ライフサイエンスコーパス: ancestral

1 Here, we assessed the in vivo role of the ancestral 14-3-3 epsilon group members.

2 intronless rod opsin gene, first emerged in ancestral Actinopterygii, and N increased to 2 by the te

3 Latin American demonstrated a high degree of ancestral admixture.

4 pecies, reflecting both parallel fixation of ancestral alleles and independent origin of distinct mut

5 Like the ancestral amniotes, the common ancestor of the extant re

6 rived from the predominate diurnality of the ancestral amniotes, which featured strong positive selec

7 hey are antigenically distinct from both the ancestral and current circulating H3N2 strains.

8 and can lead to the presence of a mixture of ancestral and derived characteristics, has been frequent

9 Comparisons between ancestral and evolved genotypes suggest hypotheses regar

10 ers, which make the deciphering of different ancestral and historical contributes particularly challe

11 you consider that the genome is a mosaic of ancestral and modern incompletely sorted sequence blocks

12 across development in animals exhibiting the ancestral and more widespread short germband mode of emb

13 tiple cellular roles of the Dig1 protein are ancestral and predate the sub-functionalization apparent

14 expression changed substantially between the ancestral and selected fungi, especially for spore produ

15 We reconstruct the ancestral angiosperm flower as bisexual and radially sym

16 ly provide insights into immune signaling in ancestral animals.

17 nd similar computational methods, many HIV-1 ancestral antibodies have been inferred, synthesized and

18 tor of the humoral innate immune system with ancestral antibody-like properties but unknown antibody-

19 shows the Indo-West Pacific as the probable ancestral area of the genus Hippolyte, which emerged in

20 Different approaches to ancestral area reconstruction suggest a complex east to

21 Ancestral area reconstructions suggest that the tribe or

22 After birds diverged from mammals, different ancestral autosomes evolved into sex chromosomes in each

23 ex chromosomes differentiated from different ancestral autosomes in various vertebrate lineages.

24 gene content with our reconstruction of the ancestral autosomes, and followed the evolutionary traje

25 represent specialized forms rather than the ancestral avemetatarsalian morphology.

26 Ancestral beta-subunit (Anbu) is homologous to HslV and

27 stor of copepods and deuterostomes, i.e. the ancestral bilaterians.

28 ts played a sustained role in the ecology of ancestral bipedal hominins is unresolved.

29 llows more efficient carbon capture than the ancestral C3 pathway.

30 le genes by light and the chloroplast in the ancestral C3 state has facilitated the repeated evolutio

31 as-containing transposons included a single, ancestral capture of a type I-F locus and two independen

32 hemichordates), it is uncertain whether the ancestral cephalochordates (i.e. the common ancestor of

33 Thus, the ancestral cephalochordates probably had GFP, but since G

34 Through ancestral character reconstruction of reaction norms, we

35 Using ancestral character state reconstruction we identify two

36 species and 86 plant families, and performed ancestral character state reconstructions.

37 Land plants evolved from an ancestral charophycean alga from which they inherited de

38 itary chromosome arose through fusion of six ancestral chromosomes, with extensive rearrangement amon

39 sist of four types of subunits, evolved from ancestral complexes of two types of subunits through gen

40 .57% of karyotypes show S-type organisation (ancestral condition), the L-type arrangement has arisen

41 Biotic pollination is the presumed ancestral condition, but this key element of the life hi

42 panzee clade, and all were reversions to the ancestral condition.

43 ey provide on chondrichthyan and gnathostome ancestral conditions.

44 likely arisen through genetic drift from the ancestral cP.

45 p III CPNs likely represent a relic from the ancestral CPN that formed distinct bacterial and archaea

46 These mutations revert Ctr2 to a more ancestral Ctr1-like state while maintaining endogenous f

47 or of Cucurbitaceae, which revealed that the ancestral Cucurbitaceae karyotypes consisted of 12 proto

48 11 bottle gourd chromosomes derive from the ancestral Cucurbitaceae karyotypes followed by 19 chromo

49 NPF) likely evolved from transporters of the ancestral cyanogenic glucosides found across more than 2

50 ecular dynamics techniques, we show that the ancestral DBD from which GR and its paralogs evolved was

51 oth nGRE and (+)GRE sequences because of the ancestral DBD's ability to assume multiple DNA-bound con

52 developmental data illuminate a potentially ancestral dental formula for sloths.

53 A number of mechanisms, including ancestral differences in census size, sedentism, exploit

54 contributes to the broader goal of increased ancestral diversity in genomic data resources.

55 ypically bind different sequences from these ancestral domains, with changes facilitated by non-base-

56 Thus, the ancestral DUX4-regulated genes are characteristic of cle

57 ion of effector-immunity gene pairs replaces ancestral effectors, yet retains the cognate immunity ge

58 Altogether, maternal and/or ancestral embryonic exposure to BPA affects liver metabo

59 ed in all high-CO2 adapted cell lines in the ancestral environment upon reciprocal transplantation.

60 Ancestral environmental exposures to non-mutagenic agent

61 lection pressures and limited dispersal from ancestral environments.

62 romiscuity may be an evolutionary vestige of ancestral enzyme activities, which have been eliminated

63 To do so, we studied five key resurrected ancestral enzymes as well as their extant counterparts.

64 an lower expression levels across the entire ancestral expression domain.

65 have become twofold up-regulated, restoring ancestral expression levels.

66 ollowed by neofunctionalization, whereby the ancestral F6H activity is partially retained in the deri

67 eomes, such as through dual-targeting, is an ancestral feature of plastid evolution.

68 nery, indicating that phototrophy was not an ancestral feature of the Cyanobacteria and that Oxyphoto

69 , and a Trypanosoma cruzi-like cytostome are ancestral features, while evolution of extant trypanosom

70 In particular, the structure of the ancestral flower of all living angiosperms is still unce

71 re we report model-based reconstructions for ancestral flowers at the deepest nodes in the phylogeny

72 se fly has sex chromosomes that resemble the ancestral fly karyotype that originated approximately 10

73 de repair in archaea perhaps suggests a more ancestral form of ribonucleotide excision repair compare

74 d FtsZ that could copolymerize with the more ancestral form to enhance FtsZ-ring dynamics may have be

75 e clustering, Anbu has been proposed as the "ancestral" form of proteasomes.

76 ns provides new opportunities to distinguish ancestral from acquired alleles and assess the effects o

77 Our results demonstrate that the more ancestral FtsZ2 and FtsZA have retained functional attri

78 ZB probably arose by duplication of the more ancestral FtsZ2 and FtsZA, respectively.

79 We find an ancestral function for this repeatedly redeployed pathwa

80 within the network of sequences encoding the ancestral function, outcomes with different genetic and

81 rnative network structures without a loss of ancestral function, thereby facilitating the formation o

82 iously associated with IFN, underscoring the ancestral functions associated with this antiviral host

83 ent to which these genes still perform their ancestral functions is largely unknown.

84 ngulfment and a channel-like function may be ancestral functions of SpoIIQ-SpoIIIAH while the require

85 thway, and consider the possibility that the ancestral functions of STING may have included activatio

86 igination, duplicates tend to maintain their ancestral functions; but as they survive longer, they mi

87 eir mating-type chromosomes, we inferred the ancestral gene order and derived chromosomal arrangement

88 provides a basic toolbox for reconstructing ancestral gene orders with duplications.

89 assicaceae may have originated from a common ancestral gene pair present before speciation.

90 port the sequencing of two diploids from the ancestral gene pools of quinoa, which enables the identi

91 en biased, with one subgenome retaining more ancestral genes and the other sustaining more gene delet

92 lel with mammalian Y chromosomes, preserving ancestral genes through selection to maintain the dosage

93 mes, and X-chromosomes mostly conserve their ancestral genes.

94 ing that they have arisen via duplication of ancestral genes.

95 l DNAm levels were associated with the local ancestral genetic context.

96 x multiplication in the cotton lineage of an ancestral genome common to cotton and cacao, and propose

97 icient for predicting whether or not a given ancestral genome will acquire specific genes.

98 onserved syntenic blocks among reconstructed ancestral genomes and present yeast species.

99 onal pipeline to reconstruct phylogenies and ancestral genomes for two high-resolution real yeast gen

100 Reconstructing ancestral genomes helps us understand mechanisms and cor

101 conidial spores, three times sooner than the ancestral genotype.

102 lgorithms and to benchmark against the known ancestral genotypes and ancestral phenotypes.

103 storical substitution into the reconstructed ancestral GKPID.

104 An ancestral glutamate-like receptor (GLR) gene encoding pu

105 belonging to the spotted fever, typhus, and ancestral groups and, in parallel, compared to otherRick

106 enomes defined a cluster distinct from other ancestral groups, and these genomes showed clear hallmar

107 isposition to cutaneous NVP HSR, seen across ancestral groups, can be attributed to a cluster of HLA-

108 ollow-up of suggestive loci in three further ancestral groups: Polynesians, South Asians and Mixed or

109 ntigenic difference between A(H3N2)v and the ancestral H3N2 strains.

110 in-rich Apocyclops does not, suggesting this ancestral habitat for Vibrios is a replete medium with m

111 The ancestral habitat of Detarioideae is postulated to be a

112 ever, within primates, the results show that ancestral Haplorrhini were likely nocturnal, suggesting

113 Here, we used ancestral haplotype analysis to fine-map this locus to 1

114 in nine families (with evidence for a shared ancestral haplotype), and another one of 45 kb was found

115 on acquirement of pulmonary circulation, the ancestral heart may have been remodelled coincidently wi

116 the United States, the possible genetic and ancestral hereditary explanations for these associations

117 cities, and individuals all show substantial ancestral heterogeneity.

118 ic endosymbiosis arose by displacement of an ancestral heterotrophic symbiosis and a report of pure c

119 at these strains are more closely related to ancestral HIV-1 strains than to previously reported stra

120 ic.IMPORTANCE Very little is known about the ancestral HIV-1 strains that founded the global pandemic

121 We found that a single ancestral Hodgkinia lineage has split at least six indep

122 h cultivated crops and may interact with the ancestral hosts in ways which are biochemically distinct

123 y of strains retaining sequences we posit as ancestral HSV-2.

124 This work provides insights into ancestral human neurobiology and suggests that Neanderth

125 rence systems that evolved as adaptations to ancestral human small-scale sociality.

126 ly characterized the religious lives of many ancestral humans, and is often proposed by anthropologis

127 inference typically invokes nocturnality as ancestral in primates; however, some recent studies posi

128 sequenced genes are arranged in the putative ancestral insect gene arrangement, while the tRNA cluste

129 served and identical to that of the putative ancestral insect.

130 The ancestral karyotype (2n = 16) has two terminal 35S sites

131 The inferred ancestral karyotype of clade E (CEK; n = 7) originated f

132 its genome resembling that predicted for the ancestral land plant.

133 desiccation tolerant spores, evolved in the ancestral land plant.

134 l as the basal position of Chiroptera and an ancestral laurasiatherian hybridization process did exhi

135 Our results indicate that subokra is the ancestral leaf shape of tetraploid cotton that gave rise

136 ATHs and the ancestral-like coding sequences rescued sensory organ fa

137 North America with Shuka Kaa on a different ancestral line compared with other North American indivi

138 ocillopora species diversified from a common ancestral lineage within the last 3 million years.

139 of the archipelago owing to the splitting of ancestral lineages (cladogenesis).

140 ndrial genetic variation, including the most ancestral lineages that are now absent from modern popul

141 he four TPR motifs in all species, including ancestral lineages, supports the hypothesis that SNAPs w

142 Using ancestral MADS domain protein reconstruction, we trace t

143 way to predict the diel activity patterns of ancestral mammals and reptiles.

144 apparent temporal niche partitioning between ancestral mammals and the relevant reptiles, our results

145 Invasion of ancestral mammals into nocturnality has long been inferr

146 analyses showed that the nocturnality of the ancestral mammals was probably derived from the predomin

147 in competitors of the temporal niches of the ancestral mammals, were found to be predominate diurnali

148 pporting the predominate nocturnality of the ancestral mammals.

149 zoic, and identifies an eastward movement of ancestral marine lineages towards the Indo-Australian Ar

150 and fat storage tissues that constitutes an ancestral mechanism governing systemic energy homeostasi

151 ogenetic analysis indicated that BAM2 is the ancestral member of one of these subfamilies.

152 four subfamilies, and each can be traced to ancestral members that contain a kinase domain and a cal

153 In ancestral methanogens, a third protein SepCysE forms a b

154 es, it is difficult to infer features of our ancestral microbiome.

155 sis, typically by one of two modes: a likely ancestral mode wherein germ cells are induced during emb

156 The ancestral molecular and cellular mechanisms stemming fro

157 crania, and samples of dogs with relatively ancestral morphology and from different time periods.

158 and determine whether they arise from common ancestral mutations or recurrent mutation events.

159 In evolving from ancestral mycobacteria, related to "M. canettii" and M.

160 linguistic groups as well as the most likely ancestral Native American populations as the ancestry, w

161 of vertebrates, it remains unresolved which ancestral neurogenesis mode prefigures the highly diverg

162 We show that the ancestral ochrophyte plastid proteome was an evolutionar

163 in a genomic position that differs from the ancestral one in the Brassicaceae.

164 We propose that ancient ancestral origins for ciHHV-6A and ciHHV-6B are also lik

165 found changes during their evolution from an ancestral pair of autosomes [1-4].

166 eutrality, both in transitions retaining the ancestral pair of sex chromosomes, and in those creating

167 regions of the PAR (one gene that was in the ancestral PAR and two from each of the added regions).

168 These genes were added to an ancestral PAR of the sex chromosome pair in two distinct

169 he green alga, red alga, and eukaryotic host ancestral participants of secondary endosymbiosis, respe

170 These results suggest that explanations of ancestral patterns of cultural complexity may need to co

171 on with coastal migration models and genetic ancestral patterns that are difficult to reconcile with

172 ese Argentine-breeding swallows might retain ancestral patterns, breeding in Argentina but returning

173 results demonstrate a critical role for the ancestral phenolic metabolism in moss erect growth and c

174 rk against the known ancestral genotypes and ancestral phenotypes.

175 Phylogenetic analyses revealed that an ancestral PIF-like gene was already present in streptoph

176 The findings suggest that ancestral plasmid instability can at least partly be exp

177 Moreover, persistence of the ancestral plasmid was increased upon overexpression of D

178 second Vibrionaceae chromosome arose from an ancestral plasmid, and that RctB may have evolved additi

179 ether these polymers descended from a single ancestral polymer or arose multiple times by convergent

180 re likely to be the descendants of a single, ancestral, polymer-forming actin-like protein.

181 e, depending on the fixation of their shared ancestral polymorphic alleles.

182 y related species may be due to retention of ancestral polymorphisms because of incomplete lineage so

183 cal adaptation that took place in the common ancestral population before their entrance into the New

184 In the IIM model, one ancestral population divides into two descendant subpopu

185 d rice, O. rufipogon, are descendants of the ancestral population that gave rise to domesticated rice

186 timating a model of admixture proportions of ancestral populations for each individual.

187 dies (GWAS) of QT were performed in European ancestral populations, leaving other groups uncharacteri

188 differentiated allele frequencies among the ancestral populations.

189 e associated with kidney diseases in African ancestral populations; yet, the underlying biologic mech

190 ction in ancestral primates, suggesting that ancestral primates decreased their emphasis on mobile pr

191 ichromatic vision and orbital convergence in ancestral primates may have helped them to efficiently d

192 olution of the retinal fovea occurred within ancestral primates rather than within haplorrhines as wa

193 These results suggest that ancestral primates were mainly diurnal with some crepusc

194 ELAX)), our results consistently showed that ancestral primates were subjected to enhanced positive s

195 how relaxed selection on motion detection in ancestral primates, suggesting that ancestral primates d

196 r a reassessment of the visual adaptation of ancestral primates.

197 endosymbionts has bombarded nuclei since the ancestral prokaryotes were engulfed by a precursor of th

198 Because the HYDIN2 locus lacks the ancestral promoter and seven terminal exons of the proge

199 roneural genes, and the closest homologue to ancestral proneural genes.

200 rom Novosibirsk and Russian Starover exhibit ancestral proportions close to that of European Eastern

201 AA+ ClpX; and Anbu, a recently characterized ancestral proteasome variant.

202 one knows the effects of all mutations in an ancestral protein background.

203 Ancestral protein reconstruction allows the resurrection

204 Here we review recent studies employing ancestral protein reconstruction and show how they have

205 Here we combine ancestral protein reconstruction with deep mutational sc

206 uent 1,600-fold change in specificity of the ancestral protein.

207 we characterized the folding trajectories of ancestral proteins of the ribonuclease H (RNase H) famil

208 Molecular dating and ancestral range reconstructions are congruent with C. ty

209 Tectonic plates that fragment ancestral ranges (vicariance) has often been assumed to

210 s structure preserves characteristics of the ancestral reaction center, providing insight into the ev

211 In higher flies like Drosophila, the ancestral receptor germ cell-expressed (gce) gene has du

212 to its diversification, supported by finding ancestral recombination events between isolates from dif

213 Ancestral recombination graphs represent potential histo

214 rdial enzymes and highlight the potential of ancestral reconstruction as a tool for protein engineeri

215 Ancestral reconstruction of transmission events reveals

216 straints in prokaryotes, using probabilistic ancestral reconstructions from 634 extant prokaryotic ge

217 divided into four major clusters reflecting ancestral relations with other breeds.

218 supporting the general hypothesis of bats as ancestral reservoirs for MERS-CoV.

219 NAs, and those that limit the persistence of ancestral RNAi by, for example, employing negative feedb

220 Together, these results demonstrate an ancestral role for dopamine signaling in tuning spatial

221 ergone a dramatic switch in function-from an ancestral role regulating sporulation to a derived role

222 the possibility that Co cells might have an ancestral role.

223 To explore ancestral roles of brachyury prior to the evolution of d

224 rrection and biochemical characterization of ancestral RuBisCOs, dating back to over one billion year

225 ic functions and reactions have evolved from ancestral scaffolds is fundamental to understanding chem

226 hat modern redistribution is perceived as an ancestral scene involving three notional players: the ne

227 e of the themes might include descendants of ancestral segments.

228 genomes allowed us to estimate a 32 MY old ancestral sequence and reconstruct a functional envelope

229 seven protein sequences were obtained using ancestral sequence reconstruction and can be dated back

230 The method of phylogenetic ancestral sequence reconstruction is a powerful approach

231 f enzyme catalysis in adenylate kinase using ancestral sequence reconstruction spanning 3 billion yea

232 of the ribonuclease H (RNase H) family using ancestral sequence reconstruction to access the evolutio

233 ere we test an alternative approach based on ancestral sequence reconstruction.

234 Ancestral sequence resurrection reveals that this conver

235 ich the main capsid proteins approximate the ancestral sequence state of AAV1, 2, 8, and 9.

236 ickleback also act as reservoirs for ancient ancestral sequences that are highly conserved among dist

237 nearly complete sets of genes present on the ancestral single lineage and presumably perform the same

238 cs survey suggested that Glt1 belongs to the ancestral Skp1 glycosylation pathway in protists and evo

239 ature in Archaean TTGs was inherited from an ancestral source lineage.

240 in the diploid grass, Aegilops tauschii, the ancestral source of D genome in hexaploid bread wheat.

241 ew ecospaces challenges our understanding of ancestral speciation and the relationships of modern spe

242 sive widening of hypomethylated intervals in ancestral species.

243 ntrogressed haplotype likely reintroduced an ancestral splice variant of OAS1 encoding a more active

244 reconstruction suggests that they represent ancestral stages in the evolution of the element.

245 This ancestral starburst appears similar to those being found

246 ng that chloroplast targeting of CA1a is the ancestral state and that loss of a functional chloroplas

247 Ancestral state reconstruction revealed that free-living

248 ches of a phylogeny, which is different from ancestral state reconstruction where the phenotype itsel

249 ppears to enhance the biological validity of ancestral state reconstruction, there has yet to be a co

250 Ancestral state reconstructions in Bayesian phylogeograp

251 Using divergence time estimation and ancestral state reconstructions, we have determined the

252 eny for the subfamily to date, reconstructed ancestral states for geography and biome/habitat, estima

253 rtmentalization was tested by reconstructing ancestral states of characters at the tips using the cri

254 eighboring sites and allows for inference of ancestral states.

255 P correlated with preexisting Ab titer to an ancestral strain Epitope A.

256 evolution disregards any conservation of the ancestral structure and enables the emergence of extensi

257 ut phasing while making no assumptions about ancestral structure, linked selection, or gene conversio

258 Overexpression of the ancestral, susceptible allele provides strong protection

259 Our data suggest that ancestral TBT exposure induces changes in chromatin orga

260 Ancestral TBT exposure induces global changes in DNA met

261 Our results suggest that ancestral TE insertions might have brought in cis-regula

262 me motif module in the in silico constructed ancestral TE that also acted cooperatively to enhance ge

263 e but also on several other antibiotics that ancestral TEM-1 had been unable to deactivate.

264 were identified: quadruplets retaining their ancestral tetraploid condition, semi-quadruplets still r

265 ploidization, doublets were diploidized with ancestral tetraploidy already blurred.

266 ition, semi-quadruplets still reflecting the ancestral tetraploidy with clear signs of advanced redip

267 s derived from an attachment reaction in the ancestral therian mammal which, in the opossum, leads di

268 hich indicates subcortical facilitation, for ancestral threats (snakes, spiders), but not for modern

269 er-order neural mechanisms for processing of ancestral threats across both ontogeny and phylogeny.

270 sm that is specialized for the processing of ancestral threats.

271 n amino acid polymorphism that arose when an ancestral threonine was mutated to alanine, greatly incr

272 nced extensive admixture that reshuffled the ancestral Tibeto-Burman gene pool.

273 evolution that displays a number of features ancestral to arthropods, including short germ embryogene

274 tha longifolia (L.) Huds., a diploid species ancestral to cultivated peppermint and spearmint.

275 ion' between a maternal octoploid progenitor ancestral to extant octoploid strawberries and a paterna

276 retation that the forstercooperiine clade is ancestral to paraceratheriines.

277 marks the appearance of both fossil hominins ancestral to the later Neandertals and the Acheulean tec

278 or two different carotenoid-binding proteins ancestral to the NTD and CTD.

279 ensity-dependent phenotypic plasticity is an ancestral trait for the genus.

280 nmineralised sclerites are plesiomorphic (an ancestral trait) for the molluscan crown.

281 An ancestral translocation or recombination event involving

282 transfer event introduced this gene into an ancestral Treponema well after its divergence from other

283 showed a lower affinity to the helicase than ancestral TrfA1 and were no longer able to activate the

284 e mid-1940s, following the acquisition of an ancestral type I SCCmec element, some 14 years before th

285 enomes against the virus-susceptible, albeit ancestral Tyr529.

286 ntenic) gene copy has generally retained the ancestral ubiquitous expression pattern, most of the nov

287 Here, we use an ancestral variant of GR as a tool to generate a high-res

288 Inferences of the ancestral vertebrate are increasingly complex because th

289 solving a century of debate over whether the ancestral vertebrate bore gills.

290 New research uncovers another ancestral vertebrate character, resolving a century of d

291 eural crest origin of dentine throughout the ancestral vertebrate dermal skeleton.

292 of dedicated lymphopoietic tissues emerge as ancestral vertebrate features, whereas the somatic diver

293 our findings suggest that VWF evolved in the ancestral vertebrate following the divergence of the uro

294 RTANCE Endogenous retroviruses are relics of ancestral virus infections in the human genome.

295 990s, but they are different from both these ancestral viruses and current circulating human seasonal

296 ntigenic difference between A(H3N2)v and the ancestral viruses.

297 and followed the evolutionary trajectory of ancestral W-linked genes across birds.

298 gue divergence in sister lineages sharing an ancestral WGD event.

299 erted duplication of W1-COE and/or W2-COE in ancestral wheat to form evolutionarily young miRNA genes

300 s retained the ancient X Chromosome, but the ancestral Y was replaced by an X Chromosome carrying a n