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1                                          Population genomic analyses were done with a hierarchical gene-by-gene approach.
2                                                        Meta-analyses were done with a random effects model.
3                                                             Analyses were done with all eligible patients who started pro
4                                         Efficacy and safety analyses were done with all randomly assigned patients who re
5                                                         All analyses were done with and without inclusion of the SHOCK tr
6                    Large-restriction-fragment (LRF) pattern analyses were done with AseI.
7                                 Univariate and multivariate analyses were done with Cox proportional hazard regression.
8 nd lack of cooperation were used as exclusion criteria, and analyses were done with data from 4869 eyes.
9                                Multiple logistic regression analyses were done with every primary outcome as the dependen
10                                                  Additional analyses were done with finer categorisation of heart rate, a
11                                          Intention-to-treat analyses were done with linear regression.
12                                                 Sensitivity analyses were done with regard to how the value of a statisti
13                                                 All further analyses were done with the BCI-L model.
14                                                 Comparative analyses were done with the deletions and the parental wild t
15                                                        Meta-analyses were done with the Mantel-Haenszel method with a ran
16                                                         All analyses were done with the modified intention-to-treat popul
17                                                  Mutational analyses were done with VZV cosmids generated from parent Oka

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