ライフサイエンスコーパス: analgesic

1 r pain, and medications (eg, anxiolytics and analgesics).

2 It remains poorly treated with current analgesics.

3 m-based approaches in the development of new analgesics.

4 ts, antibiotics, diabetes agents, and opioid analgesics.

5 es as safe and potentially abuse-free opioid analgesics.

6 d analgesia and total doses of sedatives and analgesics.

7 2.3 channels as potential targets for opioid analgesics.

8 r syndrome and discharged to be treated with analgesics.

9 tential for the generation of new classes of analgesics.

10 ent selective antagonists of Nav1.7 are weak analgesics.

11 sible for the efficacy of the most effective analgesics.

12 g therapeutic advantage over standard opioid analgesics.

13 ic pain states that are refractive to opioid analgesics.

14 er somniferum, is one of the strongest known analgesics.

15 hem prime targets for the development of new analgesics.

16 class of drugs known collectively as opioid analgesics.

17 derlie mechanisms of pain suppression by new analgesics.

18 fferent opioid and acetaminophen combination analgesics.

19 perative pain and consumption of opioids and analgesics.

20 more in patients without a regular need for analgesics.

21 nded include an opioid-antagonist and opiate analgesics.

22 To compare the efficacy of 4 oral analgesics.

23 targeting this system hold promise as novel analgesics.

24 rug discovery efforts towards novel visceral analgesics.

25 en/paracetamol is the most common first-line analgesic (49.1% of patients); opiates are the "second l

26 sease, gabapentin was the most likely second analgesic (50.0%).

27 he recent and precipitous increase in opioid analgesic abuse and overdose has inspired investigation

28 ceptors; the central and peripheral sites of analgesic actions and side effects; endogenous and exoge

29 demonstrated that A3AR agonists have potent analgesic actions in preclinical rodent models of neurop

30 variants in a knockout model eliminates the analgesic actions of delta and kappa opioids and of alph

31 Both rewarding and analgesic actions of opioids depend upon actions at the

32 n mechanisms that modulate the rewarding and analgesic actions of oxycodone.

33 spinal-projections from LC neurons can exert analgesic actions, it is not known whether they can act

34 y NaV1.7 activation, Pn3a alone displayed no analgesic activity in formalin-, carrageenan- or FCA-ind

35 inil, two wake-promoting agents that have no analgesic activity in rested mice, immediately normalize

36 A broad lack of analgesic activity was also found for the selective NaV1

37 idonoyl glycerol (2-AG) levels, resulting in analgesic activity; 2) binding to GPR18, initiating the

38 Despite improvements in analgesic administration over the past 20 years, practic

39 pain measured by pain scores and the need of analgesics after 1 year of surgery.

40 zoyl-6beta-naltrexamide (IBNtxA) is a potent analgesic against thermal, inflammatory, and neuropathic

41 A 31-question analgesic agent survey was constructed, validated, and e

42 Opiates and acetaminophen are preferred analgesic agents, and gabapentin is a contextual third c

43 core and a decreased or stable use of rescue analgesic agents, as recorded in a daily electronic diar

44 ostoperative pain relief compared with other analgesic agents.

45 Analgesic alpha-conotoxin Vc1.1, a peptide from predator

46 These include analgesics, anaesthesia required for surgery, and the de

47 SzV-1287 exerts potent analgesic and anti-inflammatory actions in chronic arthr

48 ecent years, especially with regard to their analgesic and anti-inflammatory actions.

49 This work evaluated the analgesic and anti-inflammatory activity of ruthenium(II

50 sh a blueprint for structure-based design of analgesic and anti-inflammatory agents.

51 tic approach as Ms 9a-1 produces significant analgesic and anti-inflammatory effects in mice models o

52 Evaluation of analgesic and anti-inflammatory properties revealed simi

53 wed that these compounds possess appreciable analgesic and antiinflammatory activities.

54 FAAH inhibitors have shown analgesic and antiinflammatory activity in animal models

55 Acetaminophen (paracetamol) is a widely used analgesic and antipyretic drug with only incompletely un

56 Results showed significant analgesic and hyperalgesic responses (P < 0.001), and re

57 e processes such as psychologically mediated analgesic and hyperalgesic responses.

58 o refilling of energy stores and also to the analgesic and mood-elevating effects of exercise.

59 Analgesic and sedation therapies are essential, and opia

60 3) Optimal clinical practice suggests that analgesic and sedative drugs should be used prior to and

61 Buprenorphine is a successful analgesic and treatment for opioid abuse, with both acti

62 used additive in cigarettes, is a potential analgesic and/or counterirritant at sensory nerves and m

63 cially vulnerable to the effects of pain and analgesic and/or sedative therapies and contribute to ad

64 Systemic nonopioid analgesics and adjuvant analgesics may be prescribed to

65 t to the clinical community: anticoagulants, analgesics and buffers.

66 misuse and diversion of prescription opioid analgesics and heroin.

67 v) channel inhibitors are used clinically as analgesics and local anesthetics.

68 ts the therapeutic efficacy of morphine-like analgesics and mediates the long duration of kappa opioi

69 nd depression, employment status, and use of analgesics and nonsteroidal anti-inflammatory drugs at 1

70 ysphoria is key to the development of better analgesics and to defining how the endogenous dynorphin

71 Capsaicin has also been used as an analgesic, and its topical administration is approved fo

72 and sedation-agitation behaviors; sedative, analgesic, and neuromuscular blocking drug administratio

73 take the form of, for example, antibiotics, analgesics, anti-inflammatories or growth factors.

74 Treatment usually involves analgesics, anti-inflammatory drugs, and supportive care

75 ed therapy for long-acting opioids or either analgesic anticonvulsants or low-dose cyclic antidepress

76 de variety of plants and include many common analgesic, antitussive, and anticancer compounds.

77 icenter studies describing the frequency and analgesic approaches used for heelsticks performed in NI

78 Prescription of opioid analgesics at discharge.

79 postoperatively in pain response or need for analgesics between the study groups.

80 Opiates are potent analgesics but their clinical use is limited by side eff

81 the potential to be effective, nonaddictive analgesics, but their therapeutic utility is greatly lim

82 Opioids are very effective analgesics, but they are also highly addictive.

83 Tp1a proved to be analgesic by reversing spontaneous pain induced in mice

84 des a rationale for an entirely new class of analgesics by inhibition of oxidative enzyme activity.

85 raine attacks has been limited to the use of analgesics, combinations of analgesics with caffeine, er

86 crucial for obtaining therapeutically useful analgesic compounds.

87 y interfere with parents' effective and safe analgesic decision-making when conflicting symptoms (i.e

88 ts may have important implications for their analgesic decisions, yet no studies have evaluated the i

89 Analgesic delivery data from 173 patients in French, Can

90 robiology and pharmacology into a new era of analgesic discovery.

91 ory depression, in contrast to an equipotent analgesic dose of morphine.

92 iously shown to associate with higher opioid analgesic dose were associated with higher methadone dos

93 ly to induce respiratory suppression at weak analgesic doses, while G protein signaling bias broadens

94 ne-like reinforcing activity in mice at equi-analgesic doses.

95 r channel function, potentially facilitating analgesic drug development studies.

96 NCE STATEMENT Acetaminophen is a widely used analgesic drug with multiple but only incompletely under

97 o, 2.9; p < 0.001), lower amount of sedative-analgesic drugs (odds ratio, 1.9; p = 0.03), higher vaso

98 Here, we develop a strategy to discover analgesic drugs via structure-based virtual screening ba

99 ugh to require increased use of sedative and analgesic drugs, and is among the events that predict cl

100 rget for the development of a novel class of analgesic drugs, suggesting that activation of TREK-1 co

101 ntipyretic and one of the most commonly used analgesic drugs.

102 id (aspirin), and paracetamol-caffeine-based analgesic drugs.

103 Furthermore, the consumption of analgesics during the postoperative week 1 was assessed.

104 eption, altruistic behavior had an intrinsic analgesic effect for the recipient.

105 he resolvin precursor 17-HDHA shows a strong analgesic effect in animal models of osteoarthritis and

106 inhibitors may be used to enhance the opioid analgesic effect in the treatment of chronic neuropathic

107 this technique we demonstrate a significant analgesic effect in transgenic mouse models of SCD and c

108 In light of our previous finding that the analgesic effect of acupuncture is mediated by adenosine

109 on of TGF-beta1, but not IL-10, reversed the analgesic effect of BMSCs.

110 The findings suggest that the analgesic effect of BreEStim is not likely attributed to

111 The underlying mechanisms involved in the analgesic effect of BreEStim were considered to result f

112 which was associated with a decrease in the analgesic effect of endogenous inhibitory G-protein-coup

113 during the pain challenge and the resulting analgesic effect of mu-opioid receptor activation was mo

114 limbs, but corpus callosotomy eliminated the analgesic effect that was ipsilateral, but not contralat

115 mu-Opioid agonists mediate their analgesic effect through GPCRs that are generated via al

116 uce better biological profiles (e.g., higher analgesic effect with significantly less adverse side ef

117 ncture point was sufficient to eliminate the analgesic effect, dismissing the systemic action of caff

118 prefrontal cortex (L-DLPFC) tDCS induced an analgesic effect, which was explained by reduced perfusi

119 al prednisolone and indomethacin had similar analgesic effectiveness among patients with acute gout.

120 eroidal anti-inflammatory drugs have similar analgesic effectiveness for management of gout, but the

121 gesting that signaling mechanisms regulating analgesic effectiveness of intrathecally applied EM2 als

122 Analgesic effectiveness was defined as changes in pain (

123 Morphine mediates its euphoric and analgesic effects by acting on the mu-opioid receptor (M

124 Moreover, 4a produced analgesic effects in a rodent model of acute inflammator

125 G9a in diminished MOR expression and opioid analgesic effects in animal models of neuropathic pain.

126 nomolar IC50), and has been shown to produce analgesic effects in animals.

127 -dependent anxiolytic, antiinflammatory, and analgesic effects in mice by increasing endocannabinoid

128 denosine kinase inhibition produces powerful analgesic effects in rodent models of experimental neuro

129 binoid signaling is also responsible for the analgesic effects of acetaminophen against inflammatory

130 amount of caffeine can reversibly block the analgesic effects of acupuncture, and controlling caffei

131 The analgesic effects of BMAs are modest, and they should no

132 lammatory response that directly opposes the analgesic effects of morphine.

133 Tolerance to the analgesic effects of opioids is a major problem in chron

134 e (including drug craving), reinforcing, and analgesic effects of oxycodone in human volunteers diagn

135 opioid use disorders and it may enhance the analgesic effects of oxycodone.

136 been implicated in the formation of placebo analgesic effects, with initial reports dating back thre

137 the ACC in vivo produces both anxiolytic and analgesic effects.

138 Each pathway would produce analgesic effects.

139 This study examines TAP block analgesic efficacy after caesarean section in a poorly r

140 drug regimens that do not provide comparable analgesic efficacy and problems with adherence to the pr

141 ily dose-equivalent of 3 mg/kg, 12 exhibited analgesic efficacy comparable to dose of 10 mg/kg of 1 i

142 the inhibitors will be presented along with analgesic efficacy data from the rat chronic constrictiv

143 r, clinical data have yet to demonstrate the analgesic efficacy of inhibitors of endocannabinoid-regu

144 hermore, although RGS9-2 does not affect the analgesic efficacy of oxycodone or the expression of phy

145 We investigated the analgesic efficacy of prolonged-release oxycodone-naloxo

146 dented strategy and report the synthesis and analgesic efficacy of the standard opioid morphine coval

147 of therapies to maximize and sustain opioid analgesic efficacy.

148 milar changes were found for F2 offspring of analgesic-exposed F1 fathers or mothers, we interpret th

149 F2 offspring deriving from an analgesic-exposed F1 parent also exhibited sex-specific

150 s (CAS) associated with the synthesis of the analgesic fentanyl, N-(1-phenylethylpiperidin-4-yl)-N-ph

151 onal design of proteins that bind the potent analgesic fentanyl.

152 Opioid analgesic fills in the year before transplantation were

153 These findings support repurposing this analgesic for the treatment of LID.

154 d focus on limiting supplies of prescription analgesics for abuse, including ADF technology, efforts

155 morphine and other opioids remain essential analgesics for alleviating pain.

156 wer adverse events compared with alternative analgesics for cancer pain?

157 Some 25 patients (4.2%) needed occasionally analgesics for chronic groin pain.

158 l incision or positioning that required oral analgesics for longer than 3-4 days after surgery (five

159 t intratumoral androgen synthesis and act as analgesics for metastatic disease.

160 The prescribing of opioid analgesics for pain management-particularly for manageme

161 ) has continued to be treated primarily with analgesics for pain relief.

162 ciceptor signaling to the brain and serve as analgesics for persistent pain.

163 ds hence represent a promising avenue toward analgesics for the dual treatment of acute and neuropath

164 outcomes of RCT/s comparing 2 or more opioid analgesics for the management of chronic pain were obtai

165 encoded by Oprm1) agonists are the mainstay analgesics for treating moderate to severe pain.

166 Participants (104 per each combination analgesic group) received 400 mg of ibuprofen and 1000 m

167 Development of an efficacious, non-addicting analgesic has been challenging.

168 Frequent use of analgesics has been associated with a higher risk of hea

169 amadol, previously only known as a synthetic analgesic, has now been found in the bark and wood of ro

170 for endogenous opioid neurotransmitters and analgesics, has been a major focus for drug discovery in

171 Use of analgesics (HR, 1.22; 95% CI, 1.08 to 1.37), hypnotics/s

172 HR, 1.35; 95% CI, 1.03 to 1.76); and use of analgesics (HR, 1.33; 95% CI, 1.16 to 1.52), hypnotics/s

173 otinic acetylcholine receptor (nAChR) and is analgesic in animal models of pain.

174 spinal Sig-1R mechanism and may be a useful analgesic in the management of neuropathic pain.

175 ogue had increased potency at NaV1.8 and was analgesic in the mouse formalin assay.

176 Opioids are the most potent analgesics in clinical use; however, their powerful rewa

177 ls for preclinical assessment of prospective analgesics in inflammatory pain states.

178 dequate staffing ratios; and availability of analgesics, including opioids, for pain relief.

179 and phosphorylation of GRK2 to maintain DOR analgesic incompetence in peripheral sensory neurons.

180 Prescriptions for opioid analgesics increased substantially from 2002 through 201

181 investigated if exposure of pregnant rats to analgesics (indomethacin or acetaminophen) affected GC d

182 interpret this as potentially indicating an analgesic-induced change to GC in F1.

183 tiation, 97% respondents administer sedative/analgesic infusions, and the sedation target was "sedate

184 ich began in the operating theatre, prior to analgesic injections and continued until surgery was com

185 Patients reported their worst pain score and analgesic intake at baseline and days 10 and 42 after tr

186 etween 175 and 1,500 nM, similar to those of analgesics intended to block COX enzymes.

187 Pain ratings disclosed the anticipated analgesic interaction between task difficulty and pain i

188 Unintentional overdose involving opioid analgesics is a leading cause of injury-related death in

189 While the therapeutic effect of opioids analgesics is mainly attributed to micro-opioid receptor

190 monoclinic form of paracetamol-a widely used analgesic known for its particularly problematic mechani

191 management recommend a sequential three-step analgesic ladder.

192 sants, beta-blockers, anaesthetic agents and analgesics; length of sedation and analgesia and total d

193 e stimulus level that best distinguishes the analgesic-like effects and the minimum number of worms t

194 odel provides a method for quantification of analgesic-like effects of chemical stimuli or genetic mu

195 pareunia is introital pain, preventable with analgesic liquid.

196 If so, this widely used analgesic may potentiate the adverse effects of oxidant

197 Systemic nonopioid analgesics and adjuvant analgesics may be prescribed to relieve chronic pain and

198 Moreover, they imply that analgesics may have the unwanted side effect of reducing

199 focused on opioid cessation and alternative analgesics may improve the safety and efficiency of elec

200 tterns and the mobilization of a new type of analgesic mechanism within this early temporal nocicepti

201 To determine whether the analgesic mechanisms of mindfulness meditation are diffe

202 ement consists of education and reassurance, analgesic medicines, non-pharmacological therapies, and

203 signaling using the mixed agonist/antagonist analgesic nalbuphine in reducing LID and its molecular m

204 an alignment-rate, pain-intensity and use of analgesics, no significant differences existed between g

205 e 2005, especially with regard to control of analgesics (overall decrease of 43% since 2005) and hot-

206 despite significantly less use of peripheral analgesics (P = 0.019).

207 0.02) and took a significantly lower dose of analgesics (P = 0.02).

208 Analgesic, pain, and quality-of-life scores (EORTC, Karn

209 e report on the identification of batches of analgesic paracetamol (acetaminophen) tablets using nitr

210 n endocrine disruptor as reported for fellow analgesics paracetamol and aspirin.

211 channel blockers alone may not replicate the analgesic phenotype of null mutant humans and mice, but

212 Prescription opioid analgesics play an important role in the treatment of po

213 Currently available analgesics poorly serve individuals suffering from chron

214 The scientific challenge is to retain analgesic potency while limiting the development of tole

215 ion of EOPs of immune origin, maximizing the analgesic potential of immune cells that naturally accum

216 Given the analgesic potential of subtype-selective inhibitors of v

217 The analgesic preference rankings noted by the 95 internatio

218 Parents' analgesic preferences, including their perceived importa

219 However, self-reported analgesic prescription rates were much higher than pharm

220 gonist which exhibits both antipsychotic and analgesic properties in vivo.

221 Given the powerful analgesic properties of beta-endorphin, we tested this h

222 rts have focused on trying to dissociate the analgesic properties of opioids from their undesirable s

223 Of 12 expert society analgesic recommendations for postoperative pain managem

224 Exposure to either analgesic reduced F1 fetal GC number in both sexes and a

225 s: The EP2 antagonist was the most efficient analgesic, reducing primary hyperalgesia by 80% and seco

226 tline important components of opioid-sparing analgesic regimens.

227 Subjects taking analgesics reported slightly higher maximum-pain althoug

228 Periinterventional analgesic requirements were significantly lower for radi

229 Two compounds (13l and 11b) showed analgesic response in tail flick test which was blocked

230 s significantly larger for hyperalgesic than analgesic responses (P < 0.001).

231 has shown that both electrophysiological and analgesic responses to morphine but not to fentanyl are

232 g represent a novel mechanism for modulating analgesic responsiveness to endogenous EM2 (and perhaps

233 reference to provide pain relief (over avoid analgesic risk) lessened the likelihood that parents wou

234 The effect of invasive procedures and analgesic-sedative exposure on hippocampal growth was as

235 for birth gestational age, sex, PMA, dose of analgesics/sedatives (fentanyl, morphine, midazolam), me

236 Unprecedentedly, this safe analgesic showed a synergy with OXA in vitro and proved

237 s may be useful for the development of novel analgesic strategies.

238 naling shows promise as a safe and effective analgesic strategy that lacks tolerance, dependence, and

239 logically antagonizing TRPM3 may be a useful analgesic strategy.

240 tively modulates the actions of other opioid analgesics, such as fentanyl and methadone.

241 ntinociception.SIGNIFICANCE STATEMENT Opioid analgesics, such as morphine, which target the mu opioid

242 d that, when controlling for prematurity and analgesics, supportive experiences (e.g., breastfeeding,

243 OR and beta2-AR ligands leads to substantial analgesic synergy and completely reverses opioid-induced

244 itical limitation in developing deltaR as an analgesic target, however, is that deltaR agonists show

245 7) channel, which has emerged as a promising analgesic target.

246 Identifying alternate analgesic targets is therefore of great significance.

247 Intervention participants received more analgesics than the controls across the 12 mo.

248 r the development of peripherally restricted analgesics that control BTP and improve quality of life

249 an efficacious strategy in developing future analgesics that lack abuse potential.

250 The generation of potent opioid analgesics that lack the side effects of traditional opi

251 abuse potential compared with current opioid analgesics that target the mu opioid receptor.

252 ng properties generating significantly safer analgesic therapeutics.

253 ion hold in providing new and transformative analgesic therapies for the treatment of chronic pain.

254 and bedside, are key for the development of analgesic therapies that exploit descending noradrenergi

255 ta on all heelsticks and their corresponding analgesic therapies were prospectively collected.

256 muscle IL1beta signaling may be a potential analgesic therapy for ischemic myalgia.

257 nesthesia-related events requiring change in analgesic therapy were comparable (12.2% vs 2.9%, respec

258 After discharge, parents recorded all analgesics they gave their child as well as pain scores

259 (SCD), for which patients may require opioid analgesics throughout life.

260 The choice of analgesic to treat acute pain in the emergency departmen

261 have critiqued their underuse of prescribed analgesics to treat pain in their children after painful

262 se is plagued by major side effects, such as analgesic tolerance (diminished pain-relieving effects),

263 that repeated morphine administration led to analgesic tolerance and hyperalgesia in WT mice but not

264 ned with peripheral MOR antagonists to limit analgesic tolerance and OIH.

265 cal use is limited by side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH

266 ions have detrimental side effects including analgesic tolerance and opioid-induced hyperalgesia (OIH

267 Additionally, 3 developed analgesic tolerance more slowly than morphine, showed li

268 pontaneous pain behaviours without promoting analgesic tolerance or inherent reward.

269 eptor G-protein association and blocks acute analgesic tolerance to morphine and kappa opioid recepto

270 s, such as a loss of pain-relieving effects (analgesic tolerance), paradoxical pain (hyperalgesia), a

271 eir impact is truncated by loss of efficacy (analgesic tolerance).

272 argeted to blunt the development of morphine analgesic tolerance, without affecting normal P2X7 recep

273 zation may play a role in the development of analgesic tolerance.

274 ically underlies the development of morphine analgesic tolerance.SIGNIFICANCE STATEMENT Controlling p

275 More than half reported adverse effects to analgesic treatment for moderate to severe pain that int

276 onism is on the verge of becoming a powerful analgesic treatment for numerous conditions, including o

277 Therefore, novel analgesic treatments are urgently needed.

278 tigated the relationship between duration of analgesic use and self-reported hearing loss among 55,85

279 However, the association between duration of analgesic use and the risk of hearing loss is unclear.

280 slatable to humans, they raise concerns that analgesic use in pregnancy could potentially affect fert

281 econdary analyses, mean cumulative IV opioid analgesic use was reduced by 83% with GMI-1070 vs placeb

282 To improve effective analgesic use, there is a need to shape parents' prefere

283 Considering the high prevalence of analgesic use, this may be an important modifiable contr

284 e diversion and abuse of prescription opioid analgesics using data through 2013.

285 reat millions suffering from pain, but their analgesic utility is limited due to associated side effe

286 Third-line analgesic variability appeared to be driven by neuropath

287 To advance the search for novel analgesics, we have generated a panel of monoclonal anti

288 Third-line analgesics were scarce across sites and neuropathologies

289 (anticoagulants, diabetes agents, and opioid analgesics) were implicated in an estimated 59.9% (95% C

290 Analgesics which affect prostaglandin (PG) pathways are

291 and this enhanced pain may be reduced not by analgesics, whose effectiveness is reduced, but by incre

292 ochloride extended-release (ER), an approved analgesic with opioid and nonopioid mechanisms of action

293 rynantheidine analogs show promise as potent analgesics with a mechanism of action that includes mu o

294 or antidepressants and others (e.g., 8c), as analgesics with a reduced side-effect profile.

295 ed to the use of analgesics, combinations of analgesics with caffeine, ergotamines, and the triptans.

296 receptor agonists may hold potential as new analgesics with fewer liabilities of use.

297 ng interest in the development of new opioid analgesics with improved therapeutic profiles.

298 In the development of analgesics with mixed-opioid agonist activity, periphera

299 ed the promise of these ligands as effective analgesics with reduced liability for adverse effects.

300 vious research has substantiated safe opioid analgesics without abuse liability in primates.