ライフサイエンスコーパス: analgesic action

1 d compounds representing novel mechanisms of analgesic action.

2 pioid receptor as a major contributor to its analgesic action.

3 ha(2) adrenoceptor subtypes to produce their analgesic action.

4 lead compound as a 5-HT(4)R antagonist with analgesic action.

5 2 in vivo, and thereby modulates its central analgesic actions.

6 itive antagonist of the NMDA receptor on the analgesic action and development of tolerance to the ana

7 lts in the development of tolerance to their analgesic action and the intensity of tolerance increase

8 lei in the brainstem is responsible for this analgesic action and which alpha(2) adrenoceptor subtype

9 ceptors; the central and peripheral sites of analgesic actions and side effects; endogenous and exoge

10 antagonism of NMDA receptors attenuates the analgesic action as well as development of tolerance to

11 duced release of norepinephrine mediates the analgesic action at alpha(2) adrenoceptors in the spinal

12 2-endomorphin-2 analog should produce longer analgesic actions at lower doses.

13 e nonsteroid anti-inflammatory drugs have no analgesic action in this test.

14 ar mechanisms underlying resolvins' distinct analgesic actions in mice are unclear.

15 theless, systemic [Dmt(1)]DALDA retained its analgesic actions in MOR-1 knockout animals and CXBK mic

16 demonstrated that A3AR agonists have potent analgesic actions in preclinical rodent models of neurop

17 spinal-projections from LC neurons can exert analgesic actions, it is not known whether they can act

18 c action and development of tolerance to the analgesic action of D-Ala2, Glu4 deltorphin II (deltorph

19 n as well as development of tolerance to the analgesic action of delta 2-opioid receptor agonist in t

20 MK-801 and LY 235959 also antagonized the analgesic action of deltorphin II.

21 d help us to understand the mechanism of the analgesic action of different classes of antidepressants

22 d K+ channels in thermal nociception and the analgesic action of morphine and other agents.

23 epinephrine (NE), as a possible mechanism of analgesic action of NO in the spinal cord.

24 e of the spinal and supraspinal sites in the analgesic action of systemic opioids remains uncertain.

25 10 min prior to U-50,488H did not modify the analgesic action of the latter.

26 We therefore suggest that the analgesic action of triptan can be attained specifically

27 erved on the development of tolerance to the analgesic action of U-50,488H in both the species.

28 eptor antagonists block the tolerance to the analgesic action of U-50,488H in rodents.

29 treatment of rats with LY235959 enhanced the analgesic action of U-50,488H.

30 Previously we demonstrated that the analgesic actions of alpha(2) adrenoceptor agonists are

31 nsitization is believed to contribute to the analgesic actions of capsaicin.

32 variants in a knockout model eliminates the analgesic actions of delta and kappa opioids and of alph

33 ose-dependent analgesia, and potentiated the analgesic actions of endomorphin-2, particularly on the

34 e exon 11 knockout mouse was normal, but the analgesic actions of heroin, M6G, and fentanyl were mark

35 In this assay, ibuprofen potentiated the analgesic actions of hydrocodone and oxycodone, shifting

36 o reduce the development of tolerance to the analgesic actions of MOR agonists.

37 Notably, Rgs9-2 in the NAc affects the analgesic actions of morphine as well as the development

38 tein alpha subunits differentially block the analgesic actions of mu-, delta-, and kappa-opioid agoni

39 al horn has been implicated in mediating the analgesic actions of neurosteroids.

40 epresent a relevant molecular target for the analgesic actions of neurosteroids.

41 Both rewarding and analgesic actions of opioids depend upon actions at the

42 n mechanisms that modulate the rewarding and analgesic actions of oxycodone.

43 to antinociception by opioids, we tested for analgesic actions of Rf.

44 exons all block both spinal and supraspinal analgesic actions of the delta2 ligand [D-Ala2,Glu4]delt

45 rs enhances, in a dose-dependent manner, the analgesic actions of the mu analgesic morphine, the kapp

46 e acute versus persistent pain settings, the analgesic actions of the SNRI duloxetine and the SSRI fl

47 nale of conserving the anti-inflammatory and analgesic actions of traditional nonsteroidal anti-infla

48 tenuated the development of tolerance to the analgesic actions of U-50,488H.

49 cytochrome P450 (P450) activity in mu opioid analgesic action, we generated a mutant mouse with brain

50 rea (POA) to ascertain whether the steroids' analgesic actions were mediated by membrane actions in t