ライフサイエンスコーパス: analgesic effect

1 nistration of mu opioids fails to produce an analgesic effect.

2 sary for associative tolerance to morphine's analgesic effect.

3 eous administration of RTX had a generalized analgesic effect.

4 s in the CNS to produce a centrally mediated analgesic effect.

5 idenced by induction of a centrally mediated analgesic effect.

6 ive opioid receptor agonist with very potent analgesic effect.

7 stricted sodium channel may have a selective analgesic effect.

8 9L and morphine resulted in a dose-dependent analgesic effect.

9 ave been shown to possess antinociceptive or analgesic effects.

10 to a favourable pharmacokinetic profile and analgesic effects.

11 rs (CBRs) have been implicated in the opioid analgesic effects.

12 ability of the opioid antagonist to produce analgesic effects.

13 ctive muscarinic agonists display pronounced analgesic effects.

14 ioside in mice rapidly attenuates morphine's analgesic effects.

15 nergic receptors (alpha(2)ARs) leads to mild analgesic effects.

16 mical pathways in exerting their supraspinal analgesic effects.

17 ists has been shown to result in synergistic analgesic effects.

18 the ACC in vivo produces both anxiolytic and analgesic effects.

19 and to exhibit CB1-mediated hypothermic and analgesic effects.

20 Each pathway would produce analgesic effects.

21 ENK for opioid receptor binding affinity and analgesic effects.

22 accounted for 25% of the variance in placebo analgesic effects.

23 report and loperamide produced a significant analgesic effect (2-fold increase in response times) whe

24 KOR agonists exhibit analgesic effects, although the adverse effects produced

25 ine causes addiction, tolerance to its acute analgesic effects, and profound physical dependence by s

26 how different frequencies of SCS produce the analgesic effect are unclear.

27 These analgesic effects are many times greater than unmodified

28 onizing mu opioid-induced analgesia or a net analgesic effect by reducing the hyperalgesia during opi

29 Morphine mediates its euphoric and analgesic effects by acting on the mu-opioid receptor (M

30 Morphine exerts its acute rewarding and analgesic effects by activation of inhibitory guanine nu

31 s alfentanil bolus has a clinically relevant analgesic effect compared with placebo in patients under

32 ncture point was sufficient to eliminate the analgesic effect, dismissing the systemic action of caff

33 require arrestin recruitment, whereas their analgesic effects do not.

34 eption, altruistic behavior had an intrinsic analgesic effect for the recipient.

35 d with an enhanced sensitivity to the opioid analgesic effect (IL-1beta, P = 0.0218; TNF-alpha, P = 0

36 he resolvin precursor 17-HDHA shows a strong analgesic effect in animal models of osteoarthritis and

37 onsubtype-selective alpha2AR agonist, had no analgesic effect in D79N mice, whereas the analgesic pot

38 oxylase (QHGAD67) release GABA to produce an analgesic effect in rodent models of pain.

39 inhibitors may be used to enhance the opioid analgesic effect in the treatment of chronic neuropathic

40 this technique we demonstrate a significant analgesic effect in transgenic mouse models of SCD and c

41 h synaptically and behaviorally in producing analgesic effects in a PLA(2)-dependent fashion, support

42 Moreover, 4a produced analgesic effects in a rodent model of acute inflammator

43 G9a in diminished MOR expression and opioid analgesic effects in animal models of neuropathic pain.

44 nomolar IC50), and has been shown to produce analgesic effects in animals.

45 ls, HUP-A treatment demonstrates significant analgesic effects in both regimens.

46 Consistent with its analgesic effects in humans, sanshool treatment in mice

47 al models; however, they exhibit only modest analgesic effects in humans.

48 -dependent anxiolytic, antiinflammatory, and analgesic effects in mice by increasing endocannabinoid

49 ecrosis factor (anti-TNF) therapy, which has analgesic effects in models of inflammation as well as i

50 at P and 3 alpha-Diol at moderate doses have analgesic effects in part via membrane actions within th

51 denosine kinase inhibition produces powerful analgesic effects in rodent models of experimental neuro

52 de deactivation in vivo and exerted profound analgesic effects in rodent models of nociceptive and in

53 mu opioid receptor, the most responsible for analgesic effects in the central nervous system.

54 NK gene transfer into the OT did not produce analgesic effects in the tail-flick test.

55 c agonists can produce both hyperalgesic and analgesic effects in vivo.

56 ogical profile ASIC channels to exert strong analgesic effects in vivo.

57 ctive muscarinic agonists resulted in robust analgesic effects, indicating that muscarinic analgesia

58 The analgesic effects induced by combination of alcohol and

59 The cannabinoid-induced analgesic effect is absent in mice lacking the alpha3 Gl

60 This analgesic effect is attributed to activation of peripher

61 rodent dorsal root ganglion (DRG) show their analgesic effect is mediated by inhibition of N-type (Ca

62 In Experiment 2, we tested whether this analgesic effect is mediated by the brainstem nucleus ra

63 This ingestion analgesic effect is reversed when the hedonic valence of

64 in states, and have shown that NR2B-mediated analgesic effects might be supra- rather than intra-spin

65 e found to be expressed, to show an enhanced analgesic effect, no opioid-induced tolerance, and to pr

66 effects of acupuncture may contribute to the analgesic effect observed in genuine acupuncture analges

67 In light of our previous finding that the analgesic effect of acupuncture is mediated by adenosine

68 adenosine A1 receptor agonist replicated the analgesic effect of acupuncture.

69 Tolerance to the analgesic effect of an opioid is a pharmacological pheno

70 on of TGF-beta1, but not IL-10, reversed the analgesic effect of BMSCs.

71 The findings suggest that the analgesic effect of BreEStim is not likely attributed to

72 The underlying mechanisms involved in the analgesic effect of BreEStim were considered to result f

73 The analgesic effect of clinically used exogenous opioids, s

74 did not alter the tail-flick latency or the analgesic effect of deltorphin II.

75 Finally, the analgesic effect of donepezil was markedly reduced by a

76 which was associated with a decrease in the analgesic effect of endogenous inhibitory G-protein-coup

77 spinal GIRK channels selectively blunts the analgesic effect of high but not lower doses of intrathe

78 spinal GIRK channels selectively blunted the analgesic effect of high but not lower doses of the mu-o

79 onist icilin in vitro and to investigate the analgesic effect of icilin in a neuropathic pain model i

80 cord likely plays a predominant role in the analgesic effect of intrathecal clonidine on neuropathic

81 carinic receptors play a greater role in the analgesic effect of intrathecal clonidine.

82 t that spinal nitric oxide (NO) mediates the analgesic effect of intrathecal clonidine.

83 letion of the Mrgpr cluster also blocked the analgesic effect of intrathecally applied bovine adrenal

84 Finally, we show that TRPM8 mediates the analgesic effect of moderate cooling after administratio

85 se studies tested whether IS potentiates the analgesic effect of MOR microinjected in the DRN, as pre

86 for treating bone cancer pain and improving analgesic effect of morphine clinically.

87 t as inhibiting JNK in reducing the enhanced analgesic effect of morphine in beta-arr2-/- mice to +/+

88 e, we examine the effect of tolerance to the analgesic effect of morphine on ischemic tolerance in mi

89 fferent JNK inhibitors reversed the enhanced analgesic effect of morphine, a known phenotype of beta-

90 arkable potentiation and prolongation of the analgesic effect of morphine, suggesting that muOR desen

91 during the pain challenge and the resulting analgesic effect of mu-opioid receptor activation was mo

92 These results demonstrate a novel analgesic effect of non-informative vision of the body.

93 termine the receptor subtype involved in the analgesic effect of NT69L and morphine.

94 constipation (OIC) without compromising the analgesic effect of opioids.

95 al of emotional experiences also mediate the analgesic effect of perceived control over pain.

96 praisal view of control and suggest that the analgesic effect of perceived control relies on activati

97 Behavioral results confirmed the expected analgesic effect of seeing the body, while fMRI results

98 Importantly, the analgesic effect of several antidepressant drugs, includ

99 ical studies that have demonstrated that the analgesic effect of spinally administered lipid-soluble

100 which spinal mu opioid receptors mediate the analgesic effect of systemic mu opioids.

101 In contrast, the analgesic effect of the agonist (trans)-3,4-dichloro-N-m

102 disinhibition, supporting the view that the analgesic effect of the GluN2B antagonist on neuropathic

103 binoid signaling is also responsible for the analgesic effects of acetaminophen against inflammatory

104 amount of caffeine can reversibly block the analgesic effects of acupuncture, and controlling caffei

105 nates cells expressing this receptor and the analgesic effects of alpha2-AR agonists.

106 Tolerance to the analgesic effects of an opioid occurs after its chronic

107 The analgesic effects of BMAs are modest, and they should no

108 noradrenergic cell groups contribute to the analgesic effects of both NMDA receptor antagonists and

109 The mechanisms underlying the analgesic effects of botulinum toxin serotype A (BoNT-A)

110 of TRPV1 and block of TRPA1 may underlie the analgesic effects of camphor.

111 effects of morphine is also required for the analgesic effects of cannabinoids.

112 l insight into the topical mechanisms of the analgesic effects of capsaicin and the strategies to imp

113 plays a modulatory role in the mediation of analgesic effects of certain compounds, for example tric

114 Finally, the analgesic effects of combining Cereport and loperamide w

115 tonic pain in animals and for evaluating the analgesic effects of drugs.

116 eys is the source of the ACh involved in the analgesic effects of epidural neostigmine and could be m

117 del, but it is a potential mechanism for the analgesic effects of icilin in other pain models.

118 pheral opioid receptors and tolerance to the analgesic effects of intraarticular morphine.

119 tify the neural circuitry that underlies the analgesic effects of left DLPFC rTMS, and to examine how

120 the cellular sites for the spinally mediated analgesic effects of MOR activation and the potential an

121 iors, correlative neurochemical changes, and analgesic effects of morphine and cannabinoids in transg

122 e, but also reduced their sensitivity to the analgesic effects of morphine and led to faster developm

123 esting either a decreased sensitivity to the analgesic effects of morphine and/or basal hyperalgesia.

124 hine and the development of tolerance to the analgesic effects of morphine remained unaltered by the

125 has been hypothesized that tolerance to the analgesic effects of morphine results from the developme

126 xaggerated responses to cocaine, reduces the analgesic effects of morphine, and abolishes the effects

127 How hnRNP K contributes to the analgesic effects of morphine, however, is largely unkno

128 lammatory response that directly opposes the analgesic effects of morphine.

129 cated in the development of tolerance to the analgesic effects of morphine.

130 and, in some cases, reverse tolerance to the analgesic effects of morphine.

131 analgesia, they are unlikely to mediate the analgesic effects of morphine.

132 ts in the mu opioid receptor gene change the analgesic effects of morphine.

133 binds with beta-arrestin 2 and modulates the analgesic effects of morphine.

134 how that the mu opioid receptor mediates the analgesic effects of morphine; they further suggest that

135 1bf/f/p mice exhibited significantly reduced analgesic effects of mu and delta opioid receptor agonis

136 agonists, and provide insights into the non-analgesic effects of mu opioids.

137 ents may contribute to the anesthetic and/or analgesic effects of N(2)O.

138 oid analgesia, is proposed to facilitate the analgesic effects of nonserotonergic RM terminals in the

139 Recent data have demonstrated potent analgesic effects of one factor (glial cell line-derived

140 Many of the analgesic effects of opiate drugs and of endogenous opio

141 Mu opioid receptors (MOR) mediate the analgesic effects of opioid drugs such as morphine.

142 Tolerance to the analgesic effects of opioids is a major problem in chron

143 te opioid-induced somnolence, to augment the analgesic effects of opioids, to treat depression, and t

144 e (including drug craving), reinforcing, and analgesic effects of oxycodone in human volunteers diagn

145 opioid use disorders and it may enhance the analgesic effects of oxycodone.

146 study compared the magnitude and duration of analgesic effects of smoked marijuana and dronabinol und

147 ion is not simply the sum of the independent analgesic effects of spinal kappa and delta opioid syste

148 It has been postulated that the analgesic effects of TCAs are determined by their abilit

149 endent contributions of GIRK channels to the analgesic effects of the -opioid receptor-selective agon

150 ation, providing a neurobiological basis for analgesic effects of the CB2 receptor in this model of O

151 dered by the development of tolerance to the analgesic effects of the drug.

152 are insensitive to the ataxic, sedative, and analgesic effects of the novel hypnotic drug, gaboxadol.

153 mutant receptor could be used to elicit the analgesic effects of the opioids without the accompanyin

154 nvolved in mediating the neuromodulatory and analgesic effects of the peptide.

155 The analgesic effects of these compounds involve long-term d

156 While the analgesic effects of these drugs are mediated by mu-opio

157 V1 antagonists in various types of pain, the analgesic effects of two TRPV1 antagonists with similar

158 The findings that the analgesic effects of various antidepressant drugs are di

159 We evaluate here the analgesic effect on rats of epidurally administered RTX,

160 Vision of the body produced clear analgesic effects on both subjective ratings of pain and

161 neurotensin receptors (NTS1 and NTS2) exert analgesic effects on different types of nociceptive moda

162 ateral prefrontal cortex (DLPFC) can produce analgesic effects on postoperative and laboratory-induce

163 ICa(V) in DRG neurons is unlikely to mediate analgesic effects or contribute directly to the pathogen

164 rols as to their capacity to predict placebo analgesic effects, placebo-induced activation of mu-opio

165 Although most opiates exert their analgesic effects primarily via mu opioid receptors, a n

166 atecholamine neurons may mediate part of the analgesic effect produced by systemic administration of

167 ly-Phe-Leu-Ser(beta-D-Glc)-CONH(2), produces analgesic effects similar to morphine, even when adminis

168 atively small study, but the dose-responsive analgesic effects suggest that NP2 may be effective in r

169 ne applied to skin-harvest sites produced an analgesic effect that reduced narcotic requirements comp

170 limbs, but corpus callosotomy eliminated the analgesic effect that was ipsilateral, but not contralat

171 However, in addition to the desired analgesic effects, this TRPV1 antagonist significantly i

172 mu-Opioid agonists mediate their analgesic effect through GPCRs that are generated via al

173 The analgesic effect was assessed by prolongation of the paw

174 Importantly, this analgesic effect was maintained even in animals with lat

175 prefrontal cortex (L-DLPFC) tDCS induced an analgesic effect, which was explained by reduced perfusi

176 uce better biological profiles (e.g., higher analgesic effect with significantly less adverse side ef

177 assay in mice, the pyridomorphinans produced analgesic effects with varying potencies and efficacies

178 been implicated in the formation of placebo analgesic effects, with initial reports dating back thre