ライフサイエンスコーパス: ancestry

1 onal galE of the cnl locus suggesting common ancestry.

2 15 126 cases and 95 725 controls of European ancestry.

3 ial distribution of disease by geography and ancestry.

4 tributed ESRD among people of recent African ancestry.

5 D in Choco is correlated with higher African ancestry.

6 son, study site, and principal components of ancestry.

7 haplotypes in people of Amish and Mennonite ancestry.

8 er onto a single population of recent common ancestry.

9 due to the mix of West African and European ancestry.

10 m 11 HapMap populations with a wide range of ancestry.

11 risk of CKD in individuals of recent African ancestry.

12 admixture with early farmers with Anatolian ancestry.

13 viduals, of which 6778 (16%) were of African ancestry.

14 square deviation = 1.8 A), indicating common ancestry.

15 ypic information for individuals of European ancestry.

16 y in allelic effects that is correlated with ancestry.

17 uals of European, Latino, Asian, and African ancestry.

18 inese population than in those with European ancestry.

19 ith 476 cases and 1,733 controls of European ancestry.

20 from among a set of individuals of European ancestry.

21 ion, in over 200,000 individuals of European ancestry.

22 eneity in allelic effects is correlated with ancestry.

23 estry and brown bear genomes with polar bear ancestry.

24 these loci can occur that is correlated with ancestry.

25 from ten independent populations of European ancestry.

26 equency varies by Hispanic/Latino background/ancestry.

27 re assessed in 1,705 individuals of European ancestry.

28 e additional dilution of the Early Neolithic ancestry.

29 urces of self-reported ethnicity and genetic ancestry.

30 ased on our study of individuals of European ancestry.

31 individuals had substantial Native American ancestry.

32 carrying novel material culture and genetic ancestry.

33 ent, complex disorder in elderly of European ancestry.

34 10,784 cases and 20,406 controls of European ancestry.

35 between populations of African and European ancestry.

36 ses were nearly identical, suggesting common ancestry.

37 od in 1748 unrelated individuals of European ancestry.

38 ngs with LQTS in a Spanish family of African ancestry.

39 s from other populations of largely European ancestry.

40 atal D2R were diminished when correcting for ancestry.

41 er, each one connected to a group of admixed ancestry.

42 f 1840 cases and 129016 controls of European ancestry.

43 ease genetics involving populations of Irish ancestry.

44 articipants of the UK Biobank of non-British ancestry.

45 ies across ages, accounting for variation in ancestry.

46 ey disease duration, and genetically defined ancestry.

47 g large-scale GWAS in populations of African ancestry.

48 ases in populations beyond those of European ancestry.

49 basis of the high incidence of SLE in Asian ancestry.

50 of European, African American, and Hispanic ancestry.

51 ,068 cases and 13,104 controls of East Asian ancestry.

52 a total of 149 684 individuals from multiple ancestries.

53 als have different mixtures of these ancient ancestries.

54 nce using ImmunoChip in European and African ancestries.

55 that is seen across individuals of different ancestries.

56 ell as mtDNA, X chromosome, and Y chromosome ancestries.

57 s present homogenous levels of ancient Irish ancestries.

58 om 120 286 unrelated individuals of European ancestry (2987 with AF) in the population-based UK Bioba

59 t) in 88,056 research volunteers of European Ancestry (44,574 females and 43,482 males) from 23andMe

60 l 1300 individuals (600 non-Hispanic African ancestry, 600 non-Hispanic European ancestry, and 100 Hi

61 recruited 206 women (168 [81.6%] of European ancestry; 85 [41.3%] primiparous) in late pregnancy from

62 itional 1497 research volunteers of European Ancestry (891 females and 606 males) from the Brisbane L

63 tions were identified in a proband of French ancestry; a missense (c.37G>A [p.Glu13Lys]) and a nonsen

64 ohorts of European ancestry (EA) and African ancestry (AA).

65 CpGs, respectively, and that shared genomic ancestry accounted for a median of 75.7% (IQR 45.8% to 9

66 le of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Con

67 sed on the detection of large blocks of each ancestry across each chromosome.

68 BS, that uses a hidden Markov model to infer ancestry across hybrid genomes without requiring variant

69 wever, the distribution of African and Asian ancestry across the island reveals that the admixture wa

70 ase and 132,532 control subjects of European ancestry after imputation using the 1000 Genomes multiet

71 African ancestry alleles may contribute to CKD among Hispanics/L

72 d sources and proportions of hunter-gatherer ancestry among the three regions and through time.

73 These interactions are different across ancestries and can lead to the same number of identified

74 ficients ranging from 0.522 to 0.962 between ancestries and language families or branches.

75 ary motor neuropathy pedigree with different ancestries and one additional Belgian distal hereditary

76 de the smaller sample sizes for non-European ancestries and the inability to classify approximately o

77 2,977 cases and 105,974 controls of European ancestry and 14,068 cases and 13,104 controls of East As

78 Combining both local ancestry and allele frequency based analyses, we identif

79 Fish from the trade sites show a mixed ancestry and are statistically differentiated from local

80 ets: European human genomes with Neanderthal ancestry and brown bear genomes with polar bear ancestry

81 sults represent only individuals of European-ancestry and clinically diagnosed individuals, and that

82 the traits, their predictive accuracy beyond ancestry and demographic information is limited.

83 Little however is known about the ancestry and history of Russian native cattle.

84 omozygous c.321+1G>T in a subject of Italian ancestry and homozygous c.322-10G>A in affected sibling

85 Ancestry and Kinship Toolkit (AKT) is a statistical gene

86 data has also been extended with structured ancestry and recruitment information added for all studi

87 Additional analyses adjusted for genetic ancestry and selected covariates.

88 Differences in genetic ancestry and socioeconomic status (SES) among Latin Amer

89 pproach to investigate the role that genetic ancestry and socioeconomic status (SES) play in the epid

90 nvestigated the relationship between genetic ancestry and striatal D2R.

91 iseases among 138511 individuals of European ancestry and systemically investigated pleiotropy betwee

92 is driven by a difference between Amerindian ancestry and the other two ancestries (P<5.7 x 10(-5)).

93 African ancestry, 600 non-Hispanic European ancestry, and 100 Hispanic) who meet rigorous clinical c

94 justing for sex, age, study design features, ancestry, and kinship and employed a conventional P < 5

95 the consortia, participants were of European ancestry, and the prevalence of men was approximately 50

96 lation has the highest proportion of African ancestry ( approximately 98%) of any African-descendant

97 th Asian, African, and Hispanic descent (pan-ancestry, approximately 475 000), and the other in the s

98 components of geographically defined African ancestry are associated with hereditary susceptibility f

99 ed that advanced age, male sex, and European ancestry are prominent AF risk factors.

100 We estimate that this Eurasian ancestry arrived in the Levant around 3,750-2,170 years

101 stantially more European and Native American ancestry as a result of their complex admixture historie

102 isolation over 25 generations through strong ancestry-assortative mating.

103 To enable direct comparison of ancestry background in different studies, we developed L

104 Our results suggest a shared ancestry between most of the Russian cattle and European

105 is partially explained by the shared genetic ancestry but that environmental factors not captured by

106 ival of new people with predominantly Steppe ancestry but whose ancestors had undergone sex-specific

107 ied in populations of predominantly European ancestry, but few loci have been associated with IBD in

108 ct groups that did not share a recent common ancestry, but rather one much deeper in time at the entr

109 disproportionately affects women of African ancestry, but well-powered studies to explore difference

110 s, we developed LASER to estimate individual ancestry by placing either sezquenced or genotyped sampl

111 tive value (PPV) or challenge, corrected for ancestry by principal components.

112 detect related samples, characterize sample ancestry, calculate correlation between variants, check

113 People of African ancestry carrying certain APOL1 mutant alleles are at el

114 Furthermore, PRS distinguished European ancestry case subjects who went on to acquire a schizoph

115 st-Neolithic Levantine- and Caucasus-related ancestries, compatible with maritime Bronze-Age migratio

116 In most cases, ancestry components are inferred correctly, although sam

117 and the Gaussian assumption for identifying ancestry components correctly and for inferring the corr

118 duals in a sample fractionally into discrete ancestry components.

119 tially lower error in reconstructing spatial ancestry coordinates compared to PCA.

120 so develop an association test that uses the ancestry coordinates inferred by GAP to accurately accou

121 Two graders masked to clinical and ancestry data reviewed and graded the baseline and last

122 Ancestry data support the grouping of Kwadi-Khoe, Kx'a,

123 Ancestry data yield insight into a deeper past than ling

124 an, while linguistic data provide clarity to ancestry data.

125 across the three ancestries identifies both ancestry-dependent and ancestry-independent contribution

126 This Canaanite-related ancestry derived from mixture between local Neolithic po

127 en this CRC risk haplotype and local African ancestry dosage was identified in locus 2q14 (p = 0.03).

128 uman populations is influenced by geographic ancestry due to spatial locality in historical mating an

129 % of individuals who indicated Mediterranean ancestry during consultation self-reported this on requi

130 erum 1,5-AG concentrations in 7,550 European ancestry (EA) and 2,030 African American participants (A

131 interval in 2 real-world cohorts of European ancestry (EA) and African ancestry (AA).

132 that agree with published results and global ancestry estimates in humans.

133 The server provides genetic ancestry estimation for different geographic regions and

134 rsus other psychoses in European and African ancestry FEP patients and in a second sample of 248 case

135 horts with 460 791 individuals from multiple ancestries, focused analysis is performed for a subset o

136 with European American and African American ancestry followed by metaanalysis.

137 04 FECD cases and 2,564 controls of European ancestry, followed by replication and meta-analysis, for

138 ning model trained on individuals of diverse ancestries from the 1000 Genomes Project reference panel

139 ations among 29,155 participants of European ancestry from 13 cohort studies (n=22,653 and n=6502 in

140 on among up to 4,513 individuals of European ancestry from 4 cohorts suggested that methylation at cg

141 at present-day Lebanese derive most of their ancestry from a Canaanite-related population, which ther

142 differed from Minoans in deriving additional ancestry from an ultimate source related to the hunter-g

143 r studies of 70,017 participants of European ancestry from general and clinical populations in the di

144 s shared across six populations of different ancestry from non-eQTL SNVs with an AUC of 0.939.

145 lar, having at least three-quarters of their ancestry from the first Neolithic farmers of western Ana

146 , 17 832 controls) predominantly of European ancestry from the International Age-related Macular Dege

147 16, among 1657 participants of white British ancestry from the TwinsUK study cohort without ocular pa

148 P in studies of European, African, and Asian ancestry generalize to Hispanics/Latinos.

149 udies of individuals of European and Chinese ancestries generalized, while only a single association

150 t of variant calls obtained from 642 African-ancestry genomes from the Consortium on Asthma among Afr

151 n additional 828 control subjects of African ancestry genotyped on the Illumina Multi-Ethnic Genotypi

152 686 T2D and 194 non-T2D subjects of Mexican ancestry genotyped using the Affymetrix Genome-Wide Huma

153 l analyses were performed separately in each ancestry group and then meta-analysed.

154 th atrial fibrillation in European and Asian ancestry groups.

155 nderlying causal variants are shared between ancestry groups.

156 gression of glaucoma differs between these 2 ancestry groups.

157 etic factors affecting susceptibility across ancestry groups.

158 cotine dependence and the largest-ever cross-ancestry GWAS meta-analysis for any smoking phenotype, w

159 To examine the transferability of single-ancestry GWASs, we used published summary statistics to

160 Genetic ancestry has been suggested as an alternative to this ca

161 and Portuguese [29, 32-35] and whose genetic ancestry has individual variation in European and contin

162 rring local ancestry in individuals of mixed ancestry has many applications, most notably in identify

163 black versus white'), individuals of African ancestry have a globally increased risk of malignancies

164 Healthy individuals of African ancestry have neutropenia that has been linked with the

165 Adjusting for HLA-DR-DQ and ancestry, higher childhood 25(OH)D was associated with l

166 Comparing results across the three ancestries identifies both ancestry-dependent and ancest

167 rgely skewed towards populations of European ancestry, imparting less attention to South Asian popula

168 ve mixed ancestry, with evidence of multiple ancestries in 96.8% of samples and on all continents.

169 lts show major Western hunter-gatherer (WHG) ancestry in a Romanian Eneolithic sample with a minor, b

170 r data thus suggest that the Native American ancestry in contemporary Easter Islanders was not presen

171 urobiology, and systems biology each has its ancestry in developmental biology.

172 They reflect eastern Eurasian ancestry in having low, sagittally flat, and inferiorly

173 tween urine albumin excretion and Amerindian ancestry in Hispanic/Latino populations.

174 Inferring local ancestry in individuals of mixed ancestry has many appli

175 AD-LIBS correctly infers 87-91% of ancestry in simulations and produces ancestry maps that

176 r the experimental reconstruction of protein ancestry in the absence of phylogenetic evidence.

177 In addition, we find Eurasian ancestry in the Lebanese not present in Bronze Age or ea

178 el was correlated significantly with genetic ancestry in the Southeast Asian population.

179 We then use AD-LIBS to infer ancestry in two published data sets: European human geno

180 and VNB), some haploid isolates show hybrid ancestry including some that appear to have recently int

181 tries identifies both ancestry-dependent and ancestry-independent contributions to SLE risk.

182 ility of case-control status in FEP European ancestry individuals (9.4% of the variance explained, p

183 te association results from 104 452 European-ancestry individuals from 30 cohorts, genotyped using th

184 Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lea

185 es inferred by GAP to accurately account for ancestry-induced correlations in GWAS.

186 ed local European ancestry (LEA) using Local Ancestry inference in adMixed Populations using Linkage

187 T provides convenience to run multiple local ancestry inference software.

188 ize inference results for four popular local ancestry inference software: HAPMIX, LAMP, LAMP-LD, and

189 AD-LIBS is an effective tool for ancestry inference that can be used even when few indivi

190 We developed a tool set, Local Ancestry Inference Toolkit (LAIT), which can convert sta

191 d an existing software application for local ancestry inference, HAPMIX.

192 Here, we show that ancestry-informative markers significantly predict dorsa

193 eate fictitious associations when population ancestry is correlated with both the genotype and the tr

194 tent to which they involve change in genetic ancestry is not fully understood due to the lack of rele

195 n individuals because of their recent common ancestry is now routinely estimated from marker genotype

196 METHODS AND We estimated local European ancestry (LEA) using Local Ancestry inference in adMixed

197 ting up to 2% of individuals of Puerto Rican ancestry, leading to a better understanding of the conti

198 ociated with higher intelligence, East Asian ancestry, male sex, younger age, formal music training-e

199 We validate AD-LIBS polar bear ancestry maps by recovering a geographic signal within b

200 -91% of ancestry in simulations and produces ancestry maps that agree with published results and glob

201 ancestry sample of 2,434 TS cases and 4,093 ancestry-matched controls for rare (< 1% frequency) copy

202 in more than 30000 cases and more than 45000 ancestry-matched controls.

203 GWAS in 113 European-American cases and 5109 ancestry-matched controls.

204 cer, including 154 black patients of African ancestry (mean [SD] age at diagnosis, 55.66 [13.01] year

205 ] female) and 776 white patients of European ancestry (mean [SD] age at diagnosis, 59.51 [13.11] year

206 ibrillation, we performed large-scale, trans-ancestry meta-analyses of common and rare variant associ

207 Global Lipids Genetics Consortium in a trans-ancestry meta-analysis.

208 Furthermore, the use of an ancestry model would allow better estimation of carrier

209 Himalayan Tibeto-Burmans derived East Asian ancestry not from the Tibetan/Sherpa lineage, but from l

210 ude between five to 10 % of Central Siberian ancestry, not present at this level in their European co

211 ave identified three potential mtDNA lineage ancestries of the NPR Scythians tracing back to hunter-g

212 estern central African Bantu speakers to the ancestry of African Americans, whose genomes present no

213 Inferring the ancestry of each region of admixed individuals' genomes

214 compelling evidence for the ancient chimeric ancestry of eukaryotes.

215 contributing approximately two-thirds of the ancestry of Malawi hunter-gatherers approximately 8,100-

216 years ago and approximately one-third of the ancestry of Tanzanian hunter-gatherers approximately 1,4

217 divergent lineage that comprises the primary ancestry of the southern African San had a wider distrib

218 uces chondroitin sulfate and thus extend the ancestry of this important glycosaminoglycan to the prem

219 Here, we investigate the genetic ancestry of wild rice by analyzing a diverse panel of ri

220 1c to diagnose T2D in populations of African ancestry or groups where G6PD deficiency is common.

221 D2 receptor genes should covary for genetic ancestry or study homogeneous populations.

222 s cell carcinomas with genetically supported ancestry, overall mutational frequencies and copy number

223 etween Amerindian ancestry and the other two ancestries (P<5.7 x 10(-5)).

224 r filtration rate (eGFR) in 110,517 European ancestry participants using 1000 Genomes imputed data.

225 tment for individual proportions of European ancestry (PEA), socio economic status (SES), body mass i

226 We find evidence that some hunter-gatherer ancestry persisted across the Neolithic transition in bo

227 ery few loci have been replicated in African ancestry populations and the identification of the impli

228 of this human evolutionary history, African ancestry populations have the greatest genomic diversity

229 from the Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA), sequenced

230 show that while genomic research in African ancestry populations is still in early stages, there are

231 er populations, and diversity within African ancestry populations precludes summarizing risk across d

232 ancers (TNBCs) are more common among African-ancestry populations, such as African Americans and west

233 ne-mapping of loci discovered in other human ancestry populations.

234 for erythrocyte traits in primarily European ancestry populations.

235 sub-Saharan Africans, compared with European-ancestry populations.

236 sk for kidney disease in sub-Saharan African ancestry populations.

237 to the burden of breast cancer among African-ancestry populations.

238 Our algorithm Geographic Ancestry Positioning (GAP) relates local genetic distanc

239 ng post-test genetic counseling, and genetic ancestry predicted by a statistical model, were compared

240 d genotype data, to characterize the genetic ancestry profiles of 631 individuals from 51 southern Af

241 that Colombian individuals with high African ancestry proportions at locus 2q14 harbour more IL1B-CGT

242 Ancestry proportions revealed putative hybrids of P. leu

243 f batch effects and covariates age, sex, and ancestry proportions.

244 10(-6)), but lower in individuals of African ancestry (R(2) = 1.1%, p = .004).

245 ation study in patients with IPF of European ancestry recruited from nine different centres in the UK

246 e sexual orientation on a primarily European ancestry sample of 1,077 homosexual men and 1,231 hetero

247 We analyzed a European ancestry sample of 2,434 TS cases and 4,093 ancestry-mat

248 (PRS) and AD case-control status in European ancestry samples from 4 independent genome-wide associat

249 er baseline covariate-adjustment for genetic ancestry, sex, age, weight, injection drug use history,

250 t that environmental factors not captured by ancestry significantly contribute to variation in methyl

251 ition, we evaluated the performance of local ancestry software among different supported software pac

252 sezquenced or genotyped samples in a common ancestry space, regardless of the sequencing strategy or

253 vel independent signal suggesting an African ancestry-specific allele at KCNQ1 for T2D.

254 e already many examples of novel and African ancestry-specific disease loci that have been discovered

255 ABO non-secretor genotypes for two ancestry-specific FUT2 SNPs showed strong disease associ

256 lude that there is a need to account for the ancestry-specific influence of demography on genomic arc

257 t signal at KCNQ1, represented by an African ancestry-specific variant, rs1049549 (odds ratio 1.49 [9

258 ng Cochran-Mantel-Haenszel test adjusted for ancestry strata.

259 Moreover, ancestry studies on human neurobiology should control fo

260 s on 31 data sets containing 38 802 European ancestry subjects genotyped for 5-HTTLPR and assessed fo

261 body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean

262 ividuals with a higher proportion of African ancestry, such as individuals from the Coastal Colombian

263 r data to those from individuals of European ancestry, suggesting that there might be different genet

264 In brown bears, we find more polar bear ancestry than has been published previously, using both

265 The best evidence supports 21 ancestries that delineate genetic structure of present-d

266 ia are ATP-producing organelles of bacterial ancestry that played a key role in the origin and early

267 se with whom we share the most recent common ancestry, thus offering clues to the origins of our own

268 Western Siberians trace 57% of their ancestry to ancient North Eurasians, represented by the

269 Guanches have contributed 16%-31% autosomal ancestry to modern Canary Islanders, here represented by

270 s comparing the stated sex, relatedness, and ancestry to what is inferred from the individual genotyp

271 nimal nociceptive systems may share a common ancestry, tracing back to a progenitor that lived more t

272 In populations of African ancestry, two apolipoprotein-L1 (APOL1) variants with a

273 duals from European, East Asian, and African ancestries using a Bayesian approach to account for hete

274 Peddy predicts a sample's ancestry using a machine learning model trained on indiv

275 mples obtained from 43,568 women of European ancestry using gestational duration as a continuous trai

276 Information on genetic ancestry was derived using principal component analysis.

277 t were estimated to have a different genetic ancestry was found to depend on the source of self-repor

278 ing strong evidence that Iranian Zoroastrian ancestry was maintained primarily through the male line.

279 Stratifying by ancestry, we analysed genotyped and imputed variants in

280 aits in up to 53,174 individuals of European ancestry, we detect 17 genome-wide significant SNPs in e

281 In participants of the UK Biobank of British ancestry, we found that variants that delay puberty timi

282 ropean, African, East Asian, and South Asian ancestry, we identified 60 common genetic variants assoc

283 tion study of 16,596 individuals of European ancestry, we obtained summary statistics for four indepe

284 ntified ethnicity and genetically determined ancestry were each significantly associated with methyla

285 ality rates are highest among men of African ancestry when compared with other men, both in the Unite

286 Group I CPNs have a bacterial ancestry, whereas Group II CPNs are archaeal in origin.

287 samples from white participants of European ancestry who had been diagnosed with dementia with Lewy

288 d East Asian populations shared 38% of their ancestry with a 45,000-yr-old Ust'-Ishim individual who

289 e last extant Archosaurians and share common ancestry with all extinct dinosaurs, our findings suppor

290 r alleles among patients of Ashkenazi Jewish ancestry with breast cancer.

291 e) among UK Biobank participants of European ancestry with independent replication in other cohorts,

292 uity with each other and predominantly share ancestry with modern European dogs, contradicting a prev

293 study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and leg

294 es reveal that ancient Egyptians shared more ancestry with Near Easterners than present-day Egyptians

295 breeds, apart from a few breeds that shared ancestry with the Asian taurines.

296 n of European, African, Hispanic and Chinese ancestry, with and without sex stratification, for six t

297 t majority (97.3%) of individuals have mixed ancestry, with evidence of multiple ancestries in 96.8%

298 -genetic variation owing to heterogeneity in ancestry within admixed groups [25, 26] and idiolectal v

299 rth-West French-like and West Norwegian-like ancestry within Ireland.

300 We identified 51 646 individuals of European ancestry without AF at baseline from 7 prospective popul