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1 type II PKA interaction with AKAPs (A-kinase anchoring proteins).
2 ity with an IC(50) of 811 +/- 0.56 nM of the anchoring protein.
3 xR/KxR/K) in the first 44 amino acids of the anchoring protein.
4 he PP1 catalytic subunit copurified with the anchoring protein.
5 r a flexible cross-linking, scaffolding, and anchoring protein.
6 ing protein, BIG2, which is also an A kinase-anchoring protein.
7 d by the AKAP9 (Yotiao) multi-functional PKA anchoring protein.
8 g proteins, and myosin is a protein kinase G-anchoring protein.
9 -1070) interfaces directly with sites on the anchoring protein.
10 x formation between group I mGluRs and their anchoring proteins.
11 cadherins and their associated cytoskeletal anchoring proteins.
12 rected in large part by distinct scaffold or anchoring proteins.
13 P-dependent protein kinase (PKA) through its anchoring proteins.
14 otemporal signaling is largely controlled by anchoring proteins.
15 of scaffold proteins referred to as A-kinase anchoring proteins.
17 here the N0 area homologous to dual A-kinase-anchoring protein-1 or the acyl-CoA signature motif were
18 ATR-S435A construct or deletion of A kinase-anchoring protein 12 (AKAP12) impeded platinum adduct cl
22 tudies, we demonstrate that protein kinase A anchoring protein 13 (AKAP13), a scaffold protein with G
24 iation with IPF susceptibility near A-kinase anchoring protein 13 (AKAP13; rs62025270, odds ratio [OR
27 This autoinhibitory complex, with A-kinase anchoring protein-15 (AKAP15) bound to the DCT, is hypot
28 argeted to GluA1 through binding to A-kinase anchoring protein 150 (AKAP150) in a complex with PSD-95
31 cultures because of its binding to A kinase-anchoring protein 150 (AKAP150), a scaffold for specific
33 ising adenylyl cyclase 5/6 (AC5/6), A-kinase anchoring protein 150 (AKAP150), and protein kinase A.
35 sensitization of TRPV1 activity by A-kinase anchoring protein 150 demonstrates a critical role for s
36 t al illustrate the significance of A-kinase anchoring protein 150 in tethering protein phosphatase 2
37 mplex containing PKA and I-1 by the A-kinase anchoring protein 18 (AKAP18) facilitates this regulatio
38 ban in a complex that also contains A-kinase anchoring protein-18, protein kinase type A-RII, and pro
39 rom Ile to Val in the dual-specific A kinase-anchoring protein 2 (d-AKAP2) gene, showed the strongest
42 mechanism are under the control of A-Kinase Anchoring Protein 220 (AKAP220; product of the Akap11 ge
45 egions of intrinsic disorder within A-kinase anchoring protein 79 (AKAP79) delineates PP2B access to
48 The multivalent neuronal scaffold A-kinase-anchoring protein 79 (AKAP79) is known to bind PKC and i
49 g the interaction between TRPV1 and A kinase anchoring protein 79 (AKAP79), a scaffolding protein ess
50 coimmunoprecipitated with B-Raf and A-kinase anchoring protein 79, and AVP increased this interaction
56 ted protein 97 (SAP97) that contain A-kinase anchoring protein 79/150 (AKAP79/150), protein kinase A,
58 required the binding of the protein kinase A anchoring protein-79 (AKAP79) to the carboxyl terminus o
59 ic deletion of the scaffold protein A kinase anchoring protein 9 (AKAP9) and use models of inflammato
60 ree alleles of the widely expressed A-kinase anchoring protein 9 (Akap9) gene, all of which cause gam
61 In the present study, we identified A-kinase-anchoring protein 95 (AKAP95) as a caspase 3-binding pro
62 e identified cAMP-dependent protein kinase A anchoring protein 95 kDa (AKAP95) as a potential fidgeti
63 ent, screening, and discovery of (novel) PKA anchoring proteins, a plethora of methodologies is avail
64 this report we demonstrate that the A-kinase anchoring protein AKAP-Lbc assembles an activation compl
65 that, in combination with a protein kinase A anchoring protein (AKAP 95) and CSR-BPs participate in f
66 uding SAP97 and PSD-95, and protein kinase A-anchoring protein (AKAP) 5 in the plasma membrane in a P
67 motif with SAP97 and protein kinase A (PKA)-anchoring protein (AKAP) 5, which anchor the receptor in
68 tion with the PKC-targeting protein A-kinase anchoring protein (AKAP) 79 and interferes with ionomyci
69 /calcineurin (CaN) scaffold protein A-kinase anchoring protein (AKAP) 79 is localized to excitatory n
71 f the AMPAR-linked scaffold protein A-kinase anchoring protein (AKAP) 79/150 is required for its targ
74 Here, we assessed the role of BIG2 A kinase-anchoring protein (AKAP) domains in the regulation of TN
75 e include the presence in BIG2 of 3 A kinase-anchoring protein (AKAP) domains, one of which is identi
76 protein NSF, and two members of the A kinase-anchoring protein (AKAP) family were found to be tyrosin
78 c, and proto-Lbc), a unique protein kinase A-anchoring protein (AKAP) guanine nucleotide exchange reg
79 DE4), protein kinase A (PKA) or PKA/A-kinase anchoring protein (AKAP) interaction blocked an immediat
82 en identified by RII overlays as an A-kinase anchoring protein (AKAP) that localizes the cAMP-depende
85 silencing approaches identified the A-kinase anchoring protein (AKAP) WAVE1 as an effector of OxPL ac
86 ) and beta-subunits (KCNE1) and the A kinase-anchoring protein (AKAP) Yotiao (AKAP-9), which recruits
91 ss spectrometry, we have identified A kinase-anchoring protein (AKAP)150 and the protein phosphatase
98 on domain to interact with multiple A-kinase anchoring proteins (AKAP) that localize it to different
99 tep mechanism that links rut-AC1 to A-kinase anchoring proteins (AKAP)-sequestered protein kinase A a
100 We further find that a specific A-kinase anchoring protein, AKAP-Lbc, is a major contributor to t
101 rotein kinase (PKA) anchored via an A-kinase anchoring protein (AKAP15), and the most rapid sites of
105 veal that ablation of the kinase/phosphatase anchoring protein AKAP150 impairs insulin secretion in m
106 emonstrate the critical role of the A-kinase anchoring protein AKAP150 in PKA-dependent modulation of
107 was found to be associated with the A kinase anchoring protein AKAP150 suggesting the existence of a
108 and Cbeta, with or without the prototypical anchoring protein AKAP18alpha, revealed that the dimeriz
109 We have discovered that the protein kinase A anchoring protein AKAP220 interacts with the cytoskeleta
110 we demonstrate an essential role for the PKA anchoring protein, AKAP7, in mouse MF axons and terminal
111 e plasma membrane via the involvement of the anchoring protein AKAP79, which is constitutively associ
114 ffolded to Ca(V)1.2 channels by the neuronal anchoring protein AKAP79/150, and that overexpression of
115 orming alpha subunit of BKCa and an A-kinase-anchoring protein (AKAP79/150) for beta2 agonist regulat
117 s, we show that the plasma membrane targeted anchoring protein AKAP9/Yotiao displays unique specifici
126 ulatory type II (RII) subunits with A-kinase-anchoring proteins (AKAPs) confers location, and catalyt
131 ent protein kinase (PKA) by protein kinase A-anchoring proteins (AKAPs) facilitates local protein pho
135 s and peptide disruptors of protein kinase A anchoring proteins (AKAPs) implicated PKA regulatory sub
136 cludens-1 (PDZ)-domain proteins and A-kinase anchoring proteins (AKAPs) increased receptor diffusion,
139 disruption of the binding of PKA to A-kinase anchoring proteins (AKAPs) inhibited currents through AR
140 ation of protein kinase A (PKA) via A-kinase-anchoring proteins (AKAPs) is important for cAMP respons
141 sation of Protein Kinase A (PKA) by A-Kinase Anchoring Proteins (AKAPs) is known to coordinate locali
158 pore-forming subunit is promoted by A-kinase anchoring proteins (AKAPs) that target cAMP-dependent pr
159 means, signaling scaffolds, such as A-kinase anchoring proteins (AKAPs), compartmentalize kinase acti
161 yeloid translocation gene family of A kinase anchoring proteins (AKAPs), regulates repulsive axon gui
162 lar compartments through binding to A-kinase-anchoring proteins (AKAPs), RI subunits are primarily di
163 strates by interacting with protein kinase A anchoring proteins (AKAPs), the present study was undert
185 ivity or disrupting PKC association with its anchoring protein also significantly reduced the D1 effe
186 II PKA holoenzyme, whereas dual-specificity anchoring proteins also bind the type I (RI) regulatory
187 ensity protein-95 (PSD-95), a putative NMDAR anchoring protein and core component of the PSD, at exci
188 agment uncouples AC5/6 interactions with the anchoring protein and prevents PKA-mediated inhibition o
190 domain, which shares homology with A-kinase anchoring proteins and interacts with the regulatory sub
191 -Aldrich family member WAVE-1 as an A kinase anchoring protein, and glucokinase (hexokinase IV).
193 ther proteins such as R7-binding protein, R9-anchoring protein, and the orphan receptors GPR158 and G
194 t protein kinase G through interactions with anchoring proteins, and myosin is a protein kinase G-anc
195 4 integrins are type I PKA-specific A-kinase anchoring proteins, and we now find that type I PKA is i
196 NaKA), the Na(+) channel NaV1.6, and the AIS anchoring protein ankyrin-G, as well as an increase in l
197 tebrate AIS as judged by accumulation of the anchoring protein Ankyrin1, presence of a specialized ac
198 st MetRS is part of a complex containing the anchoring protein Arc1p and the glutamyl-tRNA synthetase
200 Of importance, we illustrated that A-kinase anchoring proteins are crucial for BCAM/Lu receptor acti
201 N-terminal kinase (JNK), Bax, and the 14-3-3 anchoring proteins, as well as the responsiveness of the
202 ardiac myocytes, the muscle protein kinase A-anchoring protein beta (mAKAPbeta) coordinates cAMP-depe
203 ts that the scaffold protein muscle A-kinase anchoring protein beta (mAKAPbeta) serves as a nodal org
205 iquitination and degradation of crucial NR2B-anchoring proteins by the ubiquitin-proteasome system.
207 equence of forming this aberrant ion channel-anchoring protein complex is enhanced Ca(V)1.2-LQT8 curr
209 unofluorescence techniques, we show that the anchoring protein contributes to PKD activation in two w
210 ses, understanding the role of accessory and anchoring proteins could provide insights into pathogeni
211 The anchoring of PKA to AKAPs (A kinase-anchoring proteins) creates compartmentalized pools of P
212 of posttranslational modifications on the IF-anchoring protein desmoplakin (DP) that play an essentia
213 KAP79 on PP1 are substrate dependent, as the anchoring protein did not inhibit PP1 dephosphorylation
216 ized active epsilonPKC when not bound to its anchoring protein epsilonRACK (receptor for activated C-
217 ced translocation of both epsilonPKC and its anchoring protein, epsilonRACK to a new cytosolic site.
218 igate ternary complex with Npt2a and the PKA-anchoring protein ezrin to facilitate PTH-responsive cAM
220 decarboxylase (GAD); GABA transporter 1; the anchoring protein for GABA and glycine receptors, gephyr
221 decarboxylase (GAD); GABA transporter 1; the anchoring protein for GABA and glycine receptors, gephyr
222 that dynein light chain 1 represents a novel anchoring protein for RasGRP3 that may regulate subcellu
225 we will focus on the description of A-kinase anchoring protein function in the regulation of cardiac
226 This occurs through a mechanism whereby the anchoring protein functions like a subunit of Ca(V)1.2-L
227 e in brain AC activity, indicating that this anchoring protein functions to directly regulate cAMP pr
229 (A)R-subunits, GlyR alpha1-subunit and their anchoring protein, gephyrin, on terminals of rat spinal
230 on and association with isoform-specific PKG-anchoring proteins (GKAPs), which target the kinase to s
234 disruption of GluR2 binding to its synaptic anchoring protein (GRIP), resulting in a switch of GluR2
236 pathogen adhesins and host glycosaminoglycan-anchoring proteins (heparan sulfate proteoglycans) has l
238 activated C kinase 1 (RACK1), a scaffolding/anchoring protein implicated in various cellular functio
240 g cells and to uncover the role of clustered anchoring proteins in organizing these activity microdom
241 ity or its ability to interact with A kinase anchoring proteins inhibited the activity of the Rac GTP
242 protein kinase A inhibitors, and an A-kinase anchoring protein inhibitor significantly blocked seroto
245 sphatases to a seven-residue sequence of the anchoring protein is the predominant molecular event und
246 pendent protein kinase with protein kinase A-anchoring proteins is well described and involves a kina
247 t NHERF2, acting as a novel protein kinase G-anchoring protein, is required for cGMP inhibition of NH
249 s in the compartmentation of cAMP signaling, anchoring protein kinase A (PKA) to specific cellular or
250 with a transmembrane protein, R9AP (for RGS9 anchoring protein), known to anchor RGS9 on the surface
252 t while still interacting with the chromatin-anchoring protein LEDGF at a distinct surface formed by
253 reviously described how the protein kinase A-anchoring protein mAKAP serves as a scaffold for the cAM
255 x maintained by the muscle-specific A-kinase anchoring protein (mAKAP) that includes PKA, PDE4D3 and
256 silon scaffolded to muscle-specific A kinase-anchoring protein (mAKAP), along with PKCepsilon and PKD
258 be scaffolded to a muscle-specific A kinase anchoring protein (mAKAPbeta) in heart and NRVMs, and mA
259 drial recruitment, association with the Drp1-anchoring protein Mff (mitochondrial fission factor), an
261 rly, Homer1b/c proteins, which are prominent anchoring proteins of mGluR1/5 and are highly expressed
265 nsistent with a role for BIG2 as an A kinase-anchoring protein (or AKAP) that could coordinate cAMP a
266 anchoring using a competing muscle A-kinase anchoring protein peptide inhibited the hypertrophy of c
268 sistent with the suggestion of a DNA-binding anchoring protein present at these sites, although such
269 ow that the Rho-GTPase Rac contains A-kinase anchoring protein properties and forms a dynamic cellula
270 ent of its regulatory subunit or an A-kinase anchoring protein, providing an additional mechanism to
273 d AKAP150(-/-) mice reveals that loss of the anchoring protein results in decreased AMPA receptor-ass
274 lated binding of RSK3 to the muscle A-kinase anchoring protein scaffold, defining a novel kinase anch
275 KAP-Lbc in which increased expression of the anchoring protein selectively amplifies a signaling path
277 e and amplify the intracellular PKA-A-kinase anchoring protein signaling network and suggests a new s
278 all sacculi retain a functional form of this anchoring protein such that purified fibres can be ancho
279 -tubule complexity and reduced expression of anchoring proteins such as junctophilin-2 (Jph2) that no
280 eleted a major neuron-specific mitochondrial anchoring protein Syntaphilin (SNPH) from the mouse.
281 iggered by the bulk release of mitochondrial anchoring protein syntaphilin via a new class of mitocho
282 to another, and binding to isozyme-specific anchoring proteins termed RACKs, accompany protein kinas
284 I3K heterodimer and IRS-1, it is an A-kinase anchoring protein that binds the type I regulatory subun
285 oring protein 220 (AKAP220) is a multivalent anchoring protein that can sequester a variety of signal
286 hat the N-terminal patch binds to an unknown anchoring protein that is produced under the control of
288 a multiply spliced type II protein kinase A anchoring protein that localizes to the centrosomes in m
289 ase anchoring protein 79 (AKAP79) is a human anchoring protein that organizes cAMP-dependent protein
290 provide strong evidence that p23 acts as an anchoring protein that retains PKCdelta at the perinucle
291 y a mechanism that is distinct from A-kinase anchoring proteins that interact with the regulatory sub
292 voltage-gated Nav1.6 and Kv7.3 subunits and anchoring proteins to analyze the functional and structu
293 ich are often spatially compartmentalized by anchoring proteins to increase signalling specificity.
294 ion: RAB32, a ras family member and A-kinase-anchoring protein, was methylated in 14 of 25 (56%) MSI-
295 ither freely diffusible or bound to A kinase anchoring proteins, we demonstrate that the difference i
296 rning the localization of PopZ, a chromosome-anchoring protein whose unipolar to bipolar localization
298 member of a large family of protein A-kinase anchoring proteins with important roles in the organizat
299 dal binding groups address this challenge by anchoring proteins without loss of function and without
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