ライフサイエンスコーパス: aneuploid cell

1 ogy, we identified mechanisms that eliminate aneuploid cells.

2 into the underlying molecular physiology of aneuploid cells.

3 in vivo, mechanisms exist to select against aneuploid cells.

4 polyploid cells is error-prone and produces aneuploid cells.

5 rturbed condensation similar to that seen in aneuploid cells.

6 les can predict protein level attenuation in aneuploid cells.

7 lantation embryos are mosaics of euploid and aneuploid cells.

8 in aggregates accumulate within lysosomes in aneuploid cells.

9 nuously elevated levels of DNA damage affect aneuploid cells.

10 wild-type p53 suppresses the accumulation of aneuploid cells.

11 and cell proliferation were downregulated in aneuploid cells.

12 owever, these models are based on studies in aneuploid cells.

13 cytokinesis, and formation of polyploid and aneuploid cells.

14 these genes are involved in the survival of aneuploid cells.

15 its traits that are shared between different aneuploid cells.

16 checkpoint activity and high percentages of aneuploid cells.

17 7 was used to identify small populations of aneuploid cells.

18 s in the formation of tetraploid rather than aneuploid cells.

19 ptosis, leading to a greater accumulation of aneuploid cells.

20 regated during cell division, giving rise to aneuploid cells.

21 ith a marked decrease in the accumulation of aneuploid cells.

22 multiple levels to prevent the formation of aneuploid cells, a phenotype frequently observed in canc

23 21WAF1/CIP1-infected cells and inhibition of aneuploid cell accumulation; and an alteration of the ma

24 Aneuploid cells activate the transcription factor TFEB,

25 nown exceptions to the involvement of p53 in aneuploid cells and that tissue context may be important

26 To determine the fate of aneuploid cells and the developmental potential of mosai

27 depletion also resulted in the appearance of aneuploid cells and the formation of internuclear chroma

28 aurora result in the generation of severely aneuploid cells and, in the case of aurora, monopolar sp

29 of mutability to select specific tumor-prone aneuploid cells, and open unique avenues toward the unde

30 Aneuploid cells are characterized by incomplete chromoso

31 ease of enhanced proliferative capacity, and aneuploid cells are frequently recovered following the e

32 A number of studies indicate that aneuploid cells are present at a high frequency in the b

33 /+ or p53-/-) had an increased percentage of aneuploid cells as well as an increase in cells with sup

34 loid mouse cells could not, we conclude that aneuploid cells become drug resistant via specific chrom

35 that nondisjunction does not directly yield aneuploid cells, but rather tetraploid cells that may su

36 We provide evidence that p21 is activated in aneuploid cells by reactive oxygen species (ROS) and p38

37 Chromosome 21 aneuploid cells constitute approximately 4% of the estim

38 ransplantation therapies in which the use of aneuploid cells could be detrimental.

39 hways that are essential for the survival of aneuploid cells could serve as a new treatment strategy

40 d and euploid cells, reveal that the fate of aneuploid cells depends on lineage: aneuploid cells in t

41 oncluding that nondisjunction does not yield aneuploid cells directly, but instead gives rise to tetr

42 The aneuploid cells display increased chromosomal instabilit

43 the recent observation of inappropriate and aneuploid cell division in cell lines expressing high le

44 ome segregation errors and the appearance of aneuploid cells due to the presence of VirD5 could be vi

45 turn, results in increased apoptosis of the aneuploid cells during subsequent cell division cycles.

46 Aneuploid cells experience a number of stresses that are

47 de screen in yeast to identify a guardian of aneuploid cell fitness conserved across species.

48 dent apoptosis limits the formation of these aneuploid cells following DNA damage.

49 unrestrained propagation of tetraploids into aneuploid cells, further undermines genomic stability an

50 While the aneuploid cells generally display a growth disadvantage

51 Indeed aneuploid cells harbor increased levels of reactive oxyg

52 ss of aneuploid yeast, is a key regulator of aneuploid cell homeostasis.

53 romosomal missegregation and accumulation of aneuploid cells in 53BP1-/- p53+/+ and 53BP1-/- p53-/- t

54 a metaanalysis on gene expression data from aneuploid cells in diverse organisms, including yeast, p

55 tment also reduced the steady-state level of aneuploid cells in HPV-16 E7-expressing cell populations

56 pathway in many tumors, but the presence of aneuploid cells in some normal human and mouse tissues i

57 om death and allowed for the accumulation of aneuploid cells in the epidermis.

58 12 controls revealed a higher proportion of aneuploid cells in the exposed group (median, 18.8% [int

59 fate of aneuploid cells depends on lineage: aneuploid cells in the fetal lineage are eliminated by a

60 Aneuploid cells in these mutant mice are likely eliminat

61 ted against suggests that the persistence of aneuploid cells in tumors requires not only chromosome m

62 icroRNA-based therapeutic strategy to target aneuploid cells in VHL-associated cancers.

63 s were identified with altered expression in aneuploid cells, including overexpression of the cellula

64 e-specific phenotypes and global stresses of aneuploid cells, including oxidative and proteotoxic str

65 We found that aneuploid cells increased in a concentration- and time-d

66 Most solid tumors contain aneuploid cells, indicating that the mitotic checkpoint

67 ggest that the generation and maintenance of aneuploid cells is a widespread, if not universal, prope

68 Notably, the importance of UBP3 in aneuploid cells is conserved.

69 that the fitness ranking between euploid and aneuploid cells is dependent on context and karyotype, p

70 uman tumors, but the molecular physiology of aneuploid cells is not well characterized.

71 Overall, the proportion of aneuploid cells is progressively depleted from the blast

72 more find that although DNA damage is low in aneuploid cells, it nevertheless has dramatic consequenc

73 Cancer cells and aneuploid cell lines can acquire resistance against mult

74 Most of these aneuploid cell lines had rapid proliferation rates and e

75 ckpoint activity, increased mitotic defects, aneuploid cells marked by a specific transcriptional sig

76 early human embryo, including management of aneuploid cells, may paradoxically promote embryo develo

77 However, aneuploid cells might instead be glia, nonneural, or dyi

78 totic centrosomes, may induce an increase of aneuploid cell population and contribute to tumorigenesi

79 neuploidy in 13 of 15 patients (87%) who had aneuploid cell populations detected in premalignant epit

80 on status of the p16 promoter in flow-sorted aneuploid cell populations from 21 patients with premali

81 Aneuploid cell populations from 32 patients with Barrett

82 e patients (75%) had allelic loss at 9p21 in aneuploid cell populations.

83 ploid) cell fractions, and the appearance of aneuploid cell populations.

84 eattachment defect, and selective removal of aneuploid cell populations.

85 alysis confirmed the presence of significant aneuploid cell populations.

86 ntaneous chromosome missegregation events in aneuploid cells promote chromosomal instability (CIN) th

87 The mutation rates of aneuploid cells ranged from 10(-4) to 10(-6), but no dru

88 cells was observed in confluent cultures in aneuploid cells relative to their diploid counterparts.

89 chromosome 3q that occurs in HPV16-infected, aneuploid cells represents a pivotal genetic aberration

90 The aneuploid cells result from aberrant mitosis as multipol

91 in cells undergoing mitotic slippage and in aneuploid cells resulting from aberrant mitosis.

92 eight-cell division, we efficiently generate aneuploid cells, resulting in embryo death during peri-i

93 cription of metabolic genes, consistent with aneuploid cell state.

94 Flow cytometry revealed emergence of an aneuploid cell subpopulation.

95 lic conditional gene knockouts in diploid or aneuploid cells, such as pluripotent stem cells, 3D orga

96 e demonstrate that certain drugs that act on aneuploid cells synergize with inhibitors of Aurora B to

97 Our results suggest that aneuploid cells that accumulate during aging in some mam

98 nerate a diverse population of proliferative aneuploid cells that have the potential to contribute to

99 and a 70-gene signature derived from primary aneuploid cells was defined as a strong predictor of inc

100 We also found that many of these aneuploid cells were able to continue to grow and form c

101 chromosome missegregation rates to generate aneuploid cells with CIN.

102 The existence of aneuploid cells within the mammalian brain has suggested

103 sely resembles the stressed state of primary aneuploid cells, yet CIN is not benign; a subset of gene