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2 magnitude of the resulting immune response, and as such, a better understanding of these events coul
3 pleted, precision oncology remains unproven, and as such, a hypothesis in need of rigorous testing.
4 defining signature of aggregation-prone tau, and as such, a possible target for therapeutic intervent
5 he ligand specificity of individual NK cells and as such, a subset of NK cells can respond, expand, a
7 5beta1, the primary receptor for fibronectin and, as such, a crucial determinant for the characterist
8 reflects that seen in "proto-Kranz" species, and, as such, a key step toward engineering C4 rice has
9 e tracking of locally common host genotypes, and, as such, a necessary condition of the Red Queen hyp
12 rm enabling LC-MS-based proteomic workflows, and as such, addresses an unmet need in the LC-MS proteo
13 he was America's pioneer surgical historian and, as such, afforded surgeons their earliest measure o
14 ctively powered for statistical comparisons, and as such, all the analyses are descriptive in nature.
15 ural production center for the global market and, as such, an important source of greenhouse gas (GHG
16 such as that observed in Williams syndrome, and, as such, animal models involving vitamin D intoxica
17 and human tBregs express low levels of CD20 and, as such, anti-CD20 mostly enriches for these cells.
18 l carbon losses through the aquatic pathway, and as such, aquatic exports are fundamental to the unde
19 rmation is relayed within the nervous system and as such, are essential for normal neurological funct
20 are important sites of tertiary interaction and as such, are integral to RNA macromolecular structur
21 ith opposite experience-dependent plasticity and as such, are well positioned to foster experience-de
22 of the ionic atmosphere around nucleic acids and, as such, are a natural route for testing quantitati
24 key roles in many Ca(2+) signaling pathways and, as such, are emerging novel therapeutic and insecti
25 chemical fuels into useful electrical energy and, as such, are expected to play a major role in a sus
26 ly specific biosynthesis of glycosidic bonds and, as such, are important both as drug targets and for
27 nsposons are closely related to retroviruses and, as such, are important models for the study of vira
28 s are the co-ordinators of the immune system and, as such, are important targets for immunomodulation
29 rees of freedom to the conduction electrons, and, as such, are intimately related to the low temperat
30 e host when administered in adequate amounts and, as such, are labeled "probiotics." We review some o
31 idespread invasion and resistance to therapy and, as such, are managed clinically as if they are one
32 t also affect performance at work and school and, as such, are members of the group of severe allergi
33 en transmembrane receptor (7-TM) superfamily and, as such, are part of one of the largest mammalian m
34 ate transcription in response to fatty acids and, as such, are potential therapeutic targets for thes
36 ed to regulate the cellular microenvironment and, as such, are promising approaches for tooth develop
37 iency and related adverse pregnancy outcomes and, as such, are routinely recommended for iron supplem
38 vent and treat many cardiovascular disorders and, as such, are some of the most commonly prescribed d
39 volved in amino acid efflux from the vacuole and, as such, are the first to be shown directly to tran
40 d stuck at a prehearing stage of development and, as such, are unable to process sound information.
41 extremely resilient to temperature increases and, as such, are uniquely suited to promoting protein s
42 will be useful in regulating these processes and, as such, are valuable research tools and potentiall
43 gnaling proteins during megakaryocytopoiesis and, as such, became a critical regulator in the tempora
44 s have a genetic basis in nonhuman primates, and, as such, begin to fill the gaps in our understandin
45 ion twinning but is distinct from the latter and, as such, broadens the known mechanisms of plasticit
46 s, epigenetic changes are reversible events, and as such, can be amenable to pharmacological interven
49 so contribute to tissue-selective expression and, as such, can function as an important locus for the
50 e profoundly stressful for the human infant, and, as such, can lead to significant alterations in bra
51 ers has been mapped in various grass species and, as such, can serve as reference markers in comparat
52 ted AdvFBs exhibit pro-angiogenic properties and, as such, communicate with VVECs, in a process invol
53 the fission yeast Schizosaccharomyces pombe and, as such, competitively inhibits thioredoxin-mediate
54 gr locus dependent on the endogenous peptide and, as such, constitute a fourth S. aureus AIP pheromon
55 r susceptibility factor for tumor cell death and, as such, constitutes a potential biomarker that cou
56 groups in terms of their observed covariates and, as such, control for confounding in estimating trea
57 sition between the two stiffening mechanisms and, as such, control the dominant power-law scaling beh
58 ead and robust effects on vascular function, and as such, could be a viable treatment option for impr
59 rogate for ERalpha in clinical breast tumors and, as such, could be a useful biomarker in its own rig
60 es a noninvasive assessment of proliferation and, as such, could be a valuable imaging biomarker in o
61 ermini derived from heterologous transposons and, as such, could promote excision of large genomic re
62 e follicle and multi follicle spatial scales and, as such, could represent a core mechanism underlyin
63 ne, is a key integrator of stress responses, and, as such, CRH gene variation may contribute to indiv
64 promiscuous with respect to peptide binding, and, as such, CTL can often recognize related epitopes.
65 ity may represent persistent left-handedness and, as such, demonstrate a hemispheric asymmetry of han
66 ing DbetaH leads to reduced DbetaH activity, and as such, disulfiram might not be an effective treatm
67 to and recruits ELF3 for degradation by COP1 and, as such, dynamically gates the formation of the eve
68 teristic of a well-evolved metabolic enzyme, and as such, E. coli GmhB is set apart from most HAD pho
69 icated in eliminating infected CD4+ T cells, and as such, elite suppressors may represent a model of
70 at ES cells can generate endoderm in culture and, as such, establish this differentiation system as a
71 etaxel-related tearing is not caused by LDO, and as such, evaluation or stenting of the duct is not c
74 e adaptable to homologs in disease organisms and, as such, extendable to strategies to combat infecti
75 imited to reactions that are found in nature and, as such, facilitate fewer types of transformation t
76 he information content of these measurements and, as such, facilitate the elucidation of mechanisms a
77 lumns between 0.3 and 0.8 m have been used), and as such, fast separations are possible, comparable t
78 are the primary component in primordial ECM and, as such, FN assembly is a critical component in the
79 n quantitative phase imaging time-lapse data and, as such, functions in label-free mode, without the
80 he most susceptible nucleotide to oxidation, and as such, G-rich sequences that form G-quadruplexes c
81 n the identification of key marker compounds and, as such, give an indication of total PAH flux in th
83 n is a cornerstone of optical communication, and as such, governs the overall speed of data transmiss
84 safety and efficacy end points were assessed and, as such, had no prespecified primary end point, and
87 sses in which O2 availability is compromised and, as such, has become an increasingly attractive ther
88 lso expressed in tumors and tumor cell lines and, as such, has been classified as a cancer-germline o
89 nstruction increases experimental complexity and, as such, has been the source of recent controversy.
90 e in the de novo purine biosynthesis pathway and, as such, has been the target for antitumor drug des
91 avenue by which experience can guide choice and, as such, has broad implications for the study of de
92 r G-quadruplexes (GQ) relative to duplex DNA and, as such, has found a wide range of applications in
93 known to have a Zn ribbon-embedded wHTH fold and, as such, has potential roles both as a metal-depend
94 totransporters of Enterobacteriaceae) family and, as such, has serine protease activity and causes cy
95 or targets of a pathogenic immune response, and as such, have been implicated in the pathogenesis of
96 CD80 and CD86 mediate T cell costimulation, and as such, have been studied for their role in promoti
97 d individual picoliter reaction compartments and, as such, have great potential for quantitative high
98 romote Alzheimer's disease neuropathogenesis and, as such, have implications for use of isoflurane in
99 oligonucleotides for binding to DNA and RNA and, as such, have potential utility as probes in molecu
100 r to their mammalian NOS (mNOS) counterparts and, as such, have provided insight into the structural
102 ith a number of neurodegenerative disorders, and as such, in vivo analysis of dopamine in the presenc
103 negative regulator of neuronal regeneration and, as such, inhibiting its activity has been considere
104 isplays an elevated basal activity in vitro, and as such, inverse agonists may be therapeutically ben
105 fective inhibitor of oral anaerobic bacteria and as such, is a good candidate for treatment of period
106 the full blood odor in mammalian carnivores and as such, is a key candidate as a food/alarm cue in b
108 that is lethal upon transmission to Tg mice and as such, is reminiscent of the prion causing kuru, w
109 r analogous to avirulence factors in plants, and as such, is the first bacterial effector from a mamm
110 regulator of actin cytoskeletal architecture and, as such, is a candidate target for preventing cance
111 vert a fibroblast to a skeletal muscle cell, and, as such, is a model system in developmental biology
112 ally active decorin is a monomer in solution and, as such, is a monovalent ligand for various extrace
113 range of DNA-modifying enzymes and compounds and, as such, is a useful addition to the toolbox of bio
114 ts a short-term mutational response to AFB1, and, as such, is an early detection metric for AFB1-indu
115 unique role in dendritic cell (DC) function and, as such, is an important regulator of antigen prese
116 o support salivary gland replication in vivo and, as such, is an important tool that can be used to e
117 re of the plant material being reconstructed and, as such, is applicable to a wide variety of plant s
119 d as a key regulator of epithelial phenotype and, as such, is deeply involved in epithelial to mesenc
120 ast cancer is typically an incurable disease and, as such, is disproportionately responsible for deat
121 n in other porous materials (e.g., zeolites) and, as such, is easily scalable and industrially releva
122 nitiator of the classical complement pathway and, as such, is essential for efficient opsonization an
123 rization of a calcium complex with palytoxin and, as such, is expected to support the investigation o
124 acilitates the release of viruses from cells and, as such, is important for the replicative efficienc
125 ntegral component of the sarcoglycan complex and, as such, is important in the pathogenesis of muscul
126 nd proliferation of hematopoietic stem cells and, as such, is not only essential for steady-state hem
127 rects the development of the next generation and, as such, is profoundly different from somatic cell
128 a positively charged amphipathic alpha-helix and, as such, is similar to the MTS of the p13(II) prote
129 F-1 alpha) is a prototypic target of the UPP and, as such, is stabilized under conditions of proteaso
130 +)-binding component of the troponin complex and, as such, is the Ca(2+)-dependent switch in muscle c
132 ers, cancer, and neurodegenerative diseases, and as such, it is an essential target in medicine and c
133 ptation corrects for movements' inaccuracies and as such, it is critical in maintaining optimal motor
134 tolerate a diverse collection of reactants, and as such, it is expected that the new scaffolds and a
135 tant component of the human immune response, and as such, it is important to understand how pathogeni
136 a model native fish species in our analysis, and as such, it is likely that the lionfish invasion has
137 nt of contact between the host and pathogen, and as such, it is likely to play an important role in m
138 se can strikingly differ between subregions, and as such, it is possible that these patterns differen
140 an antiinflammatory and antioxidative agent, and as such, it may have atheroprotective properties.
141 ake of norepinephrine released from neurons, and, as such, it is an important regulator of noradrener
142 of enzymes that catalyze substrate oxidation and, as such, it plays a key role in various biological
143 y is associated with several human diseases, and as such, its inhibition offers an exciting opportuni
144 rade numerous extracellular matrix proteins, and as such, its potential involvement in diseases of th
145 kemia virus type 1 (HTLV-1) is a retrovirus, and, as such, its genome becomes chromosomally integrate
146 ction and composition of cerebrospinal fluid and, as such, its many functions of the central nervous
147 ed for multiple cytokine signaling pathways, and as such, JAK inhibitors hold promise for treatment o
148 ts, this remains a relatively rare disorder, and as such, large-scale clinical trials have not been c
149 ) rapidly degrades 85% of administered 5-FU, and as such, limits the amount of drug available for con
150 ences MMO expression in terrestrial systems, and, as such, local Cu mineralogy might provide an expla
151 material than the Apollo or Luna collections and, as such, lunar meteorite impact melt ages are the m
152 proteins in linking the OM to the cell wall and, as such, maintenance of structural integrity preven
154 a potent regulator of inflammatory pathways and, as such, may affect the severity of meningococcal d
155 ESET gene is important to neuronal survival and, as such, may be a promising treatment in HD patient
156 the broadest spectrum of antifungal coverage and, as such, may be considered for empiric therapy of e
157 ite attachment to and invasion of host cells and, as such, may be good targets for anticryptosporidia
158 ary step for efficient viral RNA replication and, as such, may be important for mediating a switch in
159 ic contact that can be altered by experience and, as such, may be involved in memories for that exper
160 NOD2-dependent signal transduction pathways and, as such, may be involved in the pathogenesis of NOD
161 independent AD disease-modifying mechanisms and, as such, may contribute to the benefits of dietary
162 r inhibiting prostate cancer bone metastasis and, as such, may enhance the therapeutic activity of do
163 that promotes MED1 association with Mediator and, as such, may facilitate a novel feed-forward action
164 easures the mobility of water within tissues and, as such, may function as a surrogate marker for bot
166 opposing effects on acute versus tonic pain and, as such, may have implications for the potential de
167 terindividual variation in toxicity response and, as such, may more accurately reflect the range of r
168 function as an antigen recognition molecule and, as such, may participate in innate immunity in tele
169 cellular localization of the exchange factor and, as such, may participate in the signaling mediated
170 strated that both S100A4 and UA act as DAMPs and, as such, may play a critical role in promoting some
171 pha release by plasmacytoid dendritic cells, and, as such, may play an important role in propagation
172 eurodegeneration seen in Parkinson's disease and, as such, may provide a marker for cognitive decline
173 to rebalance epigenetic histone modification and, as such, may provide the rationale for the design o
174 rk that causes tissue damage in scleroderma, and, as such, may provide therapeutic targets in sclerod
175 melanoma from a primary to metastatic tumor and, as such, may represent a useful therapeutic tool in
176 l for cancer cell proliferation and survival and, as such, may represent a vulnerability that can be
177 ng FcalphaRI inhibited neutrophil activation and, as such, may represent an additional attractive nov
178 proteins function as corepressors for SNAIL and, as such, may serve as a platform for the assembly o
179 n neurotrophic factor-mediated AR activation and, as such, may serve as targets of future therapeutic
180 nagement approaches or home-based activities and, as such, may ultimately have substantial public hea
182 e control of the acute inflammatory response and, as such, modulates the transmigration of neutrophil
183 often the rate-limiting step of translation and, as such, most (but not all) examples of translation
184 cell niches (classically the hematopoietic), and as such, MSCs participate in organ homeostasis, woun
185 ruses are obligatory intracellular parasites and, as such, must modulate apoptotic pathways to contro
186 for regulating numerous signaling pathways, and, as such, mutations disrupting ciliogenesis result i
187 es to the host cell differentiation program, and as such, native HPV virions are only produced in viv
188 phenotypes resulting from genetic mutations and, as such, new approaches to treatment of this arrhyt
189 antiviral activity in HIV-1-infected humans, and as such, novel approaches harnessing the anti-HIV-1
190 ) both cross-sectionally and longitudinally, and as such, offers potential opportunities to refine ou
191 functions at the oocyte-to-embryo transition and, as such, offers new insights into the initiation of
192 dity and mortality for both mother and child and, as such, optimal treatment strategies are required
194 ffs that the model embodies are fundamental, and, as such, our modeling framework has potentially wid
195 an oscillating magnetic field in the sample and, as such, permits quantitative, frequency-selective
196 CR signaling in response to immune complexes and, as such, plays a decisive role in regulating Ab res
197 tramer forms the central core of nucleosomes and, as such, plays a prominent role in assembly, disass
198 re that is insensitive for regional disease, and as such, poor for capturing the early onset of lung
200 by the presence of a significant background, and, as such, predetection background suppression is sub
201 a limiting factor for these solid catalysts, and as such, productivity remains high up to 25 degrees
202 teraction between Xist RNA and PRC2 proteins and, as such, prompt a reappraisal of the mechanism for
203 xidation/reduction under biologic conditions and, as such, provide a means for control of protein act
204 i protein signals are required for BM homing and, as such, provide a new example of the association b
205 -alpha-syn-induced neurodestructive immunity and, as such, provide a sound rationale for future Parki
206 show that MSCI is essential for male meiosis and, as such, provide insight into the differential seve
207 pans the breadth of oncology subspecialties, and, as such, providers in these subspecialties should b
208 thereby inhibiting invasive cell migration, and as such, provides an important barrier mechanism to
209 f animal movement data to inform such models and as such, provides some insight into the impact of im
210 ties emerge from the behavior of individuals and, as such, provides a mechanistic explanation of conn
211 n in both inbred and outbred strains of mice and, as such, provides a tractable small-animal model to
212 iral MHC class I ligands for any bat species and, as such, provides an important avenue for monitorin
213 which accomplishes complete adenoma removal and, as such, provides unique advantages over other surg
215 eparin derivatives counteract this mechanism and, as such, represent potentially appealing compounds
216 he del22q11-associated behavioral phenotype, and as such, represents an animal model of this complex
217 h in response to proteins produced by plants and, as such, represents a new paradigm for interspecies
218 processes that determine mutualism stability and, as such, represents a significant step in understan
219 that vascularize the gut, liver and pancreas and, as such, represents an ideal model in which to inve
220 trotransposon activity identified in mammals and, as such, represents an important additional data po
221 es of wax deposition during leaf development and, as such, represents an important step in the study
222 -12 to regulate T-helper 1 and 2 lymphocytes and, as such, seems to underlie the pathogenesis of vari
223 ural framework within the cellular cytoplasm and, as such, serve an important role in epithelial cell
225 independently predictive of postoperative AF and as such, should be integrated into the clinical deci
227 S-nitrosothiols such as S-nitrosoglutathione and, as such, should be considered as a source of RBC-de
228 et of sequenced yeast mutant alleles to date and, as such, should be singularly useful for gene and g
229 dia spp. are obligate intracellular bacteria and, as such, should be targeted by CD8(+) T cells.
230 KIF13B transports VEGFR2 to the EC surface, and as such, specific inhibition of polarized VEGFR2 tra
231 umor cells remain dependent on Src signaling and as such, Src inhibition suppresses growth of Ras/Src
232 MR analysis of a threading tetraintercalator and, as such, structurally characterizes a new topology
233 umented archaeological site in North America and, as such, substantially revises the timing of arriva
234 erns of input from sensory and motor neurons and, as such, suggest that interneuron position is a det
235 onenzymatically to pneumococcal pathogenesis and, as such, suggest that it is not a redundant bystand
236 ALL subtypes differ at the functional level, and, as such, T-ALL treatments are uniformly applied acr
237 sically plausible models of neural circuitry and, as such, takes us closer to a mechanistic understan
238 ls occurs around individual dendritic cells, and as such, that CD8Treg mediated killing of CD4Th1 cel
239 ate their dauer-like infective larval stage, and as such, the DAF-12 ligand binding domain has been i
240 and independently of instructional processes and as such, the development of memory may be a default
241 a are similar to those of the human placenta and as such, the pregnant sheep offers an excellent mode
242 omas with and without extraocular extension, and as such, the presence of peritumoral lymphatics is n
243 um one of the most complex plant structures, and as such, the regulation of its development has remai
244 -analyses reported follow-up to only 1 year, and as such, the relative long-term safety and efficacy
246 formation, the area compressibility modulus and, as such, the bending rigidity of the membrane is co
247 are influenced by protein-water interactions and, as such, the energetics of protein function are nec
248 at faithfully recapitulate these infections, and, as such, the host or bacterial factors that govern
249 to diffuse throughout the film architecture, and, as such, the major focus of this work is to define
250 for competition-defense tradeoffs is limited and, as such, the mechanisms by which consumers regulate
251 Patients with AFP >400 ng/mL were excluded, and, as such, the Milan group was modified to include on
252 idered equivalent to a highly repetitive BAC and, as such, the optimized method detailed here should
254 -free, TLS can work in an error-prone manner and, as such, the regulation of these pathways requires
255 mic entities in various cellular mechanisms, and as such, their availability, manipulation and queria
256 cells are critical mediators of inflammation and as such, their migration to inflammatory sites is a
257 embling DBS-acids have different pKa values, and as such, their self-assembly is triggered at differe
258 larly Ras and Raf, are encoded by oncogenes, and as such, their structures and functions can be modif
259 oclasts fail to organize their cytoskeleton, and, as such, their bone-resorptive capacity is arrested
260 subwavelength plates control the near field and, as such, their superlensing properties originate fr
261 in sarcoglycan-mediated muscular dystrophies and, as such, therapy should target both skeletal and ca
262 librium nature of cotranslational processes, and as such, there exist theoretical tools that offer a
263 d various autoimmune inflammatory disorders, and as such, there is a need for molecular probes to stu
264 or the maintenance of metabolic homeostasis, and as such, these arthropods have formed symbioses with
265 an provide integrated exposure measurements, and as such, these matrices can potentially be used as n
266 athology of multiple neurological disorders, and as such, these proteins are established therapeutic
267 DH2 activities are a major factor in cancer, and as such, these results implicate SIRT3 as a potentia
268 vement perception, including mirror neurons, and, as such, these findings argue against a mirror syst
269 on, blood clotting, and signal transduction, and as such, they are common targets of therapeutic agen
270 te atomic oxygen [O((3)P)] upon irradiation, and as such, they have been used to create a condensed p
271 tractive moiety in modern organic synthesis, and as such, they have been utilised in a diverse range
272 etastasis rely heavily on cellular motility, and as such, they have put PLD at center stage in cancer
273 ing signals are segment and strain specific, and as such, they have the potential to impact reassortm
274 heir static or single-component counterparts and as such, they hold higher potentialities in terms of
275 llular transport of vesicles and organelles, and as such, they play a role in neurological disease, c
276 s can lead to excitotoxic cell damage/death, and as such, they play a role in numerous neuropathologi
277 ing the translation of mRNA of target genes, and as such, they play an important role in plant develo
278 phingosine 1-phosphate, and diacylglycerol), and as such, they serve a prototypical modular function
279 les in orchestrating immunity and tolerance, and, as such, they are key targets for immunotherapy.
280 y somatic cells with bone-resorbing capacity and, as such, they have a critical role not only in norm
282 e continuously threatened by pathogen attack and, as such, they have evolved mechanisms to evade, esc
283 in-induced Akt activation in hepatic tissue, and, as such, they question any nonredundant role for Tr
284 t depend on intact and dynamic microtubules, and, as such, they represent downstream targets of micro
285 ms were specific examples of complex systems and, as such, they should display characteristics includ
286 oved resolution in frequency-domain signals, and as such, this result is important for more efficient
287 in kidney transplant patients is warranted, and as such, this review will focus on the incidence, su
288 lective high-affinity molecular recognition, and as such, this system provides a fascinating challeng
289 e in the rate of ATP synthesis in the retina and, as such, this decline may be linked to the progress
290 o primary and acquired erlotinib resistance, and as such, treatments based on EGFR inhibition may not
291 ation and intercellular movement of viruses, and as such, understanding viral assembly has great pote
292 Fox genes are associated with human disease and, as such, various animal models have been generated
293 an effective strategy for prevention of GVHD and, as such, warrants consideration for future clinical
294 displays a superior pharmacokinetic profile and, as such, was more effective in both the acute murin
295 existence of a stable multiprotein complex, and as such, we evaluated whether the MDM2 Nutlin had si
296 g the innovation systems of both industries, and as such, we suggest potentially useful changes to th
297 is of major importance for decision making, and, as such, we emphasize the need for the functioning
298 lane images (Z stacks) throughout a specimen and, as such, we report here the successful development
299 itute the entire LACS family in Arabidopsis, and as such, will serve as powerful tools in the study o
300 functions may be remnants from the RNA world and, as such, would be part of the evolutionary past of
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