ライフサイエンスコーパス: anesthetic

1 chemical stimuli (signaling lipids, volatile anesthetics).

2 rols, but only when urethane was used as the anesthetic.

3 sirtuin deacetylase SIRT2 as a target of the anesthetic.

4 bit a different pattern of spin responses to anesthetic.

5 ration of paravertebral musculature with the anesthetic.

6 in, and myosin light chain as targets of the anesthetics.

7 are used clinically as analgesics and local anesthetics.

8 mmalian brain, are major targets for general anesthetics.

9 s had active pacemakers at the time of their anesthetics.

10 nctionally inhibited by isoflurane and other anesthetics.

11 are targeted by benzodiazepines and general anesthetics.

12 diverse experimental conditions and types of anesthetics.

13 esthetics is very similar to that of general anesthetics.

14 electronic structure of proteins by general anesthetics.

15 pressure, temperature, signaling lipids, and anesthetics.

16 e fifth transmembrane domain (S5) in sensing anesthetics.

17 animals resistant to systemically delivered anesthetics.

18 at potentiates the effect of delivered local anesthetics.

19 haracterized a chemically active alkylphenol anesthetic (2-((prop-2-yn-1-yloxy)methyl)-5-(3-(trifluor

20 An alternative hypothesis proposes that anesthetics act on one or more brainstem or diencephalic

21 While the exact mechanisms of anesthetic action are unknown, the Meyer-Overton correla

22 Anesthetic action is also related to an anesthetic's hyd

23 Understanding anesthetic action may help reveal brain mechanisms under

24 thetics, but molecular mechanisms underlying anesthetic action remain debatable.

25 own as the unitary lipid-based hypothesis of anesthetic action, has been challenged by evidence for d

26 ork to study the structural basis of general anesthetic action.

27 Here we exploit the observation that pungent anesthetics activate mammalian but not Drosophila TRPA1.

28 These noxious anesthetics activate transient receptor potential ankyri

29 ts in cortical neurons and to verify loss of anesthetic-activated TASK currents from TASK(-/-) mice.

30 mpeting influences on the VLPO, a sleep- and anesthetic-active structure, has yet to be evaluated in

31 inhaled volatile (isoflurane or sevoflurane) anesthetic agent (n = 67).

32 s of initiating brexanolone infusion without anesthetic agent reinstatement in the following 24 hours

33 Propofol is a sedative and anesthetic agent that can both activate GABA(A) receptor

34 nificant correlation between the duration of anesthetic agent use and DeltaVBR was found (Spearman r

35 Volatile anesthetic agent use in the intensive care unit, aided b

36 ed mutation at an interaction site for local anesthetic agents (F1760A) partially attenuated the effe

37 ve considerable potential to be developed as anesthetic agents and as drugs to treat brain disorders

38 uch higher (toxic) concentrations of certain anesthetic agents did alter lipid bilayer properties.

39 Furthermore, because anesthetic agents have the unique ability to reversibly

40 Many general anesthetic agents regulate voltage-gated Na(+) (NaV) cha

41 Anesthetic agents were required for a median of 13 (IQR,

42 All exposed children received inhaled anesthetic agents, and anesthesia duration ranged from 2

43 endent on a known interaction site for local anesthetic agents.

44 ian TRPA1 residues into dTRPA1 recapitulates anesthetic agonism.

45 general anesthetics, barbiturates, and local anesthetics all display the same effect on melting trans

46 eta3Met-227 in betaM1 established that these anesthetics also bind to a homologous site, most likely

47 el, such as the desorption rate constants of anesthetic and agonist, are directly related to model-in

48 ng on the responses of geriatric patients to anesthetic and analgesic drugs used during ambulatory su

49 ave been solved, exhibit modulation by local anesthetic and anti-epileptic agents, allowing molecular

50 We used lidocaine, a local anesthetic and antiarrhythmic drug, to probe the role of

51 nylphenyl) barbituric acid (R-mTFD-MPAB), an anesthetic and GABAAR potentiator, has been shown to inh

52 iturate that is a potent and stereoselective anesthetic and GABAAR potentiator, has identified a seco

53 n hypothesis, or why the lipophilicity of an anesthetic and its potency are generally proportional.

54 that nitrous oxide, an inhalational general anesthetic and N-methyl-D-aspartate receptor antagonist,

55 cation with patients and theater staff, full anesthetic and operating facilities, replicated patient

56 lar surface preparation consisted of topical anesthetic and povidone-iodine 5% without the use of pre

57 terization in assessment of aortic stenosis, anesthetic and surgical techniques, as well as post-oper

58 randomized to receive a TAP block with local anesthetics and dexamethasone, PILA with dexamethasone,

59 get of allosteric modulators such as general anesthetics and ethanol and is a major locus for hyperek

60 xious and vasorelaxant properties of general anesthetics and may prove useful in understanding effect

61 a broad range of chemically diverse general anesthetics and related nonanesthetics on lipid bilayer

62 Some anesthetics and sedatives have been shown to cause neuro

63 s review, we outline the history of volatile anesthetics and their effect on kidney function, briefly

64 other relevant channels sensitive to general anesthetics and, as shown here, to barbiturates, at clin

65 der typically triggered by potent inhalation anesthetics and/or the depolarizing muscle relaxant succ

66 -azipropofol activates TRPA1 like the parent anesthetic, and identify two photolabeled residues (V954

67 en that isoflurane is a widely used volatile anesthetic, and is used for inhalational long-term sedat

68 a group of gases including anesthetics, non-anesthetics, and anesthetic/convulsants on tubulin dynam

69 sodium channels are inhibited by many local anesthetics, antiarrhythmics, and antiepileptic drugs.

70 Although anesthetics appear to activate microglia, the increased

71 General anesthetics are both neuroprotective and neurotoxic with

72 Inhalational anesthetics are bronchodilators with immunomodulatory ef

73 General anesthetics are known to cause depression of the freezin

74 imal fMRI and neurovascular studies, however anesthetics are known to profoundly affect neural and va

75 use of both mechanical vibration and topical anesthetic as effective in children regardless of age gr

76 he potential binding mode of noxious general anesthetics at TRPA1.

77 hotolabeling of beta3Met-227 in betaM1 by an anesthetic barbiturate, R-[(3)H]methyl-5-allyl-5-(m-trif

78 We show here that general anesthetics, barbiturates, and local anesthetics all dis

79 Administration of a long-acting local anesthetic between the mesh and the peritoneum significa

80 ic ligand-gated ion channels, the details of anesthetic binding and channel modulation are still deba

81 Val-136 and adjacent residues may mediate anesthetic binding and stabilize an open state regulated

82 lations presented herein demonstrate a novel anesthetic binding site in GLIC that is accessed through

83 found for a delta subunit contribution to an anesthetic binding site.

84 To identify anesthetic binding sites in an extrasynaptic GABAAR, we

85 resent a computational study identifying two anesthetic binding sites in the transmembrane domain of

86 rtook an in-depth study of alkylphenol-based anesthetic binding to synaptic membranes.

87 WT SoCal5 and SoCal5 with the local anesthetics binding site mutated (F1760A) could be expre

88 We used mutagenesis to probe the anesthetic-binding cavity as observed in a TASK-3 homolo

89 genized the residue Val-136, which lines the anesthetic-binding cavity, its flanking residues (132 to

90 ed anesthetics through binding at a putative anesthetic-binding cavity.

91 uman Na(V)1.5 variant with a mutation in the anesthetic-binding site (F1759A-Na(V)1.5) and demonstrat

92 ic modulators by binding to the intersubunit anesthetic-binding sites in the GABAAR transmembrane dom

93 date or R-mTFD-MPAB also establish that each anesthetic binds to the homologous site at the beta3-bet

94 plastic microfluidic biochip with an on-chip anesthetic biosensor that was characterized for the rapi

95 posable microfluidic biochip with an on-chip anesthetic biosensor using MIPs exhibited excellent perf

96 dure, all 3 patients underwent a retrobulbar anesthetic block followed by magnetic resonance imaging

97 possible, nonopioid medications and regional anesthetic blockade are effective alternatives for analg

98 After mesh placement, a long-acting local anesthetic (bupivacaine hydrochloride, 0.50%) or placebo

99 Fentanyl is well characterized as an anesthetic, but the basic physiological effects of fenta

100 ion channels (pLGICs) are targets of general anesthetics, but molecular mechanisms underlying anesthe

101 es indicate that early postnatal exposure to anesthetics can lead to lasting deficits in learning and

102 Postconditioning with inhalational anesthetics can reduce ischemia-reperfusion brain injury

103 How general anesthetics cause loss of consciousness is unknown.

104 Exposure of young animals to commonly used anesthetics causes neurotoxicity including impaired neur

105 n the awake state, indicating that the novel anesthetic combination significantly minimizes the impac

106 Even supra-anesthetic concentrations caused minimal bilayer effects

107 Anesthetic concentrations in the membrane are high (10-1

108 ry (derived from mean end-tidal inhalational anesthetic concentrations).

109 ceptors under a wide range of agonist and/or anesthetic concentrations.

110 This was provided using an Anesthetic Conserving Device and continued for 8 days.

111 were treated with volatile sedation using an anesthetic conserving device and isoflurane, and 322 rec

112 hypercapnia occurred more frequently during anesthetic conserving device use (6.4% vs 0%; p = 0.021)

113 ng of PaCO2 is necessary during sedation via anesthetic conserving device.

114 including anesthetics, non-anesthetics, and anesthetic/convulsants on tubulin dynamics.

115 ion provides corneal sensation in previously anesthetic corneas.

116 Volatile anesthetics did not attenuate glycocalyx shedding in hum

117 Inhalational anesthetic dose increase and reduced risk of postoperati

118 High inhalational anesthetic dose of 1.20 (1.13-1.30) (median [interquarti

119 A single sub-anesthetic dose of ketamine exerts rapid and sustained a

120 A single sub-anesthetic dose of ketamine, a short-acting NMDA recepto

121 Converging evidence suggests a single sub-anesthetic dose of the N-methyl-D-aspartate receptor ant

122 ught to determine the effect of inhalational anesthetic dose on risk of severe postoperative respirat

123 Additionally, high inhalational anesthetic dose was associated with lower 30-day mortali

124 Intraoperative use of higher inhalational anesthetic doses is strongly associated with lower odds

125 e or one of three behaviorally relevant, sub-anesthetic doses of S-ketamine (5, 10, and 25 mg/kg, s.c

126 the deactivation of NsVBa, whereas the local anesthetic drug lidocaine was shown to antagonize NsVBa

127 ions (10-15 Hz) induced by the commonly used anesthetic drug propofol are synchronized between the th

128 support for the antidepressant effect of an anesthetic drug, ketamine, by Inverse-Frequency Analysis

129 results of preclinical studies suggest that anesthetic drugs administered to neonatal animals cause

130 This is a consequence of ideal mixing of the anesthetic drugs in the membrane fluid phase and exclusi

131 troencephalogram background suppression with anesthetic drugs) was tested.

132 alone were sufficient to markedly potentiate anesthetic duration when delivered centrally or peripher

133 an effective dose equivalent of inhalational anesthetics during surgery (derived from mean end-tidal

134 Sedation with volatile anesthetics during therapeutic hypothermia may be a feas

135 transplant patients underwent 118 subsequent anesthetics during which they received neostigmine and g

136 We identified the topical anesthetic dyclonine as protective.

137 an intravenous anesthetic that produces its anesthetic effect, largely via the GABAA receptor in the

138 lly relevant concentrations, indicating that anesthetic effects on ion channel function are not bilay

139 the modulation of agonist-induced traces by anesthetic, either coapplied or continuously present.

140 anesthetic state, thus priming the brain for anesthetic emergence.

141 Patients undergoing local anesthetic endovenous thermal ablation were randomized t

142 loping safer general anesthetics, isomers of anesthetic ethers and barbiturates have been discovered

143 single in vivo treatment with the injectable anesthetic etomidate increased a tonic inhibitory curren

144 natures will be recapitulated by the general anesthetic etomidate, if the electrocortical effects of

145 a site overlapping with that of the general anesthetic etomidate.

146 ge, health status, and necessity of multiple anesthetic events.

147 ane, desflurane) and i.v. (propofol) general anesthetics excite peripheral sensory nerves to cause pa

148 General anesthetics exert their effects on the central nervous s

149 on studies support the conclusion that early anesthetic exposure may increase the risk of neurodevelo

150 ative lifelong risks and benefits of general anesthetic exposure should be considered when recommendi

151 which are thus vulnerable to perturbation by anesthetic exposure.

152 %) underwent a procedure while under general anesthetic for diagnostic purposes.

153 advantages of pharmacological sedatives and anesthetics for use in bronchoscopy.

154 ane site (TM2) that inhibits dissociation of anesthetic from the TM1 site and is consistent with the

155 rature supports the idea that common general anesthetics (GAs) cause long-term cognitive changes and

156 nts as a hypermetabolic response to volatile anesthetic gases, where susceptible persons may develop

157 ting, ventilation, and air conditioning, and anesthetic gases.

158 dine enhanced the efficacy of released local anesthetics, greatly increasing the number of triggerabl

159 At 3.0 T, the addition of steroids and anesthetics had minimal effect on signal intensity curve

160 is randomized study, we examined if volatile anesthetics have an effect on acute graft injury and cli

161 We conclude that general anesthetics have minimal effects on bilayer properties a

162 General anesthetics have revolutionized medicine by facilitating

163 Safety issues and anesthetic implications are also addressed.

164 ocols to regulatory the use of menthol as an anesthetic in aquaculture.

165 Bupivacaine is the indicated local anesthetic in caudal, epidural, and spinal anesthesia an

166 anisone/midazolam) and volatile (isoflurane) anesthetics in mice.

167 Dosing studies of local anesthetics in peripheral nerve blockade suggest that ma

168 The choice of local anesthetics in regional anesthesia depends on desired on

169 Despite the common use of sedatives and anesthetics in the acute phase of TBI management, their

170 ss of intersubunit binding sites for general anesthetics in the alpha1beta3gamma2 GABAAR transmembran

171 es of intersubunit-binding sites for general anesthetics in the GABAAR transmembrane domain.

172 ing the utilization and outcomes of regional anesthetics in this population.

173 The trend toward smaller doses of local anesthetics in ultrasound-guided regional anesthesia imp

174 inocular visual experience follows temporary anesthetic inactivation of the retinas.

175 ies suggest that modern halogenated volatile anesthetics induce potent anti-inflammatory, antinecroti

176 ental traces remarkably well, including both anesthetic-induced and agonist-induced traces, as well a

177 A recent hypothesis proposes that anesthetic-induced changes in ion channel function resul

178 Molecular mechanism of anesthetic-induced depression of myocardial contraction.

179 in regions at natural sleep onset and during anesthetic-induced loss of righting reflex in rats.

180 tion, briefly review the studies on volatile anesthetic-induced renal protection, and summarize the b

181 rlying transitions between consciousness and anesthetic-induced unconsciousness remain unclear.

182 dation, and a single dose of ketamine during anesthetic induction and with dexmedetomidine compared w

183 = 167) or placebo (n = 168) initiated after anesthetic induction.

184 This treatment allowed the general anesthetic infusions to be weaned with resolution of sta

185 We recently observed that several n-alcohol anesthetics inhibit heterogeneity in plasma-membrane-der

186 uggest that halogenated inhalational general anesthetics interact with gates and pore regions of thes

187 dentification of the low millimolar volatile anesthetic interaction site of the calcium sensor protei

188 , has been challenged by evidence for direct anesthetic interactions with a range of proteins, includ

189 Some evidence for anesthetic interactions with the cytoskeleton exists, bu

190 ral pressure that arise from partitioning of anesthetics into the bilayer.

191 tigate the efficacy of intraperitoneal local anesthetic (IPLA) on pain after acute laparoscopic appen

192 Generally the protein target for anesthetics is assumed to be neuronal membrane receptors

193 A common endpoint of general anesthetics is behavioral unresponsiveness, which is com

194 pentameric ion channels by alkylphenol-based anesthetics is sufficient to induce modulation of activi

195 Thus, the thermodynamic behavior of local anesthetics is very similar to that of general anestheti

196 Propofol, an intravenous anesthetic, is a positive modulator of the GABAA recepto

197 ic acid that finds an application as a local anesthetic, is found to adopt in its protonated form at

198 VLPO are directly depolarized by the general anesthetic isoflurane and hyperpolarized by norepinephri

199 concentration-response of TASK-3 to several anesthetics (isoflurane, desflurane, sevoflurane, haloth

200 In the process of developing safer general anesthetics, isomers of anesthetic ethers and barbiturat

201 tive to VAs yet resistant to the intravenous anesthetic ketamine [7].

202 es examining the effects of the dissociative anesthetic ketamine as a model for psychosis and as a ra

203 Administration of sub-anesthetic ketamine immediately after the exposure preve

204 Among anesthetics, ketamine is remarkable in that it induces p

205 uency discharges of excitable cells by local anesthetics (LA) is largely determined by drug-induced p

206 als comparing epidural analgesia (with local anesthetics, lasting for >/= 24 hours postoperatively) w

207 identification is through the observation of anesthetic lesions on skin; however, up to 30% of infect

208 consciousness (LOC) and on through a deeper anesthetic level.

209 We find that anesthetic levels of pentobarbital reduce taste nerve re

210 Although the local anesthetic lidocaine modulates inflammatory processes, t

211 one, and methylprednisolone) and three local anesthetics (lidocaine, ropivacaine, and bupivacaine) we

212 Anesthetic management and perioperative care were not st

213 to be aware of the unique challenges in the anesthetic management of the pediatric neurosurgical pat

214 The results therefore indicate that anesthetics may be potentially harmful not only in very

215 General anesthetics may control cell survival via their effects

216 the renal protective properties of volatile anesthetics may provide clinically useful therapeutic in

217 A better understanding of the anesthetic mechanism of action is necessary for the deve

218 ze the basic cellular mechanisms of volatile anesthetic-mediated protection against ischemic AKI.

219 hod was applied to residual determination of anesthetic menthol in fish.

220 Recent evidence suggests that anesthetics might cause persistent deficits in cognitive

221 The anesthetic mode-of-action for ketamine is mediated prima

222 widely attributed to suppressive actions of anesthetic molecules distributed by the systemic circula

223 Because of their roles as general anesthetics, n-alcohols are perhaps the best-studied amp

224 tly known modulators of GABA function (e.g., anesthetics, neurosteroids or ethanol).

225 ate the effect of a group of gases including anesthetics, non-anesthetics, and anesthetic/convulsants

226 nd the documentation of participation in the anesthetics of 20 trauma patients.

227 uires only that residents participate in the anesthetics of 20 trauma patients.

228 ngs were used to examine effects of volatile anesthetic on TASK currents in cortical neurons and to v

229 The effects of general anesthetics on apoptosis and autophagy are closely integ

230 A kinetic model of the effect of agonist and anesthetics on ligand-gated ion channels, developed in e

231 hat hexadecanol acts oppositely to n-alcohol anesthetics on membrane mixing and antagonizes ethanol-i

232 implication for inhibitory action of general anesthetics on pLGICs.

233 may prove useful in understanding effects of anesthetics on related ion channels.

234 injection, and substitution ("tampering") of anesthetic opioids is unknown.

235 s were attributable to provider tampering of anesthetic opioids.

236 ding of analgesia devoid of the influence of anesthetics or restraints.

237 n these data that sedation with inhalational anesthetics outside of the operating room may likewise h

238 The GABAergic anesthetics pentobarbital and propofol were also effecti

239 sity functional theory, we show that general anesthetics perturb and extend the highest occupied mole

240 ltrasound-guided foam sclerotherapy or local anesthetic phlebectomy.

241 hate and preperitoneal instillation of local anesthetic (PILA) with dexamethasone vs control on posto

242 -Overton correlation provides a link between anesthetic potency and solubility in a lipid-like, non-p

243 se results demonstrate that DeltaTc predicts anesthetic potency for n-alcohols better than hydrophobi

244 to further test the correlation between the anesthetic potency of n-alcohols and effects on Tc.

245 ns in a manner that is correlated with their anesthetic potency.

246 rodotoxin (TTX), which has ultrapotent local anesthetic properties.

247 Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuat

248 The anesthetic propofol elicits many different spectral prop

249 chnology for the electrical detection of the anesthetic propofol in human plasma samples for clinical

250 r critical care therapy with the widely used anesthetic propofol on recovery from acute traumatic bra

251 ziPm) is a photoactive analog of the general anesthetic propofol.

252 during loss of consciousness induced by the anesthetic propofol.

253 activated and potentiated by the intravenous anesthetic propofol.

254 asal activity with the allosterically acting anesthetics propofol, pentobarbital, or alfaxalone.

255 e cortex, and postconditioning with volatile anesthetics provides neuroprotective actions that depend

256 ects of several clinically utilized volatile anesthetics, recent studies suggest that modern halogena

257 Following fine-tuning of the anesthetic regime, stimulation elicited large and robust

258 s consistent with the high concentrations of anesthetics required to achieve clinical effects.

259 Anesthetic-resistant mutant strains of Drosophila exhibi

260 Whereas an anesthetic response is typically observed in the absence

261 values similar to those of the dissociative anesthetic (S)-(+)-ketamine.

262 Anesthetic action is also related to an anesthetic's hydrophobicity, permanent dipole, and polar

263 on method that permitted localization of the anesthetic-sensitive neurons with much improved spatial

264 Interestingly, we show that anesthetics share with the antagonist A-967079 a potenti

265 th other substrates, which suggests that the anesthetic site is either created or stabilized in enzym

266 rophysiologic-based strategies for pediatric anesthetic state monitoring.

267 abilizes, but does not fully antagonize, the anesthetic state, thus priming the brain for anesthetic

268 ates arousal and may have effects on general anesthetic state.

269 e complete mechanistic underpinnings for the anesthetic state.

270 These sites did not bind the anesthetic steroid alphaxalone, which enhanced photolabe

271 hysiology measurements suggest that volatile anesthetics such as isoflurane inhibit NaV by stabilizin

272 We demonstrated in the past that volatile anesthetics such as sevoflurane attenuate ischemia-reper

273 sults suggest that propofol and other common anesthetics, such as etomidate and ketamine, may target

274 General anesthetics suppress CNS activity by modulating the func

275 nical outcome measurement and a surrogate of anesthetic/surgical care quality.

276 sult in high plasma concentrations and local anesthetic systemic toxicity.

277 lecular motors have received no attention as anesthetic targets.

278 igns, and the ability to contact surgical or anesthetic teams outside of the theater via telephone.

279 roups (a TAP block and PILA) with a standard anesthetic technique with no regional technique (control

280 Dexmedetomidine is an anesthetic that alters the level of arousal by selective

281 Propofol, a general anesthetic that binds to GABAAR intersubunit sites, inhi

282 mal bupivacaine is a novel extended-duration anesthetic that has recently been used for local infiltr

283 Propofol is an intravenous anesthetic that produces its anesthetic effect, largely

284 arbiturate, [(3)H]R-mTFD-MPAB, photoreactive anesthetics that bind with high selectivity to distinct

285 ion of brexanolone response during and after anesthetic third-line agent (TLA) weaning.

286 channel function is activated by halogenated anesthetics through binding at a putative anesthetic-bin

287 ropofol is the most widely used i.v. general anesthetic to induce and maintain anesthesia.

288 resulting from adsorption of agonist and/or anesthetic to the bilayer in which the protein is embedd

289 Finally, asymmetric binding patterns of anesthetic to the channel were found to promote an iris-

290 The addition of steroids and/or anesthetics to gadolinium solutions for MR arthrography

291 Importantly, the early anesthetic treatment also reduced the subsequent escape

292 This effect was blocked by brief anesthetic treatment that prevented development of nocic

293 tinues or recurs despite 24 hours or more of anesthetic treatment.

294 f valve, imaging modalities, and the type of anesthetic used for the procedure.

295 nimize POCD in the choice and development of anesthetics used during surgeries for patients suffering

296 The mechanisms by which volatile anesthetics (VAs) produce their effects (loss of conscio

297 me the world's most popular volatile general anesthetic (VGA) before being abandoned because of its l

298 blood sample that was taken while a general anesthetic was administered.

299 errupted by propofol, an intravenous general anesthetic with putative actions on the inhibitory GABAA

300 ght (sitting), after instillation of topical anesthetic, with either the Icare PRO or the Tono-Pen fi