ライフサイエンスコーパス: anergize

1 ccumulation of cells that would otherwise be anergized.

2 continues to respond, whereas mutated CLL is anergized.

3 rtial deletion and were also not efficiently anergized.

4 o limited proliferation and are subsequently anergized.

5 , capable of restoring the responsiveness of anergized Ag-specific CD4(+) T cells.

6 ome MHC haplotypes conferring T1D resistance anergized AI4 T cells through decreased TCR (H2(b)) or C

7 Thus, the ability of p8 to simultaneously anergize and cluster T cells, together with its inductio

8 d cell death (Fas-AICD), we examined whether anergized and CD28-costimulated T cell clones were equal

9 uced identical levels of CD40L expression in anergized and non-anergized CD8 T cells.

10 both IL-12 and anti-CTLA-4 antibody are not anergized, and behave identically to T cells which have

11 T cells was sufficient for the expansion of anergized anti-double-stranded DNA B cells and productio

12 t naive B cells that are normally deleted or anergized are rescued from tolerance induction.

13 theless effective tolerogens and are able to anergize autoreactive T cells.

14 display features of polyreactive, partially anergized B cells related to memory B cells.

15 high Egr-2 expression distinctly persists in anergized but not proliferating murine A.E7 T cells.

16 ible that T cells within the synovium may be anergized by contact with HLA-DR+ CD80- FLS.

17 We demonstrate that primary CD4(+) T cells anergized by costimulatory blockade exhibit impaired TCR

18 e T cells, PTENDeltaT CD4(+) T cells are not anergized by delivery of TCR stimulation alone.

19 n resembling that observed in normal B cells anergized by DNA-based Ags.

20 that T cells from CTLA-4-deficient mice were anergized by injections of soluble antigenic peptide as

21 ficient in the complement protein C4 are not anergized by soluble self-antigen.

22 CD4(+) T cells from humans, RM, and SM were anergized by TCR-only stimulation (signal 1 alone) and s

23 id tissue of tumor-bearing mice and were not anergized by the tumor.

24 encephalitogenic T cells can be effectively anergized by treatment with MHC variant peptides, which

25 natural ligand of the CD4 molecule that can anergize CD4-expressing cells.

26 surface expression levels were seen both on anergized CD4 T cells and following GRAIL expression by

27 the hypothesis that CD137-mediated signaling anergized CD4(+) T cells during priming at the DC interf

28 els of CD40L expression in anergized and non-anergized CD8 T cells.

29 Although anergized cells expressed Fas and Fas ligand, they were

30 IL-6 mAb did not block CpG activation of the anergized cells.

31 x vivo recall assays, a typical phenotype of anergized cells.

32 on of actin cytoskeletal rearrangement under anergizing conditions.

33 ti-IL-10 neutralizing monoclonal antibody in anergizing cultures reversed the functional characterist

34 presentation schema, iDCs neither delete nor anergize epitope-specific CD8(+) T cells in primary or s

35 circulating B cells, variably stimulated and anergized following exposure to antigen in lymphoid tiss

36 ly transferred gag-specific T cells were not anergized in gag-TG recipients, as revealed by antitumor

37 Thus, B cells that are ignored rather than anergized in normal mice can be stimulated to produce au

38 terozygous mice autoreactive T cells are not anergized in vitro.

39 In contrast to soluble alphaGC, which anergizes iNKT cells, we found that alphaGC/OVA-loaded e

40 Interestingly, Kv channels in anergized lymphocytes actively suppress IL-4 production,

41 that B cells pulsed with defined doses of Ag anergize memory CD4 cells in vivo.

42 This study shows that blockade of B7/CD28 in anergizing mixed lymphocyte reaction (MLR) cultures of p

43 ction and failed tumor rejection observed in anergized NKT cells are rescued by Cbl-b deficiency.

44 nt), alpha-galactosylceramide (alphaGalCer) (anergized NKT cells) injected and IL-12p40(-/-) vs B6 co

45 ive B cells that escape to the periphery are anergized or perish before becoming mature B cells.

46 this, TRAF6-DeltaT T cells were resistant to anergizing signals both in vitro and in vivo.

47 ficient T cells showed impaired responses to anergizing stimuli.

48 Expression of GRAIL after an anergizing stimulus may result in ubiquitin-mediated reg

49 DGK-zeta-deficient T cells that received an anergizing stimulus proliferated similarly to wild-type

50 tive CD4(+)T cells from humans and RM became anergized, surprisingly, CD4(+) T cells from SM showed m

51 We found that the p8 protein, known to anergize T cells, is also able to increase T-cell contac

52 In addition, restimulation of anergized T cells with anti-CD3 mAbs induced normal Ca2+

53 as increased surface expression of CTLA-4 on anergized T cells, and that injection of anti-CTLA-4 blo

54 e distinct functions of naive, effector, and anergized T cells, we tested their role in immunoregulat

55 restored Ag responsiveness in the previously anergized T cells.

56 n-derived memory CD4(+) T cells in vitro and anergized them.

57 al triad and an excellent response to B-cell-anergizing therapy using the humanized monoclonal antibo

58 our patient, the implementation of a B-cell-anergizing therapy using tocilizumab, a humanized monocl

59 CD4(+) lymphocytes anergized through partial stimulation exhibit similar Kv

60 redominant Th1 lineage response that becomes anergized to cardiac self resulting in compensatory prot

61 Splenocytes from treated mice were anergized to PLP139-151, and IL-17 secretion was markedl

62 e to antitumor immunity because it tolerizes/anergizes tumor-reactive T cells by binding to its recep

63 at least a subpopulation of CD8 T cells are anergized when costimulation is provided by B cells or T