutations, especia
198 ing minute amounts of infectious prions with an excess of PrP(C) and boosting the conversion by cycle
199 articular mechanism stands out in predicting an excess of punishment under constrained lab conditions
200 r, lysis could be competitively inhibited by an excess of purified trehalose dimycolate and was aboli
201 otypes in cortical progenitors, resulting in an excess of radial glia cells at the expense of interme
204 We searched 18,668 protein-coding genes for an excess of rare deleterious genetic variation using wh
205 s with treatment-resistant schizophrenia had an excess of rare disruptive variants in gene targets of
207 and rapid human population growth has led to an excess of rare genetic variants that are expected to
208 ent explosive population growth, notable for an excess of rare genetic variants, suggesting that many
209 rmal distributions of species abundance with an excess of rare species and a tail that may be approxi
210 same intracellular loop of NaV1.7, we found an excess of rare variants in a case-control variant-bur
212 We therefore predict that there will be an excess of recessive diseases in India, which should b
213 chment to cells can be completely blocked by an excess of recombinant fiber knob protein, while solub
215 ll other reported AEs, with the exception of an excess of renal and urinary AEs among patients assign
217 In addition, consistent with other cancers, an excess of retinoblastoma diagnosed in boys suggests a
221 g., leukemic B cells) due to the presence of an excess of secondary targets (e.g., normal B cells) wa
224 MMRD/polymerase-mutant cancers rapidly amass an excess of simultaneous mutations ( approximately 600
227 l inhibition (sIPSC and mIPSC) and generated an excess of somatostatin(+) (SST) (MGE-derived) and vas
228 d dimorphic species are predicted to produce an excess of sons, whereas mothers in poor condition sho
230 ndrome and are traditionally associated with an excess of striatal dopamine in the basal ganglia.
232 udy drug at EOS, and, between days 3 and 30, an excess of stroke and systemic embolic events were obs
237 nce is perturbed in latd mutants, leading to an excess of superoxide and hydrogen peroxide and a corr
239 ormation via a mutagenic mechanism involving an excess of T>G substitutions, but not involving a prep
240 rees C, an excess of unlabeled mouse IgG, or an excess of Tau antibodies reduced uptake in slices by
241 us analysis of 474 microlensing events found an excess of ten very short events (1-2 days)-more than
245 mice have an increase in NK-cell number with an excess of the CD11b(low)CD27(high) NK subset, indicat
248 Despite this requirement for crossovers and an excess of the double-strand DNA breaks that are the i
249 0.5 (square root of its concentration) with an excess of the electrophiles ClSiMe3, 1-bromobutane (n
250 rrectly trafficked DeltaF508-CFTR results in an excess of the epithelial sodium channel (ENaC) on the
252 sion of pABA to pNBA by solutions containing an excess of the intermediate suggests that it may also
256 for the growth of B. subtilis and shows that an excess of the molecule is also harmful for the bacter
257 ene encoding the StxB subunit or addition of an excess of the nontoxic StxB subunit substantially red
262 t by injury or disease, depends on producing an excess of the relevant cell for study or transplantat
263 ples from women with TFI, but there was also an excess of the second-highest titer component in TFI c
264 abundance has been shown to be inhibited by an excess of the small regulatory protein, SlrA, and her
265 and plasma from patients with SPG5 revealed an excess of the toxic LXR ligand, 3beta-HCA, while pati
267 s to capture energy through respiration, but an excess of this critical cofactor is toxic to bacteria
268 er the enrollment of 252 patients because of an excess of thromboembolic and bleeding events among pa
269 I 48 transition plan protected patients from an excess of thrombotic and bleeding events and should b
270 vascular scaffolds (BVS) are associated with an excess of thrombotic complications compared with meta
273 , domestic populations were characterized by an excess of unique polymorphisms in two categories gene
274 d spleen uptake at 24 hours, indicating that an excess of unlabeled antibody effectively blocked PD-L
275 ontaining a 5' single-stranded overhang with an excess of unlabeled DNA to initiate thermodynamically
277 xenografts 24 h after injection of 13, while an excess of unlabeled ligand blocked 13 from binding to
278 rmore, temperature reduction to 4 degrees C, an excess of unlabeled mouse IgG, or an excess of Tau an
281 ting, and specificity was demonstrated using an excess of unlabeled precursor and a specific MMP inhi
283 he phosphate groups of phospholipids and add an excess of up to three positive charges per phosphate
287 ndergone faster than exponential growth show an excess of very rare variation and more rapid LD decay
288 n and neovascularization, causing a lack and an excess of vessels, respectively, are hallmarks of hum
291 r class I inhibition during development, and an excess of vitamin B12 coenzyme, which is essential fo
294 erate MSH2-deficient intestinal crypts among an excess of wild-type crypts (Lgr5-CreERT2;Msh2(flox/-)
296 tions, such as CAPS in this study, that have an excess of zeroes in addition to being positively skew
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