ライフサイエンスコーパス: analog

1 to the enhanced solubility of palmitic acid analog.

2 y homodimer when bound to a transition-state analog.

3 the foundation for developing a dual-labeled analog.

4 on of silicon has created a benefit over its analog.

5 le-attached, dimeric kinesin bound to an ATP analog.

6 f four common fungi and bacteria in a nectar analog.

7 oved synthetic route of uncialamycin and its analogs.

8 ionship for triterpene maslinic acid and its analogs.

9 ectra relative to previously synthesized COE analogs.

10 to consistently and effectively produce bNAb analogs.

11 cess to derivatives and potentially superior analogs.

12 o that delivered by other (68)Ga-labeled sst analogs.

13 tructure-activity data are available for its analogs.

14 nthesis of acrylate ketone, ester, and amide analogs.

15 iated by metalloproteins and their synthetic analogs.

16 rates, as recently shown with thrombopoietin analogs.

17 lide therapy using radiolabeled somatostatin analogs.

18 ted as a scaffold en route to antiplasmodial analogs.

19 ncreatic cancer patients on fluoropyrimidine analogs.

20 n through a rational design of corresponding analogs.

21 ch enabled us to optimize the potency of the analogs.

22 ned and mapped to virtually screen potential analogs.

23 alpha-GID, a desirable feature for alpha-GID analogs.

24 ent recognition specificity for DNZ over its analogs.

25 erties advantageous over those for its (18)F analogs.

26 troscopically in X-ray observations of solar analogs.

27 and a five-coordinate environment for Zn(II) analogs.

28 sorption and emission relative to all-carbon analogs.

29 or solubilized in n-dodecyl-beta-d-maltoside analogs.

30 by a 3d-Napht-A analog but bypassed smaller analogs.

31 positron emission tomography norepinephrine analog (11)C-hydroxyephedrine), lack of angiotensin inhi

32 A radiolabeled analog, [(125) I]-PD-sauvagine, with high signal-to-nois

33 The glucose analog [(18)F]fluoro-2-deoxy-2-d-glucose ([(18)F]-FDG) i

34 the presence of the non-cyclizable substrate analog 2',3'-dideoxyguanosine-5'-triphosphate, MnCl2, an

35 inase pathway activity, we used a nucleoside analog 2'3'-dideoxycytidine (ddC), which is phosphorylat

36 roids (57% versus 21%; P = 0.001), or purine analogs (22% versus 5%; P = 0.02).

37 d LLE as exemplified by a much more druglike analog 26.

38 able 3-deaza-3-methoxynaphtylethyl-adenosine analog (3d-Napht-A), and smaller 3-deaza-adenosine analo

39 Initially, we identified analog 4m that had good in vitro properties but low plas

40 tigated the anti-tumor effect of a glutamine analog (6-diazo-5-oxo-L-norleucine) as an adjuvant treat

41 this study, we demonstrate that a tamoxifen analog, 6c, which more potently inhibits PKC than tamoxi

42 ive activation of Epac by the cell-permeable analog 8-(4-chlorophenylthio)-2'-O-methyladenosine-3',5'

43 c glycoside esters, saccharumoside-B and its analogs (9b-9n, 10) have been synthesized by the Koenigs

44 leaking site in the Qinghai-Tibet Plateau to analog a "leaking CCS site".

45 dence prevents hypoglycemia, rendering GLP-1 analogs a useful and safe treatment modality in type 2 d

46 These injectable analogs achieve robust glycemic control by increasing co

47 a panel of 2-aryl-5-carboxytetrazole-lysine analogs (ACTKs) and their site-specific incorporation in

48 nephropathy caused by TFV and its more toxic analog, adefovir (ADV).

49 in the presence of the non-hydrolyzable ATP analog, ADP-beryllium fluoride, we observe additional in

50 We then applied climate analog analyses to compute vectors representing the clim

51 fPutA dimerizes in the presence of a proline analog and NAD(+) These results are consistent with the

52 Together, the new SAM analog and the high-resolution crystal structure are a s

53 luciferins based on synthetic coelenterazine analogs and corresponding mutants of NanoLuc that enable

54 iew: they act as amino acid transition state analogs and Horner-Wadsworth-Emmons reagents, respective

55 The association between long-acting insulin analogs and increased breast cancer risk is uncertain, p

56 ve to common interferences, such as oxytocin analogs and potential metabolites.

57 n of other members of the family, structural analogs and provide a practical synthetic route to these

58 lecular docking study was carried out on the analogs and reference compound (Erlotinib) into the ATP

59 ructure is distinct from previously reported analogs and relies on the HPF C-terminal extension formi

60 We use analogs and the extreme South Asian heat of 2015 as a fo

61 thiodide (a peripherally restricted naloxone analog) and by local administration at the inflamed site

62 e claim that gesture is primarily imagistic, analog, and holistic is challenged by the presence of ab

63 sents a feeding ecomorphology with no living analog, and its giant size and high mandibular strength

64 ical effects and metabolic conversion to UTP analog are L-ala,SP prodrug-dependent in cardiomyocytes.

65 Several nucleoside analogs are effective in treating leukemias and T cell l

66 Everolimus and purine analogs are suitable options for refractory or multiply

67 for the development of 1,20S(OH)2D3 and its analogs as potential therapeutic agents.

68 orpyrifos, azinphos-methyl, and their oxygen analogs at 14 farmworker and 9 non-farmworker households

69 ssing enzyme Usb1 from yeast and a substrate analog bound complex from humans.

70 idate for optogenetic tools based on retinal analog-bound vertebrate Rhs.

71 Pol II was strongly blocked by a 3d-Napht-A analog but bypassed smaller analogs.

72 orate and accumulate 2-deoxyglucose (glucose analog), but not when blocking GLUT.

73 Metabolism of glutamine and related analogs by GDH in the L cell may explain why GLP-1 secre

74 HA has a high preference for avian receptor analogs by glycan array analyses.

75 ) mice after hyperstimulation with the CCK-8 analog caerulein.

76 Cisplatin and its platinum analogs, carboplatin and oxaliplatin, are some of the mo

77 ished cell-tracking methods based on thymine analog cell labeling and developed tailored mathematical

78 Analog climates for these species shifted even further t

79 the clinical-grade alkyl-phospholipid ether analog CLR1404, 18-(p-iodophenyl)octadecyl phosphocholin

80 er, representing a promising application for analog computing based on memristor crossbar arrays.

81 Optical analog computing offers high-throughput low-power-consum

82 5-ethynyl-2'deoxyuridine (EdU)-a thymidine analog-containing minipumps were inserted at the time of

83 a suggest that 12,13-diHOME, or a functional analog, could be developed as a treatment for metabolic

84 The nucleoside analog cytarabine (Ara-C) is an essential component of p

85 study, we demonstrated that two tylophorine analogs, DCB-3503 and rac-cryptopleurine, exhibit potent

86 The stability of the analog (DeltaGU 5.0(+/-0.1) kcal/mol at 25 degrees C) wa

87 ing the incorporation of modified nucleotide analogs demonstrate that the binding affinity of the inc

88 SAMHD1 sensitizes cancer cells to nucleoside-analog derivatives through the depletion of competing dN

89 y 1000 times lower than that of conventional analog detection.

90 ng current and calcium influx, whereas other analogs did not exhibit these effects.

91 xemplifies by demonstrating high-performance analog differential amplifiers operating at a battery-co

92 fore treatment with long-acting somatostatin analogs differs from that after treatment.

93 A membrane-permeable glutamate analog (dimethylglutamate [DMG]), acting downstream of e

94 scopes opens a new era in searches for Earth-analog exoplanets with conditions suitable for sustainin

95 es, including ribose, in an interstellar ice analog experiment.

96 on studies performed with structurally close analogs explain the FD44 specificity and the mechanism o

97 flow of sensory input is not processed in an analog fashion, but rather is grouped by the perceptual

98 colic acid subunit at C14 provided the first analogs fit for human use, and derivatization at C12 led

99 However, the majority of nearest climatic analogs for protected areas are in nonprotected location

100 tion, can serve as experimentally-accessible analogs for studying a range of liquid-state molecular h

101 subsurface scCO2 reservoirs, which serve as analogs for the long-term fate of sequestered scCO2 , ha

102 gning intervention strategies and novel IAPP analogs for the management of type 2 diabetes, Alzheimer

103 tor (sstr) scintigraphy for imaging and sstr analogs for treatment have been used for more than 20 y.

104 , and suggest possible beneficial use of its analogs for treatment of pathological cardiac hypertroph

105 ment with either progesterone or a synthetic analog found in hormonal contraceptives, levonorgestrel,

106 rofile of PF-DcpSi (compound 24), one of the analogs found to be efficacious in SMA mouse model.

107 zation guided by predicted binding modes and analogs from commercial chemical libraries yielded nanom

108 aration of three classes of these nucleoside analogs from common precursors-properly substituted cycl

109 icity toward fumonisin B1 and its structural analog, fumonisin B2, was observed, together with neglig

110 TFETs considerably larger than GFETs, making analog GKTFET potentially useful for RF electronics.

111 llent selectivity for SY over its structural analogs, good stability, and adequate reproducibility.

112 er that hydrolyzes GTP and readily binds its analog guanosine 5'-3-O-(thio)triphosphate.

113 Curcumin and its analogs have been identified as potential drug candidate

114 Synthetic somatostatin analogs have been posed as a potential source of error i

115 nd their independently synthesized, cyclized analogs have been prepared to investigate their potentia

116 Tylophorine analogs have been shown to exhibit diverse activities ag

117 ochondrial-derived peptides (MDPs) and their analogs have emerged as wide-spectrum, stress response f

118 These pesticides and oxygen analogs have previously been identified in the atmospher

119 site sensitivity to chemotherapy with purine analogs; however, the disease relapses, often repeatedly

120 the crystal structure of a 1,2,4-oxadiazole analog in complex with Sirt2 and ADP-ribose reveals its

121 glycine, H2O2, malondialdehyde, and a lysine analog in PBS at a physiological temperature, which resu

122 to chlorpyrifos, azinphos-methyl, and oxygen analogs in a rural agricultural community.

123 Advanced analogs in these series exhibited high oral exposures in

124 All 4-MA analogs inhibited uptake at DAT, NET, and SERT, but leng

125 yl-CoA is a cofactor-inactivating, substrate-analog inhibitor of the mitochondrial B12-dependent meth

126 microbial-extract screening, of a nucleoside-analog inhibitor that inhibits bacterial RNA polymerase

127 (3d-Napht-A), and smaller 3-deaza-adenosine analogs, into DNA oligonucleotides to assess RNA Pol II

128 he DAT inhibitor cocaine and its fluorescent analog JHC1-64 on the plasma membrane distribution of wi

129 rom a small library of sstr antagonists, the analog JR11 (Cpa-c[d-Cys-Aph(Hor)-d-Aph(Cbm)-Lys-Thr-Cys

130 We find that KPT-9274 (and its analog, KPT-8752) can reduce the steady state level of P

131 A paromomycin analog lacking the hydroxymethyl ring I side chain is co

132 region in complex with a 5'TOP motif, a cap analog (m(7)GTP), and a capped cytidine (m(7)GpppC), res

133 demonstrated that both the 1alpha,25(OH)2D3 analog, MART-10, and 1alpha,25(OH)2D3 possessed anti-gro

134 Our findings indicate that LXA4 and its analog may be potential therapeutic candidates for psori

135 olitica O8 or Staphylococcus aureus Hepcidin analogs may be useful for treatment of siderophilic infe

136 of AT2 receptor agonists or angiotensin 1-7 analogs may similarly limit inflammatory injury to the h

137 us, carnosine, or non-hydrolysable carnosine analogs, may represent a new class of therapeutic agent

138 inhibitor VU714 but not by a higher-affinity analog ML418, suggesting that the polar side chain of T1

139 We propose an analog model for haploinsufficient transcriptional dereg

140 w octopamine, an invertebrate norepinephrine analog, modulates the neural pathways that bias Drosophi

141 yltransferase domain by the potent substrate analog moenomycin.

142 tro and in vivo, using GHRH or its agonistic analog MR-409.

143 ice, intraocular) unimNPs with the glutamate analog N-methyl-d-aspartate (NMDA), which is excito-toxi

144 s over time after cessation of nucleos(t)ide analog (NA) treatment in patients with chronic hepatitis

145 Pioglitazone or its analog NL-1 appears to inhibit the electron transfer act

146 The Ubc5BC85A product analog non-competitively inhibits Nedd4-2 (Ki = 2.0 +/-

147 l)-N-methylquinazoline-2-carboxamide), a new analog of (11)C-(R)-PK11195, showed little sensitivity t

148 pair of mice was imaged using a fluorescent analog of (125)I-iodo-DPA-713, DPA-713-IRDye800CW, for c

149 An analog of (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate

150 new psychoactive substance and the beta-keto analog of 3,4-methylenedioxy-N-methylamphetamine (MDMA).

151 -thioguanosine (6-TG-H), a sulfur-containing analog of a natural nucleoside.

152 ur data indicate that MtLAX2 is a functional analog of Arabidopsis AUX1 and is required for the accum

153 nce of behavior due to knockout of Nrxn1, an analog of autism-associated gene NRXN, exhibited marked

154 livery of amphiphile-CpG, an albumin-binding analog of CpG ODN, following systemic administration 3da

155 mmune activation with poly(I:C), a synthetic analog of double-stranded RNA, and longitudinally imaged

156 an interaction of the antibody (Ab) and the analog of E2 in the self-tuneable matrix takes place) by

157 Rok, an analog of H-NS from gamma-proteobacteria that affects ch

158 Ion-selective optodes (ISOs), the optical analog of ion-selective electrodes, have played an incre

159 -fluorobenzylguanidine ((18)F-MFBG) is a PET analog of MIBG that may allow for single-day, high-resol

160 taiodobenzylguanidine (MIBG), a guanethidine analog of norepinephrine.

161 UC-514321, a structural analog of NSC-370284, exhibited a more potent therapeuti

162 s associated with song learning in the avian analog of primary motor cortex (robust nucleus of the ar

163 ntanglement transformation and its classical analog of secrecy manipulation.

164 Unexpectedly, SJB7, a close analog of SPA70, is an hPXR agonist.

165 sulfonic acid hexasodium salt), a structural analog of suramin, has an increased affinity for TIMP-3

166 poxybenzamide (3), which turned out to be an analog of the drug nitazoxanide (1).

167 to systemic administration of a long-acting analog of the gut-hormone glucagon-like peptide-1 highli

168 iple of maximum caliber (MaxCal)-a dynamical analog of the principle of maximum entropy-and builds a

169 Here, we report that DPM-1001, an analog of the specific PTP1B inhibitor trodusquemine (MS

170 ted by the one-pot synthesis of a functional analog of the Sunflower Trypsin Inhibitor 1.

171 teractions, plasmons, polarons, and a phonon analog of the vacuum Rabi splitting in atomic systems.

172 rsion symmetry breaking, leading to a valley analog of the Zeeman effect in presence of an out-of-pla

173 ion, and are, in a sense, the electrofluidic analog of thyristors.

174 Newly prepared carbocyclic C-analog of tubercidine, profiled in MCF7 (breast cancer)

175 Ubiquinone-2, an analog of ubiquinone-10, can also oxidize the reduced mi

176 body, a metabolic tissue that is the insect analog of vertebrate liver and adipose tissue.

177 ein the structure-activity relationships for analogs of 3 with exploration of the structurally relate

178 e rather than ATP, and that non-hydrolyzable analogs of ATP cannot support the enzymatic reaction.

179 ed electronic signatures of multiply charged analogs of common neutral species (CH3 CH3 , CO2 , FeCO)

180 p (SAR) of the scaffold 1, we synthesized 14 analogs of compound 1 which revealed compounds with high

181 Ribonucleotides are the natural analogs of deoxyribonucleotides, which can be misinserte

182 Bacterial microcompartments are bacterial analogs of eukaryotic organelles in that they spatially

183 Brown dwarfs are massive analogs of extrasolar giant planets and may host types o

184 e potential therapeutic effects of agonistic analogs of growth hormone-releasing hormone (GHRH) and t

185 ) are structural, functional and mechanistic analogs of helical, cationic AMPs, which offer broad-spe

186 Ts could acylate either sn position of ether analogs of LPC The data show that the activities of LPEA

187 ances, it has remained challenging to design analogs of many electronic components to be highly stret

188 highlighted the increased potency of oxygen analogs of organophosphorus pesticides.

189 rate that these Au/C catalysts are supported analogs of single-site homogeneous Au catalysts and prop

190 stable, monovalent synthetic oligosaccharide analogs of ST-5 CPS RU induced long-term memory and prot

191 identified one positive hit compound and two analogs of the hit with high cytotoxic, pro-apoptotic an

192 Recent crystal structures of analogs of the intermediate conformations E2.Pi.2K(+) an

193 annealing and melting of mirror-image l-DNA analogs of the reaction's primers and targets.

194 latform for the design and production of new analogs of this important human hormone with non-standar

195 synaptic plasticity, which are the cellular analogs of two forms of long-term memory.

196 We recently reported a series of (+/-)MOD analogs, of which JJC8-016 (N-(2-((bis(4-fluorophenyl)me

197 meable cyclic guanosine monophosphate (cGMP) analog on KATP channel activity and insulin secretion po

198 he therapeutic effect of its (177)Lu-labeled analog on the tumor growth of NTR1-positive HT29 colon c

199 her in energy than the most stable gas-phase analogs or not even stable in the gas phase.

200 sed to increased TSH, a TSHR agonist, a cAMP analog, or a TSHR-stimulating antibody.

201 pooled mean improvement in the 100-mm visual analog pain scale, -9.95 [95% CI, -15.6 to -4.3]).

202 In both analogs, PmB led to membrane damage.

203 Double-stranded RNA and the synthetic analog polyinosinic:polycytidylic acid (poly(I:C)) bind

204 thesized on solid-phase and compared with an analog prepared using conventional methods (DA-TOC).

205 Macrolactonization of natural product analogs presents a significant challenge to both biosynt

206 alent cation, ethidium, but not its divalent analog, propidium.

207 clonal antibodies, alkylating agents, purine analogs, proteasome inhibitors, immunomodulatory drugs,

208 hat exploits ingredients in both digital and analog quantum simulations to dynamically couple or deco

209 xylic acid ((18)F-fluciclovine) is a leucine analog radiotracer that depicts amino acid transport int

210 because of the beneficial effects of GLP-1R analogs reported in experimental models of DR.

211 Experimental injections of ecdysone or its analog resulted in a decreased production of winged offs

212 n of the protein in complex with a substrate analog revealed a highly unconventional H2O2-activating

213 l structure of CYP2C9 in complex with a TCA1 analog revealed the similar interaction patterns to the

214 The analog's biphasic activity, which serendipitously resemb

215 Secondary end points included other visual analog scale (eg, high and desire to use), opioid withdr

216 ker-reported severity of illness on a visual analog scale (HR: 1.7; 95% CI: 1.1, 2.6), impaired consc

217 e, 35; 95% CI, 4.0-67.5; P = .03) and visual analog scale (median difference, 53; 95% CI, -11.6 to 12

218 -0.05 (95% CI, -0.35 to 0.25) on the visual analog scale (P = .74; I2 = 52%) and 6.58 (95% CI, -6.33

219 Main outcome was grade in a visual analog scale (VAS) consisting of 4 levels of treatment r

220 Pain assessment on the visual analog scale (VAS) during blue light illumination was no

221 The median visual analog scale (VAS) pain score (scale, 0-10) decreased fr

222 diagnostic instruments, including the visual analog scale (VAS) score, which quantifies the overall f

223 yp score and nasal polyposis severity visual analog scale (VAS) score.

224 Appetite was evaluated with a visual analog scale (VAS).

225 (LSAS) and self-reported anxiety on a visual analog scale (VAS-Anxiety).

226 line) were assessed with the EQ-5D-3L visual analog scale and Kansas City Cardiomyopathy Questionnair

227 zed to icatibant did not complete the visual analog scale and was excluded from analyses.

228 e, -1.14; 95% CI, -1.90 to -0.38 on a visual analog scale at 2 days; P = .003; I2 = 0%).

229 the elevation in depressed mood on a visual analog scale following the sad mood induction procedure

230 The visual analog scale for the overall feeling of sickness at alti

231 9 to 4.71), or quality of life (EQ-5D visual analog scale mean difference, 1.41; 95% CI, -6.42 to 3.6

232 rallel with the therapeutic response, visual analog scale scores for nasal symptoms, self-reported NH

233 y and depression, and a lower EuroQol visual analog scale scores.

234 assessed severity of swelling using a visual analog scale serially following study drug administratio

235 101-point numeric rating scale and a visual analog scale, and discomfort was evaluated using a four-

236 activity score, physician and patient visual analog scale, and treatment effectiveness score.

237 e and drug craving were measured with visual analog scales (VAS) and a Drug Effects Questionnaire.

238 ratings were assessed with the use of visual analog scales (VASs), blood samples collected, and ad li

239 e appetite ratings were obtained from visual analog scales before and after the breakfast.

240 oint was average scarring score using visual analog scales evaluating incision appearance and healing

241 ptiometry), fasting appetite ratings (visual analog scales), eating behavior traits (Three-Factor Eat

242 lar intervals over 180 min, appetite (visual analog scales), gastric emptying (3-dimensional ultrason

243 MRI fullness and liking were rated on visual analog scales.

244 algic conditions were monitored using visual analog score (VAS) 12 weeks after onset of fever in 130

245 ssay, we identified two 2'-C-methyladenosine analogs showing selective inhibition of LRV1.

246 with a small footprint can directly process analog signals and store computation results without pow

247 The most cytotoxic analog (SM15) was shown to produce chromosome segregatio

248 ge, and negative affect (NA)) followed by an analog smoking reinstatement task for which participants

249 mming distance comparator for two strings of analog states represented by voltages from the physical

250 While all tested guanosine analogs stimulate the splitting activity of HflX on the

251 A survey on 54 analog structures with similar backbone to 2-APB showed

252 is a major pathogen, and although nucleoside analogs such as acyclovir are highly effective in contro

253 Nucleoside analogs such as gemcitabine diphosphate and clofarabine

254 SAR analysis of the resulting analogs suggests that for the NOP receptor, the entire A

255 ompleting a laboratory-based smoking relapse analog task.

256 th smoking sooner during the smoking relapse-analog task.

257 lular signals, and cyclocreatine, a creatine analog that can supply ATP.

258 An analog that docked poorly in the GtfC catalytic domain f

259 we synthesized a closely related clofazimine analog that does not precipitate under physiological pH

260 Stauprimide is a staurosporine analog that promotes embryonic stem cell (ESC) different

261 phosphate prodrug of an adenosine nucleoside analog that showed therapeutic efficacy in a non-human p

262 e, pyrimidine, pyrazine, and isonicotinamide analogs that feature as building blocks in biochemistry

263 -bond energies of aromatic heterocycles with analogs that have the same H-bonding moieties but lack c

264 n cells, we synthesized a series of chemical analogs that reduce host cell toxicity while maintaining

265 Synthetic curcumin analogs that undergo oxidative transformation potently i

266 a rationally designed library of simplified analogs that unveiled three unique biofilm phenotypes fu

267 Fluorine-labeled analogs, that could be developed as PET-based imaging tr

268 BMs per day despite stable-dose somatostatin analog therapy received (1:1:1) placebo, telotristat eth

269 mposed of natural and non-natural amino acid analogs, thereby enabling screens in a much diverse chem

270 y), each paired with their native ecological analogs to better understand demographic drivers of inva

271 rrelation between the abilities of Tg and Tg analogs to deplete ER Ca(2+) stores and their detrimenta

272 city), and identified future nearest climate analogs to quantify patterns of climate relocation withi

273 tional change step may help to design better analogs to treat HIV infections and other diseases.

274 the conjugation of fatty acid (palmitic acid analog) to Uox with the HSA binding capacity and retaine

275 bility of exendin-4, a clinically used GLP-1 analog, to reduce body weight in rats, suggesting that s

276 trated that for mass spectrometers employing analog-to-digital converters (ADCs) and electron multipl

277 Furthermore, a nonbinding analog tracer showed significantly lower accumulation in

278 ecarboxylic acid (HOCPCA) and the linear GHB analog trans-4-hydroxycrotonic acid (T-HCA).

279 with shorter and longer arginine side-chain analogs translocate slower than TP2.

280 68)Ga-DOTATATE are radiolabeled somatostatin analogs used for the diagnosis of somatostatin receptor-

281 , synthesis and evaluation of novel GDC-0449 analogs using N-[3-(2-pyridinyl) phenyl] benzamide scaff

282 d conversion of alcohols to their beta-amino analogs (via in situ conversion of alcohols to imidates,

283 ence of different nucleotides and nucleotide analogs, we were able to observe four distinct conformat

284 Both analogs were conjugated to IRDye 800 using copper-free c

285 (NF-kappaB), whereas stable, non-oxidizable analogs were less active, with a correlation coefficient

286 rnative substrates and fluorinated substrate analogs were prepared to investigate the mechanism of me

287 apoptosis at low concentrations of Tg and Tg analogs, whereas high cytosolic Ca(2+) levels and SOCE a

288 but it did occur with the 18-crown-6 (crown) analog which formed {K(crown)}2{[(R2N)3Sc]2[mu-eta(1):et

289 e this difficulty, we synthesized solenopsin analogs which biochemically act as ceramides, but cannot

290 We therefore sought an ultra-stable analog whose potency and duration of action on intraveno

291 , our experiments yielded several novel IAPP analogs, whose sequences are highly similar to that of I

292 provide a binding pocket-modified vancomycin analog with a second mechanism of action that is indepen

293 accharide units to insulin to create insulin analogs with affinity for both the insulin receptor (IR)

294 for the preparation of a set of appropriate analogs with exciting applications in the area of host-g

295 proteins, a principle used to endow insulin analogs with glucose responsivity.

296 starting point for the design of structural analogs with improved activity.

297 Two analogs with improved membrane permeability showed much

298 -arylidenepropanehydrazonamides provided new analogs with nanomolar to subnanomolar antiplasmodial ac

299 at low (0.1 mum) concentrations of Tg and Tg analogs with various long-chain substitutions at the O-8

300 es through the radiolabeling of somatostatin analogs with various radionuclides has led to a revoluti