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1 openone bearing the two halves (a hydrobilin analogue).
2 115 and pasireotide, a somatostatin receptor analogue.
3 on trifluoride etherate to give a tripyrrane analogue.
4 ance intermediate of corresponding (+/-) CPC analogue.
5 camptothecin (CPT) and a capecitabine (Cap) analogue.
6 ease (NAFLD) receiving EFV plus 2 nucleoside analogues.
7 ic water ions with oxidized cometary surface analogues.
8 es compared to their non-degradable spermine analogues.
9 verall virus binding to sialic acid receptor analogues.
10 xploited for the rational design of improved analogues.
11 d amide nitrogens to rapidly produce diverse analogues.
12 t safety of currently approved nucleos(t)ide analogues.
13 ated that affinity is increased for divalent analogues.
14 unterparts and also from their graphene-like analogues.
15 erences between imidazole and 1,2,4-triazole analogues.
16 tics, chemical chaperones, or VPA structural analogues.
17 avior in comparison with chalcogen-free host analogues.
18 only sparsely used in synthetic or colloidal analogues.
19 is and structure-activity relationship of 71 analogues.
20 d, or to continue with EFV plus 2 nucleoside analogues.
21 ependent resistance to a range of auxins and analogues.
22 re synthesized by analogy with their bromine analogues.
23 nt to their much more widely studied group 7 analogues.
24 n 282 that cause resistance to nucleos(t)ide analogues.
25 nts of the previously undescribed polyketide analogues.
26 d alpha/gamma BSBHps, but not of alpha/delta analogues.
27 les using AdoMet-dependent MTases and AdoMet analogues.
28 llic and electrochemically pretreated (E-Ir) analogues.
29 in comparison to their spontaneously formed analogues.
30 s recently proposed photonic and polaritonic analogues.
32 y of a fluorescent cytidine TNA triphosphate analogue (1,3-diaza-2-oxo-phenothiazine, tCfTP) that mai
34 opsin can be achieved with the unbleachable analogue, 11-cis-6-membered ring (11-cis-6mr)-retinal, w
35 ized arylurea fatty acids and found that the analogue 16-({[4-chloro-3-(trifluoromethyl)phenyl]carbam
36 marine metabolite arsenicin A, the dimethyl analogue 2 and four isomeric methylene homologues (inclu
38 ed to stand, clean conversion to the benzene analogue 3 occurs, and this complex may be precipitated
42 physiological profiling studies suggest that analogue 4 inhibits photosystem II in isolated thylakoid
43 ciferase assays demonstrated that 2a and its analogue 4,11-bis(2-aminoethylamino)anthra[2,3-b]thiophe
45 hit anthranilic acid 4, the known benzofuran analogue 5, and the benzothiadiazine derivative 6, an op
48 tions of identified hit VA240 in synthesized analogues 6-41 afforded compound 11 (N-[(1-benzyl-1H-ind
50 A4-mRNA construct bearing a conventional cap analogue (7-methylguanosine) failed to produce ITGA4 pro
51 the adenylate cyclase in vitro, and the cAMP analogue 8-bromo-cyclic AMP partially rescued the circad
52 aumannii and Klebsiella pneumoniae; however, analogue 9 and 16 at 4 mug/mL decreased the MIC of rifam
56 acellular biosynthesis of another spermidine analogue, aminopropylcadaverine, from exogenously suppli
58 binant microbial delivery vector for a GLP-1 analogue and assess the efficacy of the therapeutic in i
60 merism, were equal in potency to the phenoxy analogues and demonstrated selectivity for the liver enz
61 the rational design and synthesis of 60 new analogues and determination of their antiviral activity
62 ffusion characteristics of fluorescent lipid analogues and GPI-anchored proteins (GPI-APs) in the liv
64 ternative approach, we generated novel ML290 analogues and tested their activity in the HEK293-RXFP1
66 Thus, the inhibitory activity of L-cIDPR analogues appears to depend upon substitution of the bas
68 study demonstrates that AR-12 and the AR-14 analogue are potential new therapeutic agents for prion
70 emperatures (TCDW) observed in the Pr and Sm analogues are approximately 200 and approximately 175 K,
73 Here, we demonstrate that largazole and its analogues are isoform-targeted histone deacetylase inhib
76 formation and pRNA transfer assay using GDP analogues as pRNA acceptors indicated that the PRNTase d
79 biochemical utility of a fluorescent NAD(+) analogue based on an isothiazolo[4,3-d]pyrimidine core (
80 erate inhibitors of CD38 by total synthesis, analogues based on the cyclic inosine 5'-diphosphate rib
81 second-line therapy); had received a purine analogue, bendamustine, anti-CD20 antibody, chlorambucil
82 VO2 oscillator network harnesses the natural analogue between optimization problems and energy minimi
83 o the use of alternate chemicals such as BPA analogues bisphenol S (BPS) and bisphenol AF (BPAF) in p
84 7 realizes a weak Mott state with no cuprate analogue by using ultrafast time-resolved optical reflec
85 ntific interest in determining whether Earth-analogues can remain habitable in such environments and
86 logue reported but also the shortest ghrelin analogue capable of binding GHS-R1a with better affinity
89 Furthermore, studies with synthetic LtnA2 analogues containing either desmethyl- or oxa-lanthionin
93 sins J (1) and H (2), together with five new analogues, cytochalasins J1-J3 (3-5) and H1 and H2 (6 an
95 c, including many plant natural products and analogues derived from these products, but has fallen sh
99 Following the identification of delamanid analogue DNDI-VL-2098 as a VL preclinical candidate, thi
100 le Triassic horseshoe crabs and their recent analogues documents anatomical conservatism for over 240
103 hesis to prepare three ShK polypeptide chain analogues, each containing either an allo-Thr or an allo
105 haracteristics of a cdPCR assay to its ddPCR analogue, establishing fully traceable ddPCR estimates o
107 O) a highly interesting fluorescent RNA base analogue for detailed FRET-based structural measurements
109 ow-cost alternative to their gold and silver analogues for numerous applications, although their pote
110 g the baseline separation of 12 Ga2 isoforms/analogues from their lactosylceramide counterparts, was
112 thiophene, dibenzothiophene, and carbazoles analogues has been achieved involving alkylation of 2-br
115 lines, unlike the pyrrolidine and piperidine analogues, have been found to be brain penetrant BACE-1
118 cture-activity relationship modeling yielded analogues (i.e., 8n: EC50 = 0.06 muM, SI 500) that estab
119 currence of N-Cl-DCAM and its two brominated analogues (i.e., N-chloro-2,2-bromochloroacetamide and N
120 oA synthetases with triacsin C, a fatty acid analogue, impairs lipid droplet (LD) biogenesis and ERAD
122 re presented for the potential use of AdoMet analogues in biology research, (epi)genetics and nanotec
125 A competition assay between GDP and GDP analogues in the GpppA formation and pRNA transfer assay
126 stigating the behaviour of Trolox, vitamin E analogue, in presence of macromolecule-bound antioxidant
129 daily for 5 days together with nucleos(t)ide analogues indefinitely yielded 1- and 3-year cumulative
130 ish HDAC10 complexed with a transition-state analogue inhibitor reveals that a glutamate gatekeeper a
131 Initial tests show that a thioamide GLP-1 analogue is biologically active in rats, with an in vivo
134 olotriarylmethanes and new bisindolylbenzoyl analogues is established through the dual C-C coupling o
138 -line therapy with tenofovir plus a cytosine analogue (lamivudine or emtricitabine) plus a non-nucleo
139 ment with sapropterin, a tetrahydrobiopterin analogue, led to dramatic and long-lasting remission of
141 he structural changes of silicate glasses as analogue materials for silicate melts at ultrahigh press
145 DRMs were found, including M184V, thymidine analogue mutations (T215F, D67N, K70R, K219Q), NNRTIs (L
147 resence of common TDRMs, including thymidine-analogue mutations/T215rev, showed no impact on response
148 In this work, two large antiaromatic acene analogues, namely, cyclopenta[pqr]indeno[2,1,7-ijk]tetra
149 deficient B. subtilis mutant, the structural analogue norspermidine, but not homospermidine, restored
152 HIV-1 drug resistance to older thymidine analogue nucleoside reverse transcriptase inhibitor drug
153 atly expand the number of known thiostrepton analogues obtained by any method and reveal a high level
154 lf-peptides (ARTELYRSL and ARFNDLRFV) and an analogue of a melanocyte autoantigen (ADAMTSL5, VRSRR-ab
156 FBC 338 transformed to express a long-acting analogue of GLP-1 or the isogenic control microbe which
158 ization of the heavier phosphorus-containing analogue of isocyanic acid (HPCO), and its isotopologue
160 crowave excitations, we report the classical analogue of Rabi oscillations in ensemble-averaged spins
161 ct technique (SIT) and cue-lure (a synthetic analogue of raspberry ketone (RK))-based male annihilati
163 ly suggested that terminin is the functional analogue of shelterin, the multi-protein complex that pr
167 hnique, previously identified as the optical analogue of the electrical Hall effect, permits here mea
168 lisocyanide)tantalum is the first isocyanide analogue of the highly unstable Ta(CO)6 and represents t
169 und, and beryllofluoridated CKI1RD (a stable analogue of the labile phosphorylated form) were identic
170 odissociation mechanism of SiH2OO, a silicon analogue of the parent Criegee intermediate, CH2OO.
173 seudomagnetic fields for sound waves are the analogue of what electrons experience in strained graphe
178 y tests reveal that BR scrambles fluorescent analogues of common phospholipids but does not transport
180 he compounds are the first examples of boron analogues of diazoalkanes (R2CNN) and ketenes (R2CCO), a
182 s has driven clandestine chemists to produce analogues of increasing structural diversity, intended t
184 hese compounds are precursors of fluorinated analogues of l-carbidopa, which is known to inhibit DOPA
187 y are demonstrated in the synthesis of novel analogues of natural product (-)-nicotine and antidepres
188 fore investigated the effect of red-shifting analogues of retinal, combined with red-shifting mutatio
193 logical evaluation of a systematic series of analogues of the original hit using a structure-based dr
196 Herein, we describe the rapid synthesis of analogues of the sansanmycin uridylpeptide natural produ
198 bled the preparation and isolation of 24 new analogues of thiostrepton, the biological testing of whi
199 igher computational cost, especially for the analogues of this state in longer polyenes, and conseque
200 dered as achiral conformationally restricted analogues of threonine with fixed spatial orientation of
201 due within the tripeptides was replaced with analogues of varying ring sizes (azetidine carboxylic ac
202 ruction of a variety of designed enantiopure analogues of viridicatumtoxin B led to the discovery of
204 ples the structures of the Michaelis complex analogue or the apo state as its dominant excited state.
209 a series of derivatives and characterize an analogue (pepstatin hexyl ester) with low nanomolar acti
210 n of this layered material and its few layer analogue, phosphorene, as an optoelectronic material.
211 e I IFN responses to the double-stranded RNA analogue poly(I:C) are reduced in mouse macrophages.
212 In this Article, the shock compression of analogue precursor chondrite material was probed using s
214 ave the way for the examination of synthetic analogues rationally designed to not only overcome vanco
215 g free energy of a series of alpha-ketoamide analogues relative to a common warhead scaffold, in both
216 his is not only the highest affinity ghrelin analogue reported but also the shortest ghrelin analogue
217 ormone glucagon-like peptide (GLP)-1 and its analogues represent a new generation of anti-diabetic dr
219 [93%] vs 462 [77%]; p<0.0001), and cytosine analogue resistance (100 [87%] vs 378 [63%]; p=0.0002).
220 ing RSPO ligands and a new non-lipidated Wnt analogue reveal that these ligands have qualitatively di
221 icted binding orientation of the quinolinium analogues revealed selective binding to the NNMT substra
222 crease the anti-HIV-1 efficacy of nucleotide analogue reverse transcription inhibitors presumably as
223 resolution; and Sub2 associated with an ATP analogue, RNA, and a C-terminal fragment of Yra1 (Yra1-C
224 ridyl)porphyrinate (CoTPyP) and its cofacial analogue [Ru8(eta(6)-iPrC6H4Me)8(dhbq)4(CoTPyP)2][OTf]8
225 sets of action (indacaterol, two indacaterol analogues, salmeterol and formoterol) in monounsaturated
226 s according to EPOS control criteria, visual analogue scale (VAS) scores for total and individual sin
229 and whole-body thermal sensation on a visual analogue scale (WBTS) ranging from 0 mm (very cold) to 2
230 owed that quality-of-life data (EQ-5D visual analogue scale and WPA-IS Question 9) are similar in use
231 patient reported pain of 8-10 in VAS (Visual Analogue Scale) and had an ODI (Oswestry Disability Inde
232 measured by the EuroQol 5 Dimensions visual analogue scale, improved by 7.2 points (SD 21.3) in the
234 ral depsipeptides, the synthetic oligolactam analogues show a correlation between ion transport abili
236 In contrast, the deuterated (OD) carbene analogue showed much reduced 1,2-D-shift reactivity with
239 circulation time, we synthesized a new SMART analogue, SMART-OH, and its polymer-drug conjugate, meth
243 us reports on VHL-HB avidity to somatostatin analogues suggested somatostatin receptor (SSTR) express
246 long acting glucagon-like peptide 1 (GLP-1) analogue that is an agonist for the GLP-1 receptor, a G-
248 series of lissoclimide natural products and analogues that expand the structure-activity relationshi
249 y the introduction of fluorotyrosine (F-Tyr) analogues that modulated the pKa and reduction potential
250 een successfully engineered to produce novel analogues, the process can be relatively slow, inefficie
252 and previous studies of glycosylated insulin analogues, this natural glycosylation may provide import
253 on 2,6-dimethoxy hydroquinone (2,6-DMHQ), an analogue to a common fungal metabolite, and its reaction
254 at NAO-related variability can be used an as analogue to predict the effects of Arctic sea ice loss o
255 ng light is the core component as an optical analogue to the electronic transistor that forms the bas
256 s in turn suggests novel uses for nucleotide analogues to inhibit HIV-1 in differentiated cells low i
258 tion calorimetry, a screening of ganglioside analogues together with a detailed characterization of v
261 (400 mg twice daily), maintaining nucleoside analogues unchanged, or to continue with EFV plus 2 nucl
262 ) are noticed than that in the higher energy analogues, underscoring the importance of noncovalent in
263 ndigo-alt-3,4-difluorothiophene) (PIID[2F]T) analogues used as "polymer acceptors" in bulk-heterojunc
265 ncrossover is studied in Fe-Co Prussian blue analogues using a dissipative quantum-mechanical model o
269 Brain-inspired device technologies using analogue weight storage allow to complete cognitive task
272 ethylazetidinyl and C1'-N-methylpyrrolidinyl analogues were found to be high affinity ligands for the
277 on(s) of Ov-GRN-1, four truncated N-terminal analogues were synthesized and characterized structurall
278 ip (SAR) study, 25 disulfide bond-containing analogues were synthesized and tested for QS inhibition
279 er of these compounds, particularly the urea analogues, were quite potent, these molecules as a whole
282 yrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine analogues which are inhibitors of human glycogen synthas
284 ned derivative 36 emerged as the most potent analogue with a KD of 76 nM against BioA and a minimum i
286 fficacy of the combination of a somatostatin analogue with everolimus in lung and thymic carcinoids.
288 nantiomer, D-RR4, emerged as the most potent analogues with a more than 32-fold improvement in antimi
291 epine alkaloid and a series of its synthetic analogues with demonstrated cancer cell antiproliferativ
294 GLP-1 analogues were superior to monovalent analogues with respect to control of glucose homeostasis
296 -modified 2'-deoxy-2'-fluorouridine (2'-F U) analogues with the aim to improve nuclease resistance an
297 operties and in the interaction of substrate analogues with the oxygen-evolving complex, enabling ass
298 pared liraglutide, a glucagon-like peptide 1 analogue, with placebo in patients with type 2 diabetes
300 hates enforces initiation with the unnatural analogue, yielding 5'-end modified transcripts that can
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